DOP2020000023A - Nuevos derivados de quinolina - Google Patents
Nuevos derivados de quinolinaInfo
- Publication number
- DOP2020000023A DOP2020000023A DO2020000023A DO2020000023A DOP2020000023A DO P2020000023 A DOP2020000023 A DO P2020000023A DO 2020000023 A DO2020000023 A DO 2020000023A DO 2020000023 A DO2020000023 A DO 2020000023A DO P2020000023 A DOP2020000023 A DO P2020000023A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- compounds
- quinoline derivatives
- preparation
- new quinoline
- pharmaceutical compositions
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 244000000013 helminth Species 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
La invención abarca nuevos compuestos de quinolina de la fórmula general (I): (I), en la cual A, R1, R2, R3, R4, R5, R6 y Q son como se definen en el presente, procedimientos para la elaboración de dichos compuestos, compuestos intermedios útiles para la elaboración de dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y el uso de dichos compuestos para la elaboración de composiciones farmacéuticas para el tratamiento, control y/o prevención de enfermedades, en particular de infecciones con helmintos, como un único agente o en combinación con otros principios activos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17185001 | 2017-08-04 | ||
| PCT/EP2018/070552 WO2019025341A1 (en) | 2017-08-04 | 2018-07-30 | QUINOLINE DERIVATIVES FOR THE TREATMENT OF INFECTIONS BY HELMINTHES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2020000023A true DOP2020000023A (es) | 2020-02-28 |
Family
ID=59558299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2020000023A DOP2020000023A (es) | 2017-08-04 | 2020-02-04 | Nuevos derivados de quinolina |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US11254661B2 (es) |
| EP (1) | EP3634959B1 (es) |
| JP (1) | JP7455294B2 (es) |
| KR (1) | KR20200036909A (es) |
| CN (1) | CN111132977B (es) |
| AU (1) | AU2018311019B2 (es) |
| CA (1) | CA3071759A1 (es) |
| CL (1) | CL2020000301A1 (es) |
| CO (1) | CO2020001244A2 (es) |
| DO (1) | DOP2020000023A (es) |
| ES (1) | ES3024942T3 (es) |
| IL (1) | IL272156B2 (es) |
| MX (1) | MX2020001403A (es) |
| PH (1) | PH12020500257A1 (es) |
| PL (1) | PL3634959T3 (es) |
| SG (1) | SG11202000266VA (es) |
| TW (1) | TWI790263B (es) |
| UY (1) | UY37831A (es) |
| WO (1) | WO2019025341A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021000293A (es) | 2018-07-09 | 2021-07-15 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos heterociclicos antihelminticos. |
| EP3643711A1 (en) * | 2018-10-24 | 2020-04-29 | Bayer Animal Health GmbH | New anthelmintic compounds |
| NZ777370A (en) | 2018-12-18 | 2024-11-29 | Elanco Tiergesundheit Ag | Bicyclic derivatives |
| US20220064159A1 (en) | 2018-12-18 | 2022-03-03 | Elanco Tiergesundheit Ag | Bicyclic derivatives |
| KR20220002890A (ko) * | 2019-03-19 | 2022-01-07 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 아자-벤조티오펜 및 아자-벤조푸란 화합물 |
| US20200385398A1 (en) | 2019-06-07 | 2020-12-10 | Elanco Tiergesundheit Ag | New bicyclic derivatives |
| TWI865563B (zh) | 2019-07-30 | 2024-12-11 | 德商拜耳動物保健有限公司 | 新穎異喹啉衍生物 |
| JP2023507173A (ja) | 2019-12-18 | 2023-02-21 | インターベット インターナショナル ベー． フェー． | キノリン構造を含む駆虫剤化合物 |
| BR112022024156A2 (pt) | 2020-05-29 | 2023-02-14 | Boehringer Ingelheim Animal Health Usa Inc | Compostos heterocílicos antelmínticos |
| US20240059680A1 (en) | 2020-11-18 | 2024-02-22 | Elanco Tiergesundheit Ag | N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections |
| TW202237600A (zh) | 2020-12-04 | 2022-10-01 | 瑞士商禮藍動物保健股份有限公司 | 雙環衍生物 |
| AU2021398540A1 (en) | 2020-12-11 | 2023-06-22 | Intervet International B.V. | Anthelmintic compounds comprising a pyridine structure |
| WO2022122988A1 (en) | 2020-12-11 | 2022-06-16 | Intervet International B.V. | Anthelmintic compounds comprising a thienopyridine structure |
| EP4148052A1 (en) * | 2021-09-09 | 2023-03-15 | Bayer Animal Health GmbH | New quinoline derivatives |
| WO2023073641A1 (en) | 2021-11-01 | 2023-05-04 | Boehringer Ingelheim Vetmedica Gmbh | Anthelmintic pyrrolopyridazine compounds |
| JP2025513725A (ja) * | 2022-03-22 | 2025-04-30 | スポロス バイオディスカバリー，インク． | Ｔｅａｄ阻害剤および使用方法 |
| EP4694887A1 (en) | 2023-04-14 | 2026-02-18 | Elanco Animal Health GmbH | Long-term prevention and/or treatment of a disease by slo-1 inhibitors |
| CN121620507A (zh) | 2023-08-02 | 2026-03-06 | 英特维特国际股份有限公司 | 具有驱虫活性的甲酰胺-4-喹啉化合物 |
| WO2026078157A2 (en) | 2024-10-10 | 2026-04-16 | Elanco Animal Health Gmbh | Slo-1 modulators for prevention and/or treatment of a disease |
| WO2026115027A1 (en) | 2024-11-28 | 2026-06-04 | Intervet International B.V. | Carboxamide-4-quinoline compounds with anthelmintic activity |
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-
2018
- 2018-07-30 US US16/636,276 patent/US11254661B2/en active Active
- 2018-07-30 SG SG11202000266VA patent/SG11202000266VA/en unknown
- 2018-07-30 JP JP2020505351A patent/JP7455294B2/ja active Active
- 2018-07-30 EP EP18745626.4A patent/EP3634959B1/en active Active
- 2018-07-30 WO PCT/EP2018/070552 patent/WO2019025341A1/en not_active Ceased
- 2018-07-30 MX MX2020001403A patent/MX2020001403A/es unknown
- 2018-07-30 ES ES18745626T patent/ES3024942T3/es active Active
- 2018-07-30 AU AU2018311019A patent/AU2018311019B2/en active Active
- 2018-07-30 CA CA3071759A patent/CA3071759A1/en active Pending
- 2018-07-30 KR KR1020207005873A patent/KR20200036909A/ko not_active Ceased
- 2018-07-30 CN CN201880064509.9A patent/CN111132977B/zh active Active
- 2018-07-30 IL IL272156A patent/IL272156B2/en unknown
- 2018-07-30 PL PL18745626.4T patent/PL3634959T3/pl unknown
- 2018-08-02 TW TW107126871A patent/TWI790263B/zh active
- 2018-08-03 UY UY0001037831A patent/UY37831A/es not_active Application Discontinuation
-
2020
- 2020-02-03 CL CL2020000301A patent/CL2020000301A1/es unknown
- 2020-02-04 CO CONC2020/0001244A patent/CO2020001244A2/es unknown
- 2020-02-04 PH PH12020500257A patent/PH12020500257A1/en unknown
- 2020-02-04 DO DO2020000023A patent/DOP2020000023A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH12020500257A1 (en) | 2020-09-14 |
| BR112020002348A2 (pt) | 2020-09-08 |
| CA3071759A1 (en) | 2019-02-07 |
| IL272156B2 (en) | 2023-09-01 |
| RU2020109388A3 (es) | 2021-11-30 |
| JP7455294B2 (ja) | 2024-03-26 |
| TW201920155A (zh) | 2019-06-01 |
| PL3634959T3 (pl) | 2025-06-09 |
| WO2019025341A1 (en) | 2019-02-07 |
| JP2020528921A (ja) | 2020-10-01 |
| AU2018311019A1 (en) | 2020-01-30 |
| TWI790263B (zh) | 2023-01-21 |
| ES3024942T3 (en) | 2025-06-05 |
| IL272156A (en) | 2020-03-31 |
| IL272156B1 (en) | 2023-05-01 |
| CN111132977B (zh) | 2024-07-23 |
| CO2020001244A2 (es) | 2020-02-18 |
| KR20200036909A (ko) | 2020-04-07 |
| RU2020109388A (ru) | 2021-09-07 |
| CN111132977A (zh) | 2020-05-08 |
| US11254661B2 (en) | 2022-02-22 |
| MX2020001403A (es) | 2020-03-09 |
| AU2018311019B2 (en) | 2022-05-26 |
| EP3634959C0 (en) | 2025-02-26 |
| UY37831A (es) | 2019-02-28 |
| SG11202000266VA (en) | 2020-02-27 |
| EP3634959A1 (en) | 2020-04-15 |
| EP3634959B1 (en) | 2025-02-26 |
| CL2020000301A1 (es) | 2020-07-31 |
| US20200377486A1 (en) | 2020-12-03 |
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