DOP2012000243A - Compuestos de sililo tricíclicos fusionados y uso de los mismos en la fabricación de medicamentos útiles en el tratamiento de enfermedades virales - Google Patents

Compuestos de sililo tricíclicos fusionados y uso de los mismos en la fabricación de medicamentos útiles en el tratamiento de enfermedades virales

Info

Publication number
DOP2012000243A
DOP2012000243A DO2012000243A DO2012000243A DOP2012000243A DO P2012000243 A DOP2012000243 A DO P2012000243A DO 2012000243 A DO2012000243 A DO 2012000243A DO 2012000243 A DO2012000243 A DO 2012000243A DO P2012000243 A DOP2012000243 A DO P2012000243A
Authority
DO
Dominican Republic
Prior art keywords
sililo
compounds
fusioned
tricyclic
same
Prior art date
Application number
DO2012000243A
Other languages
English (en)
Inventor
Anilkumar Gopinadhan Nair
Kerry M Keertikar
Seong Heon Kim
Joseph A Kozlowski
Stuart Rosenblum
Oleg B Selyutin
Michael Wong
Wensheng Yu
Qingbei Zeng
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43939669&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2012000243(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of DOP2012000243A publication Critical patent/DOP2012000243A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0816—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring comprising Si as a ring atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A NUEVOS COMPUESTOS DE SILILO TRICÍCLICOS FUSIONADOS DE FÓRMULA (I): Y SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS, EN DONDE A, B, C, D, M1, X1 Y X2 SON COMO SE DEFINEN EN EL PRESENTE DOCUMENTO. LA PRESENTE INVENCIÓN TAMBIÉN SE REFIERE A COMPOSICIONES QUE COMPRENDEN AL MENOS UN COMPUESTO DE SILILO TRICÍCLICO FUSIONADO, Y A MÉTODOS DE USO DE LOS COMPUESTOS DE SILILO TRICÍCLICOS FUSIONADOS PARA TRATAR O PREVENIR UNA INFECCIÓN POR VHC EN UN PACIENTE.
DO2012000243A 2010-03-09 2012-09-07 Compuestos de sililo tricíclicos fusionados y uso de los mismos en la fabricación de medicamentos útiles en el tratamiento de enfermedades virales DOP2012000243A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31201610P 2010-03-09 2010-03-09
US37193510P 2010-08-09 2010-08-09

Publications (1)

Publication Number Publication Date
DOP2012000243A true DOP2012000243A (es) 2012-12-31

Family

ID=43939669

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2012000243A DOP2012000243A (es) 2010-03-09 2012-09-07 Compuestos de sililo tricíclicos fusionados y uso de los mismos en la fabricación de medicamentos útiles en el tratamiento de enfermedades virales

Country Status (26)

Country Link
US (1) US8609635B2 (es)
EP (1) EP2545060B1 (es)
JP (1) JP2013522202A (es)
KR (1) KR20130008040A (es)
CN (1) CN102918049A (es)
AR (1) AR080676A1 (es)
AU (1) AU2011224698A1 (es)
BR (1) BR112012022125A2 (es)
CA (1) CA2792121A1 (es)
CL (1) CL2012002489A1 (es)
CO (1) CO6592102A2 (es)
CR (1) CR20120460A (es)
DO (1) DOP2012000243A (es)
EA (1) EA201290882A1 (es)
EC (1) ECSP12012147A (es)
ES (1) ES2558554T3 (es)
MA (1) MA34147B1 (es)
MX (1) MX2012010392A (es)
NI (1) NI201200139A (es)
PE (1) PE20130062A1 (es)
PH (1) PH12012501748A1 (es)
SG (1) SG183526A1 (es)
TN (1) TN2012000416A1 (es)
TW (1) TW201136943A (es)
WO (1) WO2011112429A1 (es)
ZA (1) ZA201206716B (es)

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MA34147B1 (fr) 2013-04-03
PE20130062A1 (es) 2013-02-28
AR080676A1 (es) 2012-05-02
WO2011112429A1 (en) 2011-09-15
CA2792121A1 (en) 2011-09-15
ES2558554T3 (es) 2016-02-05
CN102918049A (zh) 2013-02-06
TW201136943A (en) 2011-11-01
US8609635B2 (en) 2013-12-17
BR112012022125A2 (pt) 2016-11-01
US20110223134A1 (en) 2011-09-15
EP2545060B1 (en) 2015-11-25
TN2012000416A1 (en) 2014-01-30
CL2012002489A1 (es) 2012-11-30
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ECSP12012147A (es) 2012-10-30
CO6592102A2 (es) 2013-01-02
EP2545060A1 (en) 2013-01-16
KR20130008040A (ko) 2013-01-21
AU2011224698A1 (en) 2012-11-01
NI201200139A (es) 2013-01-24
EA201290882A1 (ru) 2013-04-30
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ZA201206716B (en) 2013-05-29
CR20120460A (es) 2012-11-01

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