CL2021001096A1 - Métodos para tratar el síndrome mielodisplásico. (divisional de la solicitud no. 202000196) - Google Patents
Métodos para tratar el síndrome mielodisplásico. (divisional de la solicitud no. 202000196)Info
- Publication number
- CL2021001096A1 CL2021001096A1 CL2021001096A CL2021001096A CL2021001096A1 CL 2021001096 A1 CL2021001096 A1 CL 2021001096A1 CL 2021001096 A CL2021001096 A CL 2021001096A CL 2021001096 A CL2021001096 A CL 2021001096A CL 2021001096 A1 CL2021001096 A1 CL 2021001096A1
- Authority
- CL
- Chile
- Prior art keywords
- myelodysplastic syndrome
- methods
- mds
- subject
- divisional application
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/055—Phenols the aromatic ring being substituted by halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La divulgación proporciona métodos para tratar un síndrome mielodisplásico (MDS) en un sujeto que no ha recibido tratamiento con un agente seleccionado de un agente de hipometilación (HMA) y lenalidomida, o ambos. El método incluye administrar al sujeto una cantidad eficaz de un inhibidor de la telomerasa, como por ejemplo, el imetelstat o el sodio de imetelstat. En algunos casos, el sujeto tratado se clasifica como con MDS de riesgo bajo/intermedio-1 de IPSS y/o que tiene MDS recidivante/resistente a agente estimulante de la eritropoyesis (ESA).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762538315P | 2017-07-28 | 2017-07-28 | |
| US201762595329P | 2017-12-06 | 2017-12-06 | |
| US201862685542P | 2018-06-15 | 2018-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2021001096A1 true CL2021001096A1 (es) | 2021-11-12 |
Family
ID=63209674
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2020000196A CL2020000196A1 (es) | 2017-07-28 | 2020-01-23 | Métodos para tratar el síndrome mielodisplásico. |
| CL2021001096A CL2021001096A1 (es) | 2017-07-28 | 2021-04-28 | Métodos para tratar el síndrome mielodisplásico. (divisional de la solicitud no. 202000196) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2020000196A CL2020000196A1 (es) | 2017-07-28 | 2020-01-23 | Métodos para tratar el síndrome mielodisplásico. |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US12171778B2 (es) |
| EP (2) | EP3658156B1 (es) |
| JP (4) | JP7316261B2 (es) |
| KR (2) | KR102867725B1 (es) |
| CN (2) | CN110944646A (es) |
| AU (2) | AU2018307983B2 (es) |
| BR (1) | BR112020001749A2 (es) |
| CA (1) | CA3069010A1 (es) |
| CL (2) | CL2020000196A1 (es) |
| DK (1) | DK3658156T3 (es) |
| ES (1) | ES3073105T3 (es) |
| FI (1) | FI3658156T3 (es) |
| HR (1) | HRP20260793T1 (es) |
| IL (2) | IL324714A (es) |
| LT (1) | LT3658156T (es) |
| MA (1) | MA49688B1 (es) |
| MD (1) | MD3658156T2 (es) |
| MX (1) | MX2025005894A (es) |
| NZ (2) | NZ802277A (es) |
| PL (1) | PL3658156T3 (es) |
| PT (1) | PT3658156T (es) |
| RS (1) | RS68210B1 (es) |
| SG (1) | SG11201913984RA (es) |
| SI (1) | SI3658156T1 (es) |
| SM (1) | SMT202600247T1 (es) |
| TW (2) | TWI906757B (es) |
| UA (1) | UA127701C2 (es) |
| WO (1) | WO2019023667A1 (es) |
| ZA (1) | ZA202000070B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9375485B2 (en) | 2012-12-07 | 2016-06-28 | Geron Corporation | Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms |
| EP3318276A1 (en) | 2016-11-04 | 2018-05-09 | Janssen Biotech, Inc. | Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers |
| EP3658156B1 (en) | 2017-07-28 | 2026-03-25 | Geron Corporation | Telomerase inhibitor for use in treating a myelodysplastic syndrome |
| CN113631719A (zh) * | 2018-11-29 | 2021-11-09 | 美国杰龙生物医药公司 | 治疗骨髓增生异常综合征的方法 |
| CA3181682A1 (en) | 2020-07-17 | 2022-01-20 | Anil Kapur | Subcutaneous telomerase inhibitor compositions and methods for using same |
| CN116887844A (zh) * | 2021-01-18 | 2023-10-13 | 活跃生物技术有限公司 | 用于治疗骨髓增生异常综合征的他喹莫德或其药学上可接受的盐 |
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| US5489508A (en) | 1992-05-13 | 1996-02-06 | University Of Texas System Board Of Regents | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
| US7067497B2 (en) | 1992-09-29 | 2006-06-27 | Isis Pharmaceuticals, Inc. | Modulation of telomere length by oligonucleotides having a G-core sequence |
| IL107150A0 (en) | 1992-09-29 | 1993-12-28 | Isis Pharmaceuticals Inc | Oligonucleotides having a conserved g4 core sequence |
| US5958680A (en) | 1994-07-07 | 1999-09-28 | Geron Corporation | Mammalian telomerase |
| US5583016A (en) | 1994-07-07 | 1996-12-10 | Geron Corporation | Mammalian telomerase |
| US5760062A (en) | 1995-04-18 | 1998-06-02 | Geron Corporation | Telomerase inhibitors |
| US5656638A (en) | 1995-04-18 | 1997-08-12 | Geron Corporation | Telomerase inhibitors |
| US5863936A (en) | 1995-04-18 | 1999-01-26 | Geron Corporation | Telomerase inhibitors |
| US5840490A (en) | 1995-06-07 | 1998-11-24 | Mcmaster University | Telomerase activity associated with hematological and colorectal malignancies |
| US5770613A (en) | 1995-09-29 | 1998-06-23 | Geron Corporation | Telomerase inhibitors |
| US5767278A (en) | 1995-10-06 | 1998-06-16 | Geron Corporation | Telomerase inhibitors |
| US6261836B1 (en) | 1996-10-01 | 2001-07-17 | Geron Corporation | Telomerase |
| US6444650B1 (en) | 1996-10-01 | 2002-09-03 | Geron Corporation | Antisense compositions for detecting and inhibiting telomerase reverse transcriptase |
| HK1049339B (en) | 1999-09-10 | 2008-06-27 | Geron Corporation | Oligonucleotide n3'-p5' thiophosphoramidates: their synthesis and use |
| AU2001227965A1 (en) | 2000-01-21 | 2001-07-31 | Geron Corporation | 2'-arabino-fluorooligonucleotide n3'-p5'phosphoramidates: their synthesis and use |
| US6331399B1 (en) | 2000-05-16 | 2001-12-18 | Isis Pharmaceuticals, Inc. | Antisense inhibition of tert expression |
| US7563618B2 (en) | 2001-03-23 | 2009-07-21 | Geron Corporation | Oligonucleotide conjugates |
| AU2002245717A1 (en) | 2001-03-23 | 2002-10-08 | Geron Corporation | Oligonucleotide conjugates |
| DK3342425T3 (da) | 2003-09-09 | 2020-03-16 | Geron Corp | Modificerede oligonukleotider til inhibering af telomerase |
| DE602004031975D1 (de) | 2003-11-04 | 2011-05-05 | Geron Corp | Rna-amidate und thioamidateur rnai |
| US20050282893A1 (en) | 2004-01-30 | 2005-12-22 | Au Jessie L | Methods and compositions for using suramin, pentosan, polysulfate, telomerase antisense and telomerase inhibitors |
| RS61840B1 (sr) | 2004-07-02 | 2021-06-30 | Geron Corp | Sinteza zaštićenih 3'-amino 5'-fosforamidit nukleozidnih monomera |
| FR2877013A1 (fr) | 2004-10-27 | 2006-04-28 | Assist Publ Hopitaux De Paris | Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez |
| US20060166221A1 (en) | 2005-01-21 | 2006-07-27 | Bahou Wadie F | Methods of diagnosing essential thrombocythemia |
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| LT2925889T (lt) | 2012-11-30 | 2018-12-27 | Geron Corporation | Diagnostiniai žymenys, skirti ląstelių prolifreracijos sutrikimų gydymui telomerazės inhibitoriais |
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| US20150342982A1 (en) * | 2012-12-07 | 2015-12-03 | Geron Corporation | Use of Telomerase Inhibitors for the Treatment of Myeloproliferative Disorders and Myeloproliferative Neoplasms |
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| EP3318276A1 (en) | 2016-11-04 | 2018-05-09 | Janssen Biotech, Inc. | Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers |
| EP3658156B1 (en) | 2017-07-28 | 2026-03-25 | Geron Corporation | Telomerase inhibitor for use in treating a myelodysplastic syndrome |
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2018
- 2018-07-27 EP EP18755608.9A patent/EP3658156B1/en active Active
- 2018-07-27 KR KR1020207003450A patent/KR102867725B1/ko active Active
- 2018-07-27 AU AU2018307983A patent/AU2018307983B2/en active Active
- 2018-07-27 FI FIEP18755608.9T patent/FI3658156T3/fi active
- 2018-07-27 CA CA3069010A patent/CA3069010A1/en active Pending
- 2018-07-27 TW TW113103931A patent/TWI906757B/zh active
- 2018-07-27 LT LTEPPCT/US2018/044225T patent/LT3658156T/lt unknown
- 2018-07-27 PL PL18755608.9T patent/PL3658156T3/pl unknown
- 2018-07-27 SI SI201831321T patent/SI3658156T1/sl unknown
- 2018-07-27 TW TW107126009A patent/TWI879717B/zh active
- 2018-07-27 IL IL324714A patent/IL324714A/en unknown
- 2018-07-27 JP JP2020504178A patent/JP7316261B2/ja active Active
- 2018-07-27 NZ NZ802277A patent/NZ802277A/en unknown
- 2018-07-27 MD MDE20200587T patent/MD3658156T2/ro unknown
- 2018-07-27 HR HRP20260793TT patent/HRP20260793T1/hr unknown
- 2018-07-27 EP EP26159006.1A patent/EP4763279A3/en active Pending
- 2018-07-27 WO PCT/US2018/044225 patent/WO2019023667A1/en not_active Ceased
- 2018-07-27 UA UAA202000156A patent/UA127701C2/uk unknown
- 2018-07-27 DK DK18755608.9T patent/DK3658156T3/da active
- 2018-07-27 PT PT187556089T patent/PT3658156T/pt unknown
- 2018-07-27 US US16/047,502 patent/US12171778B2/en active Active
- 2018-07-27 RS RS20260721A patent/RS68210B1/en unknown
- 2018-07-27 SM SM20260247T patent/SMT202600247T1/it unknown
- 2018-07-27 NZ NZ802272A patent/NZ802272A/en unknown
- 2018-07-27 BR BR112020001749-3A patent/BR112020001749A2/pt not_active Application Discontinuation
- 2018-07-27 CN CN201880049391.2A patent/CN110944646A/zh active Pending
- 2018-07-27 ES ES18755608T patent/ES3073105T3/es active Active
- 2018-07-27 SG SG11201913984RA patent/SG11201913984RA/en unknown
- 2018-07-27 MA MA49688A patent/MA49688B1/fr unknown
- 2018-07-27 CN CN202511334144.5A patent/CN121243203A/zh active Pending
- 2018-07-27 KR KR1020257032602A patent/KR20250151565A/ko active Pending
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2020
- 2020-01-06 ZA ZA2020/00070A patent/ZA202000070B/en unknown
- 2020-01-21 IL IL272163A patent/IL272163B1/en unknown
- 2020-01-23 CL CL2020000196A patent/CL2020000196A1/es unknown
- 2020-01-24 MX MX2025005894A patent/MX2025005894A/es unknown
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2021
- 2021-04-28 CL CL2021001096A patent/CL2021001096A1/es unknown
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2022
- 2022-11-16 JP JP2022183229A patent/JP7654615B2/ja active Active
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2023
- 2023-11-21 JP JP2023197448A patent/JP7654761B2/ja active Active
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2024
- 2024-09-20 AU AU2024219941A patent/AU2024219941B2/en active Active
- 2024-11-06 US US18/938,747 patent/US20260115223A1/en active Pending
- 2024-11-12 JP JP2024197684A patent/JP2025013669A/ja active Pending
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