CR20140251A - Inhibidores de pak para el tratamiento del síndrome del x frágil - Google Patents

Inhibidores de pak para el tratamiento del síndrome del x frágil

Info

Publication number
CR20140251A
CR20140251A CR20140251A CR20140251A CR20140251A CR 20140251 A CR20140251 A CR 20140251A CR 20140251 A CR20140251 A CR 20140251A CR 20140251 A CR20140251 A CR 20140251A CR 20140251 A CR20140251 A CR 20140251A
Authority
CR
Costa Rica
Prior art keywords
fragile
syndrome
treatment
pak inhibitors
pak
Prior art date
Application number
CR20140251A
Other languages
English (en)
Inventor
John C Mckew
Wenwei Huang
David Campbell
Sergio G Duron
Mark Behnke
Min Shen
Original Assignee
Afraxis Holdings Inc
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Afraxis Holdings Inc, Us Health filed Critical Afraxis Holdings Inc
Publication of CR20140251A publication Critical patent/CR20140251A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CR20140251A 2011-11-04 2014-05-26 Inhibidores de pak para el tratamiento del síndrome del x frágil CR20140251A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161555902P 2011-11-04 2011-11-04

Publications (1)

Publication Number Publication Date
CR20140251A true CR20140251A (es) 2014-08-20

Family

ID=48192852

Family Applications (2)

Application Number Title Priority Date Filing Date
CR20140251A CR20140251A (es) 2011-11-04 2014-05-26 Inhibidores de pak para el tratamiento del síndrome del x frágil
CR20140250A CR20140250A (es) 2011-11-04 2014-05-26 Inhibidores de pak para el tratamiento de los transtornos de proliferación celular

Family Applications After (1)

Application Number Title Priority Date Filing Date
CR20140250A CR20140250A (es) 2011-11-04 2014-05-26 Inhibidores de pak para el tratamiento de los transtornos de proliferación celular

Country Status (20)

Country Link
US (2) US20130116263A1 (es)
EP (2) EP2773642A1 (es)
JP (2) JP2015501786A (es)
KR (2) KR20140096098A (es)
CN (2) CN104039786A (es)
AR (1) AR089175A1 (es)
AU (2) AU2012327183A1 (es)
BR (2) BR112014010420A2 (es)
CA (2) CA2854462A1 (es)
CL (2) CL2014001131A1 (es)
CO (1) CO7030960A2 (es)
CR (2) CR20140251A (es)
EA (2) EA201490927A1 (es)
IL (2) IL232154A0 (es)
MA (2) MA35660B1 (es)
MX (2) MX2014005296A (es)
PH (2) PH12014500956A1 (es)
SG (2) SG11201401914WA (es)
TW (1) TW201326169A (es)
WO (2) WO2013067434A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130252967A1 (en) * 2010-06-10 2013-09-26 Afraxis, Inc. 8-(sulfonylbenzyl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders
JP6170060B2 (ja) 2011-11-04 2017-07-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規アリール−キノリン誘導体
CA2907243C (en) 2013-03-15 2021-12-28 Celgene Avilomics Research, Inc. Substituted dihydropyrimidopyrimidinone compounds and pharmaceutical compositions thereof use fgfr4 inhibitor
JP6576325B2 (ja) 2013-03-15 2019-09-18 セルジーン シーエーアール エルエルシー ヘテロアリール化合物およびそれらの使用
US9321786B2 (en) 2013-03-15 2016-04-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
TW201516045A (zh) * 2013-07-26 2015-05-01 Hoffmann La Roche 絲胺酸／蘇胺酸激酶抑制劑
EP3102577B1 (en) * 2014-02-07 2018-07-18 Principia Biopharma Inc. Quinolone derivatives as fibroblast growth factor receptor inhibitors
CA2954189A1 (en) 2014-07-26 2016-02-04 Sunshine Lake Pharma Co., Ltd. 2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cdk inhibitors and uses thereof
US20170042806A1 (en) 2015-04-29 2017-02-16 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
EP3416555A1 (en) * 2016-02-17 2018-12-26 Nuralogix Corporation System and method for detecting physiological state
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
EP3475280B1 (en) * 2016-06-23 2020-04-08 H. Hoffnabb-La Roche Ag Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives
US11685954B2 (en) * 2016-07-15 2023-06-27 Dana-Farber Cancer Institute, Inc. Biomarkers predictive of endocrine resistance in breast cancer
CN106818805A (zh) * 2016-12-27 2017-06-13 东莞市联洲知识产权运营管理有限公司 一种天然乙酰胆碱酯酶抑制剂及其杀虫应用
CN107083428B (zh) * 2017-04-10 2020-09-25 徐州医科大学 Pak5在癌症诊断预后治疗及药物筛选中的应用
TWI831829B (zh) 2018-09-12 2024-02-11 美商建南德克公司 苯氧基-吡啶基-嘧啶化合物及使用方法
WO2020086882A1 (en) * 2018-10-24 2020-04-30 Northwestern University Tumor cell aggregation inhibitors' for treating cancer
JP7539892B2 (ja) * 2019-01-03 2024-08-26 ジェネンテック， インコーポレイテッド 癌疾患の処置のためのエンドリボヌクレアーゼのイノシトール要求酵素ｉ（ｉｒｅｉアルファ）の阻害剤としてのピリド－ピリミジノン化合物及びプテリジノン化合物
CN112213400B (zh) * 2019-07-09 2022-06-07 四川弘合生物科技有限公司 一种β-榄香烯及其有关物质的检测方法
CN110496128B (zh) * 2019-09-23 2022-09-30 吉林大学 利培酮或帕潘立酮在制备治疗弥漫性大b细胞淋巴瘤的药物中的应用
JP2023549540A (ja) 2020-11-18 2023-11-27 デシフェラ・ファーマシューティカルズ，エルエルシー Ｇｃｎ２およびｐｅｒｋキナーゼ阻害剤およびその使用方法
CN117858879A (zh) * 2021-01-15 2024-04-09 南京再明医药有限公司 Cdk2/4/6抑制剂及其制备方法和应用
CN113046323A (zh) * 2021-04-02 2021-06-29 四川农业大学 一种基于miR-532-5p及其靶基因调控卵巢颗粒细胞的方法
PE20250609A1 (es) 2021-12-03 2025-02-26 Deciphera Pharmaceuticals Llc Inhibidores de gcn2 y perk quinasa y metodos de uso de los mismos
WO2025257301A1 (en) * 2024-06-13 2025-12-18 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Treatment of neurofibromatosis type 2 by inhibitors of g6pd, acsl3 and/or oxsm

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1201765A3 (en) * 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Cellular kinases involved in cytomegalovirus infection and their inhibition
WO2008055842A1 (en) * 2006-11-09 2008-05-15 F. Hoffmann-La Roche Ag Substituted 6-phenyl-pyrido [2,3-d] pyrimidin-7-one derivatives as kinase inhibitors and methods for using the same
EP2112150B1 (en) * 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Improved raf inhibitors
WO2010071846A2 (en) * 2008-12-19 2010-06-24 Afraxis, Inc. Compounds for treating neuropsychiatric conditions
EP2486037A4 (en) * 2009-10-09 2013-01-16 Afraxis Inc 8-ETHYL-6- (ARYL) PYRIDO [2,3-D] PYRIMIDIN-7 (8H) -ONES FOR THE TREATMENT OF CNS DISORDERS
EP2580214A4 (en) * 2010-06-09 2013-12-04 Afraxis Holdings Inc 8- (SULFONYLARYL) PYRIDO [2,3-D] PYRIMIDIN-7 (8H) -ONES FOR THE TREATMENT OF CNS DISORDERS
US20130252967A1 (en) * 2010-06-10 2013-09-26 Afraxis, Inc. 8-(sulfonylbenzyl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders

Also Published As

Publication number Publication date
JP2014532724A (ja) 2014-12-08
MX2014005296A (es) 2014-08-27
SG11201401914WA (en) 2014-05-29
EP2773643A1 (en) 2014-09-10
EP2773643A4 (en) 2015-07-29
MA35660B1 (fr) 2014-11-01
AR089175A1 (es) 2014-08-06
MA35661B1 (fr) 2014-11-01
EA201490925A1 (ru) 2014-09-30
SG11201401996TA (en) 2014-05-29
EP2773642A1 (en) 2014-09-10
KR20140096098A (ko) 2014-08-04
AU2012327183A8 (en) 2013-07-18
CN104039786A (zh) 2014-09-10
JP2015501786A (ja) 2015-01-19
AU2012327187A8 (en) 2013-07-25
CN104093717A (zh) 2014-10-08
CR20140250A (es) 2014-08-20
TW201326169A (zh) 2013-07-01
BR112014010420A2 (pt) 2017-04-25
CA2854471A1 (en) 2013-05-10
AU2012327187A1 (en) 2013-05-23
PH12014500956A1 (en) 2014-06-30
CO7030960A2 (es) 2014-08-21
CL2014001132A1 (es) 2014-08-22
US20150031693A1 (en) 2015-01-29
WO2013067423A1 (en) 2013-05-10
BR112014010631A2 (pt) 2017-04-25
EA201490927A1 (ru) 2014-10-30
MX2014005292A (es) 2014-09-11
US20130116263A1 (en) 2013-05-09
PH12014500995A1 (en) 2014-08-04
IL232154A0 (en) 2014-05-28
CA2854462A1 (en) 2013-05-10
WO2013067434A1 (en) 2013-05-10
KR20140105451A (ko) 2014-09-01
IL232215A0 (en) 2014-06-30
AU2012327183A1 (en) 2013-05-30
CL2014001131A1 (es) 2014-08-22

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