CN101048408B - 作为大麻素受体1活性抑制剂的化合物和组合物 - Google Patents

作为大麻素受体1活性抑制剂的化合物和组合物 Download PDF

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Publication number
CN101048408B
CN101048408B CN2005800368900A CN200580036890A CN101048408B CN 101048408 B CN101048408 B CN 101048408B CN 2005800368900 A CN2005800368900 A CN 2005800368900A CN 200580036890 A CN200580036890 A CN 200580036890A CN 101048408 B CN101048408 B CN 101048408B
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phenyl
dihydro
chloro
pyrazolo
pyrimidin
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Expired - Fee Related
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Chinese (zh)
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CN101048408A (zh
Inventor
刘宏
贺晓晖
崔夏洵
杨鲲泳
D·伍德曼西
王志成
D·A·埃里斯
B·吴
贺耘
T·N·源
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IRM LLC
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IRM LLC
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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CN2005800368900A 2004-10-26 2005-10-26 作为大麻素受体1活性抑制剂的化合物和组合物 Expired - Fee Related CN101048408B (zh)

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US62250804P 2004-10-26 2004-10-26
US60/622,508 2004-10-26
US67267005P 2005-04-18 2005-04-18
US60/672,670 2005-04-18
PCT/US2005/038361 WO2006047516A2 (en) 2004-10-26 2005-10-26 Compounds and compositions as inhibitors of cannabinoid receptor 1 activity

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CN101048408A CN101048408A (zh) 2007-10-03
CN101048408B true CN101048408B (zh) 2011-07-06

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CN2011101210450A Pending CN102241680A (zh) 2004-10-26 2005-10-26 作为大麻素受体1活性抑制剂的化合物和组合物

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US (2) US8158634B2 (2)
EP (1) EP1807429A4 (2)
JP (2) JP2008518016A (2)
KR (1) KR100919524B1 (2)
CN (2) CN101048408B (2)
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RU2431635C2 (ru) 2011-10-20
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CA2581225C (en) 2011-10-25
CN101048408A (zh) 2007-10-03
CA2730374A1 (en) 2006-05-04
US8158634B2 (en) 2012-04-17
MA28937B1 (fr) 2007-10-01
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