CL2017002731A1 - Adenovirus oncolítico que codifica una proteína b7 - Google Patents

Adenovirus oncolítico que codifica una proteína b7

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Publication number
CL2017002731A1
CL2017002731A1 CL2017002731A CL2017002731A CL2017002731A1 CL 2017002731 A1 CL2017002731 A1 CL 2017002731A1 CL 2017002731 A CL2017002731 A CL 2017002731A CL 2017002731 A CL2017002731 A CL 2017002731A CL 2017002731 A1 CL2017002731 A1 CL 2017002731A1
Authority
CL
Chile
Prior art keywords
protein
oncolytic adenovirus
adenovirus encoding
viruses
compositions
Prior art date
Application number
CL2017002731A
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English (en)
Inventor
Brian Robert Champion
Alice Claire Noel Bromley
Original Assignee
Psioxus Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1507419.8A external-priority patent/GB201507419D0/en
Priority claimed from GBGB1516936.0A external-priority patent/GB201516936D0/en
Priority claimed from GBGB1522013.0A external-priority patent/GB201522013D0/en
Application filed by Psioxus Therapeutics Ltd filed Critical Psioxus Therapeutics Ltd
Publication of CL2017002731A1 publication Critical patent/CL2017002731A1/es

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    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10371—Demonstrated in vivo effect

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Abstract

<p>La presente descripción proporciona un adenovirus de replicación oncolítico competente con selectividad para células cancerosas, donde el adenovirus comprende un transgén bajo el control de un promotor endógeno del virus, en el que el transgén comprende una secuencia de ADN que codifica una proteína B7 o un fragmento activo de la misma, composiciones que comprende los mismos, métodos para generar los virus, y uso de los virus y las composiciones en tratamiento, particularmente en el tratamiento del cáncer.</p>
CL2017002731A 2015-04-30 2017-10-26 Adenovirus oncolítico que codifica una proteína b7 CL2017002731A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1507419.8A GB201507419D0 (en) 2015-04-30 2015-04-30 Virus
GBGB1516936.0A GB201516936D0 (en) 2015-09-24 2015-09-24 Virus
GBGB1522013.0A GB201522013D0 (en) 2015-12-14 2015-12-14 Virus

Publications (1)

Publication Number Publication Date
CL2017002731A1 true CL2017002731A1 (es) 2018-06-08

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Application Number Title Priority Date Filing Date
CL2017002731A CL2017002731A1 (es) 2015-04-30 2017-10-26 Adenovirus oncolítico que codifica una proteína b7
CL2018000587A CL2018000587A1 (es) 2015-04-30 2018-03-05 Adenovirus oncolítico que codifica una proteína b7 (divisional de sol. n° 2731-2017)

Family Applications After (1)

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CL2018000587A CL2018000587A1 (es) 2015-04-30 2018-03-05 Adenovirus oncolítico que codifica una proteína b7 (divisional de sol. n° 2731-2017)

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US (6) US11000559B2 (es)
EP (2) EP3288573B1 (es)
JP (3) JP6931229B2 (es)
KR (4) KR20180118249A (es)
CN (2) CN108396015B (es)
AU (3) AU2016256582B2 (es)
BR (2) BR112017023171A2 (es)
CA (1) CA2984038C (es)
CL (2) CL2017002731A1 (es)
CO (1) CO2017010831A2 (es)
CY (1) CY1122833T1 (es)
DK (1) DK3288573T3 (es)
EA (1) EA037611B1 (es)
ES (1) ES2780366T3 (es)
HR (1) HRP20200439T1 (es)
HU (1) HUE048320T2 (es)
IL (3) IL284375B (es)
LT (1) LT3288573T (es)
MX (1) MX2017013684A (es)
MY (1) MY183703A (es)
PE (2) PE20180241A1 (es)
PH (1) PH12017501942A1 (es)
PL (1) PL3288573T3 (es)
PT (1) PT3288573T (es)
RS (1) RS60105B1 (es)
SA (2) SA517390260B1 (es)
SG (3) SG10201901482XA (es)
SI (1) SI3288573T1 (es)
SM (1) SMT202000222T1 (es)
WO (1) WO2016174200A1 (es)
ZA (1) ZA201801589B (es)

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