CN100510098C - 旋光芳香杂环β-羟基酯、由β-酮基酯制备其的方法以及这些β-酮基酯的制备方法 - Google Patents

旋光芳香杂环β-羟基酯、由β-酮基酯制备其的方法以及这些β-酮基酯的制备方法 Download PDF

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Publication number
CN100510098C
CN100510098C CNB2004800395725A CN200480039572A CN100510098C CN 100510098 C CN100510098 C CN 100510098C CN B2004800395725 A CNB2004800395725 A CN B2004800395725A CN 200480039572 A CN200480039572 A CN 200480039572A CN 100510098 C CN100510098 C CN 100510098C
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China
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compound
saccharomyces
pichia
yeast
candida
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Expired - Fee Related
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CNB2004800395725A
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English (en)
Chinese (zh)
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CN1902322A (zh
Inventor
约翰内斯·普拉策克
路德维希·措恩
贝恩德·布赫曼
维尔纳·斯库巴拉
奥尔林·彼得罗夫
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Bayer Pharma AG
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Schering AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNB2004800395725A 2003-12-31 2004-12-21 旋光芳香杂环β-羟基酯、由β-酮基酯制备其的方法以及这些β-酮基酯的制备方法 Expired - Fee Related CN100510098C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10361794.9 2003-12-31
DE10361794A DE10361794B3 (de) 2003-12-31 2003-12-31 Optisch aktive heteroaromatische ß-Hydroxy-Ester und Verfahren zu deren Herstellung sowie deren Verwendung als Zwischenprodukte bei der Epothilon-Totalsynthese

Publications (2)

Publication Number Publication Date
CN1902322A CN1902322A (zh) 2007-01-24
CN100510098C true CN100510098C (zh) 2009-07-08

Family

ID=34716267

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800395725A Expired - Fee Related CN100510098C (zh) 2003-12-31 2004-12-21 旋光芳香杂环β-羟基酯、由β-酮基酯制备其的方法以及这些β-酮基酯的制备方法

Country Status (16)

Country Link
EP (1) EP2113031A1 (pt)
JP (1) JP2007516999A (pt)
KR (1) KR20070029641A (pt)
CN (1) CN100510098C (pt)
AU (1) AU2004309076A1 (pt)
BR (1) BRPI0418254A (pt)
CA (1) CA2546981A1 (pt)
CR (1) CR8492A (pt)
DE (1) DE10361794B3 (pt)
EC (1) ECSP066740A (pt)
IL (1) IL175908A0 (pt)
MX (1) MXPA06007564A (pt)
NO (1) NO20063477L (pt)
RU (1) RU2006127553A (pt)
WO (1) WO2005064006A1 (pt)
ZA (1) ZA200606293B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104328152A (zh) * 2014-10-13 2015-02-04 青岛科技大学 一种产朊酵母催化生产亚环己基烯醇的方法
CN108118004B (zh) * 2017-12-15 2021-06-25 北京工商大学 一株喜仙人掌毕赤酵母在水果采后病害防治中的应用
CN111689982B (zh) * 2019-03-15 2023-04-07 博瑞生物医药（苏州）股份有限公司 艾日布林中间体及其制备方法
CN110283733B (zh) * 2019-06-20 2020-10-27 浙江工业大学 土星轮头酵母zjph1807及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10041470A1 (de) * 2000-08-18 2002-02-28 Schering Ag 12,13-Cyclopropyl-Epothilon-Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012884A1 (en) * 1995-10-04 1997-04-10 Fmc Corporation Herbicidal 6-heterocyclic indazole derivatives
US5942644A (en) * 1997-05-27 1999-08-24 Biocatalytics, Inc. Precursors for the production of chiral vicinal aminoalcohols
US6211412B1 (en) * 1999-03-29 2001-04-03 The University Of Kansas Synthesis of epothilones
AR023792A1 (es) * 1999-04-30 2002-09-04 Bayer Schering Pharma Ag Derivados 6-alquenilo- y 6-alquinilo-epotilona, los procedimientos para prepararlos y su empleo en productos farmaceuticos
JP2001213874A (ja) * 1999-07-22 2001-08-07 Mercian Corp イソクマリン誘導体の製造およびそのための中間体
WO2003029195A1 (en) * 2001-09-28 2003-04-10 Sumika Fine Chemicals Co., Ltd. Intermediates for epothilone derivative and process for producing these
JP4432315B2 (ja) * 2002-03-19 2010-03-17 三菱化学株式会社 光学活性３−ヒドロキシ−３−（２’−チエニル）プロピオン酸エステル誘導体の製造方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10041470A1 (de) * 2000-08-18 2002-02-28 Schering Ag 12,13-Cyclopropyl-Epothilon-Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Enantioselective Hydrogenation of -Keto Esters using ChiralDiphosphine-Ruthenium Complexes: Optimization forAcademic and Industrial Purposes and SyntheticApplications. RATOVELOMANANA-VIDAL ET AL.ADVANCED SYNTHESIS & CATALYSIS,Vol.345 No.1/2. 2003 *
DE 100 41 470 A1 2002.02.28 *

Also Published As

Publication number Publication date
ECSP066740A (es) 2006-10-31
HK1097000A1 (en) 2007-06-15
EP2113031A1 (en) 2009-11-04
BRPI0418254A (pt) 2007-04-17
JP2007516999A (ja) 2007-06-28
KR20070029641A (ko) 2007-03-14
MXPA06007564A (es) 2006-12-14
RU2006127553A (ru) 2008-02-10
CA2546981A1 (en) 2005-07-14
ZA200606293B (en) 2009-08-26
WO2005064006A1 (en) 2005-07-14
DE10361794B3 (de) 2005-10-06
CN1902322A (zh) 2007-01-24
CR8492A (es) 2007-03-08
NO20063477L (no) 2006-08-23
IL175908A0 (en) 2006-10-05
AU2004309076A1 (en) 2005-07-14

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