CL2020000039A1 - Proteínas de fusión, bacterias recombinantes y métodos de uso de las bacterias recombinantes. (divisional solicitud 201700647) - Google Patents

Proteínas de fusión, bacterias recombinantes y métodos de uso de las bacterias recombinantes. (divisional solicitud 201700647)

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Publication number
CL2020000039A1
CL2020000039A1 CL2020000039A CL2020000039A CL2020000039A1 CL 2020000039 A1 CL2020000039 A1 CL 2020000039A1 CL 2020000039 A CL2020000039 A CL 2020000039A CL 2020000039 A CL2020000039 A CL 2020000039A CL 2020000039 A1 CL2020000039 A1 CL 2020000039A1
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CL
Chile
Prior art keywords
fusion proteins
bacillus cereus
cereus family
recombinant
protein
Prior art date
Application number
CL2020000039A
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English (en)
Inventor
Brian M Thompson
Ashley Siegel
Original Assignee
Spogen Biotech Inc
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Filing date
Publication date
Application filed by Spogen Biotech Inc filed Critical Spogen Biotech Inc
Publication of CL2020000039A1 publication Critical patent/CL2020000039A1/es

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    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
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    • A01HNEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
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    • A01N37/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
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    • A01N63/00Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N63/00Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/20Bacteria; Substances produced thereby or obtained therefrom
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    • A01N63/50Isolated enzymes; Isolated proteins
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    • EFIXED CONSTRUCTIONS
    • E21EARTH OR ROCK DRILLING; MINING
    • E21BEARTH OR ROCK DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
    • E21B43/00Methods or apparatus for obtaining oil, gas, water, soluble or meltable materials or a slurry of minerals from wells
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Abstract

PROTEÍNAS DE FUSIÓN QUE CONTIENEN UNA SECUENCIA DE DIRECCIONAMIENTO, UNA PROTEÍNA DEL EXOSPORIO O UN FRAGMENTO DE UNA PROTEÍNA DEL EXOSPORIO QUE DIRECCIONA LA PROTEÍNA DE FUSIÓN HACIA EL EXOSPORIO DE UN MIEMBRO DE LA FAMILIA DE BACILLUS CEREUS. TAMBIÉN SE PROVEEN MIEMBROS RECOMBINANTES DE LA FAMILIA DE BACILLUS CEREUS QUE EXPRESAN DICHAS PROTEÍNAS DE FUSIÓN; MIEMBROS GENÉTICAMENTE INACTIVADOS DE LA FAMILIA DE BACILLUS CEREUS Y MIEMBROS RECOMBINANTES DE LA FAMILIA DE BACILLUS CEREUS QUE SOBREEXPRESAN PROTEÍNAS DEL EXOSPORIO. SE PROVEEN ASIMISMO SEMILLAS RECUBIERTAS CON LOS MIEMBROS RECOMBINANTES DE LA FAMILIA DE BACILLUS CEREUS Y MÉTODOS PARA USAR LOS MIEMBROS RECOMBINANTES DE LA FAMILIA DE BACILLUS CEREUS (POR EJEMPLO, PARA ESTIMULAR EL CRECIMIENTO VEGETAL). SE PROVEEN ADEMÁS DIVERSAS MODIFIACIONES DE LOS MIEMBROS RECOMBINANTES DE LA FAMILIA DE BACILLUS CEREUS QUE EXPRESAN LAS PROTEÍNAS DE FUSIÓN. ADEMÁS, PROTEÍNAS DE FUSIÓN QUE COMPRENDEN UNA PROTEÍNA DE LA CUBIERTA DE ESPORAS Y UNA PROTEÍNA O UN PÉPTIDO DE INTERÉS, BACTERIAS RECOMBINANTES QUE EXPRESAN DICHAS PROTEÍNAS DE FUSIÓN, SEMILLAS RECUBIERTAS CON DICHAS BACTERIAS RECOMBINANTES Y MÉTODOS PARA USAR DICHAS BACTERIAS RECOMBINANTES (POR EJEMPLO, PARA ESTIMULAR EL CRECIMIENTO VEGETAL).
CL2020000039A 2014-09-17 2020-01-06 Proteínas de fusión, bacterias recombinantes y métodos de uso de las bacterias recombinantes. (divisional solicitud 201700647) CL2020000039A1 (es)

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US201462051885P 2014-09-17 2014-09-17

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CL2017000647A CL2017000647A1 (es) 2014-09-17 2017-03-16 Proteínas de fusión, bacterias recombinantes y métodos de uso de las bacterias recombinantes
CL2020000039A CL2020000039A1 (es) 2014-09-17 2020-01-06 Proteínas de fusión, bacterias recombinantes y métodos de uso de las bacterias recombinantes. (divisional solicitud 201700647)
CL2022003269A CL2022003269A1 (es) 2014-09-17 2022-11-21 Formulacion de recubrimiento de semillas y método para estimular crecimiento y germinación en plantas (divisional de la solicitud 201700647)
CL2022003270A CL2022003270A1 (es) 2014-09-17 2022-11-21 Formulacion de recubrimiento de semillas y método para estimular crecimiento y germinación en plantas (divisional de la solicitud 201700647)

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CL2022003270A CL2022003270A1 (es) 2014-09-17 2022-11-21 Formulacion de recubrimiento de semillas y método para estimular crecimiento y germinación en plantas (divisional de la solicitud 201700647)

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US (6) US9845342B2 (es)
EP (1) EP3194425A1 (es)
CN (1) CN107208042A (es)
AR (2) AR101953A1 (es)
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BR (29) BR122023020774A2 (es)
CA (1) CA2961641A1 (es)
CL (4) CL2017000647A1 (es)
CR (1) CR20170139A (es)
IL (4) IL315468A (es)
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PH (1) PH12017500519A1 (es)
PY (1) PY1546042A (es)
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Families Citing this family (81)

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Publication number Priority date Publication date Assignee Title
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
WO2012021512A2 (en) 2010-08-10 2012-02-16 Ecole Polytechnique Federale De Lausanne Erythrocyte-binding therapeutics
US9392796B2 (en) 2013-03-15 2016-07-19 Spogen Biotech Inc. Plant growth-promoting bacteria and methods of use
US9573980B2 (en) 2013-03-15 2017-02-21 Spogen Biotech Inc. Fusion proteins and methods for stimulating plant growth, protecting plants from pathogens, and immobilizing Bacillus spores on plant roots
KR102717969B1 (ko) 2014-02-21 2024-10-15 에꼴 뽈리떼끄닉 뻬데랄 드 로잔느 (으뻬에프엘) 글리코타겟팅 치료제
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
US10610552B2 (en) * 2016-04-05 2020-04-07 Nch Corporation Nutrient rich germinant composition and spore incubation method
US10766799B2 (en) 2014-05-23 2020-09-08 Nch Corporation Method for improving quality of aquaculture pond water using a nutrient germinant composition and spore incubation method
CN119157144A (zh) 2014-09-17 2024-12-20 巴斯夫公司 包含重组芽孢杆菌细胞和杀虫剂的组合物
IL315468A (en) 2014-09-17 2024-11-01 Spogen Biotech Inc Fusion proteins, recombinant bacteria, and methods for using recombinant bacteria
AR101961A1 (es) 2014-09-17 2017-01-25 Bayer Cropscience Lp Composiciones que comprenden células recombinantes de bacillus y otro agente de control biológico
BR112017005504A2 (pt) * 2014-09-17 2018-08-14 Bayer Cropscience Lp composições que compreendem células recombinantes de bacillus e um inseticida.
WO2016044529A1 (en) 2014-09-17 2016-03-24 Bayer Cropscience Lp Compositions comprising recombinant bacillus cells and another biological control agent
RU2017113002A (ru) * 2014-09-17 2018-10-17 Байер Кропсайенс Лп Композиции, содержащие рекомбинантные клетки bacillus и фунгицид
US10273193B1 (en) * 2015-09-29 2019-04-30 Evan James Schick Horticulture growth media
WO2017157773A1 (en) * 2016-03-14 2017-09-21 Henkel Ag & Co. Kgaa Process for controlling malodors using inactivated bacterial spores capable of inhibiting or preventing the production of malodor
AU2017233034B2 (en) 2016-03-16 2021-09-30 Spogen Biotech Inc. Methods for promoting plant health using free enzymes and microorganisms that overexpress enzymes
US12097226B2 (en) 2016-04-05 2024-09-24 Nch Corporation System and method for using a single-serve nutrient spore composition for small scale farm applications
US10897922B2 (en) 2016-04-05 2021-01-26 Nch Corporation Composition and method for germinative compounds in probiotic food and beverage products for human consumption
BR112018069945A2 (pt) 2016-04-06 2019-02-05 Plant Health Care, Inc. micróbios benéficos para distribuição de peptídeos ou proteínas efetoras e uso dos mesmos
CN106282067B (zh) * 2016-08-24 2019-10-11 李丽丽 多功能农用复合微生物菌剂及微生态制剂与应用
CN106635942B (zh) * 2016-12-05 2020-05-29 齐鲁工业大学 一种芽孢表面稳定展示海藻糖合酶的工程菌及其构建方法
KR20190122647A (ko) 2016-12-06 2019-10-30 페블 랩스 유에스에이 인코포레이티드 식물 병원체의 생물방제를 위한 시스템 및 방법
CN107223663B (zh) * 2017-04-24 2019-10-29 大连理工大学 春雷霉素及其衍生物为几丁质酶抑制剂的应用
US11253579B2 (en) 2017-06-16 2022-02-22 The University Of Chicago Compositions and methods for inducing immune tolerance
UY37816A (es) * 2017-07-20 2019-02-28 Spogen Biotech Inc Polipéptidos bioactivos para mejorar la protección, crecimiento y productividad en plantas
AU2018337974B2 (en) * 2017-09-20 2024-06-27 Spogen Biotech Inc. Fusion proteins, recombinant bacteria, and exosporium fragments for plant health
AR114339A1 (es) 2017-11-16 2020-08-26 Bayer Cropscience Lp Plataforma de presentación, productos y métodos con endosporas basadas en paenibacillus
CN108018233B (zh) * 2017-12-12 2021-09-21 广州融新科技发展有限公司 一株暹罗芽孢杆菌及其微生物菌剂的制备与应用
CN109988806B (zh) * 2017-12-29 2023-02-28 弈柯莱生物科技(上海)股份有限公司 一种n-乙酰-草铵膦盐的消旋方法
CN108018245A (zh) * 2018-01-12 2018-05-11 中国科学院成都生物研究所 一株产壳聚糖酶的枯草芽孢杆菌及其应用
US20190276834A1 (en) * 2018-03-07 2019-09-12 R.J. Reynolds Tobacco Company Methods and compositions for reducing bacterial load in tobacco
US12053486B2 (en) 2018-03-09 2024-08-06 Therazure LLC Compositions for the treatment of infections in feet
EA202092723A1 (ru) 2018-05-09 2021-04-09 Зе Юниверсити Оф Чикаго Композиции и способы, касающиеся иммунной толерантности
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
CN109138946A (zh) * 2018-07-16 2019-01-04 西南石油大学 一种10MPa监测水驱油过程三维渗流实验系统
US11401500B2 (en) 2018-08-29 2022-08-02 Nch Corporation System, method, and composition for incubating spores for use in aquaculture, agriculture, wastewater, and environmental remediation applications
CN109576233A (zh) * 2018-12-03 2019-04-05 中国农业科学院兰州兽医研究所 一种蜱源性基因工程疫苗
US20200255851A1 (en) * 2019-01-23 2020-08-13 Spogen Biotech Inc. Compositions for treating citrus disease and promoting yield increase in row crops
CN109777755A (zh) * 2019-01-31 2019-05-21 自然资源部第三海洋研究所 一株暹罗芽孢杆菌dh35及其发酵上清液的应用
CN109730136A (zh) * 2019-02-26 2019-05-10 湖州周生记餐饮管理有限公司 一种卤肉熟食的储存方法
US20220169999A1 (en) * 2019-03-19 2022-06-02 Bayer Cropscience Lp Fusion proteins, recombinant bacteria, and exosporium fragements for plant health
CR20210478A (es) * 2019-03-19 2021-11-05 Bayer Cropscience Lp Proteínas de fusión, bacterias recombinantes, y fragmentos de exosporio para el control de plagas y salud vegetal
MX2021013976A (es) * 2019-05-15 2022-01-04 Bayer Cropscience Lp Secuencias de direccionamiento para plataforma de visualizacion de endosporas basada en paenibacillus.
WO2020247824A1 (en) * 2019-06-06 2020-12-10 Loveland Products, Inc. Agricultural formulations and methods for making and using same
CN110862951B (zh) * 2019-09-06 2021-09-21 海南大学 一种维氏气单胞菌减毒菌株的构建方法、菌株及其应用
US20220411844A1 (en) 2019-11-22 2022-12-29 Bayer Cropscience Lp Methods of fermentation of recombinant bacillus spores
US11576937B2 (en) 2020-02-06 2023-02-14 Nch Corporation Method of reducing gut inflammation reduction in humans by consuming a heated probiotic composition
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
CN111748497B (zh) * 2020-07-07 2022-02-08 山东农业大学 一株大山芽孢杆菌及其在快速降解亚硝酸盐中的应用
US12537071B1 (en) 2020-07-22 2026-01-27 David Gordon Bermudes Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins
CN111662856B (zh) * 2020-07-31 2022-05-06 河北省农林科学院生物技术与食品科学研究所 一种包含木醋液的复合微生物制剂及其制备方法与应用
US20240240169A1 (en) 2020-09-21 2024-07-18 Bayer Cropscience Lp Novel serine proteases
CN112175921B (zh) * 2020-10-23 2022-06-07 中国科学院成都生物研究所 一种壳聚糖酶突变体g21r及其应用
CN114437954B (zh) * 2020-11-03 2024-09-27 中国石油天然气集团有限公司 一种降解磺化钻井液的弯曲芽孢杆菌、混合菌及其应用
EP4006139A1 (en) * 2020-11-26 2022-06-01 Acies Bio d.o.o. Genetically engineered bacterium capable of producing cytokinins with isoprenoid side chains
CN112553230B (zh) * 2020-12-21 2021-08-24 山东省科学院生物研究所 高产iaa绿色木霉工程菌株及其构建方法与应用
CN112707953B (zh) * 2021-01-22 2023-05-30 南昌师范学院 Ev71病毒样颗粒产品、其制备方法及其应用
CN112795519B (zh) * 2021-03-01 2023-01-10 千禾味业食品股份有限公司 一种暹罗芽孢杆菌及其在富含乙偶姻食醋中的应用
CA3211746A1 (en) * 2021-03-11 2022-09-15 Yves HURTUBISE Microorganism displaying antigenic protein of the sars-cov2 coronavirus
CN113046328B (zh) * 2021-04-13 2023-07-25 吉林大学 一株化脓隐秘杆菌噬菌体及其医用用途
CN113151123B (zh) * 2021-06-17 2022-07-08 吉林农业大学 一种低温产纤维素酶和木聚糖酶的蜡样芽孢杆菌
CN115363058B (zh) * 2021-07-18 2024-03-22 杭州绿键生物科技有限公司 一种有效灭活新型冠状病毒的消毒剂
CN114903824B (zh) * 2021-07-21 2023-12-29 广州梵之容化妆品有限公司 一种舒缓保湿面膜
CN113549626B (zh) * 2021-07-27 2022-08-09 昆明理工大学 与腐霉利特异性结合的核酸适配体Pr-A08及其应用
CN113403209B (zh) * 2021-07-30 2022-08-26 西南大学 天冬氨酸蛋白酶基因在改良球孢白僵菌菌株中的应用
CN113913431B (zh) * 2021-09-09 2023-10-24 湖南工业大学 一种辛硫磷核酸适配体、核酸适配体衍生物及其应用
WO2023092050A1 (en) 2021-11-20 2023-05-25 Bayer Cropscience Lp Beneficial combinations with recombinant bacillus cells expressing a serine protease
CN114158508B (zh) * 2021-11-30 2023-07-25 海南归耘田农业科技有限公司 一种有效预防小龙虾受寄生虫感染的方法
CN114410481B (zh) * 2021-12-30 2023-09-15 广州市土根旺生物科技有限公司 一株棘孢木霉及其应用
EP4463003A4 (en) * 2022-01-14 2026-01-28 Syngenta Crop Protection Ag COMPOSITIONS AND SCREENING METHODS OF INSECTICIDE PROTEINS
CN114908030B (zh) * 2022-05-11 2023-11-14 南京工业大学 一种在枯草芽孢杆菌表面展示β-环糊精葡萄糖基转移酶的重组菌及其应用
AU2023293070A1 (en) * 2022-06-13 2025-01-09 Trustees Of Tufts College Methods for spore display
FR3138265A1 (fr) * 2022-07-29 2024-02-02 Biointrant composition antigerminative
CN116102640A (zh) * 2022-10-13 2023-05-12 浙江双糖生物科技有限公司 重组乳铁蛋白衍生肽及其在提高免疫力方面的应用
CN116730533B (zh) * 2023-06-13 2025-08-26 中原环保股份有限公司 一种马铃薯淀粉废水资源化利用方法
CN118834934B (zh) * 2024-08-19 2025-05-16 希莱乐检(郑州)生物科技有限公司 用于结核分枝杆菌核酸释放的裂解液及其应用
CN119372177B (zh) * 2024-12-23 2025-04-29 安徽农业大学 一种茚虫威降解酶及其编码基因、生产菌和应用

Family Cites Families (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5554521A (en) 1984-03-26 1996-09-10 Dna Plant Technology Corporation Chitinase-producing plants
CA1335364C (en) 1986-12-17 1995-04-25 Joseph Wayne Kloepper Beneficial, direct-acting soil bacteria
US5858962A (en) 1987-05-11 1999-01-12 Ambi Inc. Composition for treating mastitis and other staphylococcal infections
US5290914A (en) 1988-04-28 1994-03-01 Mycogen Corporation Hybrid diphtheria-B.t. pesticidal toxins
EP0380484B1 (en) 1988-05-26 1993-08-18 Nika Health Products Limited Use of a lysozyme dimer and/or a ribonuclease dimer for th emanufacture of an antiviral or antibiotic drug
US6309440B1 (en) 1998-08-25 2001-10-30 Thomas T. Yamashita Method and composition for promoting and controlling growth of plants
PH30997A (en) 1990-03-12 1997-12-23 Ciba Geigy Antipathologenically effective compositions comprising lytic peptides and hydrolytic enzymes.
US5849870A (en) * 1993-03-25 1998-12-15 Novartis Finance Corporation Pesticidal proteins and strains
DE4412834A1 (de) 1994-04-14 1995-10-19 Bayer Ag Insektizide Mischungen
US5766914A (en) 1995-01-26 1998-06-16 Michigan State University Method of producing and purifying enzymes
GB9510459D0 (en) 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
US5650372A (en) 1995-05-30 1997-07-22 Micro Flo Company Plant treatment with bacillus strain ATCC
ES2172795T3 (es) 1996-06-07 2002-10-01 Dsm Nv Nuevos fungicidas enzimaticos.
GB9624611D0 (en) 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
US6110372A (en) 1996-12-17 2000-08-29 Perriello; Felix Anthony Bioremediation of petroleum pollutants with alkane-utilizing bacteria
JPH10203917A (ja) 1997-01-28 1998-08-04 Idemitsu Kosan Co Ltd 微生物種子粉衣組成物
IL121404A0 (en) 1997-07-27 1998-01-04 Yissum Res Dev Co Transgenic higher plants of altered structural morphology
US7432097B2 (en) 1997-08-13 2008-10-07 Verenium Corporation Phytases, nucleic acids encoding them and methods of making and using them
US6333302B1 (en) 1997-09-03 2001-12-25 Cornell Research Foundation, Inc. Use of hypersensitive response elicitor protein or polypeptide from Clavibacter michiganensis for disease resistance, growth enhancement and insect control
US5958104A (en) 1997-09-11 1999-09-28 Nonomura; Arthur M. Methods and compositions for enhancing plant growth
US6323023B1 (en) 1998-01-13 2001-11-27 Yissum Research Development Co., Ltd. Vectors containing nucleic acids coding for Arabidopsis thaliana endo-1,4-β-glucanase secretion signal peptide
US6548743B1 (en) 1998-08-10 2003-04-15 The General Hospital Corporation Transgenic plants expressing a dual-specificity MAPK phosphatase and uses thereof
JP3140430B2 (ja) 1999-03-09 2001-03-05 株式会社 バイテク バチルス属微生物とその用途
US7033781B1 (en) 1999-09-29 2006-04-25 Diversa Corporation Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
RU2160778C1 (ru) 1999-11-10 2000-12-20 Федеральное государственное унитарное предприятие "Пермский завод им. С.М. Кирова" Штамм бактерий bacillus сereus-продуцент нитрилгидратазы
US6630340B2 (en) 2000-03-01 2003-10-07 Novozymes A/S Family 5 xyloglucanases
US20030165538A1 (en) 2000-06-26 2003-09-04 Maxygen Incorporated Methods and compositions for developing spore display systems for medicinal and industrial applications
WO2002045513A2 (en) 2000-12-04 2002-06-13 Wisconsin Alumni Research Foundation Bacterial inoculants for enhancing plant growth
KR20020045400A (ko) 2000-12-08 2002-06-19 반재구 포자 표면발현 방법
WO2002077170A2 (en) 2001-03-22 2002-10-03 Pioneer Hi-Bred International, Inc. Expansin protein and polynucleotides and methods of use
WO2003011487A1 (en) 2001-07-27 2003-02-13 Global Biosciences, Inc. Remediation of metal contaminants with hydrocarbon-utilizing bacteria
KR20030015943A (ko) 2001-08-18 2003-02-26 한국바이오비료 주식회사 섬유질 분해 효소를 분비하는 유전자, 유전자로부터분비된 효소, 유전자를 포함하는 미생물, 미생물을 이용한유기질 비료
WO2003057861A2 (en) 2002-01-07 2003-07-17 Manas Ranjan Banerjee Sulfur-oxidizing bacteria for promoting plant growth
US7615681B2 (en) 2002-02-05 2009-11-10 National Research Council Of Canada Methods for modifying plant responses to stress and correspondingly derived plants
GB0205378D0 (en) 2002-03-07 2002-04-24 Royal Holloway University Of L Bacterial spores
US20030228679A1 (en) 2002-03-27 2003-12-11 Smith Donald L. Compositions and methods for increasing plant growth by inoculation with bacillus strains
DK1495128T3 (da) 2002-03-29 2014-08-11 Genencor Int Forstærket proteinekspression i Bacillus
ES2193892B1 (es) 2002-04-29 2005-05-16 Biotecnologicos Y Mercados, S.L. Fertilizante nitrogenado y procedimiento de obtencion del mismo.
US7547534B2 (en) 2002-06-14 2009-06-16 Verenium Corporation Methods for making a composition to treat a wood, a pulp or a paper
ATE482280T1 (de) 2003-02-06 2010-10-15 Cropdesign Nv Methode zur veränderung pflanzlicher wachstumsmerkmale
CN103484486B (zh) 2003-07-02 2018-04-24 维莱尼姆公司 葡聚糖酶,编码它们的核酸以及制备和使用它们的方法
KR100518953B1 (ko) * 2003-09-19 2005-10-12 주식회사 제노포커스 포자 외막단백질을 이용한 목적단백질의 표면발현 방법
JP2005298409A (ja) 2004-04-12 2005-10-27 Yukijirushi Shubyo Kk 植物発根促進剤
RU2006139953A (ru) 2004-04-13 2008-05-20 Е.И. Дюпон Де Немур Энд Компани (Us) Антраниламидные инсектициды
EP1778714A4 (en) * 2004-07-20 2008-05-21 Phyllom Llc PROCESS FOR THE PREPARATION AND USE OF RECOMBINANT SPORES OF BACILLUS THURINGIENSIS
GB0416629D0 (en) 2004-07-27 2004-08-25 Univ Sheffield Crop spray
GB0504940D0 (en) 2005-03-10 2005-04-20 Secr Defence Vaccine formulation
WO2007086898A2 (en) 2005-03-31 2007-08-02 University Of South Carolina Methods and compositions related to anthrax spore glycoproteins
US8080404B1 (en) 2005-04-05 2011-12-20 The United States Of America As Represented By The Secretary Of The Army Enzymatic decontamination
WO2006110508A2 (en) 2005-04-07 2006-10-19 The Samuel Roberts Noble Foundation, Inc. Plants with increased phosphorous uptake
CN101228277B (zh) 2005-07-18 2013-11-27 巴斯福植物科学有限公司 过表达accdp基因的植物中的产量增加
JP2007117066A (ja) 2005-09-30 2007-05-17 Techno Giken Kk 植物種子の物理処理方法と育種、育苗方法
RU2313941C2 (ru) 2005-10-05 2008-01-10 ООО "БИО Агат Групп" Препарат для защиты растений от возбудителей болезней сельскохозяйственных культур и винограда с ростстимулирующим эффектом, способ получения этого препарата и штаммы для его осуществления
EP1948799A4 (en) 2005-11-17 2009-09-30 Univ Mcgill USE OF BACTERIOCINS TO ENHANCE GROWTH AND RESISTANCE TO PLANT DISEASES
CN100347180C (zh) 2005-12-26 2007-11-07 北京华美天意科技开发有限公司 一种以氨基酸短肽为配体的模拟sod化合物及其制备方法
KR100784261B1 (ko) 2006-01-02 2007-12-11 한국과학기술원 탄저균의 포자외막 단백질을 이용한 목적단백질의 미생물표면발현방법
BRPI0708325A2 (pt) 2006-02-27 2011-05-24 Univ Northwest formulação de suporte de planta, veìculo para a distribuição e deslocamento de substáncias fitologicamente benéficas, e composições contendo os mesmos
EP2049669A2 (en) 2006-08-09 2009-04-22 DSMIP Assets B.V. Spore surface displays of bioactive molecules
EP2069504B1 (en) 2006-12-15 2015-06-03 CropDesign N.V. Plants having enhanced seed yield-related traits and a method for making the same
CN101362799A (zh) 2007-08-10 2009-02-11 中国科学院上海生命科学研究院 调控植物株高的基因及其应用
CA2736661A1 (en) 2007-09-07 2009-03-12 Dyadic International, Inc. Novel fungal enzymes
GB0717911D0 (en) 2007-09-14 2007-10-24 Univ Stirling Vaccine
DE112008002456T5 (de) 2007-09-21 2011-01-13 Basf Plant Science Gmbh Pflanzen mit erhöhtem Ertrag
BRPI0704008A2 (pt) 2007-10-30 2009-06-23 Basf Ag uso de glicerina, método para tratamento de culturas, composição de mistura em tanque e um método para a preparação de uma composição de mistura em tanque
US8114659B2 (en) 2008-01-14 2012-02-14 Robert William Rawson Apparatus and method for catalytic treatment of a media
US9133251B2 (en) 2008-02-22 2015-09-15 The Curators Of The University Of Missouri Bacillus based delivery system and methods of use
CA2740257A1 (en) 2008-10-23 2010-04-29 Basf Plant Science Gmbh Plants with increased yield (nue)
CN101481666B (zh) 2008-11-19 2011-08-24 黄晓东 植物促生菌、含有植物促生菌的微生物制剂及其制备方法
AU2009327244B2 (en) 2008-12-18 2017-01-19 Versitech Limited Method for speeding up plant growth and improving yield by introducing phosphatases in transgenic plant
PT2411410E (pt) 2009-03-27 2015-10-09 Gojo Ind Inc Composições e métodos para screening e utilização de compostos que antagonizam interações esporo-superfície
GB0916570D0 (en) 2009-09-21 2009-10-28 Royal Holloway & Bedford New C Method
KR20120126061A (ko) 2009-10-22 2012-11-20 재단법인 작물유전체기능연구사업단 향상된 수확량 관련 형질을 갖는 식물 및 이의 제조 방법
CN101723763B (zh) * 2009-10-31 2013-04-24 黑龙江八一农垦大学 大豆生物种衣剂
CA2780707A1 (en) 2009-11-17 2011-05-26 Basf Plant Science Company Gmbh Plants with increased yield
EP2539456B1 (en) 2010-02-28 2017-04-19 Los Alamos National Security, LLC Increasing plant growth by modulating omega-amidase expression in plants
KR101086367B1 (ko) 2010-03-11 2011-11-23 강원대학교산학협력단 식물생장 촉진 활성을 갖는 신균주 바실러스 아리아바타이 ls9 및 이의 용도
ES2378040B1 (es) 2010-03-31 2013-02-18 Probelte, S.A Un preparado biológico bionematicida y estimulador del crecimiento vegetal y cultivos puros de las cepas denominadas n11, sr11 y alo1, contenidas en el mismo.
RU2439148C1 (ru) 2010-05-21 2012-01-10 Российская Федерация, От Имени Которой Выступает Министерство Промышленности И Торговли Российской Федерации ШТАММ ГИБРИДНЫХ КУЛЬТИВИРУЕМЫХ КЛЕТОК ЖИВОТНЫХ Mus musculus 1E6 - ПРОДУЦЕНТ МОНОКЛОНАЛЬНЫХ АНТИТЕЛ, СПЕЦИФИЧНЫХ К СПОРАМ Bacillus anthracis
US20130216653A1 (en) 2010-06-30 2013-08-22 Dsm Ip Assets B.V. Spore surface display of bioactive molecules
CN101919407A (zh) 2010-07-21 2010-12-22 合肥工业大学 阿维菌素与苏云金芽孢杆菌复配的生物悬浮杀虫剂
CN102031231B (zh) 2010-11-03 2013-04-03 甘肃农业大学 一种植物促生菌及其菌剂与其制备方法和应用
EP2689015B1 (en) 2011-03-23 2015-01-07 Novozymes A/S Methods for producing secreted polypeptides
US20120259101A1 (en) 2011-04-11 2012-10-11 Li Tan Isopeptide Bond Formation in Bacillus Species and Uses Thereof
JP5747625B2 (ja) 2011-04-12 2015-07-15 住友化学株式会社 マンデロニトリル化合物の製造方法
US8614078B2 (en) 2011-04-15 2013-12-24 The Curators Of The University Of Missouri Contaminant reducing amide functionalized ordered mesoporous carbon composition
WO2012146597A1 (en) 2011-04-27 2012-11-01 Aarhus Universitet High expression cereal phytase gene
CN103086784B (zh) 2011-10-27 2014-06-25 胡茂森 一种氨基酸加酶生物肥及其制备方法
CA2860848C (en) 2011-12-13 2021-02-23 Monsanto Technology Llc Plant growth-promoting microbes and uses therefor
PL2806740T3 (pl) * 2012-01-25 2018-07-31 Bayer Intellectual Property Gmbh Kombinacje związków czynnych zawierające fluopyram, Bacillus i środek do zwalczania biologicznego
AU2013205606B2 (en) 2012-02-01 2015-05-21 Corteva Agriscience Llc Synthetic Brassica-derived chloroplast transit peptides
KR102095979B1 (ko) 2012-05-30 2020-04-02 바이엘 크롭사이언스 악티엔게젤샤프트 생물학적 방제제 및 살곤충제를 포함하는 조성물
NZ742943A (en) 2012-05-30 2019-04-26 Bayer Cropscience Ag Compositions comprising a biological control agent and a fungicide from the group consisting of inhibitors of the respiratory chain at complex i or ii
EP3292764A3 (en) 2012-05-30 2018-04-25 Bayer CropScience Aktiengesellschaft Composition comprising a biological control agent and a fungicide selected from inhibitors of the respiratory chain at complex iii
JP2014001179A (ja) 2012-06-20 2014-01-09 Sumitomo Chemical Co Ltd 有害生物の防除方法
CA2877892A1 (en) 2012-06-29 2014-01-03 Pioneer Hi-Bred International, Inc. Manipulation of serine/threonine protein phosphatases for crop improvement
US9125419B2 (en) 2012-08-14 2015-09-08 Marrone Bio Innovations, Inc. Bacillus sp. strain with antifungal, antibacterial and growth promotion activity
GB2507760B (en) 2012-11-08 2015-07-08 Inst Of Food Res Methods
US20160100585A1 (en) 2012-11-22 2016-04-14 Basf Corporation Pesticidal Mixtures
AU2013349839B2 (en) 2012-11-22 2017-03-30 Basf Corporation Pesticidal mixtures
CA2892712A1 (en) 2012-11-30 2014-06-05 Bayer Cropscience Ag Ternary fungicidal and pesticidal mixtures
US9392796B2 (en) 2013-03-15 2016-07-19 Spogen Biotech Inc. Plant growth-promoting bacteria and methods of use
US9573980B2 (en) 2013-03-15 2017-02-21 Spogen Biotech Inc. Fusion proteins and methods for stimulating plant growth, protecting plants from pathogens, and immobilizing Bacillus spores on plant roots
EP2975940A1 (en) * 2013-03-20 2016-01-27 BASF Corporation Synergistic compositions comprising a bacillus subtilis strain and a biopesticide
EP3055274B1 (en) 2013-10-11 2019-08-28 Suunil Sudhakar Chaudhry A process for producing highly nutritious and bioavailable organic nitrogen fertilizer from non gmo organisms
CL2013003780A1 (es) 2013-12-30 2014-06-20 Univ Concepcion Biofertilizante y su proceso de elaboración.
CA2937694A1 (en) 2014-02-04 2015-08-13 University Of Florida Research Foundation, Inc. Pteris vittata phytase nucleotide and amino acid sequences and methods of use
HU231353B1 (hu) 2014-02-10 2023-03-28 BioFil Mikrobiológiai, Géntechnológiai és Biokémiai Kft Stressztalajok oltására szolgáló talajbaktériumok
RU2017113002A (ru) 2014-09-17 2018-10-17 Байер Кропсайенс Лп Композиции, содержащие рекомбинантные клетки bacillus и фунгицид
CN119157144A (zh) 2014-09-17 2024-12-20 巴斯夫公司 包含重组芽孢杆菌细胞和杀虫剂的组合物
WO2016044529A1 (en) 2014-09-17 2016-03-24 Bayer Cropscience Lp Compositions comprising recombinant bacillus cells and another biological control agent
BR112017005504A2 (pt) 2014-09-17 2018-08-14 Bayer Cropscience Lp composições que compreendem células recombinantes de bacillus e um inseticida.
AR101961A1 (es) 2014-09-17 2017-01-25 Bayer Cropscience Lp Composiciones que comprenden células recombinantes de bacillus y otro agente de control biológico
IL315468A (en) 2014-09-17 2024-11-01 Spogen Biotech Inc Fusion proteins, recombinant bacteria, and methods for using recombinant bacteria
BR112017005379A2 (pt) 2014-09-17 2018-08-14 Bayer Cropscience Lp composições que compreendem células recombinantes de bacillus e um fungicida.
PT3209319T (pt) 2014-10-21 2021-09-24 Hexima Ltd Um método de tratamento
US10851027B2 (en) 2014-12-22 2020-12-01 Biomineral Systems LLc Phosphorus fertilizer bio-catalyst for sustainable crop production
CN104945164A (zh) 2015-07-07 2015-09-30 卞佳林 一种种植红薯用的肥料及其制备方法
AU2017233034B2 (en) 2016-03-16 2021-09-30 Spogen Biotech Inc. Methods for promoting plant health using free enzymes and microorganisms that overexpress enzymes
CN109072177A (zh) 2016-03-16 2018-12-21 斯波根生物技术公司 用于动物健康和水产养殖的融合蛋白、重组细菌和外孢壁片段
WO2018152411A1 (en) 2017-02-17 2018-08-23 Bayer Cropscience Lp Compositions comprising recombinant bacillus cells and an insecticide
AU2018337974B2 (en) 2017-09-20 2024-06-27 Spogen Biotech Inc. Fusion proteins, recombinant bacteria, and exosporium fragments for plant health

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