CL2018002920A1 - Nuevos derivados de pirazolopirimidina - Google Patents

Nuevos derivados de pirazolopirimidina

Info

Publication number
CL2018002920A1
CL2018002920A1 CL2018002920A CL2018002920A CL2018002920A1 CL 2018002920 A1 CL2018002920 A1 CL 2018002920A1 CL 2018002920 A CL2018002920 A CL 2018002920A CL 2018002920 A CL2018002920 A CL 2018002920A CL 2018002920 A1 CL2018002920 A1 CL 2018002920A1
Authority
CL
Chile
Prior art keywords
compounds
pyrazolopyrimidine derivatives
influences
pharmaceutical compositions
new
Prior art date
Application number
CL2018002920A
Other languages
English (en)
Inventor
Johannes Köbberling
Adeline Köhler
Thomas Ilg
Ulrich Görgens
Hans-Georg Schwarz
Klaus Raming
Claudia Welz
Kirsten Börngen
Daniel Kulke
Walter Hübsch
Ulrich Ebbinghaus-Kintscher
Maike Hink
Dirk Nennstiel
Martin Adamczewski
Claudia Böhm
Original Assignee
Bayer Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health Gmbh filed Critical Bayer Animal Health Gmbh
Publication of CL2018002920A1 publication Critical patent/CL2018002920A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

LA PRESENTE INVENCIÓN ABARCA COMPUESTOS PIRAZOLOPIRIMIDINA DE FÓRMULA GENERAL (I): (I), EN DONDE N, O, X, Y, R, Q, R1, R2, R3 Y R4 SON COMO SE DEFINEN EN LA PRESENTE, MÉTODOS PARA PREPARAR DICHOS COMPUESTOS, COMPUESTOS INTERMEDIARIOS ÚTILES PARA PREPARAR DICHOS COMPUESTOS, COMPOSICIONES FARMACÉUTICAS Y COMBINACIONES QUE COMPRENDEN DICHOS COMPUESTOS Y EL USO DE DICHOS COMPUESTOS PARA LA FABRICACIÓN DE COMPOSICIONES FARMACÉUTICAS PARA EL TRATAMIENTO, CONTROL Y/O PREVENCIÓN DE ENFERMEDADES, EN PARTICULAR DE INFECCIONES HELMÍNTICAS, COMO AGENTE ÚNICO O EN COMBINACIÓN CON OTROS INGREDIENTES ACTIVOS.
CL2018002920A 2016-04-15 2018-10-12 Nuevos derivados de pirazolopirimidina CL2018002920A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16165572 2016-04-15

Publications (1)

Publication Number Publication Date
CL2018002920A1 true CL2018002920A1 (es) 2019-02-01

Family

ID=55755480

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2018002920A CL2018002920A1 (es) 2016-04-15 2018-10-12 Nuevos derivados de pirazolopirimidina

Country Status (22)

Country Link
US (3) US10604525B2 (es)
EP (1) EP3442974B8 (es)
JP (1) JP7051703B2 (es)
KR (1) KR102467347B1 (es)
CN (1) CN109071545B (es)
AR (1) AR108130A1 (es)
AU (1) AU2017251155B2 (es)
CA (1) CA3020793C (es)
CL (1) CL2018002920A1 (es)
CO (1) CO2018010966A2 (es)
DO (1) DOP2018000226A (es)
ES (1) ES2953467T3 (es)
IL (1) IL261885A (es)
MX (1) MX389697B (es)
PH (1) PH12018550173A1 (es)
PL (1) PL3442974T3 (es)
RU (1) RU2769448C2 (es)
SG (1) SG11201808214TA (es)
TW (1) TWI742067B (es)
UY (1) UY37201A (es)
WO (1) WO2017178416A1 (es)
ZA (1) ZA201807656B (es)

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US12312356B2 (en) 2020-05-29 2025-05-27 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic heterocyclic compounds
US12435068B2 (en) 2018-10-24 2025-10-07 Elanco Animal Health Gmbh Anthelmintic compounds

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CA3202092A1 (en) 2020-11-18 2022-05-27 Elanco Tiergesundheit Ag Bicyclic derivatives
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KR102660894B1 (ko) * 2021-09-17 2024-04-26 기초과학연구원 피리미딘-2-아민 화합물의 제조방법
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12435068B2 (en) 2018-10-24 2025-10-07 Elanco Animal Health Gmbh Anthelmintic compounds
US12312356B2 (en) 2020-05-29 2025-05-27 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic heterocyclic compounds

Also Published As

Publication number Publication date
US10604525B2 (en) 2020-03-31
JP2019513776A (ja) 2019-05-30
ES2953467T3 (es) 2023-11-13
AU2017251155A1 (en) 2018-10-11
KR102467347B1 (ko) 2022-11-14
JP7051703B2 (ja) 2022-04-11
NZ747056A (en) 2025-05-30
PH12018550173A1 (en) 2019-07-15
RU2018140092A (ru) 2020-05-15
TW201803874A (zh) 2018-02-01
US20200239482A1 (en) 2020-07-30
US11001590B2 (en) 2021-05-11
CN109071545A (zh) 2018-12-21
PL3442974T3 (pl) 2023-12-04
CA3020793C (en) 2024-05-21
US20190071447A1 (en) 2019-03-07
TWI742067B (zh) 2021-10-11
EP3442974B1 (en) 2023-06-07
RU2769448C2 (ru) 2022-03-31
KR20180134966A (ko) 2018-12-19
AR108130A1 (es) 2018-07-18
EP3442974B8 (en) 2023-07-12
MX389697B (es) 2025-03-20
WO2017178416A1 (en) 2017-10-19
RU2018140092A3 (es) 2020-06-25
IL261885A (en) 2018-10-31
DOP2018000226A (es) 2018-11-15
CO2018010966A2 (es) 2018-10-22
CA3020793A1 (en) 2017-10-19
ZA201807656B (en) 2024-06-26
EP3442974A1 (en) 2019-02-20
UY37201A (es) 2017-11-30
US10934301B2 (en) 2021-03-02
MX2018012544A (es) 2019-01-31
SG11201808214TA (en) 2018-10-30
US20200299299A1 (en) 2020-09-24
CN109071545B (zh) 2021-08-03
EP3442974C0 (en) 2023-06-07
AU2017251155B2 (en) 2021-08-05

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