PL2118300T3 - Zapobieganie i leczenie synukleinopatii i amyloidozy - Google Patents
Zapobieganie i leczenie synukleinopatii i amyloidozyInfo
- Publication number
- PL2118300T3 PL2118300T3 PL08725981T PL08725981T PL2118300T3 PL 2118300 T3 PL2118300 T3 PL 2118300T3 PL 08725981 T PL08725981 T PL 08725981T PL 08725981 T PL08725981 T PL 08725981T PL 2118300 T3 PL2118300 T3 PL 2118300T3
- Authority
- PL
- Poland
- Prior art keywords
- synucleinopathic
- prevention
- treatment
- amyloidogenic disease
- amyloidogenic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6056—Antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/80—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/710,248 US9034337B2 (en) | 2003-10-31 | 2007-02-23 | Treatment and delay of outset of synucleinopathic and amyloidogenic disease |
| US11/697,646 US20080014194A1 (en) | 2003-10-31 | 2007-04-06 | Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease |
| US98472107P | 2007-11-01 | 2007-11-01 | |
| PCT/US2008/002392 WO2008103472A2 (en) | 2007-02-23 | 2008-02-22 | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| EP08725981.8A EP2118300B1 (en) | 2007-02-23 | 2008-02-22 | Prevention and treatment of synucleinopathic and amyloidogenic disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2118300T3 true PL2118300T3 (pl) | 2015-11-30 |
Family
ID=39710678
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12188562T PL2583978T3 (pl) | 2007-02-23 | 2008-02-22 | Profilaktyka i leczenie chorób synukleinopatycznych i amyloidogennych |
| PL08725981T PL2118300T3 (pl) | 2007-02-23 | 2008-02-22 | Zapobieganie i leczenie synukleinopatii i amyloidozy |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12188562T PL2583978T3 (pl) | 2007-02-23 | 2008-02-22 | Profilaktyka i leczenie chorób synukleinopatycznych i amyloidogennych |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8092801B2 (pl) |
| EP (2) | EP2583978B1 (pl) |
| JP (1) | JP5558834B2 (pl) |
| CA (1) | CA2678963C (pl) |
| DK (1) | DK3067066T3 (pl) |
| PL (2) | PL2583978T3 (pl) |
| WO (1) | WO2008103472A2 (pl) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8506959B2 (en) | 2002-11-01 | 2013-08-13 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| US9034337B2 (en) | 2003-10-31 | 2015-05-19 | Prothena Biosciences Limited | Treatment and delay of outset of synucleinopathic and amyloidogenic disease |
| US20080014194A1 (en) | 2003-10-31 | 2008-01-17 | Elan Pharmaceuticals, Inc. | Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease |
| TW200509968A (en) * | 2002-11-01 | 2005-03-16 | Elan Pharm Inc | Prevention and treatment of synucleinopathic disease |
| US8697082B2 (en) | 2002-11-01 | 2014-04-15 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| US7358331B2 (en) * | 2003-05-19 | 2008-04-15 | Elan Pharmaceuticals, Inc. | Truncated fragments of alpha-synuclein in Lewy body disease |
| WO2005047860A2 (en) | 2003-11-08 | 2005-05-26 | Elan Pharmaceuticals, Inc. | Antibodies to alpha-synuclein |
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| CA2674140C (en) | 2007-01-05 | 2018-05-15 | University Of Zurich | Method of providing disease-specific binding molecules and targets |
| DK3067066T3 (da) | 2007-02-23 | 2019-05-20 | Prothena Biosciences Ltd | Forebyggelse og behandling af synukleinopatisk og amyloidogenisk sygdom |
| US8147833B2 (en) | 2007-02-23 | 2012-04-03 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| AU2015249034B2 (en) * | 2007-12-28 | 2017-07-27 | Prothena Biosciences Limited | Treatment and prophylaxis of amyloidosis |
| AT506535B1 (de) * | 2008-02-22 | 2010-04-15 | Affiris Forschungs & Entwicklungs Gmbh | Vaccine enthaltend alpha-synuclein-mimotope auf basis von peptiden |
| NZ589302A (en) | 2008-04-17 | 2012-11-30 | Declion Pharmaceuticals Inc | Design and synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders |
| EP3470079A1 (en) | 2008-04-29 | 2019-04-17 | BioArctic AB | Antibodies and vaccines for use in therapeutic and diagnostic methods for alpha-synuclein-related disorders |
| KR101781228B1 (ko) | 2008-12-19 | 2017-09-22 | 바이오겐 인터내셔널 뉴로사이언스 게엠베하 | 인간 항-알파-시누클레인 자가항체 |
| AU2011329777B2 (en) | 2010-11-17 | 2016-06-09 | Ionis Pharmaceuticals, Inc. | Modulation of alpha synuclein expression |
| MX357193B (es) | 2011-06-23 | 2018-06-29 | Univ Zuerich | Moleculas de union anti-alfa sinucleina. |
| ES2937409T3 (es) | 2011-10-28 | 2023-03-28 | Prothena Biosciences Ltd | Anticuerpos humanizados que reconocen la alfa-sinucleína |
| IN2014DN07149A (pl) * | 2012-01-27 | 2015-04-24 | Neotope Biosciences Ltd | |
| UA118441C2 (uk) * | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
| ES2766762T3 (es) | 2013-03-13 | 2020-06-15 | Prothena Biosciences Ltd | Inmunoterapia contra Tau |
| US10513555B2 (en) | 2013-07-04 | 2019-12-24 | Prothena Biosciences Limited | Antibody formulations and methods |
| WO2015075635A2 (en) * | 2013-11-19 | 2015-05-28 | Prothena Biosciences Limited | Monitoring immunotherapy of lewy body disease from constipation symptoms |
| MY176237A (en) * | 2013-11-21 | 2020-07-24 | Hoffmann La Roche | Anti-alpha-synuclein antibodies and methods of use |
| EP3129051A1 (en) | 2014-04-08 | 2017-02-15 | Prothena Biosciences Limited | Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein |
| US10155030B2 (en) | 2014-05-23 | 2018-12-18 | University Of South Florida | Methods, antibodies, and vaccines utilizing epitopes of alpha synuclein for treatment of parkinsons disease |
| WO2016061389A2 (en) | 2014-10-16 | 2016-04-21 | Genentech, Inc. | Anti-alpha-synuclein antibodies and methods of use |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| EP3247392A1 (en) * | 2015-01-22 | 2017-11-29 | Prothena Biosciences Limited | Antibodies recognizing medin |
| GB201512203D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| US10889638B2 (en) | 2016-05-02 | 2021-01-12 | Prothena Biosciences Limited | Antibodies recognizing tau |
| AU2017259039B2 (en) | 2016-05-02 | 2024-05-09 | Prothena Biosciences Limited | Antibodies recognizing tau |
| ES2933491T3 (es) | 2016-05-02 | 2023-02-09 | Prothena Biosciences Ltd | Inmunoterapia tau |
| PT3463435T (pt) * | 2016-06-02 | 2021-11-22 | Medimmune Ltd | Anticorpos para alfa-sinucleína e as suas utilizações |
| US11725232B2 (en) | 2016-10-31 | 2023-08-15 | The Hong Kong University Of Science And Technology | Compositions, methods and kits for detection of genetic variants for alzheimer's disease |
| CA3043651A1 (en) | 2016-11-15 | 2018-05-24 | H. Lundbeck A/S | Agents, uses and methods for the treatment of synucleinopathy |
| WO2018102763A1 (en) * | 2016-12-02 | 2018-06-07 | Prothena Biosciences Limited | Infrared assay detecting secondary structure profiles of alpha-synuclein |
| BR112018016717A2 (pt) | 2016-12-16 | 2018-12-26 | H Lundbeck As | agentes, usos e métodos |
| US10364286B2 (en) * | 2016-12-22 | 2019-07-30 | H. Lundbeck A/S | Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation |
| EA201991720A1 (ru) | 2017-02-17 | 2020-01-20 | Бристол-Маерс Сквибб Компани | Антитела к альфа-синуклеину и их применения |
| US11220538B2 (en) | 2017-05-01 | 2022-01-11 | The Trustees Of The University Of Pennsylvania | Monoclonal antibodies against alpha-synuclein fibrils |
| AU2018263935B2 (en) | 2017-05-02 | 2024-09-26 | Prothena Biosciences Limited | Antibodies recognizing tau |
| EP3406632A1 (en) | 2017-05-23 | 2018-11-28 | S.I.S.S.A. Scuola Internazionale Superiore di Studi Avanzati | Ligands binding to prion protein for use in the treatment of synucleinopathies |
| CN118370815A (zh) | 2017-08-22 | 2024-07-23 | 渤健马萨诸塞州股份有限公司 | 含有抗β淀粉样蛋白抗体的药物组合物 |
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| PE20201501A1 (es) | 2018-01-12 | 2020-12-29 | Bristol Myers Squibb Co | Oligonucleotidos antisentido que actuan sobre alfa-sinucleina, y usos de estos |
| MX2020007439A (es) | 2018-01-12 | 2020-09-14 | Bristol Myers Squibb Co | Oligonucleotidos antisentido que actuan sobre alfa-sinucleina y usos de estos. |
| EP3833435B1 (en) | 2018-08-09 | 2025-09-24 | F. Hoffmann-La Roche AG | Determination of parkinson's disease |
| CU24781B1 (es) | 2018-11-08 | 2026-02-09 | Prothena Biosciences Ltd | Anticuerpos humanizados que reconocen tau |
| TWI859197B (zh) | 2019-03-03 | 2024-10-21 | 愛爾蘭商普羅帝納生物科學公司 | 識別ｔａｕ之抗體 |
| BR112022021203A2 (pt) | 2020-04-24 | 2022-12-06 | Hoffmann La Roche | Modulação de enzima e via com compostos sulfidrila e seus derivados |
| WO2022024693A1 (ja) * | 2020-07-29 | 2022-02-03 | 国立大学法人東北大学 | シヌクレイノパチーを予防又は治療するために使用されるペプチド |
| US20230365665A1 (en) | 2020-09-17 | 2023-11-16 | Qatar Foundation For Education, Science And Community Development | ANTIBODY COMPOSITIONS TARGETING NON-PHOSPHORYLATED a-SYNUCLEIN AGGREGATES |
| IL301224A (en) * | 2020-09-17 | 2023-05-01 | Prothena Biosciences Ltd | Alpha-synuclein vaccine for the treatment of synucleinopathies |
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- 2008-02-22 WO PCT/US2008/002392 patent/WO2008103472A2/en not_active Ceased
- 2008-02-22 JP JP2009550933A patent/JP5558834B2/ja active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2010526028A (ja) | 2010-07-29 |
| EP2118300B1 (en) | 2015-05-27 |
| EP2118300A4 (en) | 2010-10-20 |
| PL2583978T3 (pl) | 2016-07-29 |
| CA2678963A1 (en) | 2008-08-28 |
| EP2583978A2 (en) | 2013-04-24 |
| US8092801B2 (en) | 2012-01-10 |
| WO2008103472A2 (en) | 2008-08-28 |
| EP2583978B1 (en) | 2016-04-06 |
| CA2678963C (en) | 2018-05-01 |
| EP2583978A3 (en) | 2013-09-11 |
| US20100278814A1 (en) | 2010-11-04 |
| DK3067066T3 (da) | 2019-05-20 |
| WO2008103472A3 (en) | 2009-05-28 |
| JP5558834B2 (ja) | 2014-07-23 |
| EP2118300A2 (en) | 2009-11-18 |
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