MX2017006366A - Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de la proteina quinasa. - Google Patents

Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de la proteina quinasa.

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Publication number
MX2017006366A
MX2017006366A MX2017006366A MX2017006366A MX2017006366A MX 2017006366 A MX2017006366 A MX 2017006366A MX 2017006366 A MX2017006366 A MX 2017006366A MX 2017006366 A MX2017006366 A MX 2017006366A MX 2017006366 A MX2017006366 A MX 2017006366A
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Mexico
Prior art keywords
deaza
bicyclo
amino
protein kinase
purine derivatives
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MX2017006366A
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English (en)
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MX382607B (es
Inventor
Menichincheri Maria
BUFFA Laura
MOTTO Ilaria
Quartieri Francesca
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Nerviano Medical Sciences Srl
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Application filed by Nerviano Medical Sciences Srl filed Critical Nerviano Medical Sciences Srl
Publication of MX2017006366A publication Critical patent/MX2017006366A/es
Publication of MX382607B publication Critical patent/MX382607B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a derivados de 6-amino- 7-biciclo-7-deaza-purina, que modulan la actividad de las proteínas quinasas y son por lo tanto útiles en el tratamiento de enfermedades causadas por la actividad desregulada de la proteína quinasa. La presente invención también proporciona métodos para preparar estos compuestos, composiciones farmacéuticas que comprenden estos compuestos, y métodos de tratamiento de enfermedades que utilizan composiciones farmacéuticas que comprenden estos compuestos.
MX2017006366A 2014-11-14 2015-11-12 Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de la proteína quinasa. MX382607B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14193197 2014-11-14
PCT/EP2015/076411 WO2016075224A1 (en) 2014-11-14 2015-11-12 6-amino-7-bicyclo-7-deaza-purine derivatives as protein kinase inhibitors

Publications (2)

Publication Number Publication Date
MX2017006366A true MX2017006366A (es) 2018-02-01
MX382607B MX382607B (es) 2025-03-13

Family

ID=51904767

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017006366A MX382607B (es) 2014-11-14 2015-11-12 Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de la proteína quinasa.

Country Status (13)

Country Link
US (1) US10221181B2 (es)
EP (1) EP3218378B1 (es)
JP (1) JP6421241B2 (es)
KR (1) KR102562866B1 (es)
CN (1) CN107108631B (es)
AU (1) AU2015345054B2 (es)
CA (1) CA2967125C (es)
CL (1) CL2017001204A1 (es)
EA (1) EA039885B1 (es)
ES (1) ES2792036T3 (es)
MX (1) MX382607B (es)
PL (1) PL3218378T3 (es)
WO (1) WO2016075224A1 (es)

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EP3218378A1 (en) 2017-09-20
US20170327506A1 (en) 2017-11-16
PL3218378T3 (pl) 2020-10-19
AU2015345054A1 (en) 2017-06-29
CN107108631A (zh) 2017-08-29
EA039885B1 (ru) 2022-03-23
AU2015345054B2 (en) 2020-03-05
KR20170082637A (ko) 2017-07-14
EP3218378B1 (en) 2020-01-08
ES2792036T3 (es) 2020-11-06
JP6421241B2 (ja) 2018-11-07
US10221181B2 (en) 2019-03-05
EA201791018A1 (ru) 2018-03-30
JP2017533932A (ja) 2017-11-16
CL2017001204A1 (es) 2017-12-29
CA2967125A1 (en) 2016-05-19
KR102562866B1 (ko) 2023-08-04
CA2967125C (en) 2022-10-25
WO2016075224A1 (en) 2016-05-19
MX382607B (es) 2025-03-13
CN107108631B (zh) 2020-06-16

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