CL2021003257A1 - Pirazolo-piridinas heteroaromáticas sustituidas y su uso como moduladores del receptor glun2b. - Google Patents

Pirazolo-piridinas heteroaromáticas sustituidas y su uso como moduladores del receptor glun2b.

Info

Publication number
CL2021003257A1
CL2021003257A1 CL2021003257A CL2021003257A CL2021003257A1 CL 2021003257 A1 CL2021003257 A1 CL 2021003257A1 CL 2021003257 A CL2021003257 A CL 2021003257A CL 2021003257 A CL2021003257 A CL 2021003257A CL 2021003257 A1 CL2021003257 A1 CL 2021003257A1
Authority
CL
Chile
Prior art keywords
pyridines
pyrazolo
glun2b receptor
receptor modulators
substituted heteroaromatic
Prior art date
Application number
CL2021003257A
Other languages
English (en)
Inventor
Michael A Letavic
Afton Hiscox
Brice Stenne
Christa Chrovian
Christine Gelin
Andrew Samant
Curt Dvorak
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CL2021003257A1 publication Critical patent/CL2021003257A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pirazolo-piridinas sustituidas como ligandos del receptor GluN2B. Tales compuestos pueden usarse en la modulación del receptor GluN2B y en composiciones farmacéuticas y métodos para el tratamiento de estados de enfermedad, trastornos, y afecciones mediadas por la actividad del receptor GluN2B
CL2021003257A 2019-06-14 2021-12-07 Pirazolo-piridinas heteroaromáticas sustituidas y su uso como moduladores del receptor glun2b. CL2021003257A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962861665P 2019-06-14 2019-06-14
PK34920 2020-06-03

Publications (1)

Publication Number Publication Date
CL2021003257A1 true CL2021003257A1 (es) 2022-08-19

Family

ID=73781827

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021003257A CL2021003257A1 (es) 2019-06-14 2021-12-07 Pirazolo-piridinas heteroaromáticas sustituidas y su uso como moduladores del receptor glun2b.

Country Status (21)

Country Link
US (2) US11530210B2 (es)
EP (1) EP3982958A1 (es)
JP (1) JP2022536424A (es)
KR (1) KR20220024512A (es)
CN (1) CN114007610A (es)
AU (1) AU2020291188A1 (es)
BR (1) BR112021025141A2 (es)
CA (1) CA3143276A1 (es)
CL (1) CL2021003257A1 (es)
CO (1) CO2021016860A2 (es)
CR (1) CR20210615A (es)
DO (1) DOP2021000250A (es)
EC (1) ECSP21090450A (es)
IL (1) IL288858A (es)
JO (1) JOP20210330A1 (es)
MA (1) MA56183A (es)
MX (1) MX2021015503A (es)
PE (1) PE20220806A1 (es)
SG (1) SG11202112405VA (es)
TW (1) TW202115054A (es)
WO (1) WO2020249785A1 (es)

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TW202112774A (zh) 2019-06-14 2021-04-01 比利時商健生藥品公司 經取代之吡唑并－吡啶醯胺及其作為ｇｌｕｎ２ｂ受體調節劑之用途
JP7667097B2 (ja) 2019-06-14 2025-04-22 ヤンセン ファーマシューティカ エヌ．ベー． 置換ピラゾロ－ピリジンアミド及びｇｌｕｎ２ｂ受容体調節因子としてのその使用
BR112021025141A2 (pt) 2019-06-14 2022-01-25 Janssen Pharmaceutica Nv Pirazolo-piridinas heteroaromáticas substituídas e seu uso como moduladores do receptor glun2b
CN114008052A (zh) 2019-06-14 2022-02-01 詹森药业有限公司 取代的吡唑并-吡嗪以及它们作为GluN2B受体调节剂的用途
CN114149425A (zh) * 2021-11-16 2022-03-08 上海应用技术大学 5-氟甲基吡啶衍生物和18-f同位素标记的5-氟甲基吡啶衍生物及其制备与应用

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Also Published As

Publication number Publication date
SG11202112405VA (en) 2021-12-30
MX2021015503A (es) 2022-04-20
EP3982958A1 (en) 2022-04-20
BR112021025141A2 (pt) 2022-01-25
WO2020249785A1 (en) 2020-12-17
CR20210615A (es) 2022-01-31
US20230045960A1 (en) 2023-02-16
PE20220806A1 (es) 2022-05-20
AU2020291188A1 (en) 2022-01-20
IL288858A (en) 2022-02-01
CO2021016860A2 (es) 2022-01-17
US20210017169A1 (en) 2021-01-21
JOP20210330A1 (ar) 2023-01-30
CA3143276A1 (en) 2020-12-17
CN114007610A (zh) 2022-02-01
JP2022536424A (ja) 2022-08-16
ECSP21090450A (es) 2022-01-31
TW202115054A (zh) 2021-04-16
KR20220024512A (ko) 2022-03-03
MA56183A (fr) 2022-04-20
DOP2021000250A (es) 2022-03-31
US11530210B2 (en) 2022-12-20

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