CL2017001040A1 - Methods to treat filoviridae virus infections - Google Patents
Methods to treat filoviridae virus infectionsInfo
- Publication number
- CL2017001040A1 CL2017001040A1 CL2017001040A CL2017001040A CL2017001040A1 CL 2017001040 A1 CL2017001040 A1 CL 2017001040A1 CL 2017001040 A CL2017001040 A CL 2017001040A CL 2017001040 A CL2017001040 A CL 2017001040A CL 2017001040 A1 CL2017001040 A1 CL 2017001040A1
- Authority
- CL
- Chile
- Prior art keywords
- methods
- treat
- virus
- virus infections
- filoviridae virus
- Prior art date
Links
- 241000711950 Filoviridae Species 0.000 title abstract 2
- 230000009385 viral infection Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 241001115402 Ebolavirus Species 0.000 abstract 1
- 241001115401 Marburgvirus Species 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 150000008223 ribosides Chemical class 0.000 abstract 1
Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
- A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
<p>SE PROPORCIONAN COMPUESTOS, MÉTODOS, Y COMPOSICIONES FARMACÉUTICAS PARA TRATAR INFECCIONES POR EL VIRUS FILOVIRIDAE ADMINISTRANDO RIBÓSIDOS, FOSFATOS DE RIBÓSIDO, Y PROFÁRMACOS DEL MISMO, DE FÓRMULA IV LOS COMPUESTOS, COMPOSICIONES, Y MÉTODOS PROVISTOS SON PARTICULARMENTE ÚTILES PARA EL TRATAMIENTO DE INFECCIONES POR EL VIRUS DE MARBURG, VIRUS DE EBOLA Y VIRUS CUEVA.</p><p> PHARMACEUTICAL COMPOUNDS, METHODS, AND COMPOSITIONS ARE PROVIDED TO TREAT INFECTIONS BY THE VIRUS FILOVIRIDAE MANAGING RIBOSIDS, RIBOSIDE PHOSPHATES, AND PROMISES OF THE SAME, COMPOSITION MATERIALS, AND COMPOSITION PROVES FOR THE MARBURG VIRUS, EBOLA VIRUS AND CAVE VIRUS. </p>
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462072331P | 2014-10-29 | 2014-10-29 | |
| US201562105619P | 2015-01-20 | 2015-01-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2017001040A1 true CL2017001040A1 (en) | 2018-01-19 |
Family
ID=54557474
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017001040A CL2017001040A1 (en) | 2014-10-29 | 2017-04-26 | Methods to treat filoviridae virus infections |
| CL2017002693A CL2017002693A1 (en) | 2014-10-29 | 2017-10-24 | Methods to treat filoviridae virus infections. divisional application n ° 1040-2017. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017002693A CL2017002693A1 (en) | 2014-10-29 | 2017-10-24 | Methods to treat filoviridae virus infections. divisional application n ° 1040-2017. |
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| TWI483950B (en) | 2009-09-21 | 2015-05-11 | Gilead Sciences Inc | Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs |
| PH12013500035A1 (en) | 2010-07-22 | 2013-03-11 | Gilead Sciences Inc | Methods and compounds for treating paramyxoviridae virus infections |
| TWI740546B (en) | 2014-10-29 | 2021-09-21 | 美商基利科學股份有限公司 | Methods for the preparation of ribosides |
| SG10202109869XA (en) | 2015-09-16 | 2021-10-28 | Gilead Sciences Inc | Methods for treating arenaviridae and coronaviridae virus infections |
| WO2018089306A1 (en) * | 2016-11-10 | 2018-05-17 | Oyagen, Inc. | Methods of treating and inhibiting ebola virus infection |
| JP2020500853A (en) * | 2016-11-18 | 2020-01-16 | ネウロビベ プハルマセウトイカル エービー | Liver prodrug of mitochondrial proton ionophore |
| CN110869028B (en) | 2017-03-14 | 2023-01-20 | 吉利德科学公司 | Method of treating feline coronavirus infection |
| JP6923112B2 (en) * | 2017-03-31 | 2021-08-18 | 国立大学法人北海道大学 | Biarylsulfonamide derivative with filovirus cell invasion inhibitory activity |
| ES2938859T3 (en) * | 2017-05-01 | 2023-04-17 | Gilead Sciences Inc | A crystalline form of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4 ]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate |
| WO2019014247A1 (en) * | 2017-07-11 | 2019-01-17 | Gilead Sciences, Inc. | Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections |
| US11149049B2 (en) * | 2017-09-18 | 2021-10-19 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
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| CN109748943A (en) * | 2017-11-03 | 2019-05-14 | 中国科学院上海药物研究所 | 2'-C-methyl-substituted nucleoside compounds and their preparation and use |
| CN109748944B (en) * | 2017-11-03 | 2021-12-10 | 中国科学院上海药物研究所 | 5 '-deoxy-5' -isopropyl substituted amino nucleoside compound, and preparation method and application thereof |
| CN110330540A (en) * | 2019-08-08 | 2019-10-15 | 木天(济南)生物科技有限公司 | Nucleosides salt and preparation method thereof |
| CN110613726B (en) * | 2019-09-25 | 2020-10-16 | 广州六顺生物科技股份有限公司 | Applications of Nucleoside Compounds |
| WO2021095091A1 (en) * | 2019-11-11 | 2021-05-20 | 藤本化学製品株式会社 | Aminoaryl derivative, intermediate of same, method for producing said aminoaryl derivative, and method for producing said intermediate |
| CN110776512A (en) * | 2019-11-28 | 2020-02-11 | 成都傲飞生物化学品有限责任公司 | Preparation method of nucleoside analogue |
| CN118662520A (en) | 2020-01-27 | 2024-09-20 | 吉利德科学公司 | Methods for treating SARS CoV-2 infection |
| WO2021158248A1 (en) | 2020-02-04 | 2021-08-12 | Oyagen, Inc. | Method for treating coronavirus infections |
| CN113214263B (en) * | 2020-02-06 | 2022-09-30 | 北京桦冠医药科技有限公司 | Synthetic method of Rudesiwei key intermediate |
| US20210244705A1 (en) * | 2020-02-07 | 2021-08-12 | Centre For Digestive Diseases | Therapeutic compositions, products of manufacture and methods for ameliorating or preventing coronavirus infection |
| CN111205327B (en) * | 2020-02-17 | 2022-05-31 | 南京法恩化学有限公司 | Preparation method of Reideciclovir |
| TWI794742B (en) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | Antiviral compounds |
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