CL2015001990A1 - Compuestos de pirrolopirimidina substituidos, composiciones de los mismos, y métodos de tratamiento con los mismos. - Google Patents

Compuestos de pirrolopirimidina substituidos, composiciones de los mismos, y métodos de tratamiento con los mismos.

Info

Publication number
CL2015001990A1
CL2015001990A1 CL2015001990A CL2015001990A CL2015001990A1 CL 2015001990 A1 CL2015001990 A1 CL 2015001990A1 CL 2015001990 A CL2015001990 A CL 2015001990A CL 2015001990 A CL2015001990 A CL 2015001990A CL 2015001990 A1 CL2015001990 A1 CL 2015001990A1
Authority
CL
Chile
Prior art keywords
compositions
methods
treatment therewith
pyrrolopyrimidine compounds
substituted pyrrolopyrimidine
Prior art date
Application number
CL2015001990A
Other languages
English (en)
Inventor
Jennifer Riggs
Rama K Narla
Roy L Harris
Tam Minh Tran
Yuhong Ning
Shuichan Xu
Andrew Antony Calabrese
Brandon Jeffy
Dale Robinson
Dan Zhu
Dehua Huang
Jan Elsner
John Boylan
Lida Tehrani
Mark A Nagy
Raj Kumar Raheja
Paul Erdman
Original Assignee
Signal Pharm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50031611&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015001990(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc
Publication of CL2015001990A1 publication Critical patent/CL2015001990A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPUESTOS DERIVADOS DEPIRROLO PIRIMIDINA SUSTITUIDOS; COMPOSICION FARMACEUTICA QUE LOS COMPRENDE; Y METODO DE TRATAMIENTO O PREVENCION DE CANCER DE SENO.
CL2015001990A 2013-01-16 2015-07-15 Compuestos de pirrolopirimidina substituidos, composiciones de los mismos, y métodos de tratamiento con los mismos. CL2015001990A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361753259P 2013-01-16 2013-01-16

Publications (1)

Publication Number Publication Date
CL2015001990A1 true CL2015001990A1 (es) 2016-01-22

Family

ID=50031611

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015001990A CL2015001990A1 (es) 2013-01-16 2015-07-15 Compuestos de pirrolopirimidina substituidos, composiciones de los mismos, y métodos de tratamiento con los mismos.

Country Status (24)

Country Link
US (3) US9346812B2 (es)
EP (2) EP2945636B1 (es)
JP (1) JP2016505041A (es)
KR (1) KR20150108389A (es)
CN (1) CN105188704B (es)
AR (1) AR094494A1 (es)
AU (1) AU2014207641A1 (es)
BR (1) BR112015016997A2 (es)
CA (1) CA2897985A1 (es)
CL (1) CL2015001990A1 (es)
EA (1) EA201591327A1 (es)
EC (1) ECSP15030799A (es)
ES (1) ES2638179T3 (es)
HK (1) HK1212207A1 (es)
IL (1) IL239901A0 (es)
MX (1) MX2015009209A (es)
NI (1) NI201500094A (es)
NZ (1) NZ630467A (es)
PE (1) PE20151995A1 (es)
PH (1) PH12015501576A1 (es)
SG (1) SG11201505446WA (es)
TW (1) TW201441227A (es)
WO (1) WO2014113429A2 (es)
ZA (1) ZA201505011B (es)

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US11339167B2 (en) 2017-12-28 2022-05-24 Daewoong Pharmaceutical Co., Ltd. Substituted piperidines as kinase inhibitors
US11407754B2 (en) 2017-12-28 2022-08-09 Daewoong Pharmaceutical Co., Ltd. Substituted piperidines as kinase inhibitors

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EA201790189A1 (ru) * 2014-07-14 2017-11-30 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Способы лечения злокачественного новообразования с использованием замещенных пирролопиримидиновых соединений, композиции на их основе
NZ629796A (en) * 2014-07-14 2015-12-24 Signal Pharm Llc Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
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KR20180015160A (ko) * 2015-06-22 2018-02-12 오노 야꾸힝 고교 가부시키가이샤 Brk 저해 화합물
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CN107531710B (zh) * 2015-08-13 2020-02-14 北京韩美药品有限公司 Irak4抑制剂及其应用
JP2018538241A (ja) * 2015-10-13 2018-12-27 ザ スクリプス リサーチ インスティテュート 乳癌におけるカゼインキナーゼ１δの治療標的化
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DK3464285T3 (da) 2016-06-01 2022-12-19 Biosplice Therapeutics Inc Fremgangsmåde til fremstilling af n-(5-(3-(7-(3-fluorphenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-indazol-5-yl)pyridin-3-yl)-3-methylbutanamid
CN108727400B (zh) * 2017-05-24 2021-07-09 四川晶华生物科技有限公司 一种治疗肿瘤的化合物
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JP7840066B2 (ja) * 2021-05-03 2026-04-03 ジェービーケーラボ カンパニー リミテッド ２，６－ジクロロ－４－（４－（４－ヒドロキシシクロヘキシルアミノ）－７ｈ－ピロロ［２，３－ｄ］ピリミジン－５－イル）フェノールを活性成分として含有する、がんを予防、緩和、または処置するための医薬組成物
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ZA201505011B (en) 2016-11-30
CN105188704A (zh) 2015-12-23
EP2945636A2 (en) 2015-11-25
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US20140200206A1 (en) 2014-07-17
US20140200207A1 (en) 2014-07-17
US9795607B2 (en) 2017-10-24
PE20151995A1 (es) 2016-01-13
TW201441227A (zh) 2014-11-01
MX2015009209A (es) 2016-03-17
SG11201505446WA (en) 2015-08-28
WO2014113429A3 (en) 2014-10-09
PH12015501576A1 (en) 2016-02-01
CA2897985A1 (en) 2014-07-24
EP2945636B1 (en) 2017-06-28
WO2014113429A2 (en) 2014-07-24
US9346812B2 (en) 2016-05-24
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US20160324861A1 (en) 2016-11-10
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ES2638179T3 (es) 2017-10-19
HK1212207A1 (en) 2016-06-10
EP3202403A1 (en) 2017-08-09
NZ630467A (en) 2017-02-24
CN105188704B (zh) 2017-09-19
ECSP15030799A (es) 2015-11-30
BR112015016997A2 (pt) 2017-07-11
EA201591327A1 (ru) 2015-12-30
US9428509B2 (en) 2016-08-30
AR094494A1 (es) 2015-08-05

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