CL2014003160A1 - Derivados de ariletinilo y sus usos en la fabricacion de medicamentos destinados al tratamiento de enfermedades relacionadas con los moduladores alostéricos del receptor mglur5. - Google Patents

Derivados de ariletinilo y sus usos en la fabricacion de medicamentos destinados al tratamiento de enfermedades relacionadas con los moduladores alostéricos del receptor mglur5.

Info

Publication number
CL2014003160A1
CL2014003160A1 CL2014003160A CL2014003160A CL2014003160A1 CL 2014003160 A1 CL2014003160 A1 CL 2014003160A1 CL 2014003160 A CL2014003160 A CL 2014003160A CL 2014003160 A CL2014003160 A CL 2014003160A CL 2014003160 A1 CL2014003160 A1 CL 2014003160A1
Authority
CL
Chile
Prior art keywords
ariletinyl
medicines
derivatives
manufacture
treatment
Prior art date
Application number
CL2014003160A
Other languages
English (en)
Inventor
Georg Jaeschke
Lothar Lindemann
Eric Vieira
Heinz Stadler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2014003160A1 publication Critical patent/CL2014003160A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CL2014003160A 2012-07-17 2014-11-21 Derivados de ariletinilo y sus usos en la fabricacion de medicamentos destinados al tratamiento de enfermedades relacionadas con los moduladores alostéricos del receptor mglur5. CL2014003160A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12176662 2012-07-17

Publications (1)

Publication Number Publication Date
CL2014003160A1 true CL2014003160A1 (es) 2015-03-13

Family

ID=48782352

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014003160A CL2014003160A1 (es) 2012-07-17 2014-11-21 Derivados de ariletinilo y sus usos en la fabricacion de medicamentos destinados al tratamiento de enfermedades relacionadas con los moduladores alostéricos del receptor mglur5.

Country Status (35)

Country Link
US (2) US20150133505A1 (es)
EP (1) EP2875000B1 (es)
JP (1) JP6089104B2 (es)
KR (1) KR101631041B1 (es)
CN (1) CN104364233B (es)
AR (1) AR091764A1 (es)
AU (1) AU2013292142B2 (es)
BR (1) BR112014029015A2 (es)
CA (1) CA2871389C (es)
CL (1) CL2014003160A1 (es)
CO (1) CO7111256A2 (es)
CR (1) CR20140531A (es)
CY (1) CY1118205T1 (es)
DK (1) DK2875000T3 (es)
EA (1) EA026593B1 (es)
ES (1) ES2600133T3 (es)
HR (1) HRP20161691T1 (es)
HU (1) HUE030177T2 (es)
IL (1) IL236362A (es)
LT (1) LT2875000T (es)
MA (1) MA20150280A2 (es)
MX (1) MX358998B (es)
MY (1) MY167810A (es)
NZ (1) NZ701849A (es)
PE (1) PE20150184A1 (es)
PH (1) PH12014502695A1 (es)
PL (1) PL2875000T3 (es)
PT (1) PT2875000T (es)
RS (1) RS55313B1 (es)
SG (1) SG11201407050UA (es)
SI (1) SI2875000T1 (es)
TW (1) TWI473799B (es)
UA (1) UA114911C2 (es)
WO (1) WO2014012851A1 (es)
ZA (1) ZA201408514B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA113223C2 (xx) * 2012-08-13 2016-12-26 Арилетинілпіримідини
EA026941B1 (ru) * 2012-10-18 2017-06-30 Ф. Хоффманн-Ля Рош Аг ПРОИЗВОДНЫЕ ЭТИНИЛА В КАЧЕСТВЕ МОДУЛЯТОРОВ АКТИВНОСТИ РЕЦЕПТОРА mGluR5
HRP20200638T1 (hr) 2015-06-03 2020-07-10 F. Hoffmann - La Roche Ag Derivati etinila
ES2733468T3 (es) 2015-07-15 2019-11-29 Hoffmann La Roche Derivados de etinilo como moduladores de los receptores metabotrópicos de glutamato
SI3484889T1 (sl) 2016-07-18 2020-11-30 F. Hoffmann-La Roche Ag Derivati etinila

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19546462A1 (de) * 1995-12-13 1997-06-19 Bayer Ag Diarylacetylenketone
PT1354875E (pt) 2003-05-19 2005-03-31 Servier Lab Novo processo de sintese do acido (2s, 3as, 7as)-per-hidroindole-2-carboxilico e dos seus esteres e aplicacao a sintese do perindopril
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
WO2006048771A1 (en) 2004-11-04 2006-05-11 Addex Pharmaceuticals Sa Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
NZ581817A (en) 2007-06-03 2012-05-25 Univ Vanderbilt Benzamide mglur5 positive allosteric modulators and methods of making and using same
CN101544892B (zh) * 2009-05-07 2012-10-03 石家庄诚志永华显示材料有限公司 一种合成二芳基乙炔类单体液晶的方法
US8420661B2 (en) * 2010-04-13 2013-04-16 Hoffmann-La Roche Inc. Arylethynyl derivatives
KR101554803B1 (ko) * 2011-04-26 2015-09-21 에프. 호프만-라 로슈 아게 Mglur5의 양성 알로스테릭 조절체로서 에틴일 유도체

Also Published As

Publication number Publication date
US20160039787A1 (en) 2016-02-11
CY1118205T1 (el) 2017-06-28
CA2871389C (en) 2020-08-25
CO7111256A2 (es) 2014-11-10
AU2013292142B2 (en) 2017-03-09
CR20140531A (es) 2015-01-12
ZA201408514B (en) 2015-12-23
UA114911C2 (uk) 2017-08-28
KR101631041B1 (ko) 2016-06-15
IL236362A (en) 2017-12-31
TW201408655A (zh) 2014-03-01
TWI473799B (zh) 2015-02-21
IL236362A0 (en) 2015-02-26
NZ701849A (en) 2016-07-29
EA026593B1 (ru) 2017-04-28
SG11201407050UA (en) 2014-11-27
PL2875000T3 (pl) 2017-03-31
EA201492274A1 (ru) 2015-05-29
HUE030177T2 (en) 2017-04-28
BR112014029015A2 (pt) 2017-06-27
PT2875000T (pt) 2016-11-03
MY167810A (en) 2018-09-26
CN104364233A (zh) 2015-02-18
PE20150184A1 (es) 2015-02-13
CA2871389A1 (en) 2014-01-23
PH12014502695B1 (en) 2015-01-26
KR20150023766A (ko) 2015-03-05
JP2015527993A (ja) 2015-09-24
PH12014502695A1 (en) 2015-01-26
US20150133505A1 (en) 2015-05-14
SI2875000T1 (sl) 2017-01-31
MX358998B (es) 2018-09-12
AR091764A1 (es) 2015-02-25
DK2875000T3 (en) 2016-10-24
CN104364233B (zh) 2016-06-22
HK1202544A1 (zh) 2015-10-02
JP6089104B2 (ja) 2017-03-01
WO2014012851A1 (en) 2014-01-23
MA20150280A2 (fr) 2015-08-31
RS55313B1 (sr) 2017-03-31
US9328090B2 (en) 2016-05-03
LT2875000T (lt) 2016-11-10
ES2600133T3 (es) 2017-02-07
AU2013292142A1 (en) 2014-11-06
EP2875000B1 (en) 2016-09-21
EP2875000A1 (en) 2015-05-27
HRP20161691T1 (hr) 2017-02-24
MX2014014950A (es) 2015-03-09

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