CR20170157A - Derivados de nucleósidos sustituidos con 4´-vinilo como inhibidores de la replicación del arn del virus respiratorio sincitial - Google Patents
Derivados de nucleósidos sustituidos con 4´-vinilo como inhibidores de la replicación del arn del virus respiratorio sincitialInfo
- Publication number
- CR20170157A CR20170157A CR20170157A CR20170157A CR20170157A CR 20170157 A CR20170157 A CR 20170157A CR 20170157 A CR20170157 A CR 20170157A CR 20170157 A CR20170157 A CR 20170157A CR 20170157 A CR20170157 A CR 20170157A
- Authority
- CR
- Costa Rica
- Prior art keywords
- respiratory
- nucleosids
- replication
- rna
- inhibitors
- Prior art date
Links
- 230000000241 respiratory effect Effects 0.000 title 2
- 241000700605 Viruses Species 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
- 229920002554 vinyl polymer Polymers 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Abstract
La solicitud da a conocer compuestos de fórmula I: en la que los sustituyentes variables son tal como se definen en el presente documento. Los compuestos de fórmula I y las composiciones farmacéuticas que comprenden compuestos de fórmula I son útiles para el tratamiento de enfermedades mediadas por VRS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462055704P | 2014-09-26 | 2014-09-26 | |
| PCT/US2015/052144 WO2016049415A1 (en) | 2014-09-26 | 2015-09-25 | 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20170157A true CR20170157A (es) | 2017-07-03 |
Family
ID=55582038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20170157A CR20170157A (es) | 2014-09-26 | 2015-09-25 | Derivados de nucleósidos sustituidos con 4´-vinilo como inhibidores de la replicación del arn del virus respiratorio sincitial |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10358458B2 (es) |
| EP (1) | EP3197457B1 (es) |
| JP (1) | JP6671355B2 (es) |
| KR (1) | KR102573609B1 (es) |
| CN (1) | CN107073002B (es) |
| AU (1) | AU2015320511B2 (es) |
| BR (1) | BR112017006264A2 (es) |
| CA (1) | CA2962770C (es) |
| CL (1) | CL2017000707A1 (es) |
| CO (1) | CO2017003994A2 (es) |
| CR (1) | CR20170157A (es) |
| EA (1) | EA031726B1 (es) |
| IL (1) | IL251368B (es) |
| MA (1) | MA40149A1 (es) |
| MX (1) | MX381291B (es) |
| PE (1) | PE20170698A1 (es) |
| PH (1) | PH12017500558A1 (es) |
| SG (2) | SG10201810361TA (es) |
| WO (1) | WO2016049415A1 (es) |
| ZA (1) | ZA201702858B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201810361TA (en) | 2014-09-26 | 2018-12-28 | Riboscience Llc | 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication |
| JP2022522534A (ja) * | 2019-04-02 | 2022-04-19 | アリゴス セラピューティクス インコーポレイテッド | Ｐｒｍｔ５を標的にする化合物 |
| WO2021155277A1 (en) * | 2020-01-31 | 2021-08-05 | Octagon Therapeutics, Inc. | Modulation of immune cells |
| CN112194694B (zh) * | 2020-09-29 | 2022-03-25 | 佛山科学技术学院 | 尿苷酸双苯丙酸酯基氨基磷酸酯化合物、其药物组合物及其制备方法和应用 |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
| CN119546620A (zh) | 2022-03-15 | 2025-02-28 | 罗梅治疗股份有限公司 | 用于治疗疾病的化合物和方法 |
| WO2024103016A1 (en) * | 2022-11-11 | 2024-05-16 | Rome Therapeutics, Inc. | 4'-halomethyl-cytidine phosphoramidates and related compounds and their use in treating medical conditions |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU727177B2 (en) | 1996-10-16 | 2000-12-07 | Icn Pharmaceuticals, Inc. | Purine L-nucleosides, analogs and uses thereof |
| WO1998030223A1 (en) * | 1997-01-17 | 1998-07-16 | Icn Pharmaceuticals, Inc. | Cytokine related treatments of disease |
| EP1103559A1 (en) * | 1997-01-17 | 2001-05-30 | ICN Pharmaceuticals, Inc. | Autoimmune nucleosides |
| UA72612C2 (en) * | 2000-07-06 | 2005-03-15 | Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells | |
| GB0114286D0 (en) * | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
| AU2002330154A1 (en) | 2001-09-28 | 2003-04-07 | Centre National De La Recherche Scientifique | Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides |
| WO2003026675A1 (en) | 2001-09-28 | 2003-04-03 | Idenix (Cayman) Limited | Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside |
| TWI332507B (en) * | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
| KR20110079783A (ko) * | 2003-02-19 | 2011-07-07 | 예일 유니버시티 | 항-바이러스 뉴클레오시드 유사체 및 바이러스 감염, 특히 에이치아이브이 감염의 치료방법 |
| WO2005020885A2 (en) * | 2003-05-21 | 2005-03-10 | Isis Pharmaceuticals, Inc. | Compositions and methods for the treatment of severe acute respiratory syndrome (sars) |
| CN101287472B (zh) | 2005-08-15 | 2011-10-12 | 弗·哈夫曼-拉罗切有限公司 | 抗病毒的4'-取代前核苷酸的氨基磷酸酯类化合物 |
| WO2007145593A1 (en) | 2006-06-15 | 2007-12-21 | Jyoti Chattopadhyaya | Conformationally constrained 2' -n,4' -c-ethylene-bridged thymidine (aza-ena-t) |
| US8513214B2 (en) | 2007-11-09 | 2013-08-20 | The United States Of America As Represented By The Secretary Of The Dept. Of Health And Human Services | C4′-substituted-2-deoxyadenosine analogs and methods of treating HIV |
| JP5485140B2 (ja) | 2008-04-10 | 2014-05-07 | 浜理薬品工業株式会社 | ５−メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法 |
| US8163707B2 (en) | 2008-09-15 | 2012-04-24 | Enanta Pharmaceuticals, Inc. | 4′-allene-substituted nucleoside derivatives |
| US8927513B2 (en) | 2009-07-07 | 2015-01-06 | Alnylam Pharmaceuticals, Inc. | 5′ phosphate mimics |
| WO2011133868A2 (en) | 2010-04-22 | 2011-10-27 | Alnylam Pharmaceuticals, Inc. | Conformationally restricted dinucleotide monomers and oligonucleotides |
| US20130018011A1 (en) * | 2011-06-10 | 2013-01-17 | Hassan Javanbakht | Method of treating dengue fever |
| KR102072041B1 (ko) * | 2011-12-22 | 2020-01-31 | 앨리오스 바이오파마 인크. | 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체 |
| NZ629996A (en) | 2012-03-13 | 2016-10-28 | Gilead Sciences Inc | 2’- substituted carba-nucleoside analogs for antiviral treatment |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| SI2827875T1 (sl) | 2012-03-21 | 2019-04-30 | Alios Biopharma, Inc. | Substituirani nukleozidi, nukleotidi in njihovi analogi |
| US9809616B2 (en) * | 2012-10-29 | 2017-11-07 | Emory University | Pyrimidine nucleosides and their monophosphate prodrugs for the treatment of viral infections and cancer |
| ES2952714T3 (es) | 2013-06-26 | 2023-11-03 | Janssen Pharmaceuticals Inc | Nucleósidos sustituidos, nucleótidos y análogos de los mismos |
| CN105829333A (zh) | 2013-10-11 | 2016-08-03 | 艾丽奥斯生物制药有限公司 | 取代的核苷、核苷酸及其类似物 |
| UA119050C2 (uk) | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
| SG11201610597QA (en) | 2014-06-24 | 2017-01-27 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| US9603864B2 (en) * | 2014-06-24 | 2017-03-28 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| TWI673283B (zh) * | 2014-08-21 | 2019-10-01 | 美商基利科學股份有限公司 | ２’－氯胺基嘧啶酮及嘧啶二酮核苷類 |
| SG10201810361TA (en) | 2014-09-26 | 2018-12-28 | Riboscience Llc | 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication |
-
2015
- 2015-09-25 SG SG10201810361TA patent/SG10201810361TA/en unknown
- 2015-09-25 JP JP2017516420A patent/JP6671355B2/ja active Active
- 2015-09-25 KR KR1020177011174A patent/KR102573609B1/ko active Active
- 2015-09-25 CA CA2962770A patent/CA2962770C/en active Active
- 2015-09-25 CN CN201580055281.3A patent/CN107073002B/zh not_active Expired - Fee Related
- 2015-09-25 MX MX2017003788A patent/MX381291B/es unknown
- 2015-09-25 US US14/865,135 patent/US10358458B2/en active Active
- 2015-09-25 SG SG11201702430WA patent/SG11201702430WA/en unknown
- 2015-09-25 BR BR112017006264A patent/BR112017006264A2/pt not_active IP Right Cessation
- 2015-09-25 EA EA201790632A patent/EA031726B1/ru not_active IP Right Cessation
- 2015-09-25 WO PCT/US2015/052144 patent/WO2016049415A1/en not_active Ceased
- 2015-09-25 AU AU2015320511A patent/AU2015320511B2/en not_active Ceased
- 2015-09-25 PE PE2017000521A patent/PE20170698A1/es unknown
- 2015-09-25 CR CR20170157A patent/CR20170157A/es unknown
- 2015-09-25 EP EP15844391.1A patent/EP3197457B1/en active Active
- 2015-09-25 MA MA40149A patent/MA40149A1/fr unknown
-
2017
- 2017-03-23 IL IL251368A patent/IL251368B/en active IP Right Grant
- 2017-03-24 PH PH12017500558A patent/PH12017500558A1/en unknown
- 2017-03-24 CL CL2017000707A patent/CL2017000707A1/es unknown
- 2017-04-24 ZA ZA2017/02858A patent/ZA201702858B/en unknown
- 2017-04-25 CO CONC2017/0003994A patent/CO2017003994A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2017003788A (es) | 2017-08-07 |
| PH12017500558A1 (en) | 2017-08-30 |
| KR102573609B1 (ko) | 2023-08-31 |
| MA40149A1 (fr) | 2019-04-30 |
| SG11201702430WA (en) | 2017-04-27 |
| MX381291B (es) | 2025-03-12 |
| EA031726B1 (ru) | 2019-02-28 |
| KR20170062499A (ko) | 2017-06-07 |
| EP3197457A4 (en) | 2018-08-01 |
| IL251368B (en) | 2020-05-31 |
| JP6671355B2 (ja) | 2020-03-25 |
| CN107073002B (zh) | 2019-10-15 |
| EP3197457A1 (en) | 2017-08-02 |
| ZA201702858B (en) | 2018-08-29 |
| EP3197457B1 (en) | 2022-11-09 |
| US10358458B2 (en) | 2019-07-23 |
| NZ730923A (en) | 2020-09-25 |
| CA2962770C (en) | 2023-08-22 |
| AU2015320511A1 (en) | 2017-05-04 |
| WO2016049415A1 (en) | 2016-03-31 |
| SG10201810361TA (en) | 2018-12-28 |
| CN107073002A (zh) | 2017-08-18 |
| IL251368A0 (en) | 2017-05-29 |
| PE20170698A1 (es) | 2017-06-05 |
| CA2962770A1 (en) | 2016-03-31 |
| CO2017003994A2 (es) | 2017-07-11 |
| JP2017529375A (ja) | 2017-10-05 |
| AU2015320511B2 (en) | 2020-11-12 |
| CL2017000707A1 (es) | 2017-12-15 |
| EA201790632A1 (ru) | 2017-09-29 |
| US20160264611A1 (en) | 2016-09-15 |
| BR112017006264A2 (pt) | 2017-12-12 |
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