CL2014003285A1 - Formas en estado sólido de n-((s)-2,3-dihidroxi-propil)-3-(2-fluoro-4-yodo-fenilamino)-isonicotinamida y sus sales; sus usos contra el cancer. - Google Patents
Formas en estado sólido de n-((s)-2,3-dihidroxi-propil)-3-(2-fluoro-4-yodo-fenilamino)-isonicotinamida y sus sales; sus usos contra el cancer.Info
- Publication number
- CL2014003285A1 CL2014003285A1 CL2014003285A CL2014003285A CL2014003285A1 CL 2014003285 A1 CL2014003285 A1 CL 2014003285A1 CL 2014003285 A CL2014003285 A CL 2014003285A CL 2014003285 A CL2014003285 A CL 2014003285A CL 2014003285 A1 CL2014003285 A1 CL 2014003285A1
- Authority
- CL
- Chile
- Prior art keywords
- isonicotinamide
- phenylamino
- iodo
- dihydroxy
- fluoro
- Prior art date
Links
- -1 (s) -2,3-dihydroxy-propyl Chemical group 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261653037P | 2012-05-30 | 2012-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014003285A1 true CL2014003285A1 (es) | 2015-03-06 |
Family
ID=48537929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014003285A CL2014003285A1 (es) | 2012-05-30 | 2014-11-28 | Formas en estado sólido de n-((s)-2,3-dihidroxi-propil)-3-(2-fluoro-4-yodo-fenilamino)-isonicotinamida y sus sales; sus usos contra el cancer. |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US9260393B2 (es) |
| EP (1) | EP2855434B1 (es) |
| JP (1) | JP6280543B2 (es) |
| KR (1) | KR20150022923A (es) |
| CN (1) | CN104334530A (es) |
| AR (1) | AR091186A1 (es) |
| AU (1) | AU2013269994B2 (es) |
| BR (1) | BR112014029838A2 (es) |
| CA (1) | CA2875145C (es) |
| CL (1) | CL2014003285A1 (es) |
| DK (1) | DK2855434T3 (es) |
| EA (1) | EA028059B1 (es) |
| ES (1) | ES2592860T3 (es) |
| HK (1) | HK1206733A1 (es) |
| HR (1) | HRP20161135T1 (es) |
| HU (1) | HUE028850T2 (es) |
| IL (1) | IL235947A (es) |
| LT (1) | LT2855434T (es) |
| MX (1) | MX350295B (es) |
| MY (1) | MY169266A (es) |
| NZ (1) | NZ701103A (es) |
| PL (1) | PL2855434T3 (es) |
| PT (1) | PT2855434T (es) |
| RS (1) | RS55167B1 (es) |
| SG (1) | SG11201407842TA (es) |
| SI (1) | SI2855434T1 (es) |
| TW (1) | TWI570108B (es) |
| UA (1) | UA112899C2 (es) |
| WO (1) | WO2013178320A1 (es) |
| ZA (1) | ZA201409426B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015127234A1 (en) * | 2014-02-20 | 2015-08-27 | Board Of Regents, The University Of Texas System | Use of ibrutinib to treat egfr mutant cancer |
| US10179132B2 (en) | 2015-05-26 | 2019-01-15 | Industry-Academic Cooperation Foundation, Yonsei University | Composition for inducing differentiation of multipotent neural stem cells into dopaminergic neurons and method for inducing differentiation of multipotent neural stem cells into dopaminergic neurons by using the same |
| KR20160138756A (ko) * | 2015-05-26 | 2016-12-06 | 연세대학교 산학협력단 | 신경줄기세포로부터 도파민 신경세포로의 분화 유도용 조성물 및 이를 이용하여 신경줄기세포로부터 도파민 신경세포로 분화시키는 방법 |
| DK3425390T3 (da) | 2016-11-25 | 2021-02-15 | Genuv Inc | Sammensætning til fremme af differentiering og beskyttelse af neurale stamceller og fremgangsmåde til induktion af neural regenerering ved anvendelse heraf |
| KR101833412B1 (ko) | 2017-07-24 | 2018-02-28 | 연세대학교 산학협력단 | 신경줄기세포로부터 도파민 신경세포로의 분화 유도용 조성물 및 이를 이용하여 신경줄기세포로부터 도파민 신경세포로 분화시키는 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9810385A (pt) * | 1997-07-01 | 2000-09-05 | Warner Lambert Co | Derivados de ácido benzóico 2-(4-bromo ou 4-iodo fenilamino) e sua utilização como inibidores de mek |
| DE69926914T2 (de) * | 1999-01-13 | 2006-06-29 | Warner-Lambert Co. Llc | 1-heterozyklus-substituierte diarylaminen |
| JP2005529160A (ja) * | 2002-05-31 | 2005-09-29 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | 糖尿病及び糖尿病−関連障害の処置のための化合物及び組成物 |
| ZA200703912B (en) | 2004-10-20 | 2008-09-25 | Serono Lab | 3-arylamino pyridine derivatives |
| CN102134218A (zh) * | 2009-06-15 | 2011-07-27 | 凯美隆(北京)药业技术有限公司 | 6-芳氨基吡啶酮磺酰胺和6-芳氨基吡嗪酮磺酰胺mek抑制剂 |
-
2013
- 2013-05-07 US US14/404,060 patent/US9260393B2/en active Active
- 2013-05-07 MY MYPI2014703509A patent/MY169266A/en unknown
- 2013-05-07 HR HRP20161135TT patent/HRP20161135T1/hr unknown
- 2013-05-07 KR KR20147036740A patent/KR20150022923A/ko not_active Ceased
- 2013-05-07 SG SG11201407842TA patent/SG11201407842TA/en unknown
- 2013-05-07 AU AU2013269994A patent/AU2013269994B2/en not_active Ceased
- 2013-05-07 RS RS20160795A patent/RS55167B1/sr unknown
- 2013-05-07 CA CA2875145A patent/CA2875145C/en active Active
- 2013-05-07 BR BR112014029838A patent/BR112014029838A2/pt not_active Application Discontinuation
- 2013-05-07 EP EP13725913.1A patent/EP2855434B1/en active Active
- 2013-05-07 LT LTEP13725913.1T patent/LT2855434T/lt unknown
- 2013-05-07 SI SI201330301A patent/SI2855434T1/sl unknown
- 2013-05-07 ES ES13725913.1T patent/ES2592860T3/es active Active
- 2013-05-07 PT PT137259131T patent/PT2855434T/pt unknown
- 2013-05-07 NZ NZ701103A patent/NZ701103A/en not_active IP Right Cessation
- 2013-05-07 HU HUE13725913A patent/HUE028850T2/en unknown
- 2013-05-07 WO PCT/EP2013/001352 patent/WO2013178320A1/en not_active Ceased
- 2013-05-07 CN CN201380028114.0A patent/CN104334530A/zh active Pending
- 2013-05-07 PL PL13725913.1T patent/PL2855434T3/pl unknown
- 2013-05-07 DK DK13725913.1T patent/DK2855434T3/en active
- 2013-05-07 JP JP2015514374A patent/JP6280543B2/ja not_active Expired - Fee Related
- 2013-05-07 MX MX2014014520A patent/MX350295B/es active IP Right Grant
- 2013-05-07 EA EA201401341A patent/EA028059B1/ru not_active IP Right Cessation
- 2013-05-07 HK HK15107274.5A patent/HK1206733A1/xx unknown
- 2013-05-29 AR ARP130101864 patent/AR091186A1/es unknown
- 2013-05-29 TW TW102119003A patent/TWI570108B/zh not_active IP Right Cessation
- 2013-07-05 UA UAA201413849A patent/UA112899C2/uk unknown
-
2014
- 2014-11-27 IL IL235947A patent/IL235947A/en not_active IP Right Cessation
- 2014-11-28 CL CL2014003285A patent/CL2014003285A1/es unknown
- 2014-12-19 ZA ZA2014/09426A patent/ZA201409426B/en unknown
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