CL2017000707A1 - Derivados de nucleosidos sustituidos de 4'-vinilo como inhibidores de la replicación del arn del virus sincicial respiratorio - Google Patents

Derivados de nucleosidos sustituidos de 4'-vinilo como inhibidores de la replicación del arn del virus sincicial respiratorio

Info

Publication number
CL2017000707A1
CL2017000707A1 CL2017000707A CL2017000707A CL2017000707A1 CL 2017000707 A1 CL2017000707 A1 CL 2017000707A1 CL 2017000707 A CL2017000707 A CL 2017000707A CL 2017000707 A CL2017000707 A CL 2017000707A CL 2017000707 A1 CL2017000707 A1 CL 2017000707A1
Authority
CL
Chile
Prior art keywords
inhibitors
respiratory syncytial
syncytial virus
virus rna
rna replication
Prior art date
Application number
CL2017000707A
Other languages
English (en)
Inventor
Mark Smith
Klaus G Klumpp
Original Assignee
Riboscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riboscience Llc filed Critical Riboscience Llc
Publication of CL2017000707A1 publication Critical patent/CL2017000707A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

<p>LA SOLICITUD DA A CONOCER COMPUESTOS DE FÓRMULA I, EN LA QUE LOS SUSTITUYENTES VARIABLES SON TAL COMO SE DEFINEN EN EL PRESENTE DOCUMENTO. LOS COMPUESTOS DE FÓRMULA I Y LAS COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN COMPUESTOS DE FÓRMULA I SON ÚTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR VRS.</p>
CL2017000707A 2014-09-26 2017-03-24 Derivados de nucleosidos sustituidos de 4'-vinilo como inhibidores de la replicación del arn del virus sincicial respiratorio CL2017000707A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462055704P 2014-09-26 2014-09-26

Publications (1)

Publication Number Publication Date
CL2017000707A1 true CL2017000707A1 (es) 2017-12-15

Family

ID=55582038

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017000707A CL2017000707A1 (es) 2014-09-26 2017-03-24 Derivados de nucleosidos sustituidos de 4'-vinilo como inhibidores de la replicación del arn del virus sincicial respiratorio

Country Status (20)

Country Link
US (1) US10358458B2 (es)
EP (1) EP3197457B1 (es)
JP (1) JP6671355B2 (es)
KR (1) KR102573609B1 (es)
CN (1) CN107073002B (es)
AU (1) AU2015320511B2 (es)
BR (1) BR112017006264A2 (es)
CA (1) CA2962770C (es)
CL (1) CL2017000707A1 (es)
CO (1) CO2017003994A2 (es)
CR (1) CR20170157A (es)
EA (1) EA031726B1 (es)
IL (1) IL251368B (es)
MA (1) MA40149A1 (es)
MX (1) MX381291B (es)
PE (1) PE20170698A1 (es)
PH (1) PH12017500558A1 (es)
SG (2) SG10201810361TA (es)
WO (1) WO2016049415A1 (es)
ZA (1) ZA201702858B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017006264A2 (pt) 2014-09-26 2017-12-12 Riboscience Llc derivados de nucleosídeo substituído com 4?-vinila como inibidores de replicação de rna do vírus sincitial respiratório
CA3134613A1 (en) * 2019-04-02 2020-10-08 Aligos Therapeutics, Inc. Compounds targeting prmt5
WO2021155277A1 (en) * 2020-01-31 2021-08-05 Octagon Therapeutics, Inc. Modulation of immune cells
CN112194694B (zh) * 2020-09-29 2022-03-25 佛山科学技术学院 尿苷酸双苯丙酸酯基氨基磷酸酯化合物、其药物组合物及其制备方法和应用
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
EP4493573A1 (en) 2022-03-15 2025-01-22 Rome Therapeutics, Inc. Compounds and methods for treating disease
WO2024103016A1 (en) * 2022-11-11 2024-05-16 Rome Therapeutics, Inc. 4'-halomethyl-cytidine phosphoramidates and related compounds and their use in treating medical conditions

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69729887T2 (de) * 1996-10-16 2005-07-28 ICN Pharmaceuticals, Inc., Costa Mesa Purin-L-Nukleoside, Analoga und deren Verwendung
EP1103559A1 (en) * 1997-01-17 2001-05-30 ICN Pharmaceuticals, Inc. Autoimmune nucleosides
SI9820003A (sl) * 1997-01-17 1999-06-30 Icn Pharmaceuticals, Inc. Zdravljenje bolezni povezano s citokini
UA72612C2 (en) * 2000-07-06 2005-03-15 Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
AU2002330154A1 (en) 2001-09-28 2003-04-07 Centre National De La Recherche Scientifique Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
EP1438054A4 (en) 2001-09-28 2006-07-26 Idenix Cayman Ltd METHODS AND COMPOSITIONS FOR TREATING FLAVIVIRUS AND PESTIVIRUS USING MODIFIED NUCLEOSIDE AT 4 'POSITION
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
BRPI0407374A (pt) * 2003-02-19 2006-01-10 Univ Yale Análogos de nucleosìdeo antiviral e métodos para tratar infecções virais, especialmente infecções de hiv
WO2005020885A2 (en) * 2003-05-21 2005-03-10 Isis Pharmaceuticals, Inc. Compositions and methods for the treatment of severe acute respiratory syndrome (sars)
JP2009504704A (ja) 2005-08-15 2009-02-05 エフ．ホフマン−ラ ロシュ アーゲー 抗ウイルス４′−置換プロヌクレオチドホスホルアミダート
WO2007145593A1 (en) 2006-06-15 2007-12-21 Jyoti Chattopadhyaya Conformationally constrained 2' -n,4' -c-ethylene-bridged thymidine (aza-ena-t)
EP2207554A2 (en) 2007-11-09 2010-07-21 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services C4'-substituted-2-deoxyadenosine analogs and methods of treating hiv
US8445669B2 (en) 2008-04-10 2013-05-21 Hamari Chemicals, Ltd. Production process of ethynylthymidine compounds from 5-methyluridine as a starting material
WO2010030858A1 (en) 2008-09-15 2010-03-18 Enanta Pharmaceuticals, Inc. 4'-allene-substituted nucleoside derivatives
WO2011005860A2 (en) 2009-07-07 2011-01-13 Alnylam Pharmaceuticals, Inc. 5' phosphate mimics
US20130260460A1 (en) 2010-04-22 2013-10-03 Isis Pharmaceuticals Inc Conformationally restricted dinucleotide monomers and oligonucleotides
US20130018011A1 (en) * 2011-06-10 2013-01-17 Hassan Javanbakht Method of treating dengue fever
SG10201610936RA (en) * 2011-12-22 2017-02-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
KR102068856B1 (ko) 2012-03-13 2020-01-21 길리애드 사이언시즈, 인코포레이티드 항바이러스 치료를 위한 2'-치환된 카바-뉴클레오시드 유사체
RS58437B1 (sr) 2012-03-21 2019-04-30 Alios Biopharma Inc Supstituisani nukleozidi, nukleotidi i njihovi analozi
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
MX2015005500A (es) * 2012-10-29 2016-02-09 Cocrystal Pharma Inc Nucleotidos de pirimidina y sus profarmacos de monofosfato para el tratamiento de infecciones virales y cancer.
HK1224229A1 (zh) 2013-06-26 2017-08-18 Alios Biopharma, Inc. 取代的核苷，核苷酸及其类似物
JP6562908B2 (ja) * 2013-10-11 2019-08-21 ヤンセン バイオファーマ インク． 置換ヌクレオシド、置換ヌクレオチドおよびその類似体
UA119050C2 (uk) 2013-11-11 2019-04-25 Ґілеад Саєнсиз, Інк. ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
HUE051986T2 (hu) * 2014-06-24 2021-04-28 Janssen Biopharma Inc Helyettesített nukleozidok, nukleotidek és analógjaik virális fertõzés kezelésére való alkalmazásra
TN2016000566A1 (en) 2014-06-24 2018-04-04 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
TWI673283B (zh) * 2014-08-21 2019-10-01 美商基利科學股份有限公司 ２’－氯胺基嘧啶酮及嘧啶二酮核苷類
BR112017006264A2 (pt) 2014-09-26 2017-12-12 Riboscience Llc derivados de nucleosídeo substituído com 4?-vinila como inibidores de replicação de rna do vírus sincitial respiratório

Also Published As

Publication number Publication date
KR102573609B1 (ko) 2023-08-31
EP3197457A4 (en) 2018-08-01
AU2015320511A1 (en) 2017-05-04
EA031726B1 (ru) 2019-02-28
ZA201702858B (en) 2018-08-29
SG11201702430WA (en) 2017-04-27
CR20170157A (es) 2017-07-03
CO2017003994A2 (es) 2017-07-11
MA40149A1 (fr) 2019-04-30
EA201790632A1 (ru) 2017-09-29
EP3197457A1 (en) 2017-08-02
CA2962770A1 (en) 2016-03-31
PH12017500558A1 (en) 2017-08-30
IL251368A0 (en) 2017-05-29
AU2015320511B2 (en) 2020-11-12
EP3197457B1 (en) 2022-11-09
US10358458B2 (en) 2019-07-23
CA2962770C (en) 2023-08-22
WO2016049415A1 (en) 2016-03-31
KR20170062499A (ko) 2017-06-07
CN107073002A (zh) 2017-08-18
MX2017003788A (es) 2017-08-07
JP6671355B2 (ja) 2020-03-25
JP2017529375A (ja) 2017-10-05
MX381291B (es) 2025-03-12
IL251368B (en) 2020-05-31
PE20170698A1 (es) 2017-06-05
BR112017006264A2 (pt) 2017-12-12
CN107073002B (zh) 2019-10-15
NZ730923A (en) 2020-09-25
SG10201810361TA (en) 2018-12-28
US20160264611A1 (en) 2016-09-15

Similar Documents

Publication Publication Date Title
CR20160518A (es) Compuestos para tratar atrofia muscular espinal
CO2017006962A2 (es) Derivados de 2-anilinopirimidina sustituida como moudladores de egfr
MX2018005890A (es) Composiciones para tratar atrofia muscular espinal.
NI201600144A (es) Derivados de quinoxalina utiles como moduladores del fgfr cinasa
MX2016013689A (es) Compuestos 4-amino-imidazoquinolina.
UY36126A (es) ?compuestos de 6,8-dioxabiciclo[3.2.1]octano-2,3-diol sustituidos como agentes de direccionamiento al asgpr?.
MX2016010213A (es) Formulaciones farmaceuticas novedosas.
UY35213A (es) Compuestos del tipo de las carbamilpiridonas policíclicas y su uso farmaceutico
CL2018002758A1 (es) Derivados de indolina sustituidos como inhibidores de la replicación viral del dengue.
CU20140048A7 (es) Novedosos derivados de purina útiles en el tratamiento del cáncer y trastornos neurodegenerativos
CU20190101A7 (es) Imidazopirimidinas diazabicíclicas sustituidas
CL2016001973A1 (es) Derivados de nucleosido sustituidos con 4&#39; -difluorometilo como inhibidores de la replicación de arn de la influenza.
MX2014005342A (es) Inhibidores del virus de la hepatitis c.
CO2017003994A2 (es) Derivados de nucleósidos sustituidos con 4’-vinilo como inhibidores de la replicación del arn del virus respiratorio sincitial
UY36868A (es) Composiciones para tratamiento de enfermedades mediadas por interleuquina 5 (il-5)
DOP2016000308A (es) Compuestos de 1, 3, 4-tiadiazol y uso de los mismos para el tratamiento del cáncer
EA201591406A1 (ru) C-19 модифицированные тритерпеноиды с ингибиторной активностью созревания вич
DOP2017000034A (es) Compuestos de imidazopiridazina
MX2019003026A (es) Compuestos de heteroarilcarboxamida como inhibidores de ripk2.
CU20160152A7 (es) Nuevos compuestos macrocíclicos en calidad de inhibidores de cdk9, un proceso para su preparación y los compuestos intermediarios útiles en la preparación de estos compuestos
MX2016012784A (es) Composiciones farmaceuticas solidas que comprenden derivados de biopterina y usos de tales composiciones.
UY36070A (es) Triterpenoides con actividad inhibidora de la maduración de hiv
CO2017009989A2 (es) Piridopirimidinonas y utilización de las mismas como moduladores de receptores de nmda
DOP2016000297A (es) Composiciones farmacéuticas útiles para tratar enfermedades infecciosas
CO2017000011A2 (es) Derivados de quinolizinona como inhibidores de pi3k