CN100422143C - 那格列奈b型结晶的制造方法 - Google Patents

那格列奈b型结晶的制造方法 Download PDF

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Publication number
CN100422143C
CN100422143C CNB018212999A CN01821299A CN100422143C CN 100422143 C CN100422143 C CN 100422143C CN B018212999 A CNB018212999 A CN B018212999A CN 01821299 A CN01821299 A CN 01821299A CN 100422143 C CN100422143 C CN 100422143C
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CN
China
Prior art keywords
nateglinide
crystals
type
crystal
manufacture method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB018212999A
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English (en)
Chinese (zh)
Other versions
CN1483018A (zh
Inventor
澄川通人
丸尾诚
宫崎和雄
仁科重宏
松泽由纪子
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Ajinomoto Co Inc
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Ajinomoto Co Inc
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Publication of CN1483018A publication Critical patent/CN1483018A/zh
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Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB018212999A 2000-10-24 2001-10-23 那格列奈b型结晶的制造方法 Expired - Fee Related CN100422143C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP324375/2000 2000-10-24
JP324375/00 2000-10-24
JP2000324375 2000-10-24

Publications (2)

Publication Number Publication Date
CN1483018A CN1483018A (zh) 2004-03-17
CN100422143C true CN100422143C (zh) 2008-10-01

Family

ID=18801920

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018212999A Expired - Fee Related CN100422143C (zh) 2000-10-24 2001-10-23 那格列奈b型结晶的制造方法

Country Status (18)

Country Link
US (2) US20030229249A1 (2)
EP (1) EP1334964B1 (2)
JP (1) JP4225057B2 (2)
KR (1) KR100810930B1 (2)
CN (1) CN100422143C (2)
AT (1) ATE370115T1 (2)
AU (1) AU2001296001A1 (2)
BR (1) BR0114846A (2)
CA (1) CA2426745C (2)
CY (1) CY1106839T1 (2)
DE (1) DE60130014T2 (2)
DK (1) DK1334964T3 (2)
ES (1) ES2288997T3 (2)
MX (1) MXPA03003575A (2)
PT (1) PT1334964E (2)
RU (1) RU2275354C2 (2)
TW (1) TWI293290B (2)
WO (1) WO2002034713A1 (2)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104402756A (zh) * 2014-11-27 2015-03-11 天方药业有限公司 一种高纯度那格列奈的制备方法

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CA2425538C (en) * 2000-10-18 2010-10-12 Ajinomoto Co., Inc. Methods for producing nateglinide crystals
RU2271805C2 (ru) * 2000-10-24 2006-03-20 Адзиномото Ко., Инк. Препарат, содержащий натеглинид
ATE429217T1 (de) * 2000-10-24 2009-05-15 Ajinomoto Kk Nateglinid enthaltende hydrophile arzneimittelpräparate
US7411089B2 (en) 2002-04-15 2008-08-12 Ajinomoto Co., Inc. Nateglinide crystals
EP2264004A1 (en) * 2002-04-15 2010-12-22 Ajinomoto Co., Inc. New nateglinide crystals
US6861553B2 (en) 2002-07-03 2005-03-01 Teva Pharmaceuticals Industries Ltd. Process for preparing nateglinide and intermediates thereof
US7534913B2 (en) 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
EP1467964A1 (en) * 2002-07-18 2004-10-20 Teva Pharmaceutical Industries Limited Polymorphic forms of nateglinide
US7420084B2 (en) 2002-07-18 2008-09-02 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7148376B2 (en) 2002-07-18 2006-12-12 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7358390B2 (en) 2002-07-18 2008-04-15 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
DE60310734T2 (de) * 2003-11-26 2007-10-11 A.M.S.A. Anonima Matèrie Sintètiche e Affini S.p.A. Verfahren zur Herstellung von Nateglinid in der B-Form
KR20070009726A (ko) * 2004-05-07 2007-01-18 테바 파마슈티컬 인더스트리즈 리미티드 나테글리나이드의 다형태
US20070231393A1 (en) * 2004-05-19 2007-10-04 University Of South Carolina System and Device for Magnetic Drug Targeting with Magnetic Drug Carrier Particles
WO2005113485A2 (en) * 2004-05-20 2005-12-01 Dr. Reddy's Laboratories Ltd. Stable nateglinide form b compositions
US7425648B2 (en) 2005-01-03 2008-09-16 A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. Process for the preparation of nateglinide, preferably in B-form
EP1891971A4 (en) * 2005-01-31 2010-02-03 Ajinomoto Kk MEDICAL COMPOSITION USING HYPERGLY CRAB MEDICAMENT TO TREAT OR TREAT GLUCOSE-INTOLERANCE, BORDERLINE DIABETES, INSULIN RESISTANCE AND HYPERINSULINEMIA
WO2007135533A1 (en) * 2006-05-23 2007-11-29 Aurobindo Pharma Limited Process for preparing nateglinide b-type crystals
KR100837843B1 (ko) * 2006-12-26 2008-06-13 씨제이제일제당 (주) 나테글리나이드 결정형, 그 제조방법, 및 그를 포함하는약제학적 조성물
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CN109369443A (zh) * 2018-11-05 2019-02-22 扬子江药业集团江苏海慈生物药业有限公司 一种新的那格列奈h晶型的制备方法

Citations (1)

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US5463116A (en) * 1991-07-30 1995-10-31 Ajinomoto Co., Inc. Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them

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CA2425538C (en) * 2000-10-18 2010-10-12 Ajinomoto Co., Inc. Methods for producing nateglinide crystals
PT1334962E (pt) * 2000-10-18 2007-10-09 Ajinomoto Kk ''processo de preparação de acilfenilalaninas''
RU2271805C2 (ru) * 2000-10-24 2006-03-20 Адзиномото Ко., Инк. Препарат, содержащий натеглинид
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Patent Citations (1)

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US5463116A (en) * 1991-07-30 1995-10-31 Ajinomoto Co., Inc. Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104402756A (zh) * 2014-11-27 2015-03-11 天方药业有限公司 一种高纯度那格列奈的制备方法
CN104402756B (zh) * 2014-11-27 2016-08-31 天方药业有限公司 一种高纯度那格列奈的制备方法

Also Published As

Publication number Publication date
RU2275354C2 (ru) 2006-04-27
DK1334964T3 (da) 2007-09-24
CY1106839T1 (el) 2012-05-23
EP1334964A1 (en) 2003-08-13
KR20030059212A (ko) 2003-07-07
ATE370115T1 (de) 2007-09-15
EP1334964B1 (en) 2007-08-15
PT1334964E (pt) 2007-09-20
WO2002034713A1 (en) 2002-05-02
BR0114846A (pt) 2004-02-25
MXPA03003575A (es) 2003-07-14
US20070232829A1 (en) 2007-10-04
TWI293290B (2) 2008-02-11
CA2426745C (en) 2009-09-15
JPWO2002034713A1 (ja) 2004-03-04
DE60130014D1 (de) 2007-09-27
US20030229249A1 (en) 2003-12-11
ES2288997T3 (es) 2008-02-01
KR100810930B1 (ko) 2008-03-10
CA2426745A1 (en) 2003-04-23
JP4225057B2 (ja) 2009-02-18
EP1334964A4 (en) 2005-09-28
CN1483018A (zh) 2004-03-17
AU2001296001A1 (en) 2002-05-06
DE60130014T2 (de) 2008-05-08
US7544834B2 (en) 2009-06-09

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