CL2017001438A1 - Antagonistas de miostatina o activina para el tratamiento de sarcopenia - Google Patents

Antagonistas de miostatina o activina para el tratamiento de sarcopenia

Info

Publication number
CL2017001438A1
CL2017001438A1 CL2017001438A CL2017001438A CL2017001438A1 CL 2017001438 A1 CL2017001438 A1 CL 2017001438A1 CL 2017001438 A CL2017001438 A CL 2017001438A CL 2017001438 A CL2017001438 A CL 2017001438A CL 2017001438 A1 CL2017001438 A1 CL 2017001438A1
Authority
CL
Chile
Prior art keywords
sarcopenia
myostatin
treatment
activin antagonists
activine
Prior art date
Application number
CL2017001438A
Other languages
English (en)
Inventor
Dimitris Papanicolaou
David Glass
Patrick Kortebein
Daniel Rooks
Lloyd B Klickstein
Ronenn Roubenoff
Estelle Trifilieff
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55024187&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2017001438(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2017001438A1 publication Critical patent/CL2017001438A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

<p>LA PRESENTE INVENCION SE REFIERE A ANTAGONISTAS DE MIOSTATINA O ACTIVINA, REGIMEN DE DOSIFICACIÔN Y SUS COMPOSICIONES FARMACÉUTICAS, PARA EL TRATAMIENTO DE SARCOPENIA, EN PARTICULAR, SARCOPENIA RELACIONADA CON IA EDAD. ESPECIALMENTE, SE HALLÓ QUE EL ANTAGONISTA DE MIOSTATINA O ACTIVINA BIMAGRUMAB ERA BENEFICIOSO EN EL TRATAMIENTO DE ADULTOS MAYORES CON SARCOPENIA, CON RESPECTO AL AUMERITO DE IA FUERZA Y FUNCION DEL MÜSCULO ESQUELETICO.</p>
CL2017001438A 2014-12-08 2017-06-07 Antagonistas de miostatina o activina para el tratamiento de sarcopenia CL2017001438A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462088802P 2014-12-08 2014-12-08

Publications (1)

Publication Number Publication Date
CL2017001438A1 true CL2017001438A1 (es) 2018-02-16

Family

ID=55024187

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017001438A CL2017001438A1 (es) 2014-12-08 2017-06-07 Antagonistas de miostatina o activina para el tratamiento de sarcopenia

Country Status (17)

Country Link
US (1) US20170260275A1 (es)
EP (1) EP3229907A1 (es)
JP (1) JP2017538701A (es)
KR (1) KR20170094292A (es)
CN (1) CN106999589A (es)
AU (2) AU2015358939A1 (es)
BR (1) BR112017011411A2 (es)
CA (1) CA2969800A1 (es)
CL (1) CL2017001438A1 (es)
IL (1) IL252507A0 (es)
MX (1) MX2017007519A (es)
PH (1) PH12017500965A1 (es)
RU (1) RU2017123880A (es)
SG (1) SG11201704094QA (es)
TN (1) TN2017000217A1 (es)
TW (1) TW201627007A (es)
WO (1) WO2016092439A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104761637B (zh) 2006-03-31 2021-10-15 中外制药株式会社 调控抗体血液动力学的方法
CN101874042B9 (zh) 2007-09-26 2019-01-01 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
EP2275443B1 (en) 2008-04-11 2015-12-02 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
TWI654204B (zh) 2010-11-30 2019-03-21 Chugai Seiyaku Kabushiki Kaisha 具有鈣依存性的抗原結合能力之抗體
WO2013125667A1 (ja) 2012-02-24 2013-08-29 中外製薬株式会社 FcγRIIBを介して抗原の消失を促進する抗原結合分子
WO2014030750A1 (ja) 2012-08-24 2014-02-27 中外製薬株式会社 マウスFcγRII特異的Fc抗体
SG11201500873XA (en) 2012-08-24 2015-04-29 Chugai Pharmaceutical Co Ltd Fcgriib-specific fc region variant
TWI636062B (zh) 2013-04-02 2018-09-21 中外製藥股份有限公司 Fc region variant
NZ730607A (en) 2014-12-19 2022-07-01 Chugai Pharmaceutical Co Ltd Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
WO2016125495A1 (en) 2015-02-05 2016-08-11 Chugai Seiyaku Kabushiki Kaisha Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof
WO2017110981A1 (en) 2015-12-25 2017-06-29 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
CA3015277A1 (en) 2016-03-10 2017-09-14 Acceleron Pharma Inc. Activin type 2 receptor binding proteins and uses thereof
BR112019001902A2 (pt) 2016-08-05 2019-07-09 Chugai Seiyaku Kabushiki Kaisha composição para profilaxia ou tratamento de doenças relacionadas à il-8
US10485502B2 (en) * 2016-12-20 2019-11-26 General Electric Company System and method for assessing muscle function of a patient
JOP20190152A1 (ar) * 2016-12-21 2019-06-20 Novartis Ag مضادات الميوستاتين، الآكتيفين أو مستقبلات الآكتيفين للاستخدام في علاج السمنة والحالات ذات الصلة
KR101917794B1 (ko) 2018-05-10 2018-11-13 한국과학기술원 진세노사이드 Rh2를 포함하는 근육 질환 개선, 예방 또는 치료용 조성물
KR101966117B1 (ko) 2018-05-25 2019-04-05 (주)녹십자웰빙 가공인삼추출물을 포함하는 근육 분화 촉진용 조성물
KR102017282B1 (ko) 2019-01-28 2019-09-02 (주)녹십자웰빙 가공인삼추출물을 포함하는 근육 분화 촉진용 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1968621A2 (en) * 2005-12-06 2008-09-17 Amgen Inc. Uses of myostatin antagonists
US20070190056A1 (en) * 2006-02-07 2007-08-16 Ravi Kambadur Muscle regeneration compositions and uses therefor
TW201803890A (zh) * 2007-02-02 2018-02-01 艾瑟勒朗法瑪公司 衍生自ＡｃｔＲＩＩＢ的變體與其用途
US7947646B2 (en) * 2007-03-06 2011-05-24 Amgen Inc. Variant activin receptor polypeptides
CA2993053A1 (en) 2009-04-27 2010-11-04 Novartis Ag Antagonistic activin receptor iib (actriib) antibodies for increasing muscle growth
AR081556A1 (es) * 2010-06-03 2012-10-03 Glaxo Group Ltd Proteinas de union al antigeno humanizadas
DK2726099T3 (en) * 2011-07-01 2018-11-05 Novartis Ag Method of treating metabolic disorders
EA201492282A1 (ru) * 2012-06-11 2015-07-30 Амген Инк. Антагонистические антигенсвязывающие белки к двум рецепторам и их применение
CA2918300A1 (en) * 2013-08-14 2015-02-19 Novartis Ag Methods of treating sporadic inclusion body myositis
TW201622746A (zh) * 2014-04-24 2016-07-01 諾華公司 改善或加速髖部骨折術後身體復原之方法

Also Published As

Publication number Publication date
AU2019200082A1 (en) 2019-01-31
JP2017538701A (ja) 2017-12-28
US20170260275A1 (en) 2017-09-14
MX2017007519A (es) 2017-08-22
AU2015358939A1 (en) 2017-06-15
EP3229907A1 (en) 2017-10-18
PH12017500965A1 (en) 2017-10-18
CA2969800A1 (en) 2016-06-16
TN2017000217A1 (en) 2018-10-19
RU2017123880A3 (es) 2019-08-29
BR112017011411A2 (pt) 2018-02-14
IL252507A0 (en) 2017-07-31
TW201627007A (zh) 2016-08-01
CN106999589A (zh) 2017-08-01
WO2016092439A1 (en) 2016-06-16
RU2017123880A (ru) 2019-01-10
KR20170094292A (ko) 2017-08-17
SG11201704094QA (en) 2017-06-29

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