CL2017001249A1 - Forma cristalina de sulfato de hidrógeno (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirrolidinaa-1-il)-pirazolo[1,5-a] pirimidinaa-3-il)-3-hidroxipirrolidinaa-1-carboxamida. - Google Patents

Forma cristalina de sulfato de hidrógeno (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirrolidinaa-1-il)-pirazolo[1,5-a] pirimidinaa-3-il)-3-hidroxipirrolidinaa-1-carboxamida.

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Publication number
CL2017001249A1
CL2017001249A1 CL2017001249A CL2017001249A CL2017001249A1 CL 2017001249 A1 CL2017001249 A1 CL 2017001249A1 CL 2017001249 A CL2017001249 A CL 2017001249A CL 2017001249 A CL2017001249 A CL 2017001249A CL 2017001249 A1 CL2017001249 A1 CL 2017001249A1
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CL
Chile
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carboxamide
crystalline form
hydroxypyrrolidine
pyrazolo
difluorophenyl
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CL2017001249A
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English (en)
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Alisha B Arrigo
Derrick Juengst
Khalid Shah
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Array Biopharma Inc
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Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of CL2017001249A1 publication Critical patent/CL2017001249A1/es

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Abstract

<p>SE REVELAN UNA NUEVA FORMA CRISTALINA DE (S)-N-(5-((R)-2-(2,5-DIFLUOROFENIL)PIRROLIDIN-1-IL)-PIRAZOLO[1, 5-A]PIRIMIDIN-3-IL)-3-HIDROXIPIRROIIDIN-1-CARBOXAMIDA, COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN DICHA FORMA CRISTALINA Y EL USO DE DICHA FORMA CRISTALINA EN EL TRATAMIENTO DE DOLOR, CÁNCER, INFLAMACIÓN, ENFERMEDAD NEURODEGENERATIVA O INFECCIÓN POR TRYPANOSOMA CRUZI. EN ALGUNAS FORMAS DE REALIZACIÓN, LA NUEVA FORMA CRISTALINA COMPRENDE UN POLIMORFO ESTABLE DE SULFATO DE HIDROGENO DE (S)-N-(5-((R)-2-(2,5-DIFLUOROFENIL) PIRROLIDIN-1-II)-PIRAZOLO[1 ,5-A]PIRIMIDIN-3-IL)-3- HIDROXIPIRROLIDIN-1-CARBOXAMIDA. LA PRESENTE INVENCIÓN TAMBIÉN SE REFIERE A UN PROCESO PARA LA PREPARACIÓN DE LA NUEVA FORMA CRISTALINA.</p>
CL2017001249A 2014-11-16 2017-05-16 Forma cristalina de sulfato de hidrógeno (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirrolidinaa-1-il)-pirazolo[1,5-a] pirimidinaa-3-il)-3-hidroxipirrolidinaa-1-carboxamida. CL2017001249A1 (es)

Applications Claiming Priority (2)

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US201462080374P 2014-11-16 2014-11-16
US201562169545P 2015-06-01 2015-06-01

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CL2017001249A1 true CL2017001249A1 (es) 2017-12-15

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EP (2) EP3218380B1 (es)
JP (2) JP6914834B2 (es)
KR (1) KR102649887B1 (es)
CN (2) CN113354649B (es)
AU (1) AU2015346046B2 (es)
BR (1) BR112017010141A2 (es)
CA (1) CA2967951C (es)
CL (1) CL2017001249A1 (es)
CO (1) CO2017005483A2 (es)
CR (1) CR20170263A (es)
CY (1) CY1125935T1 (es)
DK (1) DK3699181T3 (es)
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UA (1) UA123044C2 (es)
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