ECSP21090450A - Pirazolo piridinas heteroaromáticas sustituidas y su uso como moduladores del receptor glun2b - Google Patents

Pirazolo piridinas heteroaromáticas sustituidas y su uso como moduladores del receptor glun2b

Info

Publication number
ECSP21090450A
ECSP21090450A ECSENADI202190450A ECDI202190450A ECSP21090450A EC SP21090450 A ECSP21090450 A EC SP21090450A EC SENADI202190450 A ECSENADI202190450 A EC SENADI202190450A EC DI202190450 A ECDI202190450 A EC DI202190450A EC SP21090450 A ECSP21090450 A EC SP21090450A
Authority
EC
Ecuador
Prior art keywords
pyridines
pyrizolo
glun2b receptor
receptor modulators
substituted heteroaromatic
Prior art date
Application number
ECSENADI202190450A
Other languages
English (en)
Inventor
Christine Gelin
Curt Dvorak
Michael A Letavic
Afton Hiscox
Brice Stenne
Christa Chrovian
Andrew Samant
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ECSP21090450A publication Critical patent/ECSP21090450A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Pirazolo-piridinas sustituidas como ligandos del receptor GluN2B. Tales compuestos pueden usarse en la modulación del receptor GluN2B y en composiciones farmacéuticas y métodos para el tratamiento de estados de enfermedad, trastornos, y afecciones mediadas por la actividad del receptor GluN2B.
ECSENADI202190450A 2019-06-14 2021-12-14 Pirazolo piridinas heteroaromáticas sustituidas y su uso como moduladores del receptor glun2b ECSP21090450A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962861665P 2019-06-14 2019-06-14
PK34920 2020-06-03

Publications (1)

Publication Number Publication Date
ECSP21090450A true ECSP21090450A (es) 2022-01-31

Family

ID=73781827

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202190450A ECSP21090450A (es) 2019-06-14 2021-12-14 Pirazolo piridinas heteroaromáticas sustituidas y su uso como moduladores del receptor glun2b

Country Status (21)

Country Link
US (2) US11530210B2 (es)
EP (1) EP3982958A1 (es)
JP (1) JP2022536424A (es)
KR (1) KR20220024512A (es)
CN (1) CN114007610A (es)
AU (1) AU2020291188A1 (es)
BR (1) BR112021025141A2 (es)
CA (1) CA3143276A1 (es)
CL (1) CL2021003257A1 (es)
CO (1) CO2021016860A2 (es)
CR (1) CR20210615A (es)
DO (1) DOP2021000250A (es)
EC (1) ECSP21090450A (es)
IL (1) IL288858A (es)
JO (1) JOP20210330A1 (es)
MA (1) MA56183A (es)
MX (1) MX2021015503A (es)
PE (1) PE20220806A1 (es)
SG (1) SG11202112405VA (es)
TW (1) TW202115054A (es)
WO (1) WO2020249785A1 (es)

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TW201819376A (zh) 2016-10-06 2018-06-01 比利時商健生藥品公司 經取代之１Ｈ－咪唑並［４，５－ｂ］吡啶－２（３Ｈ）－酮及其作為ＧＬＵＮ２Ｂ受體調節劑之用途
US11447503B2 (en) 2019-06-14 2022-09-20 Janssen Pharmaceutica Nv Pyridine carbamates and their use as GLUN2B receptor modulators
CN113993583A (zh) 2019-06-14 2022-01-28 詹森药业有限公司 取代的吡唑并[4,3-b]吡啶及其作为GLUN2B受体调节剂的用途
BR112021025141A2 (pt) * 2019-06-14 2022-01-25 Janssen Pharmaceutica Nv Pirazolo-piridinas heteroaromáticas substituídas e seu uso como moduladores do receptor glun2b
KR20220024403A (ko) 2019-06-14 2022-03-03 얀센 파마슈티카 엔.브이. 치환된 피라졸로-피라진 및 이들의 glun2b 수용체 조절제로서의 용도
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EP3983075A1 (en) 2019-06-14 2022-04-20 Janssen Pharmaceutica NV Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators

Also Published As

Publication number Publication date
AU2020291188A1 (en) 2022-01-20
US11530210B2 (en) 2022-12-20
BR112021025141A2 (pt) 2022-01-25
SG11202112405VA (en) 2021-12-30
TW202115054A (zh) 2021-04-16
US20230045960A1 (en) 2023-02-16
US20210017169A1 (en) 2021-01-21
IL288858A (en) 2022-02-01
PE20220806A1 (es) 2022-05-20
MX2021015503A (es) 2022-04-20
JP2022536424A (ja) 2022-08-16
CA3143276A1 (en) 2020-12-17
WO2020249785A1 (en) 2020-12-17
CN114007610A (zh) 2022-02-01
MA56183A (fr) 2022-04-20
DOP2021000250A (es) 2022-03-31
CL2021003257A1 (es) 2022-08-19
JOP20210330A1 (ar) 2023-01-30
EP3982958A1 (en) 2022-04-20
CO2021016860A2 (es) 2022-01-17
CR20210615A (es) 2022-01-31
KR20220024512A (ko) 2022-03-03

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