CL2020002695A1 - Péptidos macrocíclicos contra actinetobacter baumannii - Google Patents

Péptidos macrocíclicos contra actinetobacter baumannii

Info

Publication number
CL2020002695A1
CL2020002695A1 CL2020002695A CL2020002695A CL2020002695A1 CL 2020002695 A1 CL2020002695 A1 CL 2020002695A1 CL 2020002695 A CL2020002695 A CL 2020002695A CL 2020002695 A CL2020002695 A CL 2020002695A CL 2020002695 A1 CL2020002695 A1 CL 2020002695A1
Authority
CL
Chile
Prior art keywords
actinetobacter
baumannii
macrocyclic peptides
peptides against
formula
Prior art date
Application number
CL2020002695A
Other languages
English (en)
Inventor
Theodor Stoll
taishan Hu
Patrizio Mattei
Giorgio Patrick Di
Petra Schmitz
Konrad Bleicher
Daniella Cheang
Christian Jenny
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2020002695A1 publication Critical patent/CL2020002695A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona compuestos de fórmula (I); en la que X1, X2, R1 a R6 y A son tal como se indica en la presente memoria, así como sales farmacéuticamente aceptables de los<br /> mismos. Además, la presente invención se refiere a la preparación de los compuestos de fórmula (I), composiciones farmacéuticas que los comprenden y a su utilización como medicamentos destinados al tratamiento de enfermedades e infecciones causadas por bacterias.
CL2020002695A 2018-04-23 2020-10-16 Péptidos macrocíclicos contra actinetobacter baumannii CL2020002695A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNPCT/CN2018/084131 2018-04-23

Publications (1)

Publication Number Publication Date
CL2020002695A1 true CL2020002695A1 (es) 2021-02-19

Family

ID=66290410

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020002695A CL2020002695A1 (es) 2018-04-23 2020-10-16 Péptidos macrocíclicos contra actinetobacter baumannii

Country Status (20)

Country Link
US (2) US11819532B2 (es)
EP (1) EP3784262A1 (es)
JP (3) JP7460541B2 (es)
KR (1) KR102855963B1 (es)
CN (1) CN111886020B (es)
AR (1) AR114290A1 (es)
AU (1) AU2019260124B2 (es)
BR (1) BR112020021729A2 (es)
CA (1) CA3089688A1 (es)
CL (1) CL2020002695A1 (es)
CR (1) CR20200488A (es)
IL (2) IL309537A (es)
MA (1) MA52352A (es)
MX (1) MX2020007633A (es)
PE (1) PE20210855A1 (es)
PH (1) PH12020551762A1 (es)
SG (1) SG11202007219PA (es)
TW (1) TWI833748B (es)
UA (1) UA126943C2 (es)
WO (1) WO2019206853A1 (es)

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CN115916784A (zh) 2020-06-09 2023-04-04 豪夫迈·罗氏有限公司 新型咪唑并吡嗪衍生物
CN115989225A (zh) 2020-08-31 2023-04-18 豪夫迈·罗氏有限公司 作为抗菌药物的咪唑-吡唑衍生物
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CN118119609A (zh) 2021-07-15 2024-05-31 豪夫迈·罗氏有限公司 咪唑衍生物及其作为抗生素的用途
TW202342493A (zh) * 2022-02-14 2023-11-01 瑞士商赫孚孟拉羅股份公司 製造大環肽之方法
WO2023161316A1 (en) 2022-02-25 2023-08-31 F. Hoffmann-La Roche Ag Zwitterionic antibacterial compounds
JP2025511869A (ja) 2022-04-07 2025-04-16 エフ． ホフマン－ラ ロシュ アーゲー 大環状ペプチド抗生物質の結晶形態
CN119677765A (zh) 2022-08-09 2025-03-21 豪夫迈·罗氏有限公司 用于制造抗生素大环肽的方法
WO2025067477A1 (zh) * 2023-09-27 2025-04-03 武汉人福创新药物研发中心有限公司 抗鲍曼不动杆菌的环肽及其应用
CN120424159A (zh) * 2024-02-02 2025-08-05 武汉人福创新药物研发中心有限公司 抗鲍曼不动杆菌的含羧酸取代的环肽及其应用
CN118932710A (zh) * 2024-07-01 2024-11-12 宿迁逸达新材料有限公司 一种抗菌涤纶面料的制备方法
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Also Published As

Publication number Publication date
AR114290A1 (es) 2020-08-12
US11819532B2 (en) 2023-11-21
CN111886020B (zh) 2024-04-05
CA3089688A1 (en) 2019-10-31
AU2019260124B2 (en) 2024-12-12
CR20200488A (es) 2021-02-26
IL309537A (en) 2024-02-01
MA52352A (fr) 2021-03-03
UA126943C2 (uk) 2023-02-22
AU2019260124A1 (en) 2020-08-06
IL278053B1 (en) 2024-01-01
JP2025148419A (ja) 2025-10-07
TWI833748B (zh) 2024-03-01
CN111886020A (zh) 2020-11-03
JP7460541B2 (ja) 2024-04-02
PE20210855A1 (es) 2021-05-18
KR102855963B1 (ko) 2025-09-05
BR112020021729A2 (pt) 2021-01-26
KR20210005574A (ko) 2021-01-14
JP2021522210A (ja) 2021-08-30
IL278053B2 (en) 2024-05-01
US20190321440A1 (en) 2019-10-24
EP3784262A1 (en) 2021-03-03
JP2024050700A (ja) 2024-04-10
WO2019206853A1 (en) 2019-10-31
IL278053A (en) 2020-11-30
SG11202007219PA (en) 2020-08-28
MX2020007633A (es) 2020-09-14
US20240050516A1 (en) 2024-02-15
TW201945386A (zh) 2019-12-01
PH12020551762A1 (en) 2021-06-14

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