CL2014000496A1 - Uso de 2-hidroxietoxi-amida del acido 6-(4-bromo-2-fluorofenilamini)-7-fluoro-3-metil-3h-benzoimidazol-5-carboxilico para el tratamiento del sindrome de noonan; composicion farmaceutica; y un envase - Google Patents

Uso de 2-hidroxietoxi-amida del acido 6-(4-bromo-2-fluorofenilamini)-7-fluoro-3-metil-3h-benzoimidazol-5-carboxilico para el tratamiento del sindrome de noonan; composicion farmaceutica; y un envase

Info

Publication number
CL2014000496A1
CL2014000496A1 CL2014000496A CL2014000496A CL2014000496A1 CL 2014000496 A1 CL2014000496 A1 CL 2014000496A1 CL 2014000496 A CL2014000496 A CL 2014000496A CL 2014000496 A CL2014000496 A CL 2014000496A CL 2014000496 A1 CL2014000496 A1 CL 2014000496A1
Authority
CL
Chile
Prior art keywords
fluorophenylamini
benzoimidazol
hydroxyethoxy
bromo
fluoro
Prior art date
Application number
CL2014000496A
Other languages
English (en)
Inventor
Jessie Gu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2014000496A1 publication Critical patent/CL2014000496A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CL2014000496A 2011-09-01 2014-02-28 Uso de 2-hidroxietoxi-amida del acido 6-(4-bromo-2-fluorofenilamini)-7-fluoro-3-metil-3h-benzoimidazol-5-carboxilico para el tratamiento del sindrome de noonan; composicion farmaceutica; y un envase CL2014000496A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161530128P 2011-09-01 2011-09-01

Publications (1)

Publication Number Publication Date
CL2014000496A1 true CL2014000496A1 (es) 2014-09-26

Family

ID=46826924

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014000496A CL2014000496A1 (es) 2011-09-01 2014-02-28 Uso de 2-hidroxietoxi-amida del acido 6-(4-bromo-2-fluorofenilamini)-7-fluoro-3-metil-3h-benzoimidazol-5-carboxilico para el tratamiento del sindrome de noonan; composicion farmaceutica; y un envase

Country Status (18)

Country Link
US (2) US9034909B2 (es)
EP (1) EP2750672A1 (es)
JP (1) JP2014528928A (es)
KR (1) KR20140068037A (es)
CN (1) CN103764134A (es)
AU (1) AU2012302106B2 (es)
BR (1) BR112014002885A2 (es)
CA (1) CA2845571A1 (es)
CL (1) CL2014000496A1 (es)
IL (1) IL231126A0 (es)
MA (1) MA35363B1 (es)
MX (1) MX2014002480A (es)
PH (1) PH12014500191A1 (es)
RU (1) RU2014112324A (es)
SG (1) SG2014005029A (es)
TN (1) TN2014000031A1 (es)
WO (1) WO2013033133A1 (es)
ZA (1) ZA201400460B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ586418A (en) 2007-12-19 2012-09-28 Cancer Rec Tech Ltd Pyrido[2,3-b]pyrazine-8-substituted compounds and their use
DK2531502T3 (da) 2010-02-01 2014-05-19 Cancer Rec Tech Ltd 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea og associerede forbindelser og ders anvendelse i terapi
CA3079071C (en) 2012-10-19 2022-06-07 Array Biopharma Inc. Preparation of crystallized benzimidazole derivative as mek inhibitor and formulation comprising same
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
JP6670494B2 (ja) * 2014-10-09 2020-03-25 国立大学法人 東京大学 心筋細胞の製造方法、心室型心筋細胞及びその製造方法、並びにスクリーニング方法
CN109438362B (zh) * 2017-11-14 2020-07-21 深圳市塔吉瑞生物医药有限公司 一种取代的苯并咪唑化合物及包含该化合物的组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG2013013339A (en) * 2002-03-13 2014-12-30 Array Biopharma Inc N3 alkylated benzimidazole derivatives as mek inhibitors
WO2008022335A2 (en) * 2006-08-18 2008-02-21 The Brigham And Women's Hospital, Inc. Diagnosis and treatment of noonan syndrome and neoplastic disorders
WO2009135000A2 (en) * 2008-04-30 2009-11-05 H. Lee Moffitt Cancer Center And Research Institute, Inc. Inhibition of shp2/ptpn11 protein tyrosine phosphatase by nsc-117199 and analogs

Also Published As

Publication number Publication date
MX2014002480A (es) 2014-03-27
JP2014528928A (ja) 2014-10-30
RU2014112324A (ru) 2015-10-10
US20140200249A1 (en) 2014-07-17
AU2012302106B2 (en) 2015-04-09
CN103764134A (zh) 2014-04-30
US20150320725A1 (en) 2015-11-12
IL231126A0 (en) 2014-03-31
CA2845571A1 (en) 2013-03-07
NZ620542A (en) 2014-12-24
TN2014000031A1 (en) 2015-07-01
AU2012302106A1 (en) 2014-03-06
WO2013033133A1 (en) 2013-03-07
BR112014002885A2 (pt) 2017-02-21
US9034909B2 (en) 2015-05-19
ZA201400460B (en) 2014-11-26
PH12014500191A1 (en) 2014-03-03
SG2014005029A (en) 2014-03-28
KR20140068037A (ko) 2014-06-05
MA35363B1 (fr) 2014-08-01
EP2750672A1 (en) 2014-07-09

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