CL2013000709A1 - Composicion que contiene nifurtimox y un antihelmintico seleccionado de: pf1022, emopdepsido, tribendimidina, amidantel, bay d 9216, praziquantel o benzoato de bencilo; util en el tratamiento de enfermedades causadas por giardias (div. sol. 1577-10). - Google Patents

Composicion que contiene nifurtimox y un antihelmintico seleccionado de: pf1022, emopdepsido, tribendimidina, amidantel, bay d 9216, praziquantel o benzoato de bencilo; util en el tratamiento de enfermedades causadas por giardias (div. sol. 1577-10).

Info

Publication number: CL2013000709A1
Authority: CL; Chile
Prior art keywords: emopdepside; giardias; amidantel; tribendimidine; praziquantel
Prior art date: 2008-07-02

Application number

CL2013000709A

Other languages

English (en)

Inventor

Gisela Greif

Achim Harder

Gabriele Petry

Eva-Maria Kruedewagen

Thomas Bach

Original Assignee

Bayer Animal Health Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-07-02

Filing date

2013-03-15

Publication date

2013-08-23

2013-03-15 Application filed by Bayer Animal Health Gmbh filed Critical Bayer Animal Health Gmbh

2013-03-15 Priority to CL2013000709A priority Critical patent/CL2013000709A1/es

2013-08-23 Publication of CL2013000709A1 publication Critical patent/CL2013000709A1/es

Links

SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 title 2
FSVJFNAIGNNGKK-UHFFFAOYSA-N 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one Chemical compound C1C(C2=CC=CC=C2CC2)N2C(=O)CN1C(=O)C1CCCCC1 FSVJFNAIGNNGKK-UHFFFAOYSA-N 0.000 title 1
241000224466 Giardia Species 0.000 title 1
ARFHIAQFJWUCFH-IZZDOVSWSA-N Nifurtimox Chemical compound CC1CS(=O)(=O)CCN1\N=C\C1=CC=C([N+]([O-])=O)O1 ARFHIAQFJWUCFH-IZZDOVSWSA-N 0.000 title 1
229950004370 amidantel Drugs 0.000 title 1
230000000507 anthelmentic effect Effects 0.000 title 1
229960002903 benzyl benzoate Drugs 0.000 title 1
MKFMTNNOZQXQBP-UVTDQMKNSA-N chembl2105966 Chemical compound COCC(=O)NC1=CC=C(\N=C(\C)N(C)C)C=C1 MKFMTNNOZQXQBP-UVTDQMKNSA-N 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
JUUCSAKZQUXQQB-UHFFFAOYSA-N n'-(4-aminophenyl)-n,n-dimethylethanimidamide Chemical compound CN(C)C(C)=NC1=CC=C(N)C=C1 JUUCSAKZQUXQQB-UHFFFAOYSA-N 0.000 title 1
229960002644 nifurtimox Drugs 0.000 title 1
229960002957 praziquantel Drugs 0.000 title 1
XOIOGKHKNQYULW-HTNNXBMUSA-N tribendimidine Chemical compound C1=CC(/N=C(\C)N(C)C)=CC=C1\N=C\C(C=C1)=CC=C1\C=N\C1=CC=C(\N=C(/C)N(C)C)C=C1 XOIOGKHKNQYULW-HTNNXBMUSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Tropical Medicine & Parasitology (AREA)
Dispersion Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Fodder In General (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Catching Or Destruction (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

CL2013000709A 2008-07-02 2013-03-15 Composicion que contiene nifurtimox y un antihelmintico seleccionado de: pf1022, emopdepsido, tribendimidina, amidantel, bay d 9216, praziquantel o benzoato de bencilo; util en el tratamiento de enfermedades causadas por giardias (div. sol. 1577-10). CL2013000709A1 (es)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CL2013000709A CL2013000709A1 (es)	2008-07-02	2013-03-15	Composicion que contiene nifurtimox y un antihelmintico seleccionado de: pf1022, emopdepsido, tribendimidina, amidantel, bay d 9216, praziquantel o benzoato de bencilo; util en el tratamiento de enfermedades causadas por giardias (div. sol. 1577-10).

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE102008031284A DE102008031284A1 (de)	2008-07-02	2008-07-02	Neue Bekämpfungsmöglichkeit der Giardiose
CL2010001577A CL2010001577A1 (es)	2008-07-02	2010-12-27	Uso de nifurtimox para preparar un medicamento util en el tratamiento de enfermedades causadas por giardias.
CL2013000709A CL2013000709A1 (es)	2008-07-02	2013-03-15	Composicion que contiene nifurtimox y un antihelmintico seleccionado de: pf1022, emopdepsido, tribendimidina, amidantel, bay d 9216, praziquantel o benzoato de bencilo; util en el tratamiento de enfermedades causadas por giardias (div. sol. 1577-10).

Publications (1)

Publication Number	Publication Date
CL2013000709A1 true CL2013000709A1 (es)	2013-08-23

Family

ID=41077987

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CL2010001577A CL2010001577A1 (es)	2008-07-02	2010-12-27	Uso de nifurtimox para preparar un medicamento util en el tratamiento de enfermedades causadas por giardias.
CL2013000709A CL2013000709A1 (es)	2008-07-02	2013-03-15	Composicion que contiene nifurtimox y un antihelmintico seleccionado de: pf1022, emopdepsido, tribendimidina, amidantel, bay d 9216, praziquantel o benzoato de bencilo; util en el tratamiento de enfermedades causadas por giardias (div. sol. 1577-10).

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
CL2010001577A CL2010001577A1 (es)	2008-07-02	2010-12-27	Uso de nifurtimox para preparar un medicamento util en el tratamiento de enfermedades causadas por giardias.

Country Status (29)

Country	Link
US (1)	US8440612B2 (es)
EP (1)	EP2310018B1 (es)
JP (1)	JP5627579B2 (es)
KR (1)	KR101720805B1 (es)
CN (1)	CN102083441B (es)
AR (1)	AR072425A1 (es)
AU (1)	AU2009266125B2 (es)
BR (1)	BRPI0913889B1 (es)
CA (1)	CA2729730C (es)
CL (2)	CL2010001577A1 (es)
CO (1)	CO6321270A2 (es)
CR (1)	CR20110022A (es)
DE (1)	DE102008031284A1 (es)
DK (1)	DK2310018T3 (es)
DO (1)	DOP2010000405A (es)
EC (1)	ECSP10010720A (es)
ES (1)	ES2444581T3 (es)
IL (1)	IL209698A (es)
MX (1)	MX2010014446A (es)
MY (1)	MY157007A (es)
NI (1)	NI201100008A (es)
NZ (1)	NZ590276A (es)
PE (1)	PE20110283A1 (es)
PL (1)	PL2310018T3 (es)
RU (1)	RU2538713C9 (es)
SV (1)	SV2011003785A (es)
UA (1)	UA103328C2 (es)
WO (1)	WO2010000399A1 (es)
ZA (1)	ZA201009225B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9173898B2 (en) *	2010-10-12	2015-11-03	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Methods of treating giardiasis
RS62130B1 (sr)	2015-05-20	2021-08-31	Boehringer Ingelheim Animal Health Usa Inc	Antihelmintička depsipeptidna jedinjenja
EP3397638B1 (en)	2015-12-28	2023-08-23	Boehringer Ingelheim Animal Health USA Inc.	Anthelmintic depsipeptide compounds
BR112019009977A2 (pt)	2016-11-16	2019-08-27	Boehringer Ingelheim Animal Health Usa Inc	compostos depsipeptídicos anti-helmínticos
EP3750527A1 (en) *	2019-06-13	2020-12-16	Bayer AG	Stable tablet formulation of nifurtimox and process for producing the same
CN114377018B (zh) *	2020-10-21	2024-02-06	中国医学科学院药物研究所	硝呋莫司在制备抗流感病毒药物中的应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1170957B (de) *	1962-11-23	1964-05-27	Bayer Ag	Verfahren zur Herstellung von 5-Nitro-furfuryliden-(2)-iminoderivaten
JPH081908B2 (ja) *	1987-07-22	1996-01-10	三菱電機株式会社	超格子半導体素子
NO176766C (no) *	1989-02-07	1995-05-24	Meiji Seika Kaisha	Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet
DK0634408T3 (da)	1992-03-17	2002-04-22	Fujisawa Pharmaceutical Co	Depsipeptidderivater, fremstilling og anvendelse deraf
DE4317458A1 (de)	1992-06-11	1993-12-16	Bayer Ag	Verwendung von cyclischen Depsipeptiden mit 18 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 18 Ringatomen und Verfahren zu ihrer Herstellung
CN1073560C (zh)	1993-02-19	2001-10-24	明治制果株式会社	环缩酚酸肽pf1022衍生物
DE4317432A1 (de)	1993-05-26	1994-12-01	Bayer Ag	Octacyclodepsipeptide mit endoparasitizider Wirkung
DE4317457A1 (de)	1993-05-26	1994-12-01	Bayer Ag	Octacyclodepsipeptide mit endoparasitizider Wirkung
EP0718293B1 (en)	1993-09-06	2002-03-13	Fujisawa Pharmaceutical Co., Ltd.	Cyclodepsipeptide compound
DE4401389A1 (de)	1994-01-19	1995-07-20	Bayer Ag	Verwendung von cyclischen Depsipeptiden mit 12 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 12 Ringatomen und Verfahren zu ihrer Herstellung
DE4406025A1 (de)	1994-02-24	1995-08-31	Bayer Ag	Milchsäure-haltige cyclische Depsipeptide mit 18 Ringatomen als endoparasitizide Mittel und Verfahren zu ihrer Herstellung
DE4437198A1 (de)	1994-10-18	1996-04-25	Bayer Ag	Verfahren zur Sulfonylierung, Sulfenylierung und Phosphorylierung von cyclischen Depsipeptiden
EP0872481B1 (en)	1995-06-30	2009-03-18	Astellas Pharma Inc.	Depsipeptide derivative, process for production thereof, and novel intermediate therefor
DE69634961T2 (de)	1995-09-22	2006-04-20	Bayer Ag	Neue zyklische depsipeptid pf1022 derivate
DE19545639A1 (de)	1995-12-07	1997-06-12	Bayer Ag	Verfahren zur Herstellung von substituierten Arylmilchsäure-haltigen Cyclodepsipeptiden mit 24 Ringatomen
US6503881B2 (en)	1996-08-21	2003-01-07	Micrologix Biotech Inc.	Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
US5874630A (en) *	1998-01-06	1999-02-23	Occidental Chemical Corporation	Synthesis of mercaptans from alcohols
US6133228A (en) *	1998-05-28	2000-10-17	Firmenich Sa	Slow release of fragrant compounds in perfumery using 2-benzoyl benzoates, 2-alkanoyl benzoates or α-keto esters
DE19828047A1 (de) *	1998-06-24	1999-12-30	Bayer Ag	Substituierte Cyclooctadepsipeptide
WO2006053160A2 (en) *	2004-11-12	2006-05-18	Celgene Corporation	Methods and compositions using immunomodulatory compounds for treatment and management of parasitic diseases
DE102005033496A1 (de)	2005-07-19	2007-01-25	Bayer Healthcare Ag	Desinfektionsmittel

2008
- 2008-07-02 DE DE102008031284A patent/DE102008031284A1/de not_active Withdrawn
2009
- 2009-06-20 WO PCT/EP2009/004475 patent/WO2010000399A1/de not_active Ceased
- 2009-06-20 RU RU2011103475/15A patent/RU2538713C9/ru not_active IP Right Cessation
- 2009-06-20 US US13/000,715 patent/US8440612B2/en not_active Expired - Fee Related
- 2009-06-20 MY MYPI2010006319A patent/MY157007A/en unknown
- 2009-06-20 BR BRPI0913889A patent/BRPI0913889B1/pt not_active IP Right Cessation
- 2009-06-20 KR KR1020117002111A patent/KR101720805B1/ko not_active Expired - Fee Related
- 2009-06-20 CA CA2729730A patent/CA2729730C/en not_active Expired - Fee Related
- 2009-06-20 AU AU2009266125A patent/AU2009266125B2/en not_active Ceased
- 2009-06-20 CN CN2009801255081A patent/CN102083441B/zh not_active Expired - Fee Related
- 2009-06-20 PE PE2010001201A patent/PE20110283A1/es not_active Application Discontinuation
- 2009-06-20 JP JP2011515179A patent/JP5627579B2/ja not_active Expired - Fee Related
- 2009-06-20 MX MX2010014446A patent/MX2010014446A/es active IP Right Grant
- 2009-06-20 PL PL09772099T patent/PL2310018T3/pl unknown
- 2009-06-20 DK DK09772099.9T patent/DK2310018T3/da active
- 2009-06-20 EP EP09772099.9A patent/EP2310018B1/de not_active Not-in-force
- 2009-06-20 NZ NZ590276A patent/NZ590276A/xx not_active IP Right Cessation
- 2009-06-20 UA UAA201101135A patent/UA103328C2/uk unknown
- 2009-06-20 ES ES09772099.9T patent/ES2444581T3/es active Active
- 2009-06-30 AR ARP090102439A patent/AR072425A1/es not_active Application Discontinuation
2010
- 2010-12-01 IL IL209698A patent/IL209698A/en active IP Right Grant
- 2010-12-22 ZA ZA2010/09225A patent/ZA201009225B/en unknown
- 2010-12-27 CO CO10162857A patent/CO6321270A2/es active IP Right Grant
- 2010-12-27 CL CL2010001577A patent/CL2010001577A1/es unknown
- 2010-12-27 DO DO2010000405A patent/DOP2010000405A/es unknown
- 2010-12-27 EC EC2010010720A patent/ECSP10010720A/es unknown
2011
- 2011-01-03 SV SV2011003785A patent/SV2011003785A/es active IP Right Grant
- 2011-01-05 NI NI201100008A patent/NI201100008A/es unknown
- 2011-01-11 CR CR20110022A patent/CR20110022A/es unknown
2013
- 2013-03-15 CL CL2013000709A patent/CL2013000709A1/es unknown

Also Published As

Publication number	Publication date
HK1158113A1 (en)	2012-07-13
CO6321270A2 (es)	2011-09-20
CR20110022A (es)	2011-05-10
IL209698A0 (en)	2011-02-28
ZA201009225B (en)	2012-03-28
US20110105388A1 (en)	2011-05-05
ECSP10010720A (es)	2011-01-31
EP2310018B1 (de)	2013-12-18
CN102083441A (zh)	2011-06-01
BRPI0913889B1 (pt)	2019-02-05
PL2310018T3 (pl)	2014-05-30
RU2538713C9 (ru)	2015-08-20
JP2011526265A (ja)	2011-10-06
UA103328C2 (uk)	2013-10-10
PE20110283A1 (es)	2011-05-07
NI201100008A (es)	2011-08-10
CA2729730C (en)	2016-03-22
DOP2010000405A (es)	2011-01-15
RU2011103475A (ru)	2012-08-10
KR101720805B1 (ko)	2017-03-28
BRPI0913889A2 (pt)	2015-10-27
WO2010000399A1 (de)	2010-01-07
DK2310018T3 (da)	2014-03-24
AU2009266125A1 (en)	2010-01-07
CA2729730A1 (en)	2010-01-07
NZ590276A (en)	2012-12-21
JP5627579B2 (ja)	2014-11-19
DE102008031284A1 (de)	2010-01-07
ES2444581T3 (es)	2014-02-25
EP2310018A1 (de)	2011-04-20
MY157007A (en)	2016-04-15
AU2009266125B2 (en)	2015-06-04
IL209698A (en)	2016-03-31
US8440612B2 (en)	2013-05-14
RU2538713C2 (ru)	2015-01-10
AR072425A1 (es)	2010-08-25
CL2010001577A1 (es)	2011-05-06
MX2010014446A (es)	2011-02-22
KR20110031357A (ko)	2011-03-25
SV2011003785A (es)	2011-05-20
CN102083441B (zh)	2013-07-24

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