MA40149A1 - Dérivés de nucléoside 4'-vinyle substitués utiles en tant qu'inhibiteurs de la réplication due l'arn du virus respiratoire syncytial - Google Patents

Dérivés de nucléoside 4'-vinyle substitués utiles en tant qu'inhibiteurs de la réplication due l'arn du virus respiratoire syncytial

Info

Publication number
MA40149A1
MA40149A1 MA40149A MA40149A MA40149A1 MA 40149 A1 MA40149 A1 MA 40149A1 MA 40149 A MA40149 A MA 40149A MA 40149 A MA40149 A MA 40149A MA 40149 A1 MA40149 A1 MA 40149A1
Authority
MA
Morocco
Prior art keywords
respiratory syncytial
syncytial virus
inhibitors
substituted
derivatives useful
Prior art date
Application number
MA40149A
Other languages
English (en)
Inventor
Mark Smith
Klaus G Klumpp
Original Assignee
Riboscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riboscience Llc filed Critical Riboscience Llc
Publication of MA40149A1 publication Critical patent/MA40149A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'application concerne des composés de formule (i), dans laquelle les substituants variables sont tels que définis dans la description. Les composés de formule (i) et des compositions pharmaceutiques comprenant des composés de formule i sont utiles pour le traitement de maladies médiées par le virus respiratoire syncytial.
MA40149A 2014-09-26 2015-09-25 Dérivés de nucléoside 4'-vinyle substitués utiles en tant qu'inhibiteurs de la réplication due l'arn du virus respiratoire syncytial MA40149A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462055704P 2014-09-26 2014-09-26
PCT/US2015/052144 WO2016049415A1 (fr) 2014-09-26 2015-09-25 Dérivés de nucléoside 4'-vinyle substitués utiles en tant qu'inhibiteurs de la réplication due l'arn du virus respiratoire syncytial

Publications (1)

Publication Number Publication Date
MA40149A1 true MA40149A1 (fr) 2019-04-30

Family

ID=55582038

Family Applications (1)

Application Number Title Priority Date Filing Date
MA40149A MA40149A1 (fr) 2014-09-26 2015-09-25 Dérivés de nucléoside 4'-vinyle substitués utiles en tant qu'inhibiteurs de la réplication due l'arn du virus respiratoire syncytial

Country Status (20)

Country Link
US (1) US10358458B2 (fr)
EP (1) EP3197457B1 (fr)
JP (1) JP6671355B2 (fr)
KR (1) KR102573609B1 (fr)
CN (1) CN107073002B (fr)
AU (1) AU2015320511B2 (fr)
BR (1) BR112017006264A2 (fr)
CA (1) CA2962770C (fr)
CL (1) CL2017000707A1 (fr)
CO (1) CO2017003994A2 (fr)
CR (1) CR20170157A (fr)
EA (1) EA031726B1 (fr)
IL (1) IL251368B (fr)
MA (1) MA40149A1 (fr)
MX (1) MX381291B (fr)
PE (1) PE20170698A1 (fr)
PH (1) PH12017500558A1 (fr)
SG (2) SG10201810361TA (fr)
WO (1) WO2016049415A1 (fr)
ZA (1) ZA201702858B (fr)

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BR112017006264A2 (pt) 2014-09-26 2017-12-12 Riboscience Llc derivados de nucleosídeo substituído com 4?-vinila como inibidores de replicação de rna do vírus sincitial respiratório
CA3134613A1 (fr) * 2019-04-02 2020-10-08 Aligos Therapeutics, Inc. Composes ciblant prmt5
WO2021155277A1 (fr) * 2020-01-31 2021-08-05 Octagon Therapeutics, Inc. Modulation de cellules immunitaires
CN112194694B (zh) * 2020-09-29 2022-03-25 佛山科学技术学院 尿苷酸双苯丙酸酯基氨基磷酸酯化合物、其药物组合物及其制备方法和应用
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
EP4493573A1 (fr) 2022-03-15 2025-01-22 Rome Therapeutics, Inc. Composés et méthodes pour traiter une maladie
WO2024103016A1 (fr) * 2022-11-11 2024-05-16 Rome Therapeutics, Inc. 4'-halométhyl-cytidine phosphoramidates et composés apparentés et leur utilisation dans le traitement d'affections médicales

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BR112017006264A2 (pt) 2014-09-26 2017-12-12 Riboscience Llc derivados de nucleosídeo substituído com 4?-vinila como inibidores de replicação de rna do vírus sincitial respiratório

Also Published As

Publication number Publication date
KR102573609B1 (ko) 2023-08-31
EP3197457A4 (fr) 2018-08-01
AU2015320511A1 (en) 2017-05-04
EA031726B1 (ru) 2019-02-28
ZA201702858B (en) 2018-08-29
SG11201702430WA (en) 2017-04-27
CR20170157A (es) 2017-07-03
CO2017003994A2 (es) 2017-07-11
EA201790632A1 (ru) 2017-09-29
EP3197457A1 (fr) 2017-08-02
CA2962770A1 (fr) 2016-03-31
PH12017500558A1 (en) 2017-08-30
IL251368A0 (en) 2017-05-29
AU2015320511B2 (en) 2020-11-12
EP3197457B1 (fr) 2022-11-09
US10358458B2 (en) 2019-07-23
CA2962770C (fr) 2023-08-22
WO2016049415A1 (fr) 2016-03-31
KR20170062499A (ko) 2017-06-07
CL2017000707A1 (es) 2017-12-15
CN107073002A (zh) 2017-08-18
MX2017003788A (es) 2017-08-07
JP6671355B2 (ja) 2020-03-25
JP2017529375A (ja) 2017-10-05
MX381291B (es) 2025-03-12
IL251368B (en) 2020-05-31
PE20170698A1 (es) 2017-06-05
BR112017006264A2 (pt) 2017-12-12
CN107073002B (zh) 2019-10-15
NZ730923A (en) 2020-09-25
SG10201810361TA (en) 2018-12-28
US20160264611A1 (en) 2016-09-15

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