CL2016003281A1 - Ácidos grasos y su uso en conjugación con biomoleculas - Google Patents

Ácidos grasos y su uso en conjugación con biomoleculas

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Publication number
CL2016003281A1
CL2016003281A1 CL2016003281A CL2016003281A CL2016003281A1 CL 2016003281 A1 CL2016003281 A1 CL 2016003281A1 CL 2016003281 A CL2016003281 A CL 2016003281A CL 2016003281 A CL2016003281 A CL 2016003281A CL 2016003281 A1 CL2016003281 A1 CL 2016003281A1
Authority
CL
Chile
Prior art keywords
biomolecules
conjugation
fatty acids
formulas
derived
Prior art date
Application number
CL2016003281A
Other languages
English (en)
Inventor
Zecri Frederic
Kanter Aaron
Lou Changgang
Richardson Usera Aimee
Marshall Bruce Alexandra
Yuan Jun
Weninger Barnes David
Yamada Ken
Ibebunjo Chikwendu
Durraroy Alokesh
Clare Kirman Louise
Bose Avirup
Original Assignee
Novartis Ag
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53491695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2016003281(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2016003281A1 publication Critical patent/CL2016003281A1/es

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
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    • A61K38/1841—Transforming growth factor [TGF]
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    • A61K38/22—Hormones
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    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
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    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

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  • Engineering & Computer Science (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Wood Science & Technology (AREA)
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  • Biotechnology (AREA)
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  • Obesity (AREA)
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Abstract

<p>CONJUGADO DE BIOMOLECULAS ENLAZADAS A UN ÁCIDO GRASO POR MEDIO DE UN ENLAZADOR, EN DONDE EL ACIDO GRASO TIENE LAS FORMULAS A1 DERIVADAS DE UN CARBOXILARO Y LAS FORMULAS A2 Y A3 DERIVADAS DE  DICARBOXILATOS</p>
CL2016003281A 2014-06-23 2016-12-21 Ácidos grasos y su uso en conjugación con biomoleculas CL2016003281A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462015862P 2014-06-23 2014-06-23
US201462082327P 2014-11-20 2014-11-20
US201562107016P 2015-01-23 2015-01-23

Publications (1)

Publication Number Publication Date
CL2016003281A1 true CL2016003281A1 (es) 2017-06-09

Family

ID=53491695

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016003281A CL2016003281A1 (es) 2014-06-23 2016-12-21 Ácidos grasos y su uso en conjugación con biomoleculas

Country Status (36)

Country Link
US (4) US10588980B2 (es)
EP (2) EP3157571B1 (es)
JP (5) JP6636959B2 (es)
KR (2) KR20230056796A (es)
CN (3) CN114099693A (es)
AP (1) AP2016009585A0 (es)
AU (1) AU2015280351C1 (es)
CA (1) CA2953480A1 (es)
CL (1) CL2016003281A1 (es)
CR (1) CR20160596A (es)
CU (1) CU24455B1 (es)
CY (1) CY1125006T1 (es)
DK (1) DK3157571T3 (es)
EA (1) EA039074B1 (es)
EC (1) ECSP17004665A (es)
ES (1) ES2905479T3 (es)
GT (1) GT201600263A (es)
HR (1) HRP20220152T1 (es)
HU (1) HUE057845T2 (es)
IL (1) IL248990B (es)
JO (1) JO3813B1 (es)
LT (1) LT3157571T (es)
MA (1) MA40278A (es)
MX (1) MX367520B (es)
MY (1) MY193993A (es)
PE (1) PE20171095A1 (es)
PH (1) PH12016502294B1 (es)
PL (1) PL3157571T3 (es)
PT (1) PT3157571T (es)
RS (1) RS62907B1 (es)
SG (2) SG10201912965TA (es)
SI (1) SI3157571T1 (es)
TN (1) TN2016000558A1 (es)
TW (3) TWI750725B (es)
UY (1) UY36186A (es)
WO (1) WO2015200078A1 (es)

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TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
JP5977814B2 (ja) 2011-04-08 2016-08-24 アムジエン・インコーポレーテツド 増殖分化因子１５（ｇｄｆ−１５）を使用して代謝障害を治療または改善する方法
UA116665C2 (uk) 2013-07-31 2018-04-25 Емджен Інк. Гібридний білок, що містить область фактора диференціації та росту 15 (gdf-15)
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
EP3227319B1 (en) 2014-12-04 2019-11-27 Novartis AG Methods and compositions using klotho variant polypeptides
CA2972871A1 (en) * 2015-01-23 2016-07-28 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
WO2016161388A1 (en) 2015-04-03 2016-10-06 University Of Massachusetts Fully stabilized asymmetric sirna
WO2017030973A1 (en) 2015-08-14 2017-02-23 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
CN108367053A (zh) * 2015-12-22 2018-08-03 诺华股份有限公司 使用生长分化因子15(gdf-15)治疗或改善代谢性疾病的方法
US10478503B2 (en) 2016-01-31 2019-11-19 University Of Massachusetts Branched oligonucleotides
MA45113A (fr) 2016-05-24 2019-04-10 Novo Nordisk As Composés mic-1 et leur utilisation
KR101727506B1 (ko) * 2016-07-14 2017-05-04 충남대학교 산학협력단 Gdf15 단백질 또는 이를 암호화하는 폴리뉴클레오티드를 유효성분으로 함유하는 지방간의 예방 또는 치료용 약학적 조성물
US11753638B2 (en) 2016-08-12 2023-09-12 University Of Massachusetts Conjugated oligonucleotides
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