CN101679340B - 抗肿瘤二氢吡喃-2-酮化合物 - Google Patents

抗肿瘤二氢吡喃-2-酮化合物 Download PDF

Info

Publication number: CN101679340B
Authority: CN; China
Prior art keywords: unsubstituted; compound; replacement; hydrogen; mmol
Prior art date: 2006-06-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CN2007800222645A

Other languages

English (en)

Chinese (zh)

Other versions

CN101679340A (zh

Inventor

玛·赫苏斯·马丁洛佩斯

劳拉·克尔罗莫利纳罗

约瑟·费尔南多·雷耶斯贝尼特斯

阿尔贝托·罗德瑞谷兹维肯特

玛丽亚·佳兰佐加西亚-艾巴罗拉

卡门·莫西亚佩雷兹

安德烈斯·弗兰切斯基索洛索

弗朗西斯科·杉切兹杉楚

玛丽亚·德尔卡门·奎瓦斯马昌特

罗格利奥·费尔南德斯罗德里库斯

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pharmamar SA

Original Assignee

Pharmamar SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-06-16

Filing date

2007-06-15

Publication date

2013-06-05

2007-06-15 Application filed by Pharmamar SA filed Critical Pharmamar SA

2010-03-24 Publication of CN101679340A publication Critical patent/CN101679340A/zh

2013-06-05 Application granted granted Critical

2013-06-05 Publication of CN101679340B publication Critical patent/CN101679340B/zh

Status Expired - Fee Related legal-status Critical Current

2027-06-15 Anticipated expiration legal-status Critical

Links

0 *C(C1[C@@](*)C(CCCCC(N(*)C(*)C(N(*)*)=O)=O)C1)C(CC(C1)[C@@]2C1I)OC2=O Chemical compound *C(C1[C@@](*)C(CCCCC(N(*)C(*)C(N(*)*)=O)=O)C1)C(CC(C1)[C@@]2C1I)OC2=O 0.000 description 5
PCQSEGAJVJGHSU-JHGQCBIDSA-N C[C@H]([C@H](CC=C1OC)OC1=O)/C=C(\C)/C=C\I Chemical compound C[C@H]([C@H](CC=C1OC)OC1=O)/C=C(\C)/C=C\I PCQSEGAJVJGHSU-JHGQCBIDSA-N 0.000 description 1
FVCZHKGFVFNDJT-NICUBOHASA-N C[C@H]([C@H](CCOC)N=O)/C=C(\C)/C=C/C=C/O Chemical compound C[C@H]([C@H](CCOC)N=O)/C=C(\C)/C=C/C=C/O FVCZHKGFVFNDJT-NICUBOHASA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pyrane Compounds (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CN2007800222645A 2006-06-16 2007-06-15 抗肿瘤二氢吡喃-2-酮化合物 Expired - Fee Related CN101679340B (zh)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP06380173		2006-06-16
EP06380173.2		2006-06-16
PCT/EP2007/055959 WO2007144423A1 (en)	2006-06-16	2007-06-15	Antitumoral dihydropyran-2-one compounds

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
CN2011102036625A Division CN102336730A (zh)	2006-06-16	2007-06-15	抗肿瘤二羟基吡喃-2-酮化合物

Publications (2)

Publication Number	Publication Date
CN101679340A CN101679340A (zh)	2010-03-24
CN101679340B true CN101679340B (zh)	2013-06-05

Family

ID=38508885

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CN2007800222645A Expired - Fee Related CN101679340B (zh)	2006-06-16	2007-06-15	抗肿瘤二氢吡喃-2-酮化合物
CN2011102036625A Pending CN102336730A (zh)	2006-06-16	2007-06-15	抗肿瘤二羟基吡喃-2-酮化合物

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
CN2011102036625A Pending CN102336730A (zh)	2006-06-16	2007-06-15	抗肿瘤二羟基吡喃-2-酮化合物

Country Status (29)

Country	Link
US (2)	US8324406B2 (pt)
EP (3)	EP2404912A3 (pt)
JP (2)	JP5117491B2 (pt)
KR (1)	KR101474031B1 (pt)
CN (2)	CN101679340B (pt)
AR (1)	AR061506A1 (pt)
AT (1)	ATE522514T1 (pt)
AU (1)	AU2007259257B8 (pt)
BR (2)	BRPI0713031B8 (pt)
CA (1)	CA2654334C (pt)
CY (1)	CY1112103T1 (pt)
DK (1)	DK2032551T3 (pt)
ES (1)	ES2371942T3 (pt)
HR (1)	HRP20110845T1 (pt)
IL (1)	IL195676A (pt)
MX (1)	MX2008015754A (pt)
MY (1)	MY145788A (pt)
NO (2)	NO341508B1 (pt)
NZ (1)	NZ573706A (pt)
PL (1)	PL2032551T3 (pt)
PT (1)	PT2032551E (pt)
RS (1)	RS52034B (pt)
RU (2)	RU2444519C2 (pt)
SG (1)	SG174830A1 (pt)
SI (1)	SI2032551T1 (pt)
TW (2)	TWI373469B (pt)
UA (1)	UA97369C2 (pt)
WO (1)	WO2007144423A1 (pt)
ZA (1)	ZA200810315B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0821116B8 (pt)	2007-12-20	2021-05-25	Pharma Mar Sa	composto, composição farmacêutica que o contem, uso deste e processo para a preparação do mesmo
ES2411930T3 (es)	2008-02-20	2013-07-09	Actelion Pharmaceuticals Ltd.	Compuestos antibióticos azatricíclicos
JP5404652B2 (ja)	2008-02-22	2014-02-05	アクテリオンファーマシューティカルズリミテッド	オキサゾリジノン誘導体
KR101294962B1 (ko)	2008-10-07	2013-08-12	액테리온 파마슈티칼 리미티드	트리사이클 옥사졸리디논 항생제 화합물
MX2011003188A (es)	2008-10-10	2011-04-27	Actelion Pharmaceuticals Ltd	Antibioticos de oxazolidinilo.
WO2010149688A2 (en)	2009-06-24	2010-12-29	Pharma Mar, S.A.	Antitumoral compounds
GB201309807D0 (en) *	2013-05-31	2013-07-17	Pharma Mar Sau	Antibody drug conjugates
CN108467378A (zh) *	2017-02-23	2018-08-31	复旦大学	一种二氢吡喃酮类化合物及其制备方法和用途
US11332480B2 (en)	2017-04-27	2022-05-17	Pharma Mar, S.A.	Antitumoral compounds
CN110790737B (zh) *	2019-11-07	2022-07-22	河南中烟工业有限责任公司	一种2,3-二氢-3,5-二羟基-6-乙基-4h-吡喃-4-酮的制备方法
EP4419513B1 (en)	2021-10-22	2025-08-27	Pharma Mar S.A.	Antitumoral compounds
CN117510448A (zh) *	2023-11-13	2024-02-06	贵州中医药大学	一种二氢吡喃酮衍生物及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA938019B (en) *	1992-11-13	1995-04-28	Upjohn Co	Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
ATE263761T1 (de) *	1993-11-19	2004-04-15	Parke Davis & Co	5,6-dihydropyronderivate als proteaseinhibitoren und antiviralmittel
US7446196B2 (en) *	2004-06-03	2008-11-04	Kosan Biosciences, Incorporated	Leptomycin compounds

2007
- 2007-06-15 AT AT07765445T patent/ATE522514T1/de active
- 2007-06-15 MX MX2008015754A patent/MX2008015754A/es active IP Right Grant
- 2007-06-15 BR BRPI0713031A patent/BRPI0713031B8/pt not_active IP Right Cessation
- 2007-06-15 ES ES07765445T patent/ES2371942T3/es active Active
- 2007-06-15 KR KR1020097000830A patent/KR101474031B1/ko not_active Expired - Fee Related
- 2007-06-15 PL PL07765445T patent/PL2032551T3/pl unknown
- 2007-06-15 UA UAA200900292A patent/UA97369C2/ru unknown
- 2007-06-15 EP EP11177474A patent/EP2404912A3/en not_active Withdrawn
- 2007-06-15 BR BRPI0722429-0A patent/BRPI0722429A2/pt not_active IP Right Cessation
- 2007-06-15 RU RU2009101150/04A patent/RU2444519C2/ru active
- 2007-06-15 RS RS20110495A patent/RS52034B/sr unknown
- 2007-06-15 EP EP11177479A patent/EP2404913A3/en not_active Withdrawn
- 2007-06-15 DK DK07765445.7T patent/DK2032551T3/da active
- 2007-06-15 MY MYPI20085040A patent/MY145788A/en unknown
- 2007-06-15 WO PCT/EP2007/055959 patent/WO2007144423A1/en not_active Ceased
- 2007-06-15 HR HR20110845T patent/HRP20110845T1/hr unknown
- 2007-06-15 AU AU2007259257A patent/AU2007259257B8/en not_active Ceased
- 2007-06-15 CN CN2007800222645A patent/CN101679340B/zh not_active Expired - Fee Related
- 2007-06-15 CA CA2654334A patent/CA2654334C/en active Active
- 2007-06-15 US US12/304,123 patent/US8324406B2/en not_active Expired - Fee Related
- 2007-06-15 NZ NZ573706A patent/NZ573706A/en not_active IP Right Cessation
- 2007-06-15 CN CN2011102036625A patent/CN102336730A/zh active Pending
- 2007-06-15 SI SI200730781T patent/SI2032551T1/sl unknown
- 2007-06-15 EP EP07765445A patent/EP2032551B9/en active Active
- 2007-06-15 JP JP2009514811A patent/JP5117491B2/ja not_active Expired - Fee Related
- 2007-06-15 SG SG2011067998A patent/SG174830A1/en unknown
- 2007-06-15 PT PT07765445T patent/PT2032551E/pt unknown
- 2007-06-19 AR ARP070102670A patent/AR061506A1/es active IP Right Grant
- 2007-06-20 TW TW096122071A patent/TWI373469B/zh not_active IP Right Cessation
- 2007-06-20 TW TW100146802A patent/TW201213316A/zh unknown
2008
- 2008-12-02 IL IL195676A patent/IL195676A/en active IP Right Grant
- 2008-12-04 ZA ZA2008/10315A patent/ZA200810315B/en unknown
2009
- 2009-01-06 NO NO20090054A patent/NO341508B1/no unknown
2011
- 2011-06-29 US US13/171,567 patent/US8501968B2/en not_active Expired - Fee Related
- 2011-08-05 RU RU2011133128/04A patent/RU2011133128A/ru not_active Application Discontinuation
- 2011-09-14 NO NO20111248A patent/NO20111248L/no not_active Application Discontinuation
- 2011-10-05 JP JP2011220925A patent/JP2012021023A/ja active Pending
- 2011-11-30 CY CY20111101175T patent/CY1112103T1/el unknown

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Kuhnt M et al.Microbial Conversion Products of Leptomycin B.《Applied and Environmental Microbiology》.1998,第64卷(第2期),全文. *

Also Published As

Publication number	Publication date
CA2654334C (en)	2014-06-10
NO341508B1 (no)	2017-11-27
TW201213316A (en)	2012-04-01
JP2009539943A (ja)	2009-11-19
EP2404912A2 (en)	2012-01-11
ES2371942T3 (es)	2012-01-11
TWI373469B (en)	2012-10-01
HK1130052A1 (en)	2009-12-18
EP2404912A3 (en)	2012-07-25
JP5117491B2 (ja)	2013-01-16
SI2032551T1 (sl)	2012-01-31
NO20111248L (no)	2008-12-16
RU2444519C2 (ru)	2012-03-10
CY1112103T1 (el)	2015-11-04
PT2032551E (pt)	2011-12-06
IL195676A0 (en)	2009-09-01
RU2011133128A (ru)	2013-02-10
MY145788A (en)	2012-04-30
RS52034B (sr)	2012-04-30
AR061506A1 (es)	2008-09-03
KR20090024261A (ko)	2009-03-06
CN102336730A (zh)	2012-02-01
PL2032551T3 (pl)	2012-01-31
US8501968B2 (en)	2013-08-06
IL195676A (en)	2012-06-28
US8324406B2 (en)	2012-12-04
DK2032551T3 (da)	2012-01-02
BRPI0713031B1 (pt)	2020-10-06
BRPI0713031B8 (pt)	2021-05-25
AU2007259257A1 (en)	2007-12-21
ZA200810315B (en)	2010-02-24
CN101679340A (zh)	2010-03-24
AU2007259257B8 (en)	2012-04-05
EP2404913A3 (en)	2012-06-06
NO20090054L (no)	2009-01-06
WO2007144423A1 (en)	2007-12-21
AU2007259257A8 (en)	2012-04-05
US20120190870A1 (en)	2012-07-26
JP2012021023A (ja)	2012-02-02
AU2007259257B2 (en)	2011-12-08
NZ573706A (en)	2011-09-30
HRP20110845T1 (hr)	2011-12-31
BRPI0713031A2 (pt)	2013-03-12
MX2008015754A (es)	2009-01-12
TW200811128A (en)	2008-03-01
EP2032551B1 (en)	2011-08-31
SG174830A1 (en)	2011-10-28
EP2032551A1 (en)	2009-03-11
KR101474031B1 (ko)	2014-12-17
RU2009101150A (ru)	2010-07-27
EP2404913A2 (en)	2012-01-11
EP2032551B9 (en)	2012-02-29
ATE522514T1 (de)	2011-09-15
BRPI0722429A2 (pt)	2013-11-26
US20090186938A1 (en)	2009-07-23
US20100048690A2 (en)	2010-02-25
UA97369C2 (ru)	2012-02-10
CA2654334A1 (en)	2007-12-21

Legal Events

Date	Code	Title	Description
2010-03-24	C06	Publication
2010-03-24	PB01	Publication
2010-05-05	C10	Entry into substantive examination
2010-05-05	SE01	Entry into force of request for substantive examination
2013-06-05	C14	Grant of patent or utility model
2013-06-05	GR01	Patent grant
2013-06-19	C56	Change in the name or address of the patentee	Owner name: PHARMA MAR, S. A. Free format text: FORMER NAME: PHARMA MAR S. A. U.
2013-06-19	CP01	Change in the name or title of a patent holder	Address after: Madrid Patentee after: PHARMA MAR, S.A. Address before: Madrid Patentee before: PHARMA MAR, S.A.U.
2025-06-06	CF01	Termination of patent right due to non-payment of annual fee	Granted publication date: 20130605
2025-06-06	CF01	Termination of patent right due to non-payment of annual fee