CR20170157A - Derivados de nucleósidos sustituidos con 4´-vinilo como inhibidores de la replicación del arn del virus respiratorio sincitial - Google Patents
Derivados de nucleósidos sustituidos con 4´-vinilo como inhibidores de la replicación del arn del virus respiratorio sincitialInfo
- Publication number
- CR20170157A CR20170157A CR20170157A CR20170157A CR20170157A CR 20170157 A CR20170157 A CR 20170157A CR 20170157 A CR20170157 A CR 20170157A CR 20170157 A CR20170157 A CR 20170157A CR 20170157 A CR20170157 A CR 20170157A
- Authority
- CR
- Costa Rica
- Prior art keywords
- respiratory
- nucleosids
- replication
- rna
- inhibitors
- Prior art date
Links
- 230000000241 respiratory effect Effects 0.000 title 2
- 241000700605 Viruses Species 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
- 229920002554 vinyl polymer Polymers 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Abstract
La solicitud da a conocer compuestos de fórmula I: en la que los sustituyentes variables son tal como se definen en el presente documento. Los compuestos de fórmula I y las composiciones farmacéuticas que comprenden compuestos de fórmula I son útiles para el tratamiento de enfermedades mediadas por VRS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462055704P | 2014-09-26 | 2014-09-26 | |
| PCT/US2015/052144 WO2016049415A1 (en) | 2014-09-26 | 2015-09-25 | 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20170157A true CR20170157A (es) | 2017-07-03 |
Family
ID=55582038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20170157A CR20170157A (es) | 2014-09-26 | 2015-09-25 | Derivados de nucleósidos sustituidos con 4´-vinilo como inhibidores de la replicación del arn del virus respiratorio sincitial |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10358458B2 (es) |
| EP (1) | EP3197457B1 (es) |
| JP (1) | JP6671355B2 (es) |
| KR (1) | KR102573609B1 (es) |
| CN (1) | CN107073002B (es) |
| AU (1) | AU2015320511B2 (es) |
| BR (1) | BR112017006264A2 (es) |
| CA (1) | CA2962770C (es) |
| CL (1) | CL2017000707A1 (es) |
| CO (1) | CO2017003994A2 (es) |
| CR (1) | CR20170157A (es) |
| EA (1) | EA031726B1 (es) |
| IL (1) | IL251368B (es) |
| MA (1) | MA40149A1 (es) |
| MX (1) | MX381291B (es) |
| PE (1) | PE20170698A1 (es) |
| PH (1) | PH12017500558A1 (es) |
| SG (2) | SG11201702430WA (es) |
| WO (1) | WO2016049415A1 (es) |
| ZA (1) | ZA201702858B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015320511B2 (en) | 2014-09-26 | 2020-11-12 | Riboscience Llc | 4'-vinyl substituted nucleoside derivatives as inhibitors of Respiratory Syncytial Virus RNA replication |
| MA55556A (fr) * | 2019-04-02 | 2022-02-09 | Aligos Therapeutics Inc | Composés ciblant prmt5 |
| US20230123911A1 (en) * | 2020-01-31 | 2023-04-20 | Octagon Therapeutics, Inc. | Modulation of immune cells |
| CN112194694B (zh) * | 2020-09-29 | 2022-03-25 | 佛山科学技术学院 | 尿苷酸双苯丙酸酯基氨基磷酸酯化合物、其药物组合物及其制备方法和应用 |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
| IL315480A (en) | 2022-03-15 | 2024-11-01 | Rome Therapeutics Inc | Compounds and methods for treating disease |
| WO2024103016A1 (en) * | 2022-11-11 | 2024-05-16 | Rome Therapeutics, Inc. | 4'-halomethyl-cytidine phosphoramidates and related compounds and their use in treating medical conditions |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9714349A (pt) | 1996-10-16 | 2000-11-14 | Icn Pharmaceuticals | L-nucleosìdeos purina, seus análogos e utilizacões dos mesmos |
| EP0998293A4 (en) * | 1997-01-17 | 2002-07-17 | Icn Pharmaceuticals | TREATMENTS FOR CYTOKIN-RELATED DISEASES |
| EP1103559A1 (en) * | 1997-01-17 | 2001-05-30 | ICN Pharmaceuticals, Inc. | Autoimmune nucleosides |
| UA72612C2 (en) | 2000-07-06 | 2005-03-15 | Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells | |
| GB0114286D0 (en) * | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
| EP1435974A4 (en) | 2001-09-28 | 2006-09-06 | Idenix Cayman Ltd | METHODS AND COMPOSITIONS FOR THE TREATMENT OF HEPATITIS C VIRUS USING 4 'MODIFIED NUCLEOSIDES |
| US20040006002A1 (en) | 2001-09-28 | 2004-01-08 | Jean-Pierre Sommadossi | Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside |
| TWI332507B (en) | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
| CN102174038A (zh) * | 2003-02-19 | 2011-09-07 | 耶鲁大学 | 用于治疗病毒感染的抗病毒核苷 |
| WO2005020885A2 (en) | 2003-05-21 | 2005-03-10 | Isis Pharmaceuticals, Inc. | Compositions and methods for the treatment of severe acute respiratory syndrome (sars) |
| WO2007020193A2 (en) | 2005-08-15 | 2007-02-22 | F. Hoffmann-La Roche Ag | Antiviral phosphoramidates of 4 ' -substituted pronucleotides |
| WO2007145593A1 (en) | 2006-06-15 | 2007-12-21 | Jyoti Chattopadhyaya | Conformationally constrained 2' -n,4' -c-ethylene-bridged thymidine (aza-ena-t) |
| EP2207554A2 (en) | 2007-11-09 | 2010-07-21 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | C4'-substituted-2-deoxyadenosine analogs and methods of treating hiv |
| US8445669B2 (en) | 2008-04-10 | 2013-05-21 | Hamari Chemicals, Ltd. | Production process of ethynylthymidine compounds from 5-methyluridine as a starting material |
| US8163707B2 (en) | 2008-09-15 | 2012-04-24 | Enanta Pharmaceuticals, Inc. | 4′-allene-substituted nucleoside derivatives |
| WO2011005860A2 (en) | 2009-07-07 | 2011-01-13 | Alnylam Pharmaceuticals, Inc. | 5' phosphate mimics |
| WO2011133868A2 (en) | 2010-04-22 | 2011-10-27 | Alnylam Pharmaceuticals, Inc. | Conformationally restricted dinucleotide monomers and oligonucleotides |
| US20130018011A1 (en) | 2011-06-10 | 2013-01-17 | Hassan Javanbakht | Method of treating dengue fever |
| SG10201913554YA (en) | 2011-12-22 | 2020-03-30 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| MD4496C1 (ro) | 2012-03-13 | 2018-02-28 | Gilead Sciences, Inc. | Analogi carba-nucleozidici 2'-substituiţi pentru tratament antiviral |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| GEP201706721B (en) | 2012-03-21 | 2017-08-25 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| HK1214270A1 (zh) * | 2012-10-29 | 2016-07-22 | 共晶制药股份有限公司 | 用於治療病毒感染和癌症的嘧啶核苷及其單磷酸酯前藥 |
| AU2014302711A1 (en) | 2013-06-26 | 2015-12-10 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| WO2015054465A1 (en) | 2013-10-11 | 2015-04-16 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| UA119050C2 (uk) | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
| HUE051986T2 (hu) * | 2014-06-24 | 2021-04-28 | Janssen Biopharma Inc | Helyettesített nukleozidok, nukleotidek és analógjaik virális fertõzés kezelésére való alkalmazásra |
| MA40031A (fr) | 2014-06-24 | 2015-12-30 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| TWI673283B (zh) * | 2014-08-21 | 2019-10-01 | 美商基利科學股份有限公司 | ２’－氯胺基嘧啶酮及嘧啶二酮核苷類 |
| AU2015320511B2 (en) | 2014-09-26 | 2020-11-12 | Riboscience Llc | 4'-vinyl substituted nucleoside derivatives as inhibitors of Respiratory Syncytial Virus RNA replication |
-
2015
- 2015-09-25 AU AU2015320511A patent/AU2015320511B2/en not_active Ceased
- 2015-09-25 CA CA2962770A patent/CA2962770C/en active Active
- 2015-09-25 MX MX2017003788A patent/MX381291B/es unknown
- 2015-09-25 BR BR112017006264A patent/BR112017006264A2/pt not_active IP Right Cessation
- 2015-09-25 CN CN201580055281.3A patent/CN107073002B/zh not_active Expired - Fee Related
- 2015-09-25 CR CR20170157A patent/CR20170157A/es unknown
- 2015-09-25 US US14/865,135 patent/US10358458B2/en active Active
- 2015-09-25 JP JP2017516420A patent/JP6671355B2/ja active Active
- 2015-09-25 SG SG11201702430WA patent/SG11201702430WA/en unknown
- 2015-09-25 MA MA40149A patent/MA40149A1/fr unknown
- 2015-09-25 PE PE2017000521A patent/PE20170698A1/es unknown
- 2015-09-25 WO PCT/US2015/052144 patent/WO2016049415A1/en not_active Ceased
- 2015-09-25 KR KR1020177011174A patent/KR102573609B1/ko active Active
- 2015-09-25 EA EA201790632A patent/EA031726B1/ru not_active IP Right Cessation
- 2015-09-25 SG SG10201810361TA patent/SG10201810361TA/en unknown
- 2015-09-25 EP EP15844391.1A patent/EP3197457B1/en active Active
-
2017
- 2017-03-23 IL IL251368A patent/IL251368B/en active IP Right Grant
- 2017-03-24 CL CL2017000707A patent/CL2017000707A1/es unknown
- 2017-03-24 PH PH12017500558A patent/PH12017500558A1/en unknown
- 2017-04-24 ZA ZA2017/02858A patent/ZA201702858B/en unknown
- 2017-04-25 CO CONC2017/0003994A patent/CO2017003994A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH12017500558A1 (en) | 2017-08-30 |
| KR102573609B1 (ko) | 2023-08-31 |
| US10358458B2 (en) | 2019-07-23 |
| BR112017006264A2 (pt) | 2017-12-12 |
| SG10201810361TA (en) | 2018-12-28 |
| EP3197457B1 (en) | 2022-11-09 |
| PE20170698A1 (es) | 2017-06-05 |
| EA031726B1 (ru) | 2019-02-28 |
| CN107073002B (zh) | 2019-10-15 |
| ZA201702858B (en) | 2018-08-29 |
| MX2017003788A (es) | 2017-08-07 |
| MX381291B (es) | 2025-03-12 |
| CA2962770C (en) | 2023-08-22 |
| EA201790632A1 (ru) | 2017-09-29 |
| JP2017529375A (ja) | 2017-10-05 |
| JP6671355B2 (ja) | 2020-03-25 |
| AU2015320511A1 (en) | 2017-05-04 |
| IL251368B (en) | 2020-05-31 |
| EP3197457A1 (en) | 2017-08-02 |
| IL251368A0 (en) | 2017-05-29 |
| AU2015320511B2 (en) | 2020-11-12 |
| SG11201702430WA (en) | 2017-04-27 |
| KR20170062499A (ko) | 2017-06-07 |
| WO2016049415A1 (en) | 2016-03-31 |
| CO2017003994A2 (es) | 2017-07-11 |
| CA2962770A1 (en) | 2016-03-31 |
| EP3197457A4 (en) | 2018-08-01 |
| US20160264611A1 (en) | 2016-09-15 |
| MA40149A1 (fr) | 2019-04-30 |
| CN107073002A (zh) | 2017-08-18 |
| CL2017000707A1 (es) | 2017-12-15 |
| NZ730923A (en) | 2020-09-25 |
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