CL2025003071A1 - Formas cristalinas de inhibidores de ras, composiciones que las contienen y su uso. - Google Patents

Formas cristalinas de inhibidores de ras, composiciones que las contienen y su uso.

Info

Publication number
CL2025003071A1
CL2025003071A1 CL2025003071A CL2025003071A CL2025003071A1 CL 2025003071 A1 CL2025003071 A1 CL 2025003071A1 CL 2025003071 A CL2025003071 A CL 2025003071A CL 2025003071 A CL2025003071 A CL 2025003071A CL 2025003071 A1 CL2025003071 A1 CL 2025003071A1
Authority
CL
Chile
Prior art keywords
crystalline forms
compositions containing
ras inhibitors
ras
inhibitors
Prior art date
Application number
CL2025003071A
Other languages
English (en)
Inventor
Li Shaoling
Chou Kang-Jye
Huang Jun
Huang Xiaojun
Manthati Suresh
Original Assignee
Revolution Medicines Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Revolution Medicines Inc filed Critical Revolution Medicines Inc
Publication of CL2025003071A1 publication Critical patent/CL2025003071A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/504—Pyridazines; Hydrogenated pyridazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La divulgación presenta formas cristalinas de inhibidores de RAS (RMC-6236), composiciones farmacéuticas de estas y sus usos en el tratamiento de cánceres.
CL2025003071A 2023-04-14 2025-10-08 Formas cristalinas de inhibidores de ras, composiciones que las contienen y su uso. CL2025003071A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202363459403P 2023-04-14 2023-04-14

Publications (1)

Publication Number Publication Date
CL2025003071A1 true CL2025003071A1 (es) 2025-12-19

Family

ID=91376045

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2025003071A CL2025003071A1 (es) 2023-04-14 2025-10-08 Formas cristalinas de inhibidores de ras, composiciones que las contienen y su uso.

Country Status (12)

Country Link
US (1) US20240352038A1 (es)
EP (1) EP4695261A1 (es)
JP (1) JP2026514015A (es)
KR (1) KR20250169290A (es)
CN (2) CN121464140A (es)
AU (1) AU2024252105A1 (es)
CL (1) CL2025003071A1 (es)
IL (1) IL323809A (es)
MX (1) MX2025012181A (es)
PE (1) PE20252754A1 (es)
TW (1) TW202448897A (es)
WO (1) WO2024216048A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022005359A (es) 2019-11-04 2022-06-02 Revolution Medicines Inc Inhibidores de ras.
IL301298A (en) 2020-09-15 2023-05-01 Revolution Medicines Inc Indole derivatives as RAS inhibitors in cancer therapy
EP4596552A1 (en) 2022-09-29 2025-08-06 Guangzhou Joyo Pharmatech Co., Ltd Macrocyclic derivative and use thereof
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026090245A1 (en) 2024-10-22 2026-04-30 Revolution Medicines, Inc. Use of ras inhibitors for treating cancer
WO2026102199A1 (en) 2024-11-08 2026-05-15 Amgen Inc. Combination therapy of a prmt5 inhibitor and daraxonrasib for use in the treatment of mtap-null cancer

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