MA46665B1 - Composés de tyrosine tyrosine de peptide cyclique couplés à un anticorps en tant que modulateurs des récepteurs du neuropeptide y - Google Patents

Composés de tyrosine tyrosine de peptide cyclique couplés à un anticorps en tant que modulateurs des récepteurs du neuropeptide y

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Publication number
MA46665B1
MA46665B1 MA46665A MA46665A MA46665B1 MA 46665 B1 MA46665 B1 MA 46665B1 MA 46665 A MA46665 A MA 46665A MA 46665 A MA46665 A MA 46665A MA 46665 B1 MA46665 B1 MA 46665B1
Authority
MA
Morocco
Prior art keywords
tyrosine
neuropeptide
antibody
cyclic peptide
receptor modulators
Prior art date
Application number
MA46665A
Other languages
English (en)
Other versions
MA46665A (fr
Inventor
Ellen Chi
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62020814&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA46665(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MA46665A publication Critical patent/MA46665A/fr
Publication of MA46665B1 publication Critical patent/MA46665B1/fr

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57545—Neuropeptide Y
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    • C07K—PEPTIDES
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    • C07K2317/55—Fab or Fab'
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    • C07K2317/567—Framework region [FR]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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Abstract

La présente invention comprend des conjugués comprenant un anticorps monoclonal conjugué à un peptide pyy cyclique. L'invention concerne également des compositions pharmaceutiques et des procédés d'utilisation de celles-ci. Les nouveaux conjugués sont utiles pour la prévention, le traitement ou l'amélioration des troubles de maladies et d'affections décrites ici.
MA46665A 2016-10-27 2017-10-26 Composés de tyrosine tyrosine de peptide cyclique couplés à un anticorps en tant que modulateurs des récepteurs du neuropeptide y MA46665B1 (fr)

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US201662413613P 2016-10-27 2016-10-27
US201662413586P 2016-10-27 2016-10-27
PCT/US2017/058451 WO2018081367A1 (fr) 2016-10-27 2017-10-26 Composés peptidiques cycliques tyrosine-tyrosine à titre de modulateurs des récepteurs du neuropeptide y

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MA046718A MA46718A (fr) 2016-10-27 2017-10-26 Composés peptidiques cycliques tyrosine-tyrosine à titre de modulateurs des récepteurs du neuropeptide y
MA046672A MA46672A (fr) 2016-10-27 2017-10-26 Immunoglobulines et utilisations de celles-ci

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