LT2827900T - Amorfinė kieta dispersija, skirta panaudoti smegenų vėžio gydymui - Google Patents

Amorfinė kieta dispersija, skirta panaudoti smegenų vėžio gydymui

Info

Publication number
LT2827900T
LT2827900T LTEP13714497.8T LT13714497T LT2827900T LT 2827900 T LT2827900 T LT 2827900T LT 13714497 T LT13714497 T LT 13714497T LT 2827900 T LT2827900 T LT 2827900T
Authority
LT
Lithuania
Prior art keywords
treatment
solid dispersion
amorphous solid
brain cancer
brain
Prior art date
Application number
LTEP13714497.8T
Other languages
English (en)
Inventor
Patrice Lee
Shannon WINSKI
Kevin Koch
Original Assignee
Array Biopharma, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48048296&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2827900(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Array Biopharma, Inc. filed Critical Array Biopharma, Inc.
Publication of LT2827900T publication Critical patent/LT2827900T/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
LTEP13714497.8T 2012-03-23 2013-03-25 Amorfinė kieta dispersija, skirta panaudoti smegenų vėžio gydymui LT2827900T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261615082P 2012-03-23 2012-03-23
PCT/US2013/033751 WO2013142875A1 (en) 2012-03-23 2013-03-25 Treatment of brain cancer

Publications (1)

Publication Number Publication Date
LT2827900T true LT2827900T (lt) 2018-05-10

Family

ID=48048296

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP13714497.8T LT2827900T (lt) 2012-03-23 2013-03-25 Amorfinė kieta dispersija, skirta panaudoti smegenų vėžio gydymui

Country Status (30)

Country Link
US (3) US20150110780A1 (lt)
EP (4) EP3400943B1 (lt)
JP (6) JP2015514075A (lt)
KR (3) KR102317166B1 (lt)
CN (2) CN109223791A (lt)
AU (4) AU2013234921A1 (lt)
CA (1) CA2867723C (lt)
CL (1) CL2014002497A1 (lt)
CO (1) CO7071139A2 (lt)
CY (2) CY1120204T1 (lt)
DK (2) DK3400943T3 (lt)
ES (2) ES2855142T3 (lt)
HR (1) HRP20180659T1 (lt)
HU (2) HUE037966T2 (lt)
IL (3) IL234627B (lt)
LT (1) LT2827900T (lt)
MX (1) MX354024B (lt)
MY (2) MY202114A (lt)
NZ (4) NZ756264A (lt)
PH (2) PH12021550360A1 (lt)
PL (2) PL3400943T3 (lt)
PT (2) PT3400943T (lt)
RS (1) RS57140B1 (lt)
RU (2) RU2018138976A (lt)
SG (1) SG11201405954YA (lt)
SI (2) SI2827900T1 (lt)
SM (1) SMT201800251T1 (lt)
TR (1) TR201808450T4 (lt)
UA (1) UA122044C2 (lt)
WO (1) WO2013142875A1 (lt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012323890A1 (en) 2011-10-14 2014-05-29 Array Biopharma Inc. Polymorphs of arry-380, a selective ErbB2 inhibitor and pharmaceutical compositions containing them
WO2013056108A2 (en) 2011-10-14 2013-04-18 Array Biopharma Inc. Solid dispersion
EP3400943B1 (en) 2012-03-23 2020-12-02 Array Biopharma, Inc. Compounds for use in the treatment of brain metastases in a patient with erbb2+ breast cancer
WO2018165015A1 (en) * 2017-03-09 2018-09-13 The Board Of Trustees Of The Leland Stanford Junior University Treatment of pediatric brain tumors with targeting of cd47 pathway
BR112019022280A2 (pt) 2017-04-28 2020-05-19 Seattle Genetics Inc tratamento de cânceres de her2 positivo
IL276398B2 (en) 2018-01-31 2026-03-01 Deciphera Pharmaceuticals Llc Combination therapy for mastocytosis
CN118416236A (zh) 2018-01-31 2024-08-02 德西费拉制药有限责任公司 治疗胃肠道间质瘤的组合疗法
JP7139448B2 (ja) * 2018-04-09 2022-09-20 ノボキュア ゲーエムベーハー TTFields及びオーロラキナーゼ阻害剤による腫瘍の治療
CN109942576B (zh) * 2019-03-07 2020-09-11 上海工程技术大学 Irbinitinib及中间体的制备方法
WO2020185812A1 (en) 2019-03-11 2020-09-17 Teva Pharmaceuticals International Gmbh Solid state forms of ripretinib
CN111825604A (zh) * 2019-04-16 2020-10-27 宁波药腾医药科技有限公司 一种图卡替尼及其中间产物的合成方法
EP4013412B1 (en) 2019-08-12 2026-01-28 Deciphera Pharmaceuticals, LLC Ripretinib for treating gastrointestinal stromal tumors
MX2022008103A (es) * 2019-12-30 2022-09-19 Deciphera Pharmaceuticals Llc Formulaciones de inhibidores de la cinasa amorfa y metodos de estas.
EP4084779B1 (en) 2019-12-30 2024-10-09 Deciphera Pharmaceuticals, LLC Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH690163A5 (fr) * 1995-07-28 2000-05-31 Symphar Sa Dérivés gem-diphosphonates substitués utiles en tant qu'agents anti-cancers.
US6350786B1 (en) 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
RU2255765C2 (ru) * 2000-01-21 2005-07-10 Чилдренз Хоспитал Лос-Анджелес Способ ингибирования роста опухолей головного мозга с помощью отобранных антагонистов интегринов
WO2001091794A2 (en) 2000-05-30 2001-12-06 Virginia Commonwealth University Vitamin d3 analogs as radiosensitizers for the treatment of cancer
DK1660090T3 (da) 2003-08-14 2012-12-17 Array Biopharma Inc Quinazolin-analoger som receptor-tyrosinkinase-inhibitorer
JP2008501690A (ja) 2004-06-03 2008-01-24 スミスクライン ビーチャム (コーク) リミテッド がんの治療方法
CN1989112A (zh) * 2004-06-03 2007-06-27 史密丝克莱恩比彻姆(科克)有限公司 癌症治疗方法
ATE446294T1 (de) * 2005-11-15 2009-11-15 Array Biopharma Inc N4-phenyl-chinazolin-4-aminderivate und verwandte verbindungen als inhibitoren der erbb-typ-i- rezeptortyrosinkinase zur behandlung hyperproliferativer krankheiten
BRPI0706788A2 (pt) 2006-01-31 2011-04-05 Novartis Ag anticorpos antagonistas il-17
WO2009042618A1 (en) * 2007-09-24 2009-04-02 Tragara Pharmaceuticals, Inc. Therapies for treating cancer using combinations of cox-2 inhibitors and anti-her2(erbb2) antibodies or combinations of cox-2 inhibitors and her2(erbb2) receptor tyrosine kinase inhibitors
DK2644194T3 (en) * 2008-03-18 2017-07-03 Genentech Inc Combinations of an anti-HER2 antibody-drug conjugate and docetaxel
WO2013056108A2 (en) * 2011-10-14 2013-04-18 Array Biopharma Inc. Solid dispersion
AU2012323890A1 (en) * 2011-10-14 2014-05-29 Array Biopharma Inc. Polymorphs of arry-380, a selective ErbB2 inhibitor and pharmaceutical compositions containing them
EP3400943B1 (en) 2012-03-23 2020-12-02 Array Biopharma, Inc. Compounds for use in the treatment of brain metastases in a patient with erbb2+ breast cancer

Also Published As

Publication number Publication date
PT3400943T (pt) 2021-02-02
JP2015514075A (ja) 2015-05-18
HUE053156T2 (hu) 2021-06-28
PT2827900T (pt) 2018-06-14
CO7071139A2 (es) 2014-09-30
PL2827900T3 (pl) 2018-08-31
CN104203279B (zh) 2018-10-30
EP2827900A1 (en) 2015-01-28
JP2019081792A (ja) 2019-05-30
RU2018138976A (ru) 2018-12-06
CA2867723A1 (en) 2013-09-26
PL3400943T3 (pl) 2021-06-14
JP2022190126A (ja) 2022-12-22
EP3400943A1 (en) 2018-11-14
NZ630843A (en) 2017-01-27
CL2014002497A1 (es) 2014-11-14
MX354024B (es) 2018-02-08
WO2013142875A1 (en) 2013-09-26
US11504370B2 (en) 2022-11-22
AU2021261849A1 (en) 2021-12-02
HK1206276A1 (en) 2016-01-08
CN109223791A (zh) 2019-01-18
KR20210131426A (ko) 2021-11-02
DK2827900T3 (en) 2018-05-07
IL234627B (en) 2018-10-31
IL261659A (en) 2018-10-31
HRP20180659T1 (hr) 2018-06-01
ES2673165T3 (es) 2018-06-20
DK3400943T3 (da) 2021-02-08
AU2017272232C1 (en) 2019-08-15
CA2867723C (en) 2022-11-08
JP2017141302A (ja) 2017-08-17
KR20200115656A (ko) 2020-10-07
RU2672575C2 (ru) 2018-11-16
US20230190749A1 (en) 2023-06-22
UA122044C2 (uk) 2020-09-10
RU2018138976A3 (lt) 2022-04-08
AU2019203618B2 (en) 2021-08-05
SG11201405954YA (en) 2014-10-30
RU2014142700A (ru) 2016-05-20
AU2013234921A1 (en) 2014-10-02
EP3400943B1 (en) 2020-12-02
CY1123837T1 (el) 2022-05-27
HUE037966T2 (hu) 2018-09-28
PH12014502032A1 (en) 2014-11-24
SI3400943T1 (sl) 2021-03-31
KR102317166B1 (ko) 2021-10-26
JP2024019526A (ja) 2024-02-09
SI2827900T1 (en) 2018-06-29
MY202114A (en) 2024-04-04
CY1120204T1 (el) 2018-12-12
EP4252855A3 (en) 2023-11-15
IL269205A (en) 2019-11-28
EP2827900B1 (en) 2018-03-21
JP6898960B2 (ja) 2021-07-07
JP2021178820A (ja) 2021-11-18
CN104203279A (zh) 2014-12-10
PH12021550360A1 (en) 2023-04-03
AU2017272232A1 (en) 2018-01-04
NZ756264A (en) 2022-09-30
TR201808450T4 (tr) 2018-07-23
EP4252855A2 (en) 2023-10-04
KR102490961B1 (ko) 2023-01-19
ES2855142T3 (es) 2021-09-23
US20190255051A1 (en) 2019-08-22
IL269205B (en) 2020-06-30
AU2017272232B2 (en) 2019-02-28
JP7404485B2 (ja) 2023-12-25
KR102160462B1 (ko) 2020-09-28
MX2014011437A (es) 2014-11-10
NZ741615A (en) 2019-10-25
MY174883A (en) 2020-05-20
SMT201800251T1 (it) 2018-07-17
AU2019203618A1 (en) 2019-06-13
KR20140139009A (ko) 2014-12-04
US20150110780A1 (en) 2015-04-23
NZ724544A (en) 2018-05-25
RS57140B1 (sr) 2018-07-31
EP3842044A1 (en) 2021-06-30

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