CL2021001042A1 - Nuevos compuestos antihelmínticos - Google Patents

Nuevos compuestos antihelmínticos

Info

Publication number
CL2021001042A1
CL2021001042A1 CL2021001042A CL2021001042A CL2021001042A1 CL 2021001042 A1 CL2021001042 A1 CL 2021001042A1 CL 2021001042 A CL2021001042 A CL 2021001042A CL 2021001042 A CL2021001042 A CL 2021001042A CL 2021001042 A1 CL2021001042 A1 CL 2021001042A1
Authority
CL
Chile
Prior art keywords
compounds
anthelmintic compounds
preparing
new anthelmintic
new
Prior art date
Application number
CL2021001042A
Other languages
English (en)
Inventor
Adeline Köhler
Thomas Ilg
Hans-Georg Schwarz
Daniel Kulke
Walter Hübsch
Wei Zhuang
Nils Griebenow
Iring Heisler
Bernd Alig
Original Assignee
Bayer Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health Gmbh filed Critical Bayer Animal Health Gmbh
Publication of CL2021001042A1 publication Critical patent/CL2021001042A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/12—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 3 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a novedosos compuestos de fórmula general (I): en donde T, X, Y, Ro, R1, R10 y R11 son según lo definido en el presente texto, métodos para preparar dichos compuestos, compuestos intermedios útiles para preparar dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y el uso de dichos compuestos para el tratamiento, control y/o prevención de enfermedades, específicamente de infecciones helmínticas, como único agente o en combinación con otros principios activos.
CL2021001042A 2018-10-24 2021-04-23 Nuevos compuestos antihelmínticos CL2021001042A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18202419.0A EP3643711A1 (en) 2018-10-24 2018-10-24 New anthelmintic compounds

Publications (1)

Publication Number Publication Date
CL2021001042A1 true CL2021001042A1 (es) 2021-11-26

Family

ID=63965551

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021001042A CL2021001042A1 (es) 2018-10-24 2021-04-23 Nuevos compuestos antihelmínticos

Country Status (16)

Country Link
US (1) US12435068B2 (es)
EP (2) EP3643711A1 (es)
JP (1) JP7459082B2 (es)
KR (1) KR102874579B1 (es)
CN (2) CN119409690A (es)
AU (1) AU2019368661B2 (es)
BR (1) BR112021007771A2 (es)
CA (1) CA3117343A1 (es)
CL (1) CL2021001042A1 (es)
CO (1) CO2021005226A2 (es)
CR (1) CR20210201A (es)
MX (1) MX2021004707A (es)
PH (1) PH12021550931A1 (es)
TW (1) TWI827702B (es)
UY (1) UY38428A (es)
WO (1) WO2020083971A2 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020003242A (es) 2017-09-22 2020-09-18 Jubilant Epipad LLC Compuestos heterociclicos como inhibidores de pad.
AU2018352142B2 (en) 2017-10-18 2022-08-25 Jubilant Epipad LLC Imidazo-pyridine compounds as PAD inhibitors
KR20200085836A (ko) 2017-11-06 2020-07-15 주빌런트 프로델 엘엘씨 Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체
BR112020010322A2 (pt) 2017-11-24 2020-11-17 Jubilant Episcribe Llc composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer
SG11202008950PA (en) 2018-03-13 2020-10-29 Jubilant Prodel LLC Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation
AU2019301510B2 (en) 2018-07-09 2024-06-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anthelminthic heterocyclic compounds
EP3643711A1 (en) 2018-10-24 2020-04-29 Bayer Animal Health GmbH New anthelmintic compounds
CN113490527B (zh) * 2018-12-18 2024-10-25 瑞士伊兰科动物保健有限公司 双环衍生物
CA3133100A1 (en) 2019-03-19 2020-09-24 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic aza-benzothiophene and aza-benzofuran compounds
BR112021024726A2 (pt) 2019-06-07 2022-01-18 Elanco Tiergesundheit Ag Novos derivados bicíclicos
CN112851732B (zh) * 2019-11-28 2023-03-07 成都先导药物开发股份有限公司 一种合成On-DNA 2-羧基-3-氨基芳并噻吩化合物的方法
KR20230028268A (ko) 2020-05-29 2023-02-28 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 헤테로시클릭 화합물
EP4159728A4 (en) 2020-06-22 2024-06-26 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. MANUFACTURING PROCESS FOR CDK4/6 INHIBITOR
MA61866B1 (fr) * 2020-10-08 2026-02-27 Merck Sharp & Dohme Llc Préparation de dérivés de benzimidazolone servant de nouveaux inhibiteurs de diacylglycéride o-acyltransférase 2
US20240043385A1 (en) * 2020-12-11 2024-02-08 Intervet Inc. Anthelmintic compounds comprising a pyridine structure
CA3228542A1 (en) * 2021-08-12 2023-02-16 Tyk Medicines, Inc. Polycyclic compound and use thereof
UY39995A (es) 2021-11-01 2023-05-15 Boehringer Ingelheim Vetmedica GmbH Compuestos de pirrolopiridazina como antihelmínticos
CN114181276A (zh) * 2021-12-17 2022-03-15 安徽大学 硫酯肽合成方法
WO2024213752A1 (en) 2023-04-14 2024-10-17 Elanco Animal Health Gmbh Long-term prevention and/or treatment of a disease by slo-1 inhibitors
IL326231A (en) 2023-08-02 2026-03-01 Intervet Int Bv Carboxamide-4-quinoline compounds with anthelmintic activity
WO2026078157A2 (en) 2024-10-10 2026-04-16 Elanco Animal Health Gmbh Slo-1 modulators for prevention and/or treatment of a disease

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3639877A1 (de) 1986-11-21 1988-05-26 Bayer Ag Hetarylalkyl substituierte 5- und 6-ringheterocyclen
JP2004511538A (ja) * 2000-10-17 2004-04-15 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 殺昆虫性１，８−ナフタレンジカルボキサミド類
TWI245761B (en) 2001-03-01 2005-12-21 Telik Inc Antagonists of MCP-1 function and methods of use thereof
GB0213715D0 (en) 2002-06-14 2002-07-24 Syngenta Ltd Chemical compounds
TWI312272B (en) 2003-05-12 2009-07-21 Sumitomo Chemical Co Pyrimidine compound and pests controlling composition containing the same
WO2005012283A1 (en) 2003-07-31 2005-02-10 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzothiophene compounds and uses thereof
GB0414438D0 (en) 2004-06-28 2004-07-28 Syngenta Participations Ag Chemical compounds
WO2006043635A1 (ja) 2004-10-20 2006-04-27 Kumiai Chemical Industry Co., Ltd. ３－トリアゾリルフェニルスルフィド誘導体及びそれを有効成分として含有する殺虫・殺ダニ・殺線虫剤
US20070129359A1 (en) * 2005-04-14 2007-06-07 Christoph Huwe Tetrahydronaphthalene derivatives, processes for their preparation and their use as antiinflammatory agents
US8338607B2 (en) 2005-10-06 2012-12-25 Nippon Soda Co., Ltd. Cyclic amine compounds and agents for pest control
TW200740776A (en) 2006-02-06 2007-11-01 Osi Pharm Inc N-phenylbenzotriazolyl c-kit inhibitors
WO2008121333A1 (en) 2007-03-30 2008-10-09 Cytokinetics, Incorporated Certain chemical entities, compositions and methods
US8324405B2 (en) 2008-02-05 2012-12-04 Fibrogen, Inc. Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors
US8338604B2 (en) 2008-06-20 2012-12-25 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors
JP5268461B2 (ja) 2008-07-14 2013-08-21 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Ｐｆ１３６４物質、その製造方法、生産菌株、及び、それを有効成分とする農園芸用殺虫剤
CN101337940B (zh) 2008-08-12 2012-05-02 国家农药创制工程技术研究中心 具杀虫活性的含氮杂环二氯烯丙醚类化合物
CN101337937B (zh) 2008-08-12 2010-12-22 国家农药创制工程技术研究中心 具有杀虫活性的n-苯基-5-取代氨基吡唑类化合物
CN101715774A (zh) 2008-10-09 2010-06-02 浙江化工科技集团有限公司 一个具有杀虫活性化合物制备及用途
EP2184273A1 (de) 2008-11-05 2010-05-12 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
GB0820344D0 (en) 2008-11-06 2008-12-17 Syngenta Ltd Herbicidal compositions
AU2009324389B2 (en) 2008-12-12 2016-04-28 Syngenta Crop Protection Ag Spiroheterocyclic N-oxypiperidines as pesticides
JP2013501792A (ja) * 2009-08-10 2013-01-17 サミュメッド リミテッド ライアビリティ カンパニー Ｗｎｔ／ｂ−カテニンシグナル伝達経路阻害剤としてのインダゾールおよびその治療的使用
WO2011085575A1 (zh) 2010-01-15 2011-07-21 江苏省农药研究所股份有限公司 邻杂环甲酰苯胺类化合物及其合成方法和应用
AR081721A1 (es) 2010-02-25 2012-10-17 Nippon Soda Co Compuesto de amina ciclica y acaricida
BR112012030408A2 (pt) 2010-05-31 2015-09-29 Syngenta Participations Ag método de melhoramento de culturas
AU2011297160B2 (en) 2010-08-31 2014-11-20 Mitsui Chemicals Crop & Life Solutions, Inc. Noxious organism control agent
CN101967139B (zh) 2010-09-14 2013-06-05 中化蓝天集团有限公司 一种含一氟甲氧基吡唑的邻甲酰氨基苯甲酰胺类化合物、其合成方法及应用
EP2661428B1 (en) 2010-12-23 2017-06-07 Merck Sharp & Dohme Corp. Quinoxalines and aza-quinoxalines as crth2 receptor modulators
CN103608346B (zh) 2011-02-02 2016-06-15 菲布罗根有限公司 作为缺氧诱导因子(hif)羟化酶抑制剂的萘啶衍生物
WO2012112363A1 (en) 2011-02-14 2012-08-23 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2013050317A1 (en) 2011-10-03 2013-04-11 Syngenta Limited Polymorphs of an isoxazoline derivative
CN102391261A (zh) 2011-10-14 2012-03-28 上海交通大学 一种n-取代噁二嗪类化合物及其制备方法和应用
TWI566701B (zh) 2012-02-01 2017-01-21 日本農藥股份有限公司 芳烷氧基嘧啶衍生物及包含該衍生物作為有效成分的農園藝用殺蟲劑及其使用方法
EP2830421B1 (en) 2012-03-30 2017-03-01 Basf Se N-substituted pyridinylidene thiocarbonyl compounds and their use for combating animal pests
EP2647626A1 (en) 2012-04-03 2013-10-09 Syngenta Participations AG. 1-Aza-spiro[4.5]dec-3-ene and 1,8-diaza-spiro[4.5]dec-3-ene derivatives as pesticides
BR122014028247A2 (pt) 2012-04-27 2019-05-07 Dow Agrosciences Llc composições pesticidas, processo para controlar praga, uso de uma molécula, processo para aumentar a saúde, rendimento, vigor, qualidade ou tolerância de uma planta e processos para produção de compostos
US9282739B2 (en) 2012-04-27 2016-03-15 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
NZ723198A (en) * 2012-11-20 2018-11-30 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic compounds and compositions and methods of using thereof
CN103109816B (zh) 2013-01-25 2014-09-10 青岛科技大学 硫代苯甲酰胺类化合物及其应用
CN103232431B (zh) 2013-01-25 2014-11-05 青岛科技大学 一种二卤代吡唑酰胺类化合物及其应用
CN105121439A (zh) 2013-02-19 2015-12-02 辉瑞公司 作为pde4亚型抑制剂用于治疗cns和其他病症的氮杂苯并咪唑化合物
US20140275503A1 (en) 2013-03-13 2014-09-18 Dow Agrosciences Llc Process for the preparation of certain triaryl rhamnose carbamates
JP6595985B2 (ja) 2013-05-23 2019-10-23 シンジェンタ パーティシペーションズ アーゲー タンク混合配合物
RU2543374C2 (ru) 2013-05-30 2015-02-27 государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ПГФА Минздрава России) Амид 2-(3-метил-6-метокси-7-этокси-3,4-дигидроизохинолил-1)-этановой кислоты гидрохлорид, проявляющий антигельминтное действие
CN103265527B (zh) 2013-06-07 2014-08-13 江苏省农用激素工程技术研究中心有限公司 邻氨基苯甲酰胺化合物及其制备方法和应用
CN103524422B (zh) 2013-10-11 2015-05-27 中国农业科学院植物保护研究所 苯并咪唑衍生物及其制备方法和用途
EP3057429A4 (en) 2013-10-17 2017-08-09 Dow AgroSciences LLC Processes for the preparation of pesticidal compounds
JP2016539092A (ja) 2013-10-17 2016-12-15 ダウ アグロサイエンシィズ エルエルシー 有害生物防除性化合物の製造方法
ES2842592T3 (es) 2014-05-19 2021-07-14 Boehringer Ingelheim Animal Health Usa Inc Compuestos antihelmínticos
TW201613866A (en) 2014-07-07 2016-04-16 Bayer Cropscience Ag Process for preparing fluorinated iminopyridine compounds
US10272074B2 (en) 2015-01-29 2019-04-30 Sanford Burnham Prebys Medical Discovery Institute Inhibitors of glucocorticoid receptor translocation
CA2975982C (en) 2015-02-17 2018-11-27 Nippon Soda Co., Ltd. Agrochemical composition
KR20180110132A (ko) 2016-02-16 2018-10-08 반더빌트유니버시티 무스카린성 아세틸콜린 수용체 m1의 양성 알로스테릭 조절제
WO2017178416A1 (en) 2016-04-15 2017-10-19 Bayer Animal Health Gmbh Pyrazolopyrimidine derivatives
JP7165129B2 (ja) 2016-11-11 2022-11-02 バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 新規な駆虫性キノリン－３－カルボキサミド誘導体
SG11202000266VA (en) 2017-08-04 2020-02-27 Bayer Animal Health Gmbh Quinoline derivatives for treating infections with helminths
EP3793565B1 (en) 2018-05-14 2022-01-05 Gilead Sciences, Inc. Mcl-1 inhibitors
AU2019301510B2 (en) * 2018-07-09 2024-06-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anthelminthic heterocyclic compounds
PE20211591A1 (es) 2018-09-19 2021-08-18 Biogen Ma Inc Inhibidores de o-glicoproteina-2-acetamido-2-desoxi-3-d-glucopiranosidasa
EP3643705A1 (en) 2018-10-24 2020-04-29 Basf Se Pesticidal compounds
PE20211110A1 (es) 2018-10-24 2021-06-17 Bristol Myers Squibb Co Distrofinas miniaturizadas y usos de las mismas
EP3643711A1 (en) 2018-10-24 2020-04-29 Bayer Animal Health GmbH New anthelmintic compounds
MX2021004593A (es) 2018-10-24 2021-06-15 Viiv Healthcare Uk No 5 Ltd Inhibidores de la replicacion del virus de la inmunodeficiencia humana.
JP7297227B2 (ja) 2018-10-24 2023-06-26 学校法人 芝浦工業大学 新規ペプチド及びその利用方法

Also Published As

Publication number Publication date
EP3847168B8 (en) 2026-04-08
CR20210201A (es) 2021-05-26
EP3847168B1 (en) 2026-02-25
US20210380566A1 (en) 2021-12-09
JP7459082B2 (ja) 2024-04-01
CO2021005226A2 (es) 2021-04-30
PH12021550931A1 (en) 2021-11-08
TWI827702B (zh) 2024-01-01
BR112021007771A2 (pt) 2021-07-27
TW202030188A (zh) 2020-08-16
AU2019368661B2 (en) 2025-04-24
CN113166123A (zh) 2021-07-23
CA3117343A1 (en) 2020-04-30
EP3847168A2 (en) 2021-07-14
UY38428A (es) 2020-05-29
JP2022505591A (ja) 2022-01-14
EP3643711A1 (en) 2020-04-29
CN113166123B (zh) 2025-09-05
MX2021004707A (es) 2021-06-04
CN119409690A (zh) 2025-02-11
WO2020083971A2 (en) 2020-04-30
EP3847168C0 (en) 2026-02-25
AU2019368661A1 (en) 2021-04-29
KR20210086653A (ko) 2021-07-08
WO2020083971A3 (en) 2020-06-04
US12435068B2 (en) 2025-10-07
KR102874579B1 (ko) 2025-10-22

Similar Documents

Publication Publication Date Title
CL2021001042A1 (es) Nuevos compuestos antihelmínticos
CO2018010966A2 (es) Nuevos derivados de pirazolopirimidina
ECSP19030002A (es) 1,2,4-triazolonas 2,4,5-trisustituidas
DOP2020000023A (es) Nuevos derivados de quinolina
CO2019014484A2 (es) Nuevos derivados de azaquinolina
DOP2019000117A (es) Nuevos derivados de quinolina
CO2020013876A2 (es) Nuevos derivados de quinolina
NI201900085A (es) 2-heteroaril-3-oxo-2,3-dihidropiridazin-4-carboxamidas
ECSP20008441A (es) Dihidrooxadiazinonas
DOP2019000275A (es) Nuevos derivados de pirazol bicíclicos
UY36665A (es) Derivados de ciclohexano sustituidos con amidas
UY38816A (es) Nuevos derivados de isoquinolina
UY37577A (es) Dihidroimidazopiridindionas sustituidas
CL2024000710A1 (es) Nuevos derivados de quinolina
UY36983A (es) Pirazolopiridinaminas sustituidas
UY37032A (es) Compuestos de heteroarilbenzimidazol