CL2022002885A1 - Modulación de enzimas y vías con compuestos de sulfhidrilo y sus derivados - Google Patents

Modulación de enzimas y vías con compuestos de sulfhidrilo y sus derivados

Info

Publication number
CL2022002885A1
CL2022002885A1 CL2022002885A CL2022002885A CL2022002885A1 CL 2022002885 A1 CL2022002885 A1 CL 2022002885A1 CL 2022002885 A CL2022002885 A CL 2022002885A CL 2022002885 A CL2022002885 A CL 2022002885A CL 2022002885 A1 CL2022002885 A1 CL 2022002885A1
Authority
CL
Chile
Prior art keywords
relates
proteins
antibodies
present
pathways
Prior art date
Application number
CL2022002885A
Other languages
English (en)
Inventor
Shao Zhixin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2022002885A1 publication Critical patent/CL2022002885A1/es
Priority to CL2025000038A priority Critical patent/CL2025000038A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invención se refiere a proteínas, en particular, anticuerpos, tales como anticuerpos biespecíficos anti-CD20/anti-CD3 y anticuerpos anti-a-sinucleína, que tienen glucanos monogalactosilados (G1) y digalactosilados (G2). Más en particular, la presente invención se refiere a ingeniería de galactosilación para generar proteínas con propiedades terapéuticas mejoradas, que incluyen proteínas con título aumentado. Además, la invención se refiere a un medio de cultivo celular y una célula de mamífero, así como a métodos que usan dicho medio de cultivo celular y dicha célula de mamífero para producir dichas proteínas. Además, la presente invención se refiere al uso de dichos anticuerpos como un medicamento, tal como para el tratamiento de cáncer, en particular, cáncer asociado a linfocitos B, o enfermedad de Parkinson.
CL2022002885A 2020-04-24 2022-10-18 Modulación de enzimas y vías con compuestos de sulfhidrilo y sus derivados CL2022002885A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CL2025000038A CL2025000038A1 (es) 2020-04-24 2025-01-07 Modulación de enzimas y vías con compuestos de sulfhidrilo y sus derivados

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP20171356 2020-04-24

Publications (1)

Publication Number Publication Date
CL2022002885A1 true CL2022002885A1 (es) 2023-06-16

Family

ID=70464886

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2022002885A CL2022002885A1 (es) 2020-04-24 2022-10-18 Modulación de enzimas y vías con compuestos de sulfhidrilo y sus derivados
CL2025000038A CL2025000038A1 (es) 2020-04-24 2025-01-07 Modulación de enzimas y vías con compuestos de sulfhidrilo y sus derivados

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2025000038A CL2025000038A1 (es) 2020-04-24 2025-01-07 Modulación de enzimas y vías con compuestos de sulfhidrilo y sus derivados

Country Status (18)

Country Link
US (2) US20230265204A1 (es)
EP (2) EP4400515A3 (es)
JP (3) JP2023522417A (es)
KR (1) KR20230005172A (es)
CN (1) CN115427443A (es)
AR (1) AR121918A1 (es)
AU (1) AU2021258475A1 (es)
BR (1) BR112022021203A2 (es)
CA (1) CA3178472A1 (es)
CL (2) CL2022002885A1 (es)
CR (2) CR20220531A (es)
IL (1) IL296664A (es)
MX (1) MX2022013173A (es)
PE (1) PE20230078A1 (es)
SA (1) SA522441031B1 (es)
TW (2) TWI908792B (es)
WO (1) WO2021214277A1 (es)
ZA (1) ZA202210643B (es)

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Publication number Priority date Publication date Assignee Title
EP3658172A4 (en) 2017-07-25 2021-05-05 TrueBinding, Inc. TREATING CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND HIS LIGAND
CN113711036B (zh) 2019-01-30 2025-03-18 真和制药有限公司 抗gal3抗体及其用途
CN116157151A (zh) 2020-05-26 2023-05-23 真和制药有限公司 通过阻断半乳凝素-3治疗炎性疾病的方法

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Also Published As

Publication number Publication date
EP4400515A3 (en) 2024-10-23
US20230265204A1 (en) 2023-08-24
BR112022021203A2 (pt) 2022-12-06
CL2025000038A1 (es) 2025-05-23
EP4400515A2 (en) 2024-07-17
US20250353922A1 (en) 2025-11-20
MX2022013173A (es) 2022-11-30
AU2021258475A1 (en) 2022-10-20
WO2021214277A1 (en) 2021-10-28
AR121918A1 (es) 2022-07-20
CN115427443A (zh) 2022-12-02
CA3178472A1 (en) 2021-10-28
IL296664A (en) 2022-11-01
PE20230078A1 (es) 2023-01-11
SA522441031B1 (ar) 2025-05-15
JP2023522417A (ja) 2023-05-30
TW202206459A (zh) 2022-02-16
CR20250142A (es) 2025-10-30
TWI908792B (zh) 2025-12-21
JP2025157400A (ja) 2025-10-15
CR20220531A (es) 2022-11-28
TW202547878A (zh) 2025-12-16
ZA202210643B (en) 2023-06-28
KR20230005172A (ko) 2023-01-09
EP4139349A1 (en) 2023-03-01
JP2025072512A (ja) 2025-05-09

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