CL2018000621A1 - Ciano tienotriazolpirazinas y usos de las mismas solicitudes relacionadas. - Google Patents

Ciano tienotriazolpirazinas y usos de las mismas solicitudes relacionadas.

Info

Publication number
CL2018000621A1
CL2018000621A1 CL2018000621A CL2018000621A CL2018000621A1 CL 2018000621 A1 CL2018000621 A1 CL 2018000621A1 CL 2018000621 A CL2018000621 A CL 2018000621A CL 2018000621 A CL2018000621 A CL 2018000621A CL 2018000621 A1 CL2018000621 A1 CL 2018000621A1
Authority
CL
Chile
Prior art keywords
thienotriazolpyrazines
cyano
related applications
same related
neurologive
Prior art date
Application number
CL2018000621A
Other languages
English (en)
Inventor
James E Bradner
Jun Qi
Minoru Tanaka
Dennis Buckley
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Publication of CL2018000621A1 publication Critical patent/CL2018000621A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

<p>COMPUESTOS DERIVADOS DE CIANOTIENOTRIAZOLPIRAZINAS; COMPOSICION FARMACEUTICA; KIT; Y METODOS PARA INHIBIR LA ACTIVIDAD DE UNA PROTEINA QUE CONTIENE BROMODOMINIO Y PARA TRATAR ENFERMEDADES PROLIFERATIVAS, INFLAMATORIAS, CARDIOVASCULARES, AUTOINMUNES, NEUROLOGIVAS, METABOLICAS, FIBROTICAS E INFECCIONES VIRICAS, ENTRE OTROS.</p>
CL2018000621A 2015-09-11 2018-03-09 Ciano tienotriazolpirazinas y usos de las mismas solicitudes relacionadas. CL2018000621A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562217521P 2015-09-11 2015-09-11

Publications (1)

Publication Number Publication Date
CL2018000621A1 true CL2018000621A1 (es) 2018-07-20

Family

ID=58240288

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2018000621A CL2018000621A1 (es) 2015-09-11 2018-03-09 Ciano tienotriazolpirazinas y usos de las mismas solicitudes relacionadas.
CL2020002530A CL2020002530A1 (es) 2015-09-11 2020-09-30 Ciano tienotriazolpirazinas y usos de las mismas.(divisional de solicitud 621-2018)

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2020002530A CL2020002530A1 (es) 2015-09-11 2020-09-30 Ciano tienotriazolpirazinas y usos de las mismas.(divisional de solicitud 621-2018)

Country Status (20)

Country Link
US (1) US11306105B2 (es)
EP (1) EP3347021A4 (es)
JP (1) JP2018526421A (es)
KR (1) KR20180049058A (es)
CN (1) CN108472300A (es)
AU (1) AU2016319116B2 (es)
BR (1) BR112018004618A2 (es)
CA (1) CA2996974A1 (es)
CL (2) CL2018000621A1 (es)
CO (1) CO2018002483A2 (es)
CR (1) CR20180200A (es)
HK (1) HK1256417A1 (es)
IL (1) IL257594A (es)
MX (1) MX2018003031A (es)
PE (1) PE20181287A1 (es)
PH (1) PH12018550027A1 (es)
RU (1) RU2750164C2 (es)
SG (1) SG10202007090UA (es)
WO (1) WO2017044849A1 (es)
ZA (1) ZA201801548B (es)

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PE20181287A1 (es) 2015-09-11 2018-08-07 Dana Farber Cancer Inst Inc Ciano tienotriazolpirazinas y usos de las mismas
CA3003288A1 (en) 2015-11-25 2017-06-01 Dana-Farber Cancer Institute, Inc. Bivalent bromodomain inhibitors and uses thereof
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