CL2014002497A1 - Uso de n4-(4-([1,2,4]triazolo[1,5-a]piridin-7-iloxi)-3-metilfenil)-n6-(4,4-dimetil-4,5-dihidrooxazol-2-il)quinazolina-4,6-diamina o (2-((4-((4-([1,2,4]triazolo[1,5-a]piridin-7-iloxi)-3-metilfenil)amino)quinazolin-6-il)amino)-4-metil-4,5-dihidrooxazol-4-il)metanol para el tratamiento contra el cancer cerebral metastasico o local. - Google Patents

Uso de n4-(4-([1,2,4]triazolo[1,5-a]piridin-7-iloxi)-3-metilfenil)-n6-(4,4-dimetil-4,5-dihidrooxazol-2-il)quinazolina-4,6-diamina o (2-((4-((4-([1,2,4]triazolo[1,5-a]piridin-7-iloxi)-3-metilfenil)amino)quinazolin-6-il)amino)-4-metil-4,5-dihidrooxazol-4-il)metanol para el tratamiento contra el cancer cerebral metastasico o local.

Info

Publication number: CL2014002497A1
Authority: CL; Chile
Prior art keywords: dihydrooxazol; triazolo; yloxy; pyridin; methylphenyl
Prior art date: 2012-03-23

Application number

CL2014002497A

Other languages

English (en)

Inventor

Patrice A Lee

Shannon L Winski

Kevin Koch

Original Assignee

Array Biopharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-03-23

Filing date

2014-09-22

Publication date

2014-11-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48048296&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014002497(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-09-22 Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc

2014-11-14 Publication of CL2014002497A1 publication Critical patent/CL2014002497A1/es

Links

125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 2
-1 4 - ([1,2,4] triazolo [1,5-a] pyridin-7-yloxy) -3-methylphenyl Chemical group 0.000 title 1
SDEAXTCZPQIFQM-UHFFFAOYSA-N 6-n-(4,4-dimethyl-5h-1,3-oxazol-2-yl)-4-n-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]quinazoline-4,6-diamine Chemical compound C=1C=C(OC2=CC3=NC=NN3C=C2)C(C)=CC=1NC(C1=C2)=NC=NC1=CC=C2NC1=NC(C)(C)CO1 SDEAXTCZPQIFQM-UHFFFAOYSA-N 0.000 title 1
208000003174 Brain Neoplasms Diseases 0.000 title 1
230000001394 metastastic effect Effects 0.000 title 1
206010061289 metastatic neoplasm Diseases 0.000 title 1
125000004547 quinazolin-6-yl group Chemical group N1=CN=CC2=CC(=CC=C12)* 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Mycology (AREA)
Microbiology (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)

CL2014002497A 2012-03-23 2014-09-22 Uso de n4-(4-([1,2,4]triazolo[1,5-a]piridin-7-iloxi)-3-metilfenil)-n6-(4,4-dimetil-4,5-dihidrooxazol-2-il)quinazolina-4,6-diamina o (2-((4-((4-([1,2,4]triazolo[1,5-a]piridin-7-iloxi)-3-metilfenil)amino)quinazolin-6-il)amino)-4-metil-4,5-dihidrooxazol-4-il)metanol para el tratamiento contra el cancer cerebral metastasico o local. CL2014002497A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201261615082P	2012-03-23	2012-03-23

Publications (1)

Publication Number	Publication Date
CL2014002497A1 true CL2014002497A1 (es)	2014-11-14

Family

ID=48048296

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL2014002497A CL2014002497A1 (es)	2012-03-23	2014-09-22	Uso de n4-(4-([1,2,4]triazolo[1,5-a]piridin-7-iloxi)-3-metilfenil)-n6-(4,4-dimetil-4,5-dihidrooxazol-2-il)quinazolina-4,6-diamina o (2-((4-((4-([1,2,4]triazolo[1,5-a]piridin-7-iloxi)-3-metilfenil)amino)quinazolin-6-il)amino)-4-metil-4,5-dihidrooxazol-4-il)metanol para el tratamiento contra el cancer cerebral metastasico o local.

Country Status (30)

Country	Link
US (3)	US20150110780A1 (es)
EP (4)	EP4252855A3 (es)
JP (6)	JP2015514075A (es)
KR (3)	KR102490961B1 (es)
CN (2)	CN104203279B (es)
AU (4)	AU2013234921A1 (es)
CA (1)	CA2867723C (es)
CL (1)	CL2014002497A1 (es)
CO (1)	CO7071139A2 (es)
CY (2)	CY1120204T1 (es)
DK (2)	DK3400943T3 (es)
ES (2)	ES2673165T3 (es)
HR (1)	HRP20180659T1 (es)
HU (2)	HUE053156T2 (es)
IL (3)	IL234627B (es)
LT (1)	LT2827900T (es)
MX (1)	MX354024B (es)
MY (2)	MY202114A (es)
NZ (4)	NZ630843A (es)
PH (2)	PH12021550360A1 (es)
PL (2)	PL3400943T3 (es)
PT (2)	PT2827900T (es)
RS (1)	RS57140B1 (es)
RU (2)	RU2672575C2 (es)
SG (1)	SG11201405954YA (es)
SI (2)	SI2827900T1 (es)
SM (1)	SMT201800251T1 (es)
TR (1)	TR201808450T4 (es)
UA (1)	UA122044C2 (es)
WO (1)	WO2013142875A1 (es)

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RU2629116C2 (ru)	2011-10-14	2017-08-24	Эррэй Биофарма Инк.	Полиморфы arry-380, селективного ингибитора erbb2, и фармацевтические составы, содержащие их
BR122020010643B1 (pt)	2011-10-14	2022-05-17	Array Biopharma Inc	Dispersão sólida, composições farmacêuticas compreendendo a referida dispersão, usos das composições farmacêuticas e processo de preparação de uma dispersão sólida
WO2013142875A1 (en)	2012-03-23	2013-09-26	Array Biopharma Inc.	Treatment of brain cancer
US11078272B2 (en)	2017-03-09	2021-08-03	The Board Of Trustees Of The Leland Stanford Junior University	Treatment of pediatric brain tumors with targeting of CD47 pathway
CA3060407A1 (en)	2017-04-28	2018-11-01	Seattle Genetics, Inc.	Treatment of her2 positive cancers
IL276398B2 (en)	2018-01-31	2026-03-01	Deciphera Pharmaceuticals Llc	Combination therapy for mastocytosis
KR102708177B1 (ko)	2018-01-31	2024-09-23	데시페라 파마슈티칼스, 엘엘씨.	위장관 기질 종양의 치료를 위한 병용 요법
US11298422B2 (en) *	2018-04-09	2022-04-12	Novocure Gmbh	Treating tumors with TTFields and an aurora kinase inhibitor
CN109942576B (zh) *	2019-03-07	2020-09-11	上海工程技术大学	Irbinitinib及中间体的制备方法
EP3938363A1 (en)	2019-03-11	2022-01-19	Teva Pharmaceuticals International GmbH	Solid state forms of ripretinib
CN111825604A (zh) *	2019-04-16	2020-10-27	宁波药腾医药科技有限公司	一种图卡替尼及其中间产物的合成方法
LT4013412T (lt)	2019-08-12	2026-03-25	Deciphera Pharmaceuticals, Llc	Ripretinibas, skirtas virškinamojo trakto stromos navikų gydymui
HRP20231699T1 (hr)	2019-12-30	2024-05-10	Deciphera Pharmaceuticals, Llc	Formulacije inhibitora amorfne kinaze i postupci njihove primjene
CN115243681B (zh)	2019-12-30	2024-08-16	德西费拉制药有限责任公司	1-(4-溴-5-(1-乙基-7-(甲氨基)-2-侧氧基-1,2-二氢-1,6-萘啶-3-基)-2-氟苯基)-3-苯基脲的组合物

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US6350786B1 (en) *	1998-09-22	2002-02-26	Hoffmann-La Roche Inc.	Stable complexes of poorly soluble compounds in ionic polymers
RU2255765C2 (ru) *	2000-01-21	2005-07-10	Чилдренз Хоспитал Лос-Анджелес	Способ ингибирования роста опухолей головного мозга с помощью отобранных антагонистов интегринов
WO2001091794A2 (en)	2000-05-30	2001-12-06	Virginia Commonwealth University	Vitamin d3 analogs as radiosensitizers for the treatment of cancer
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BRPI0511754A (pt)	2004-06-03	2008-01-02	Smithkline Beechman Cork Ltd	uso de um composto ou sais ou solvatos do mesmo
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BR122020010643B1 (pt)	2011-10-14	2022-05-17	Array Biopharma Inc	Dispersão sólida, composições farmacêuticas compreendendo a referida dispersão, usos das composições farmacêuticas e processo de preparação de uma dispersão sólida
WO2013142875A1 (en)	2012-03-23	2013-09-26	Array Biopharma Inc.	Treatment of brain cancer

2013
- 2013-03-25 WO PCT/US2013/033751 patent/WO2013142875A1/en not_active Ceased
- 2013-03-25 PL PL18162971T patent/PL3400943T3/pl unknown
- 2013-03-25 HU HUE18162971A patent/HUE053156T2/hu unknown
- 2013-03-25 PT PT137144978T patent/PT2827900T/pt unknown
- 2013-03-25 PH PH1/2021/550360A patent/PH12021550360A1/en unknown
- 2013-03-25 EP EP23163332.2A patent/EP4252855A3/en not_active Withdrawn
- 2013-03-25 EP EP20210661.3A patent/EP3842044A1/en not_active Withdrawn
- 2013-03-25 DK DK18162971.8T patent/DK3400943T3/da active
- 2013-03-25 EP EP13714497.8A patent/EP2827900B1/en active Active
- 2013-03-25 CN CN201380015856.XA patent/CN104203279B/zh active Active
- 2013-03-25 RS RS20180484A patent/RS57140B1/sr unknown
- 2013-03-25 KR KR1020217033686A patent/KR102490961B1/ko active Active
- 2013-03-25 ES ES13714497.8T patent/ES2673165T3/es active Active
- 2013-03-25 JP JP2015501952A patent/JP2015514075A/ja active Pending
- 2013-03-25 US US14/387,533 patent/US20150110780A1/en not_active Abandoned
- 2013-03-25 NZ NZ630843A patent/NZ630843A/en unknown
- 2013-03-25 DK DK13714497.8T patent/DK2827900T3/en active
- 2013-03-25 SG SG11201405954YA patent/SG11201405954YA/en unknown
- 2013-03-25 SM SM20180251T patent/SMT201800251T1/it unknown
- 2013-03-25 TR TR2018/08450T patent/TR201808450T4/tr unknown
- 2013-03-25 PL PL13714497T patent/PL2827900T3/pl unknown
- 2013-03-25 RU RU2014142700A patent/RU2672575C2/ru active
- 2013-03-25 MY MYPI2019003395A patent/MY202114A/en unknown
- 2013-03-25 AU AU2013234921A patent/AU2013234921A1/en not_active Abandoned
- 2013-03-25 MX MX2014011437A patent/MX354024B/es active IP Right Grant
- 2013-03-25 NZ NZ756264A patent/NZ756264A/en unknown
- 2013-03-25 EP EP18162971.8A patent/EP3400943B1/en not_active Revoked
- 2013-03-25 KR KR1020147029340A patent/KR102160462B1/ko active Active
- 2013-03-25 HU HUE13714497A patent/HUE037966T2/hu unknown
- 2013-03-25 RU RU2018138976A patent/RU2018138976A/ru unknown
- 2013-03-25 SI SI201331019T patent/SI2827900T1/en unknown
- 2013-03-25 HR HRP20180659TT patent/HRP20180659T1/hr unknown
- 2013-03-25 KR KR1020207027176A patent/KR102317166B1/ko active Active
- 2013-03-25 NZ NZ74161513A patent/NZ741615A/en unknown
- 2013-03-25 LT LTEP13714497.8T patent/LT2827900T/lt unknown
- 2013-03-25 CA CA2867723A patent/CA2867723C/en active Active
- 2013-03-25 NZ NZ724544A patent/NZ724544A/en unknown
- 2013-03-25 UA UAA201411479A patent/UA122044C2/uk unknown
- 2013-03-25 PT PT181629718T patent/PT3400943T/pt unknown
- 2013-03-25 MY MYPI2014702686A patent/MY174883A/en unknown
- 2013-03-25 ES ES18162971T patent/ES2855142T3/es active Active
- 2013-03-25 SI SI201331844T patent/SI3400943T1/sl unknown
- 2013-03-25 CN CN201811150918.9A patent/CN109223791A/zh active Pending
2014
- 2014-09-12 PH PH12014502032A patent/PH12014502032A1/en unknown
- 2014-09-14 IL IL234627A patent/IL234627B/en active IP Right Grant
- 2014-09-19 CO CO14208829A patent/CO7071139A2/es unknown
- 2014-09-22 CL CL2014002497A patent/CL2014002497A1/es unknown
2017
- 2017-05-25 JP JP2017103957A patent/JP2017141302A/ja active Pending
- 2017-12-06 AU AU2017272232A patent/AU2017272232C1/en active Active
2018
- 2018-05-14 CY CY20181100493T patent/CY1120204T1/el unknown
- 2018-09-06 IL IL261659A patent/IL261659A/en unknown
2019
- 2019-02-27 JP JP2019034250A patent/JP6898960B2/ja active Active
- 2019-05-02 US US16/402,068 patent/US11504370B2/en active Active
- 2019-05-23 AU AU2019203618A patent/AU2019203618B2/en active Active
- 2019-09-09 IL IL269205A patent/IL269205B/en active IP Right Grant
2021
- 2021-02-16 CY CY20211100126T patent/CY1123837T1/el unknown
- 2021-06-11 JP JP2021097676A patent/JP2021178820A/ja active Pending
- 2021-11-01 AU AU2021261849A patent/AU2021261849A1/en not_active Abandoned
2022
- 2022-10-28 US US17/975,709 patent/US20230190749A1/en active Pending
- 2022-11-04 JP JP2022177278A patent/JP7404485B2/ja active Active
2023
- 2023-12-13 JP JP2023209972A patent/JP2024019526A/ja active Pending

Also Published As

Publication number	Publication date
KR20200115656A (ko)	2020-10-07
CA2867723A1 (en)	2013-09-26
AU2021261849A1 (en)	2021-12-02
IL269205A (en)	2019-11-28
PT3400943T (pt)	2021-02-02
JP2019081792A (ja)	2019-05-30
KR102490961B1 (ko)	2023-01-19
CN104203279A (zh)	2014-12-10
JP2021178820A (ja)	2021-11-18
NZ630843A (en)	2017-01-27
KR20140139009A (ko)	2014-12-04
US20230190749A1 (en)	2023-06-22
HK1206276A1 (en)	2016-01-08
RU2014142700A (ru)	2016-05-20
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Publication	Publication Date	Title
CL2014002497A1 (es)	2014-11-14	Uso de n4-(4-([1,2,4]triazolo[1,5-a]piridin-7-iloxi)-3-metilfenil)-n6-(4,4-dimetil-4,5-dihidrooxazol-2-il)quinazolina-4,6-diamina o (2-((4-((4-([1,2,4]triazolo[1,5-a]piridin-7-iloxi)-3-metilfenil)amino)quinazolin-6-il)amino)-4-metil-4,5-dihidrooxazol-4-il)metanol para el tratamiento contra el cancer cerebral metastasico o local.
CY1119837T1 (el)	2018-06-27	Στερεα διασπορα
BR112013033940A2 (pt)	2017-02-14	terapia combinada compreendendo um inibidor de cdk4/6 e um inibidor de pi3k para uso no tratamento de câncer
HUE061909T2 (hu)	2023-08-28	Pirazolo[1,5-a]pirimidinek alkalmazása ATR kináz inhibítorként, rákos megbetegedések kezelésére
BR112014010206A2 (pt)	2017-05-16	composto, composição farmacêutica, uso de composto, e, método para a profilaxia ou tratamento de um estado ou condição de doença
CL2012000163A1 (es)	2012-07-13	Compuestos derivados de quinazolina o pirido[2,3-d]pirimidina, inhibidores de la autofagia; composicion farmaceutica; y su uso para el tratamiento del cancer, pancreatitis, neurodegeneracion, entre otras.
BR112014029705A2 (pt)	2017-06-27	composto ou sal, medicamento, métodos para inibir quinase de janus em um mamífero, e para a profilaxia ou tratamento de doenças autoimunes, e, uso de um composto ou sal
CL2014000932A1 (es)	2014-07-11	Polimorfos cristalinos de n4-(4-([1,2,4]triazolo[1,5-a]piridin-7-iloxi)-3-metilfenil)-n6-(4,4-dimetil-4,5-dihidrooxazol-2-il)quinazolina-4,6-diamina, inhibidores de erbb2; procedimiento para prepararlos; composicion farmaceutica; metodo para prevenir o tratar; y uso para tratar el cancer de mama, gastrico y biliar, entre otros.
BRPI1015006A2 (pt)	2019-09-24	uso tópico, periocular, ou intraocular de tocotrienóis para o tratamento de doenças oftálmicas
BR112012004970A2 (pt)	2016-04-12	inibidores de jak2 e seu uso para o tratamento de doenças mieloproliferativas e câncer
BR112015003397A2 (pt)	2019-09-24	composto, composição farmacêutica, uso do composto e método para tratar uma doença ou condição mediada por rorgammat em um paciente.
CL2013002177A1 (es)	2013-11-29	Compuestos derivados de 9h-purinas y 7h-pirrolo[2,3-d]-pirimidinas sustituidas, inhibidores de la pi3k de clase i y/o mtor; su composicon farmaceutica; su combinacion farmaceutica; y su uso en el tratamiento o la prevencion del cancer o trastornos neurodegenerativos.
CL2013003306A1 (es)	2014-07-11	Uso de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1h-bencimidazol-2-il]-1h-quinolin-2-ona, un tautómero o sal de la misma para preparar un medicamento útil para el tratamiento de carcinoma adenoide quístico.
CL2013003051A1 (es)	2014-07-11	Compuestos derivados de pirazolo (4.3-d) pirimidinas, inhibidores de quinasa; composicion farmaceutica; y uso para el tratamiento de enfermedades y trastornos del aparato respiratorio
CL2014001049A1 (es)	2014-10-24	Compuestos derivados de purina sustituida, inhibidores de mtor; composicion farmaceutica; combinacion farmaceutica; uso para el tratamiento o prevencion del cancer, un trastorno neurodegenerativo o una enfermedad oftalmologica.
BRPI0917119A2 (pt)	2015-11-17	composto, composição farmacêutica, métodos para inibir a poli(adp-ribose) polimerase em um paciente, para tratar uma doença, uso de um composto, e, artigo de fabricação.
BR112015006019A2 (pt)	2017-07-04	composto selecionado, composição farmacêutica, método para tratar uma doença ou distúrbio, uso de um composto, kit para tratar uma condição mediada por pim quinase e invenção.
BR112015001830A2 (pt)	2017-07-04	composto, uso de um composto, método para o tratamento ou profilaxia de câncer e invenção
BR112015003332A2 (pt)	2017-09-26	composto, composição farmacêutica, uso do composto e método para tratar uma doença ou condição mediada por rorgammat em um paciente
BRPI0807717A2 (pt)	2014-05-20	Inibidores de quinase úteis para o tratamento de doenças mieloproliferativas e outras doenças proliferativas.
BR112015003398A2 (pt)	2018-04-24	composto, composição farmacêutica, uso do composto e método para tratar uma doença ou condição mediada por rorgammat em um paciente
BR112015004547A2 (pt)	2017-07-04	compostos, composição farmacêutica, uso de um composto e método para o tratamento ou melhoria do cãncer
MX384142B (es)	2025-03-14	Antagonista de unión al eje pd-1 e inhibidores de tigit para usarse en el tratamiento de cáncer.
CO6930363A2 (es)	2014-04-28	Benzilindazoles sustituidos para uso como inhibidores de la quinasa bub1 en el tratamiento de enfermedades hiperproliferativas
BR112014010179A2 (pt)	2017-04-25	composto, composição farmacêutica, uso de um composto, e, método para a profilaxia ou tratamento de um estado ou condição