CL2020003357A1 - Métodos para tratar el cáncer de pulmón con un antagonista de fijación al eje pd-1, un agente de platino y un inhibidor de la topoisomerasa ii. - Google Patents

Métodos para tratar el cáncer de pulmón con un antagonista de fijación al eje pd-1, un agente de platino y un inhibidor de la topoisomerasa ii.

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Publication number
CL2020003357A1
CL2020003357A1 CL2020003357A CL2020003357A CL2020003357A1 CL 2020003357 A1 CL2020003357 A1 CL 2020003357A1 CL 2020003357 A CL2020003357 A CL 2020003357A CL 2020003357 A CL2020003357 A CL 2020003357A CL 2020003357 A1 CL2020003357 A1 CL 2020003357A1
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CL
Chile
Prior art keywords
lung cancer
methods
binding antagonist
axis binding
topoisomerase
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Application number
CL2020003357A
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English (en)
Inventor
Ariel Lopez-Chavez
Daniel Antonius Waterkamp
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Genentech Inc
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Publication of CL2020003357A1 publication Critical patent/CL2020003357A1/es

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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/365—Lactones
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
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    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente divulgación proporciona métodos para tratar el cáncer de pulmón (tal como el cáncer de pulmón de células pequeñas, por ejemplo, el cáncer de pulmón de células pequeñas en estadio extensivo) en un individuo. Los métodos comprenden administrar al individuo un antagonista de fijación al eje PD-1 (tal como un anticuerpo anti-PD-L1, por ejemplo, atezolizumab), un agente de platino (por ejemplo, cisplatino o carboplatino) y un inhibidor de la topoisomerasa II (por ejemplo, etopósido).
CL2020003357A 2018-06-23 2020-12-22 Métodos para tratar el cáncer de pulmón con un antagonista de fijación al eje pd-1, un agente de platino y un inhibidor de la topoisomerasa ii. CL2020003357A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862689105P 2018-06-23 2018-06-23
US201862719461P 2018-08-17 2018-08-17
US201862736326P 2018-09-25 2018-09-25

Publications (1)

Publication Number Publication Date
CL2020003357A1 true CL2020003357A1 (es) 2021-05-14

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CL2020003357A CL2020003357A1 (es) 2018-06-23 2020-12-22 Métodos para tratar el cáncer de pulmón con un antagonista de fijación al eje pd-1, un agente de platino y un inhibidor de la topoisomerasa ii.

Country Status (16)

Country Link
US (2) US20200030443A1 (es)
EP (1) EP3810653A1 (es)
JP (2) JP7399895B2 (es)
KR (2) KR102934775B1 (es)
CN (1) CN112585166A (es)
AU (2) AU2019288728A1 (es)
BR (1) BR112020026384A2 (es)
CA (1) CA3103017A1 (es)
CL (1) CL2020003357A1 (es)
IL (1) IL279548A (es)
MA (1) MA52968A (es)
MX (1) MX2020014091A (es)
MY (1) MY205645A (es)
SG (1) SG11202012446UA (es)
TW (2) TWI819011B (es)
WO (1) WO2019246557A1 (es)

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WO2021138578A1 (en) * 2019-12-31 2021-07-08 The Trustees Of Indiana University Repurposing fda-approved drugs as a novel cancer therapeutic avenue through inhibition of prmt5
WO2022098619A1 (en) * 2020-11-06 2022-05-12 The Regents Of The University Of Michigan Compositions and methods for improving cancer therapy
MX2023007780A (es) * 2021-01-08 2023-07-10 Bristol Myers Squibb Co Terapia de combinacion usando un anticuerpo anti-fucosil-gm1.
EP4281063A4 (en) * 2021-01-19 2024-11-13 Lixte Biotechnology, Inc. OXABICYCLOHEPTANE FOR THE TREATMENT OF SMALL CELL LUNG CANCER
TW202508632A (zh) * 2023-08-15 2025-03-01 瑞士商百濟神州瑞士有限責任公司 使用抗ｐｄ－１及化學療法治療肺癌
TW202602492A (zh) * 2024-04-05 2026-01-16 瑞典商阿斯特捷利康公司 局限期小細胞肺癌之治療

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