PT2922576T - Métodos de administração e avaliação de fármacos sequestradores de azoto para o tratamento de encefalopatia hepática - Google Patents

Métodos de administração e avaliação de fármacos sequestradores de azoto para o tratamento de encefalopatia hepática

Info

Publication number
PT2922576T
PT2922576T PT138574553T PT13857455T PT2922576T PT 2922576 T PT2922576 T PT 2922576T PT 138574553 T PT138574553 T PT 138574553T PT 13857455 T PT13857455 T PT 13857455T PT 2922576 T PT2922576 T PT 2922576T
Authority
PT
Portugal
Prior art keywords
drugs
administration
evaluation
nitrogen
treatment
Prior art date
Application number
PT138574553T
Other languages
English (en)
Inventor
Scharschmidt Bruce
Mokhtarani Masoud
Original Assignee
Horizon Therapeutics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Horizon Therapeutics Llc filed Critical Horizon Therapeutics Llc
Publication of PT2922576T publication Critical patent/PT2922576T/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4925—Blood measuring blood gas content, e.g. O2, CO2, HCO3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
PT138574553T 2012-11-21 2013-11-21 Métodos de administração e avaliação de fármacos sequestradores de azoto para o tratamento de encefalopatia hepática PT2922576T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261728967P 2012-11-21 2012-11-21
US201361759292P 2013-01-31 2013-01-31

Publications (1)

Publication Number Publication Date
PT2922576T true PT2922576T (pt) 2018-01-24

Family

ID=50728524

Family Applications (1)

Application Number Title Priority Date Filing Date
PT138574553T PT2922576T (pt) 2012-11-21 2013-11-21 Métodos de administração e avaliação de fármacos sequestradores de azoto para o tratamento de encefalopatia hepática

Country Status (21)

Country Link
US (3) US9289406B2 (pt)
EP (2) EP2922576B1 (pt)
JP (1) JP2016506378A (pt)
KR (1) KR20150086510A (pt)
CN (1) CN104797272A (pt)
AU (1) AU2013347905B2 (pt)
BR (1) BR112015011778A2 (pt)
CA (1) CA2891657A1 (pt)
CY (1) CY1120163T1 (pt)
DK (1) DK2922576T3 (pt)
ES (1) ES2654774T3 (pt)
HK (1) HK1210699A1 (pt)
HR (1) HRP20180041T1 (pt)
HU (1) HUE036133T2 (pt)
LT (1) LT2922576T (pt)
PL (1) PL2922576T3 (pt)
PT (1) PT2922576T (pt)
RS (1) RS56757B1 (pt)
SI (1) SI2922576T1 (pt)
SM (1) SMT201800022T1 (pt)
WO (1) WO2014081977A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2652187T3 (es) 2009-04-03 2018-01-31 Ocera Therapeutics, Inc. Fenilacetato de l-ornitina y métodos para elaborar el mismo
EP2440200B8 (en) 2009-06-08 2014-10-15 UCL Business PLC Treatment of portal hypertension using l-ornithine phenylacetate
SI2760479T1 (sl) 2011-09-30 2017-07-31 Horizon Therapeutics, Llc Zdravilo, ki odstranjuje dušik, za uporabo v postopku zdravljenja motnje retencije dušika
RS55870B1 (sr) 2012-04-20 2017-08-31 Horizon Therapeutics Llc Hpn-100 za upotrebu u lečenju poremećaja nakupljanja azota
SMT201800022T1 (it) * 2012-11-21 2018-03-08 Horizon Therapeutics Llc Metodi per somministrare e valutare farmaci di rimozione dell'azoto per il trattamento di encefalopatia epatica
KR102487376B1 (ko) 2014-11-24 2023-01-10 유씨엘 비즈니스 리미티드 암모니아-저감 치료를 이용한 간성상세포 활성화와 연관된 질병의 치료
JP6990170B2 (ja) 2015-08-18 2022-01-12 オセラ セラピューティクス， インコーポレイテッド Ｌ－オルニチンをフェニルアセテートおよびフェニルブチレートのうちの少なくとも１つと組み合わせて用いる筋肉喪失の治療および予防
US9914692B2 (en) 2016-05-25 2018-03-13 Horizon Therapeutics, Llc Procedure for the preparation of 4-phenyl butyrate and uses thereof
CN110740988A (zh) 2017-05-11 2020-01-31 欧塞拉治疗有限公司 制备l-鸟氨酸苯乙酸盐的方法
US10668040B2 (en) 2017-09-11 2020-06-02 Horizon Therapeutics, Llc Treatment of urea cycle disorders in neonates and infants
MX2023002868A (es) 2020-09-14 2023-03-24 Wellstat Therapeutics Corp 2',3'-diacetiluridina sustituida por acetoacetilo en la posicion 5'.
MX2023006343A (es) * 2020-12-01 2023-06-12 Wellstat Therapeutics Corp 5'-o-fenilacetiluridina y uso terapeutico.

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284647A (en) 1980-03-31 1981-08-18 The Johns Hopkins University Process for waste nitrogen removal
US4457942A (en) 1982-08-20 1984-07-03 Brusilow Saul W Process for waste nitrogen removal
US5635532A (en) 1991-10-21 1997-06-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Compositions and methods for therapy and prevention of pathologies including cancer, AIDS and anemia
US5879657A (en) 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
CA2212047C (en) 1995-02-07 2010-11-16 Saul W. Brusilow Triglycerides and ethyl esters of phenylalkanoic acid and phenylalkenoic acid useful in treatment of various disorders
US6219567B1 (en) 1999-06-21 2001-04-17 Cardiox Corporation Monitoring of total ammoniacal concentration in blood
US20030195255A1 (en) 2002-04-12 2003-10-16 Summar Marshall L. Method for treating hepatic encephalopathies
US20040229948A1 (en) 2002-04-12 2004-11-18 Summar Marshall L. Method for preventing hepatic encephalopathic episodes
US20050273359A1 (en) 2004-06-03 2005-12-08 Young David E System and method of evaluating preoperative medical care and determining recommended tests based on patient health history and medical condition and nature of surgical procedure
CN1778963A (zh) * 2004-11-23 2006-05-31 苏州艾杰生物科技有限公司 血氨含量测定方法及血氨诊断试剂盒
ES2448549T3 (es) 2004-11-26 2014-03-14 Ucl Business Plc Composiciones que comprenden ornitina y fenilacetato o fenilbutirato para tratar encefalopatía hepática
US20060135612A1 (en) 2004-12-17 2006-06-22 U.S. Department Of Veterans Affairs Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as amyotrophic lateral sclerosis (ALS), by using a HDAC inhibiting agent
US20070004805A1 (en) 2005-07-01 2007-01-04 Navinta Llc Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate
WO2007059031A2 (en) 2005-11-10 2007-05-24 Massachusetts Institute Of Technology Methods and compositions for raising levels and release of gamma aminobutyric acid
US8094521B2 (en) 2007-02-28 2012-01-10 Nightingale Products LLC Caregiver personal alert device
CN101959429B (zh) 2008-01-08 2014-09-10 阿克塞利亚制药公司 抗微生物肽系统的激动剂
GB2465250B (en) 2008-08-29 2011-01-26 Ucyclyd Pharma Inc Dosing and monitoring patients on nitrogen-scavenging drugs
PL3133396T3 (pl) 2008-04-29 2019-03-29 Horizon Therapeutics, Llc Sposób leczenia z zastosowaniem leków wychwytujących amoniak
ES2593378T3 (es) * 2008-08-29 2016-12-09 Horizon Therapeutics, Llc Métodos de tratamiento usando fármacos de secuestro de ammonia
EP2456304B1 (en) 2009-07-24 2015-08-19 Baylor College Of Medicine Methods of modulation of branched chain acids and uses thereof
US20130224277A1 (en) 2010-08-31 2013-08-29 Institut National De La Sante Et De La Recherche Medicale (Inserm) Porous polysaccharide scaffold comprising nano-hydroxyapatite and use for bone formation
SI2760479T1 (sl) * 2011-09-30 2017-07-31 Horizon Therapeutics, Llc Zdravilo, ki odstranjuje dušik, za uporabo v postopku zdravljenja motnje retencije dušika
RS55870B1 (sr) 2012-04-20 2017-08-31 Horizon Therapeutics Llc Hpn-100 za upotrebu u lečenju poremećaja nakupljanja azota
SMT201800022T1 (it) * 2012-11-21 2018-03-08 Horizon Therapeutics Llc Metodi per somministrare e valutare farmaci di rimozione dell'azoto per il trattamento di encefalopatia epatica
WO2015048818A1 (en) 2013-09-30 2015-04-02 Hyperion Therapeutics, Inc. Diagnosing, grading, monitoring, and treating hepatic encephalopathy
SI2986325T1 (sl) 2013-10-14 2020-02-28 Immedica Pharma Ab Postopki zdravljenja motenj ciklusa sečnine

Also Published As

Publication number Publication date
HUE036133T2 (hu) 2018-06-28
US9289406B2 (en) 2016-03-22
PL2922576T3 (pl) 2018-08-31
US20160223520A1 (en) 2016-08-04
HK1210699A1 (en) 2016-05-06
WO2014081977A1 (en) 2014-05-30
CA2891657A1 (en) 2014-05-30
US20180017546A1 (en) 2018-01-18
BR112015011778A2 (pt) 2017-07-11
SMT201800022T1 (it) 2018-03-08
KR20150086510A (ko) 2015-07-28
HK1213778A1 (en) 2016-07-15
US20140142186A1 (en) 2014-05-22
CN104797272A (zh) 2015-07-22
CY1120163T1 (el) 2018-12-12
EP2922576A4 (en) 2016-05-04
AU2013347905B2 (en) 2018-10-04
JP2016506378A (ja) 2016-03-03
AU2013347905A1 (en) 2015-04-30
SI2922576T1 (en) 2018-04-30
ES2654774T3 (es) 2018-02-15
EP2922576B1 (en) 2017-11-08
DK2922576T3 (en) 2018-01-15
RS56757B1 (sr) 2018-04-30
LT2922576T (lt) 2018-02-12
HRP20180041T1 (hr) 2018-06-01
EP2922576A1 (en) 2015-09-30
EP3335735A1 (en) 2018-06-20

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