CL2019001129A1 - Compuestos del péptido tirosina tirosina cíclico con anticuerpo acoplado como moduladores de receptores de neuropéptido y. - Google Patents
Compuestos del péptido tirosina tirosina cíclico con anticuerpo acoplado como moduladores de receptores de neuropéptido y.Info
- Publication number
- CL2019001129A1 CL2019001129A1 CL2019001129A CL2019001129A CL2019001129A1 CL 2019001129 A1 CL2019001129 A1 CL 2019001129A1 CL 2019001129 A CL2019001129 A CL 2019001129A CL 2019001129 A CL2019001129 A CL 2019001129A CL 2019001129 A1 CL2019001129 A1 CL 2019001129A1
- Authority
- CL
- Chile
- Prior art keywords
- tyrosine
- compounds
- cyclic
- receptor modulators
- peptide
- Prior art date
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
LA PRESENTE INVENCIÓN COMPRENDE CONJUGADOS QUE COMPRENDEN UN ANTICUERPO MONOCLONAL CONJUGADO CON UN PÉPTIDO PYY CÍCLICO. LA INVENCIÓN SE REFIERE, ADEMÁS, A COMPOSICIONES FARMACÉUTICAS Y A MÉTODOS PARA USARLAS. LOS CONJUGADOS NOVEDOSOS SON ÚTILES PARA PREVENIR, TRATAR O CORREGIR ENFERMEDADES Y TRASTORNOS DESCRITOS EN LA PRESENTE DESCRIPCIÓN.
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| US11780900B2 (en) | 2018-04-25 | 2023-10-10 | Janssen Sciences Ireland Unlimited Company | Glucagon like peptide 1 (GLP-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof |
| TWI847981B (zh) | 2018-04-25 | 2024-07-11 | 比利時商健生藥品公司 | 類升糖素肽1 (glp-1)融合肽偶合環狀酪酪肽接合物及其用途 |
| KR20210141600A (ko) * | 2019-03-19 | 2021-11-23 | 엔진 바이오사이언스 리미티드 | 글루카곤 유사 펩티드-1(glp-1) 수용체 작용제 및 이의 유사물의 제조 방법 |
| CN111944055B (zh) * | 2019-05-16 | 2022-08-02 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的融合蛋白 |
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