MA46718A - Composés peptidiques cycliques tyrosine-tyrosine à titre de modulateurs des récepteurs du neuropeptide y - Google Patents

Composés peptidiques cycliques tyrosine-tyrosine à titre de modulateurs des récepteurs du neuropeptide y

Info

Publication number
MA46718A
MA46718A MA046718A MA46718A MA46718A MA 46718 A MA46718 A MA 46718A MA 046718 A MA046718 A MA 046718A MA 46718 A MA46718 A MA 46718A MA 46718 A MA46718 A MA 46718A
Authority
MA
Morocco
Prior art keywords
tyrosine
neuropeptide
peptidic
receptor modulators
cyclic compounds
Prior art date
Application number
MA046718A
Other languages
English (en)
Inventor
Martin A Case
Mark Macielag
Raymond J Patch
Mark Wall
Rui Zhang
Yue-Mei Zhang
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62020814&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA46718(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MA46718A publication Critical patent/MA46718A/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57545—Neuropeptide Y
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10513546B2 (en) 2013-12-18 2019-12-24 President And Fellows Of Harvard College CRP capture/detection of gram positive bacteria
JOP20190095A1 (ar) 2016-10-27 2019-04-28 Janssen Pharmaceutica Nv مركبات ببتيد تيروسين-تيروسين الحلقية كمعدلات لمستقبلات الببتيد العصبي y
US11780900B2 (en) 2018-04-25 2023-10-10 Janssen Sciences Ireland Unlimited Company Glucagon like peptide 1 (GLP-1) fusion peptide coupled cyclic peptide tyrosine tyrosine conjugates and uses thereof
TWI847981B (zh) 2018-04-25 2024-07-11 比利時商健生藥品公司 類升糖素肽1 (glp-1)融合肽偶合環狀酪酪肽接合物及其用途
KR20210141600A (ko) * 2019-03-19 2021-11-23 엔진 바이오사이언스 리미티드 글루카곤 유사 펩티드-1(glp-1) 수용체 작용제 및 이의 유사물의 제조 방법
CN111944055B (zh) * 2019-05-16 2022-08-02 浙江道尔生物科技有限公司 一种治疗代谢疾病的融合蛋白
WO2020262590A1 (fr) * 2019-06-28 2020-12-30 味の素株式会社 Procédé de production de peptide cyclique
CR20220206A (es) 2019-11-11 2022-06-16 Boehringer Ingelheim Int Agonistas del receptor npy2
MX2022006861A (es) * 2019-12-04 2022-07-11 Scripps Research Inst Agonistas del receptor glp2 y metodos de uso.
CN111494606B (zh) * 2020-04-24 2021-12-14 广州医科大学 神经肽y的新应用
JP7661478B2 (ja) 2020-08-07 2025-04-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 可溶性ｎｐｙ２受容体アゴニスト
EP4288078A4 (fr) * 2021-02-03 2024-12-11 Sun Pharmaceutical Industries Ltd Forme pharmaceutique prête à perfuser d'oxytocine
CN115073556A (zh) * 2021-03-12 2022-09-20 上海天慈生命科学发展有限公司 一类阿片/神经肽ff受体多靶点环肽分子及其制备和应用
IL309341A (en) * 2021-06-14 2024-02-01 Darbix Llc GLP-1 receptor agonists with improved pharmacological properties and drug delivery
KR20230004135A (ko) * 2021-06-30 2023-01-06 한미약품 주식회사 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체를 포함하는 조합물의 치료학적 용도
WO2023097363A1 (fr) * 2021-11-30 2023-06-08 Garvan Institute Of Medical Research Protéines de liaison améliorées et leurs utilisations
CN115028551B (zh) * 2022-07-15 2024-01-05 成都普康生物科技有限公司 一种叠氮-九甘醇-丙酸的制备方法
CN116098987A (zh) * 2023-02-09 2023-05-12 华东医院 甘丙肽在制备治疗非酒精性脂肪性肝病药物中的用途
WO2025252023A1 (fr) * 2024-06-03 2025-12-11 Fortvita Biologics Inc. Modulateurs de gipr, glp1r et/ou gcgr et leurs utilisations

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2434149A1 (fr) 1978-06-22 1980-03-21 Parcor Nouveaux derives de la l-cysteine
US5393669A (en) 1993-02-05 1995-02-28 Martek Biosciences Corp. Compositions and methods for protein structural determinations
US7166575B2 (en) 2002-12-17 2007-01-23 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity
US8603969B2 (en) * 2004-02-11 2013-12-10 Amylin Pharmaceuticals, Llc Pancreatic polypeptide family motifs and polypeptides comprising the same
EP1718671A2 (fr) * 2004-02-23 2006-11-08 Rheoscience A/S Analogues du peptide yy
EA011860B1 (ru) 2004-03-17 2009-06-30 7ТиЭм ФАРМА А/С Селективные агонисты рецептора y2 для терапевтического воздействия
WO2006028936A2 (fr) 2004-09-02 2006-03-16 Genentech, Inc. Molecules heteromultimeriques
DK1791565T3 (en) * 2004-09-23 2016-08-01 Genentech Inc Cysteingensplejsede antibodies and conjugates
AU2006232287B2 (en) 2005-03-31 2011-10-06 Chugai Seiyaku Kabushiki Kaisha Methods for producing polypeptides by regulating polypeptide association
DE102005028778A1 (de) 2005-06-22 2006-12-28 SUNJÜT Deutschland GmbH Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage
CA2638800A1 (fr) 2006-02-22 2007-09-07 Merck & Co., Inc. Derives d'oxyntomoduline
WO2007109354A2 (fr) 2006-03-21 2007-09-27 Amylin Pharmaceuticals, Inc. Conjugués inhibiteur de peptidase-peptide et procédés d'utilisation de ceux-ci
JP2009541275A (ja) 2006-06-22 2009-11-26 ノボ・ノルデイスク・エー／エス 二重特異性抗体の生産
CA2665808A1 (fr) 2006-10-05 2008-05-22 Centocor Ortho Biotech Inc. Antagonistes de ccr2 pour le traitement de la fibrose
JP2008169195A (ja) * 2007-01-05 2008-07-24 Hanmi Pharmaceutical Co Ltd キャリア物質を用いたインスリン分泌ペプチド薬物結合体
EP2527369A3 (fr) * 2007-09-13 2012-12-19 University Of Zurich Prorektorat Forschung Anticorps monoclonal anti-bêta-amyloide (abêta) et ses utilisations
AU2008343589A1 (en) 2007-12-19 2009-07-09 Centocor Ortho Biotech Inc. Design and generation of human de novo pIX phage display libraries via fusion to pIX or pVII, vectors, antibodies and methods
CN102272151B (zh) 2008-11-04 2014-08-20 詹森药业有限公司 Crhr2肽激动剂及其用途
CN102202681A (zh) * 2008-11-05 2011-09-28 霍夫曼-拉罗奇有限公司 神经肽-2受体(y-2r)激动剂及其用途
WO2010129304A2 (fr) 2009-04-27 2010-11-11 Oncomed Pharmaceuticals, Inc. Procédé de fabrication de molécules hétéromultimères
AU2010272944B2 (en) 2009-07-13 2015-11-19 Zealand Pharma A/S Acylated glucagon analogues
WO2011033068A1 (fr) 2009-09-18 2011-03-24 Novo Nordisk A/S Agonistes du récepteur y2 à action prolongée
CN104147611A (zh) 2009-09-30 2014-11-19 葛兰素集团有限公司 具有延长的半衰期的药物融合体和缀合物
EP2552951A1 (fr) * 2010-03-26 2013-02-06 Novo Nordisk A/S Nouveaux analogues du glucagon
HRP20241208T1 (hr) 2010-04-20 2024-11-22 Genmab A/S Heterodimerni proteini koji sadrže fc fragment protutijela i postupci za njihovu proizvodnju
US8906649B2 (en) * 2010-09-27 2014-12-09 Janssen Biotech, Inc. Antibodies binding human collagen II
ES2757857T3 (es) 2010-09-27 2020-04-30 Janssen Biotech Inc Anticuerpos de unión a colágeno II humano
ES2758994T3 (es) 2010-11-05 2020-05-07 Zymeworks Inc Diseño anticuerpo heterodimérico estable con mutaciones en el dominio Fc
SG192117A1 (en) * 2011-01-28 2013-08-30 Sanofi Sa Human antibodies to pcsk9 for use in methods of treating particular groups of subjects
RU2607365C2 (ru) 2011-06-17 2017-01-10 Ханми Сайенс Ко., Лтд. Конъюгат, содержащий оксинтомодулин и фрагмент иммуноглобулина, и его применение
BR112014010580B1 (pt) 2011-11-04 2021-01-12 Zymeworks, Inc. constructo de fc heteromultimérico isolado, composição, uso de um constructo de fc heteromultimérico isolado, composição de ácido nucléico e método para expressar o constructo de fc heteromultimérico isolado
RU2684595C2 (ru) * 2012-07-04 2019-04-09 Ф.Хоффманн-Ля Рош Аг Ковалентно связанные конъюгаты антиген-антитело
WO2014073842A1 (fr) * 2012-11-06 2014-05-15 Hanmi Pharm. Co., Ltd. Formulation liquide d'un conjugué protéique comprenant l'oxyntomoduline et un fragment d'immunoglobuline
HK1210713A1 (en) 2012-12-27 2016-05-06 Sanofi Anti-lamp1 antibodies and antibody drug conjugates, and uses thereof
EP2943512A4 (fr) 2013-01-11 2016-06-01 California Inst Biomedical Res Anticorps bovins de fusion
AU2014261111B2 (en) 2013-05-02 2017-03-16 Glaxosmithkline Intellectual Property Development Limited Therapeutic peptides
JP6685924B2 (ja) * 2014-04-11 2020-04-22 メディミューン，エルエルシー システイン操作抗体を含むコンジュゲート化合物
AR100978A1 (es) * 2014-06-26 2016-11-16 Hoffmann La Roche LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS
AU2015296640B2 (en) 2014-07-30 2020-05-21 Ngm Biopharmaceuticals, Inc. Compositions and methods of use for treating metabolic disorders
EA201891084A1 (ru) 2015-11-02 2019-10-31 Антитела к il1rap, биспецифические антигенсвязывающие молекулы, которые связываются с il1rap и cd3, и их применение
JOP20190095A1 (ar) * 2016-10-27 2019-04-28 Janssen Pharmaceutica Nv مركبات ببتيد تيروسين-تيروسين الحلقية كمعدلات لمستقبلات الببتيد العصبي y
TWI847981B (zh) * 2018-04-25 2024-07-11 比利時商健生藥品公司 類升糖素肽1 (glp-1)融合肽偶合環狀酪酪肽接合物及其用途

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US20190263879A1 (en) 2019-08-29
JP2022137031A (ja) 2022-09-21
JP7724196B2 (ja) 2025-08-15
IL266206B2 (en) 2025-01-01
IL314935A (en) 2024-10-01
KR20190073492A (ko) 2019-06-26
NZ752576A (en) 2025-09-26
CO2019004186A2 (es) 2019-05-10
AU2022200089A1 (en) 2022-02-03
US11401315B2 (en) 2022-08-02
US20180125998A1 (en) 2018-05-10
US10640544B2 (en) 2020-05-05
US20250026803A1 (en) 2025-01-23
NI201900044A (es) 2019-09-09
TW201827456A (zh) 2018-08-01
BR112019008351A2 (pt) 2019-10-01
CA3041672A1 (fr) 2018-05-03
CO2019004203A2 (es) 2019-05-10
IL301843B2 (en) 2026-01-01
US20210163566A1 (en) 2021-06-03
MX2019004954A (es) 2019-06-24
EP3988123C0 (fr) 2025-02-26
US20210206822A1 (en) 2021-07-08
MY199449A (en) 2023-10-30
JOP20190096A1 (ar) 2019-04-28
CO2019003938A2 (es) 2019-04-30
JP7387431B2 (ja) 2023-11-28
EP3988123B1 (fr) 2025-02-26
SG10202107777XA (en) 2021-08-30
US20200385439A1 (en) 2020-12-10
MX2019004955A (es) 2019-06-24
MX2023005465A (es) 2023-05-22
KR20190072616A (ko) 2019-06-25
SI3532486T1 (sl) 2021-12-31
CN109890410A (zh) 2019-06-14
SG11201902879SA (en) 2019-05-30
AU2025201677A1 (en) 2025-03-27
DOP2019000107A (es) 2019-09-30
US10968265B2 (en) 2021-04-06
KR102653376B1 (ko) 2024-04-02
EP3532486B1 (fr) 2021-09-22
SG11201902873RA (en) 2019-05-30
AU2017348180B2 (en) 2024-12-12
TWI781118B (zh) 2022-10-21
CA3041674A1 (fr) 2018-05-03
IL266204B1 (en) 2024-09-01
CN110036022A (zh) 2019-07-19
TW201827081A (zh) 2018-08-01
KR102573684B1 (ko) 2023-09-04

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