CL2014002807A1 - Metodos de monitoreo terapeutico de profarmacos de acido fenilacetico; metodos para tratar un tratornono de retencion de nitrogeno en un sujeto. - Google Patents

Metodos de monitoreo terapeutico de profarmacos de acido fenilacetico; metodos para tratar un tratornono de retencion de nitrogeno en un sujeto.

Info

Publication number
CL2014002807A1
CL2014002807A1 CL2014002807A CL2014002807A CL2014002807A1 CL 2014002807 A1 CL2014002807 A1 CL 2014002807A1 CL 2014002807 A CL2014002807 A CL 2014002807A CL 2014002807 A CL2014002807 A CL 2014002807A CL 2014002807 A1 CL2014002807 A1 CL 2014002807A1
Authority
CL
Chile
Prior art keywords
methods
prodrugs
treat
subject
phenylacetic acid
Prior art date
Application number
CL2014002807A
Other languages
English (en)
Inventor
Bruce Scharschmidt
Masoud Mokhtarani
Original Assignee
Hyperion Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49380684&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014002807(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hyperion Therapeutics Inc filed Critical Hyperion Therapeutics Inc
Publication of CL2014002807A1 publication Critical patent/CL2014002807A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806Determination of free amino acids
    • G01N33/6812Assays for specific amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Emergency Medicine (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
CL2014002807A 2012-04-20 2014-10-17 Metodos de monitoreo terapeutico de profarmacos de acido fenilacetico; metodos para tratar un tratornono de retencion de nitrogeno en un sujeto. CL2014002807A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261636256P 2012-04-20 2012-04-20

Publications (1)

Publication Number Publication Date
CL2014002807A1 true CL2014002807A1 (es) 2015-02-27

Family

ID=49380684

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2014002807A CL2014002807A1 (es) 2012-04-20 2014-10-17 Metodos de monitoreo terapeutico de profarmacos de acido fenilacetico; metodos para tratar un tratornono de retencion de nitrogeno en un sujeto.
CL2017001375A CL2017001375A1 (es) 2012-04-20 2017-05-30 Métodos de monitoreo terapéutico de profármacos de ácido fenilacético.

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2017001375A CL2017001375A1 (es) 2012-04-20 2017-05-30 Métodos de monitoreo terapéutico de profármacos de ácido fenilacético.

Country Status (25)

Country Link
US (4) US9561197B2 (es)
EP (2) EP3222275B1 (es)
JP (3) JP6234436B2 (es)
KR (2) KR20150013170A (es)
CN (3) CN104540507A (es)
AU (3) AU2012377389A1 (es)
BR (1) BR112014026138A2 (es)
CL (2) CL2014002807A1 (es)
CY (1) CY1118838T1 (es)
DK (1) DK2846791T3 (es)
EC (1) ECSP14024561A (es)
ES (2) ES2807951T3 (es)
HR (1) HRP20170651T1 (es)
HU (1) HUE032726T2 (es)
IL (2) IL235127A (es)
LT (1) LT2846791T (es)
MX (1) MX365302B (es)
PL (1) PL2846791T3 (es)
PT (1) PT2846791T (es)
RS (1) RS55870B1 (es)
SG (2) SG11201406745VA (es)
SI (1) SI2846791T1 (es)
SM (1) SMT201700219T1 (es)
WO (1) WO2013158145A1 (es)
ZA (1) ZA201407597B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3263102A1 (en) 2011-09-30 2018-01-03 Horizon Therapeutics, LLC Methods of therapeutic monitoring of nitrogen scavenging drugs
PT2846791T (pt) * 2012-04-20 2017-05-25 Horizon Therapeutics Llc Métodos de monitorização terapêutica de profármacos de ácido fenilacético
PT2922576T (pt) * 2012-11-21 2018-01-24 Horizon Therapeutics Llc Métodos de administração e avaliação de fármacos sequestradores de azoto para o tratamento de encefalopatia hepática
HUE045106T2 (hu) 2013-10-14 2019-12-30 Immedica Pharma Ab Eljárások a karbamidciklus rendellenességeinek kezelésére
US20170087113A1 (en) * 2014-06-04 2017-03-30 Horizon Therapeutics, Llc Methods for treating urea cycle disorders to prevent hyperammonemic crises by controlling blood ammonia levels
US9914692B2 (en) 2016-05-25 2018-03-13 Horizon Therapeutics, Llc Procedure for the preparation of 4-phenyl butyrate and uses thereof
US20190076383A1 (en) * 2017-09-08 2019-03-14 Horizon Therapeutics, Llc Methods for treating urea cycle disorders
US10668040B2 (en) * 2017-09-11 2020-06-02 Horizon Therapeutics, Llc Treatment of urea cycle disorders in neonates and infants

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284647A (en) 1980-03-31 1981-08-18 The Johns Hopkins University Process for waste nitrogen removal
US4457942A (en) 1982-08-20 1984-07-03 Brusilow Saul W Process for waste nitrogen removal
US5635532A (en) 1991-10-21 1997-06-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Compositions and methods for therapy and prevention of pathologies including cancer, AIDS and anemia
US5879657A (en) 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
DE69612755T2 (de) 1995-02-07 2001-08-23 Brusilow Enterprises, Llc Triglyceride und ethylester von phenylalkansäuren und phenylalkensäuren zur behandlung verschiedener erkrankungen
US6219567B1 (en) 1999-06-21 2001-04-17 Cardiox Corporation Monitoring of total ammoniacal concentration in blood
US20030195255A1 (en) 2002-04-12 2003-10-16 Summar Marshall L. Method for treating hepatic encephalopathies
US20040229948A1 (en) 2002-04-12 2004-11-18 Summar Marshall L. Method for preventing hepatic encephalopathic episodes
US20050273359A1 (en) 2004-06-03 2005-12-08 Young David E System and method of evaluating preoperative medical care and determining recommended tests based on patient health history and medical condition and nature of surgical procedure
SI2153870T1 (sl) 2004-11-26 2014-05-30 Ucl Business Plc Sestavki, ki obsegajo ornitin in fenilacetat ali fenilbutirat, za zdravljenje hepatitične encefalopatije
US20060135612A1 (en) 2004-12-17 2006-06-22 U.S. Department Of Veterans Affairs Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as amyotrophic lateral sclerosis (ALS), by using a HDAC inhibiting agent
US20070004805A1 (en) 2005-07-01 2007-01-04 Navinta Llc Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate
US20100016207A1 (en) 2005-11-10 2010-01-21 Wurtman Richard J Methods and Compositions for Raising Levels and Release of Gamma Aminobutyric Acid
US8094521B2 (en) 2007-02-28 2012-01-10 Nightingale Products LLC Caregiver personal alert device
GB2451259B (en) * 2007-07-25 2011-07-20 Gp Acoustics Loudspeaker
WO2009087474A2 (en) 2008-01-08 2009-07-16 Akthelia Pharmaceuticals Agonists for antimicrobial peptide systems
WO2009134460A1 (en) 2008-04-29 2009-11-05 Hyperion Therapeutics Methods of treatment using ammonia-scavenging drugs
WO2010025303A1 (en) * 2008-08-29 2010-03-04 Hyperion Therapeutics Dosing and monitoring patients on nitrogen-scavenging drugs
ES2695534T3 (es) * 2008-08-29 2019-01-08 Horizon Therapeutics Llc Métodos de tratamiento usando fármacos de captación de amoniaco
CN102481271A (zh) * 2009-05-11 2012-05-30 博格生物系统有限责任公司 利用表观代谢转变剂、多维细胞内分子或环境影响剂治疗代谢障碍的方法
WO2011011781A1 (en) 2009-07-24 2011-01-27 Baylor College Of Medicine Methods of modulation of branched chain acids and uses thereof
WO2012028620A1 (en) 2010-08-31 2012-03-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Porous polysaccharide scaffold comprising nano-hydroxyapatite and use for bone formation
EP3263102A1 (en) * 2011-09-30 2018-01-03 Horizon Therapeutics, LLC Methods of therapeutic monitoring of nitrogen scavenging drugs
PT2846791T (pt) * 2012-04-20 2017-05-25 Horizon Therapeutics Llc Métodos de monitorização terapêutica de profármacos de ácido fenilacético
PT2922576T (pt) 2012-11-21 2018-01-24 Horizon Therapeutics Llc Métodos de administração e avaliação de fármacos sequestradores de azoto para o tratamento de encefalopatia hepática

Also Published As

Publication number Publication date
EP3222275A1 (en) 2017-09-27
WO2013158145A9 (en) 2014-05-01
HUE032726T2 (en) 2017-10-30
SG11201406745VA (en) 2014-12-30
AU2019201811B2 (en) 2020-07-09
US9561197B2 (en) 2017-02-07
JP2019219413A (ja) 2019-12-26
SI2846791T1 (sl) 2017-06-30
ZA201407597B (en) 2017-05-31
CN111991383A (zh) 2020-11-27
CL2017001375A1 (es) 2018-01-05
ES2807951T3 (es) 2021-02-24
KR20190116552A (ko) 2019-10-14
SMT201700219T1 (it) 2017-05-08
AU2012377389A1 (en) 2014-10-30
RS55870B1 (sr) 2017-08-31
US20130281530A1 (en) 2013-10-24
EP2846791A1 (en) 2015-03-18
JP6234436B2 (ja) 2017-11-22
ECSP14024561A (es) 2015-09-30
EP2846791A4 (en) 2015-08-19
ES2623470T3 (es) 2017-07-11
CN113995743A (zh) 2022-02-01
KR20150013170A (ko) 2015-02-04
LT2846791T (lt) 2017-04-10
AU2018200163A1 (en) 2018-02-01
SG10201608749UA (en) 2016-12-29
MX2014012694A (es) 2015-06-03
AU2018200163B2 (en) 2018-12-20
JP2018039830A (ja) 2018-03-15
PT2846791T (pt) 2017-05-25
US20180015058A1 (en) 2018-01-18
DK2846791T3 (en) 2017-03-27
WO2013158145A1 (en) 2013-10-24
US20180263938A1 (en) 2018-09-20
CN104540507A (zh) 2015-04-22
EP2846791B1 (en) 2017-02-08
AU2019201811A1 (en) 2019-04-04
JP6637941B2 (ja) 2020-01-29
KR102264579B1 (ko) 2021-06-11
HK1208380A1 (en) 2016-03-04
CY1118838T1 (el) 2018-01-10
US20170266143A1 (en) 2017-09-21
IL235127A (en) 2017-12-31
BR112014026138A2 (pt) 2017-06-27
IL255918A (en) 2018-01-31
JP2015514757A (ja) 2015-05-21
EP3222275B1 (en) 2020-06-24
MX365302B (es) 2019-05-29
IL255918B (en) 2019-06-30
PL2846791T3 (pl) 2017-07-31
HRP20170651T1 (hr) 2017-06-30
HK1243959A1 (en) 2018-07-27

Similar Documents

Publication Publication Date Title
CL2014002807A1 (es) Metodos de monitoreo terapeutico de profarmacos de acido fenilacetico; metodos para tratar un tratornono de retencion de nitrogeno en un sujeto.
IL227298A0 (en) Use of the phytocannabinoid cannabidiol (cbd) in combination with a standard anti-epileptic drug (saed) in the treatment of epilepsy
EP2880482A4 (en) OPTOELECTRONIC CONTACT AND METHOD
EP2890672A4 (en) NEW PROCEDURE
BR112013023067A2 (pt) aparelhos e métodos para a produção de fibras
HUE039671T2 (hu) Eljárás gyermekpáciensek dexmedetomidin alkalmazásával történõ kezelésére
BR112013033720A2 (pt) método para tratar eczema
IL229097A0 (en) A limiter for a dispensing device
CL2014002622A1 (es) Un metodo para modificar beta-estuco utilizando acido dietilen-triamin-pentaacetico.
BR112014006702A2 (pt) método para tratar osteoporose
CO6910182A2 (es) Producción mejorada de ácido nítrico
BR112014028726A2 (pt) método para alisar o cabelo
BR112015002681A2 (pt) método para tratar um paciente e kit
BR112013008528A2 (pt) métodos para tratar psoríase
ZA201308459B (en) A topical formulation for treatment of hyperkeratotic skin
CO6842021A2 (es) Análogos de ácido epoxieicosatrienoico y métodos para elaborarlosy utilizarlos
DK2750673T3 (da) Transdermalt terapeutisk system for 5-aminolevulinsyrehydrochlorid
BR112013023465A2 (pt) método para produzir l-cisteína
BRDI7105383S (pt) Configuração aplicada em banda de rodagem para pneumático
BRDI7105384S (pt) Configuração aplicada em banda de rodagem para pneumático
CL2014001878A1 (es) Proceso y aparatos para preparacion de ácido nítrico
BR112015015258A2 (pt) métodos para tratar distúrbios do trato gastrintestinal
BR112013033851A2 (pt) método para formar sevoflurano
BR112014013045A2 (pt) método e sistema para difusão a uma pluralidade de dispositivos do lado do cliente
IL233225A0 (en) Methods and formulations for the treatment of sialic acid deficiencies