CL2014000007A1 - Compuestos derivados de oxazol y tiazol, inhibidores selectivos de proteinas quinasas; composicion farmaceutica; combinacion farmaceutica; su uso en el tratamiento de enfermedades tales como mastocitosis, neoplasia hematologica, trastorno mieloproliferativo, enfermedad autoinmune, enfermedad inflamatoria, alergias o enfermedad neurologica. - Google Patents
Compuestos derivados de oxazol y tiazol, inhibidores selectivos de proteinas quinasas; composicion farmaceutica; combinacion farmaceutica; su uso en el tratamiento de enfermedades tales como mastocitosis, neoplasia hematologica, trastorno mieloproliferativo, enfermedad autoinmune, enfermedad inflamatoria, alergias o enfermedad neurologica.Info
- Publication number
- CL2014000007A1 CL2014000007A1 CL2014000007A CL2014000007A CL2014000007A1 CL 2014000007 A1 CL2014000007 A1 CL 2014000007A1 CL 2014000007 A CL2014000007 A CL 2014000007A CL 2014000007 A CL2014000007 A CL 2014000007A CL 2014000007 A1 CL2014000007 A1 CL 2014000007A1
- Authority
- CL
- Chile
- Prior art keywords
- disease
- mastocytosis
- oxazol
- allergies
- thiazole
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 206010020751 Hypersensitivity Diseases 0.000 title 1
- 208000014767 Myeloproliferative disease Diseases 0.000 title 1
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 208000012902 Nervous system disease Diseases 0.000 title 1
- 208000025966 Neurological disease Diseases 0.000 title 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 title 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 title 1
- 230000007815 allergy Effects 0.000 title 1
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002489 hematologic effect Effects 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 208000008585 mastocytosis Diseases 0.000 title 1
- 230000009826 neoplastic cell growth Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
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- Psychology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161512165P | 2011-07-27 | 2011-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014000007A1 true CL2014000007A1 (es) | 2014-09-05 |
Family
ID=46601793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014000007A CL2014000007A1 (es) | 2011-07-27 | 2014-01-03 | Compuestos derivados de oxazol y tiazol, inhibidores selectivos de proteinas quinasas; composicion farmaceutica; combinacion farmaceutica; su uso en el tratamiento de enfermedades tales como mastocitosis, neoplasia hematologica, trastorno mieloproliferativo, enfermedad autoinmune, enfermedad inflamatoria, alergias o enfermedad neurologica. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9168245B2 (es) |
| EP (1) | EP2736904B1 (es) |
| JP (1) | JP5944503B2 (es) |
| KR (1) | KR101924247B1 (es) |
| CN (1) | CN103717591B (es) |
| AR (1) | AR087354A1 (es) |
| AU (1) | AU2012288900B2 (es) |
| BR (1) | BR112014001977A2 (es) |
| CA (1) | CA2840029C (es) |
| CL (1) | CL2014000007A1 (es) |
| ES (1) | ES2573831T3 (es) |
| IL (1) | IL230504A0 (es) |
| MX (1) | MX2014001079A (es) |
| PH (1) | PH12014500168A1 (es) |
| RU (1) | RU2612972C2 (es) |
| TW (1) | TW201311676A (es) |
| WO (1) | WO2013014170A1 (es) |
| ZA (1) | ZA201400465B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2796276T3 (es) | 2015-02-05 | 2020-11-26 | Ab Science | Compuestos con actividad antitumoral |
| WO2018106643A1 (en) * | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| TWI667236B (zh) * | 2017-06-13 | 2019-08-01 | 財團法人國家衛生研究院 | 作為蛋白激酶抑制劑的胺基噻唑化合物 |
| WO2019164996A1 (en) * | 2018-02-21 | 2019-08-29 | Southern Research Institute | 2-aminoaryl-5-aryloxazole analogs for the treatment of neurodegenerative diseases |
| US11718593B2 (en) | 2018-05-17 | 2023-08-08 | Southern Research Institute | 2,5-aryl-thiazole analogs for the treatment of neurodegenerative diseases |
| EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
| US20220265670A1 (en) * | 2019-05-22 | 2022-08-25 | Ac Bioscience Sa | Composition and use thereof for the treatment of cutaneous mastocytosis |
| CN111718310B (zh) * | 2019-08-19 | 2021-06-11 | 中国药科大学 | 苯基取代的五元杂环类化合物及其制备方法、用途和药物组合物 |
| TW202126306A (zh) * | 2019-10-04 | 2021-07-16 | 美商纜圖藥品公司 | 嗜酸性球性病症之治療 |
| CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| WO2023205463A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| KR20240127909A (ko) * | 2023-02-16 | 2024-08-23 | (주) 사이러스테라퓨틱스 | Sos1 억제제로서의 아졸릴피리딘 피리다지논 아미드 |
| WO2024175803A1 (en) * | 2023-02-24 | 2024-08-29 | Ab Science | Compounds for treating myeloid diseases with chromosomal abnormalities |
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| US3740420A (en) | 1967-11-28 | 1973-06-19 | Crown Zellerbach Corp | Pharmaceutical compositions with dimethyl sulfoxide |
| US3743727A (en) | 1970-11-16 | 1973-07-03 | Crown Zellerbach Corp | Enhancing tissue penetration of certain antimicrobial agents with dimethyl sulfoxide |
| US3989816A (en) | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
| US4405616A (en) | 1975-06-19 | 1983-09-20 | Nelson Research & Development Company | Penetration enhancers for transdermal drug delivery of systemic agents |
| CA1163561A (en) | 1979-11-06 | 1984-03-13 | Cyril Boroda | Preparation containing nitroglycerine and optionally other medicaments and preparation thereof |
| US4460372A (en) | 1981-02-17 | 1984-07-17 | Alza Corporation | Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer |
| US4379454A (en) | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
| US4411893A (en) | 1981-08-14 | 1983-10-25 | Minnesota Mining And Manufacturing Company | Topical medicament preparations |
| CA1236029A (en) | 1984-05-14 | 1988-05-03 | Edmund Sandborn | Pharmaceutical solutions comprising dimethyl sulfoxide |
| US4615699A (en) | 1985-05-03 | 1986-10-07 | Alza Corporation | Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes |
| DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
| US5906202A (en) | 1996-11-21 | 1999-05-25 | Aradigm Corporation | Device and method for directing aerosolized mist to a specific area of the respiratory tract |
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| US20040266797A1 (en) | 2001-06-29 | 2004-12-30 | Alain Moussy | Use of potent,selective and non toxic c-kit inhibitors for treating tumor angiogensis |
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| JP2004537542A (ja) | 2001-06-29 | 2004-12-16 | アブ サイエンス | 炎症性腸疾患（ｉｂｄ）を治療するための、チロシンキナーゼ阻害剤の使用 |
| US20040259892A1 (en) | 2001-06-29 | 2004-12-23 | Alain Moussy | Use of tyrosine kinase inhibitors for treating multiple sclerosis (ms) |
| WO2003002109A2 (en) | 2001-06-29 | 2003-01-09 | Ab Science | Use of tyrosine kinase inhibitors for treating autoimmune diseases |
| ES2274993T3 (es) | 2001-06-29 | 2007-06-01 | Ab Science | Utilizacion de inhibidores de tirosina cinasa para el tratamiento de enfermedades alergicas. |
| EP1401429A2 (en) | 2001-06-29 | 2004-03-31 | AB Science | Use of potent, selective and non toxic c-kit inhibitors for treating mastocytosis |
| ATE388711T1 (de) | 2001-09-20 | 2008-03-15 | Ab Science | C-kithemmer zur behandlung von bakteriellen infektionen |
| EP1427422A1 (en) | 2001-09-20 | 2004-06-16 | AB Science | Use of tyrosine kinase inhibitors for whitening human skin and treating melanocyte dysfunction associated diseases |
| EP1461032B1 (en) | 2001-09-20 | 2008-07-16 | AB Science | Use of c-kit inhibitors for promoting hair growth |
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| ATE508747T1 (de) | 2003-03-10 | 2011-05-15 | Eisai R&D Man Co Ltd | C-kit kinase-hemmer |
| EP1684750B1 (en) * | 2003-10-23 | 2010-04-28 | AB Science | 2-aminoaryloxazole compounds as tyrosine kinase inhibitors |
| GB0325031D0 (en) | 2003-10-27 | 2003-12-03 | Novartis Ag | Organic compounds |
| CA2554925A1 (en) * | 2004-01-30 | 2005-08-11 | Ab Science | 2-(3-substituted-aryl)amino-4-aryl-thiazoles as tyrosine kinase inhibitors |
| WO2006106437A2 (en) * | 2005-04-04 | 2006-10-12 | Ab Science | Substituted oxazole derivatives and their use as tyrosine kinase inhibitors |
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-
2012
- 2012-07-24 CN CN201280037457.9A patent/CN103717591B/zh not_active Expired - Fee Related
- 2012-07-24 EP EP12741307.8A patent/EP2736904B1/en not_active Not-in-force
- 2012-07-24 JP JP2014522071A patent/JP5944503B2/ja not_active Expired - Fee Related
- 2012-07-24 AU AU2012288900A patent/AU2012288900B2/en not_active Ceased
- 2012-07-24 RU RU2014107463A patent/RU2612972C2/ru active
- 2012-07-24 US US14/234,935 patent/US9168245B2/en not_active Expired - Fee Related
- 2012-07-24 MX MX2014001079A patent/MX2014001079A/es not_active Application Discontinuation
- 2012-07-24 BR BR112014001977A patent/BR112014001977A2/pt not_active IP Right Cessation
- 2012-07-24 PH PH1/2014/500168A patent/PH12014500168A1/en unknown
- 2012-07-24 WO PCT/EP2012/064539 patent/WO2013014170A1/en not_active Ceased
- 2012-07-24 ES ES12741307.8T patent/ES2573831T3/es active Active
- 2012-07-24 KR KR1020137034946A patent/KR101924247B1/ko not_active Expired - Fee Related
- 2012-07-24 CA CA2840029A patent/CA2840029C/en not_active Expired - Fee Related
- 2012-07-27 AR ARP120102736A patent/AR087354A1/es unknown
- 2012-07-27 TW TW101127351A patent/TW201311676A/zh unknown
-
2014
- 2014-01-03 CL CL2014000007A patent/CL2014000007A1/es unknown
- 2014-01-16 IL IL230504A patent/IL230504A0/en active IP Right Grant
- 2014-01-20 ZA ZA2014/00465A patent/ZA201400465B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012288900A1 (en) | 2014-01-16 |
| CN103717591A (zh) | 2014-04-09 |
| AR087354A1 (es) | 2014-03-19 |
| CA2840029A1 (en) | 2013-01-31 |
| EP2736904B1 (en) | 2016-03-16 |
| AU2012288900B2 (en) | 2016-10-06 |
| TW201311676A (zh) | 2013-03-16 |
| MX2014001079A (es) | 2014-09-12 |
| ZA201400465B (en) | 2015-04-29 |
| JP5944503B2 (ja) | 2016-07-05 |
| RU2014107463A (ru) | 2015-09-10 |
| US20140179698A1 (en) | 2014-06-26 |
| ES2573831T3 (es) | 2016-06-10 |
| NZ618953A (en) | 2015-05-29 |
| EP2736904A1 (en) | 2014-06-04 |
| US9168245B2 (en) | 2015-10-27 |
| KR101924247B1 (ko) | 2019-02-22 |
| CN103717591B (zh) | 2016-08-24 |
| CA2840029C (en) | 2021-07-20 |
| WO2013014170A1 (en) | 2013-01-31 |
| IL230504A0 (en) | 2014-03-31 |
| RU2612972C2 (ru) | 2017-03-14 |
| JP2014521624A (ja) | 2014-08-28 |
| KR20140041609A (ko) | 2014-04-04 |
| PH12014500168A1 (en) | 2014-02-24 |
| BR112014001977A2 (pt) | 2017-02-21 |
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