CN102224151A - 新的抗微生物剂 - Google Patents

新的抗微生物剂 Download PDF

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Publication number
CN102224151A
CN102224151A CN2009801465662A CN200980146566A CN102224151A CN 102224151 A CN102224151 A CN 102224151A CN 2009801465662 A CN2009801465662 A CN 2009801465662A CN 200980146566 A CN200980146566 A CN 200980146566A CN 102224151 A CN102224151 A CN 102224151A
Authority
CN
China
Prior art keywords
alkyl
heteroaryl
cycloalkyl
aryl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801465662A
Other languages
English (en)
Chinese (zh)
Inventor
拉杰什·贾殷
桑贾伊·特雷汉
加戈塔兰·达斯
桑迪普·坎沃尔
西塔拉姆·库马尔·马格蒂
苏迪尔·库马尔·夏尔玛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Panacea Biotec Ltd
Original Assignee
Panacea Biotec Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panacea Biotec Ltd filed Critical Panacea Biotec Ltd
Publication of CN102224151A publication Critical patent/CN102224151A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2009801465662A 2008-11-20 2009-11-18 新的抗微生物剂 Pending CN102224151A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2623DE2008 2008-11-20
IN2623/DEL/2008 2008-11-20
PCT/IN2009/000658 WO2010058423A2 (en) 2008-11-20 2009-11-18 Novel antimicrobials

Publications (1)

Publication Number Publication Date
CN102224151A true CN102224151A (zh) 2011-10-19

Family

ID=42198604

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801465662A Pending CN102224151A (zh) 2008-11-20 2009-11-18 新的抗微生物剂

Country Status (12)

Country Link
US (1) US8841306B2 (2)
EP (1) EP2367820B1 (2)
JP (1) JP5662940B2 (2)
KR (1) KR20110092309A (2)
CN (1) CN102224151A (2)
AR (1) AR074387A1 (2)
AU (1) AU2009318783A1 (2)
CA (1) CA2743971A1 (2)
MX (1) MX2011005365A (2)
RU (1) RU2522582C2 (2)
WO (1) WO2010058423A2 (2)
ZA (1) ZA201103978B (2)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103450173A (zh) * 2013-09-07 2013-12-18 吉首大学 吡咯酮-苯基-噁唑烷酮型化合物及其制法和用途

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012049161A1 (en) * 2010-10-13 2012-04-19 Glaxo Group Limited 3 -amino- pyrazole derivatives useful against tuberculosis
PT106651A (pt) * 2012-11-20 2014-05-20 Tecnimede Sociedade Tecnico Medicinal S A Quinolil hidrazonas para o tratamento de tuberculose e doenças relacionadas
WO2017156519A1 (en) 2016-03-11 2017-09-14 The Board Of Trustees Of The University Of Illinois Small-molecules active against gram-negative bacteria
WO2018237140A1 (en) 2017-06-23 2018-12-27 The Board Of Trustees Of The University Of Illinois Topoisomerase inhibitors with antibacterial and antcancer activity
EP4100023A4 (en) * 2020-02-07 2024-03-13 University of South Florida Inhibition of beta-arrestin oligomerization in tauopathy

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0610265B1 (en) 1991-11-01 1996-12-27 PHARMACIA & UPJOHN COMPANY Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
SK283420B6 (sk) 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
NZ271739A (en) 1993-09-06 1996-09-25 Fujisawa Pharmaceutical Co Cyclodepsipeptide compounds and pharmaceutical compositions thereof
DE69614847T2 (de) 1995-05-11 2002-04-04 Pharmacia & Upjohn Co., Kalamazoo Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone
HUP9901979A3 (en) 1995-09-01 2000-03-28 Upjohn Co Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings and pharmaceutical compositions containing the same
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
WO1999064417A2 (en) * 1998-06-05 1999-12-16 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
JP2000204084A (ja) * 1998-11-11 2000-07-25 Hokuriku Seiyaku Co Ltd チオカルバミド酸誘導体
AU1379900A (en) 1998-11-17 2000-06-05 Bayer Aktiengesellschaft Novel substituted phenyloxazolidone derivatives
JP2003501351A (ja) 1999-05-27 2003-01-14 ファルマシア・アンド・アップジョン・カンパニー 抗菌剤としての二環系オキサゾリジノン
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
AU5889701A (en) 2000-06-05 2001-12-17 Dong A Pharm Co Ltd Novel oxazolidinone derivatives and a process for the preparation thereof
AU2001272961A1 (en) 2000-06-30 2002-01-14 Pharmacia & Upjohn Company Compositions for treating bacterial infections containing oxazolidinone compound, sulbactam and an ampicillin
WO2003008389A1 (en) 2001-07-16 2003-01-30 Ranbaxy Laboratories Limited Oxazolidinone derivatives as potential antimicrobials
DOP2002000333A (es) 2001-02-14 2002-09-30 Warner Lambert Co Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz
GB0108793D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
DE60212959T2 (de) 2001-04-07 2007-02-15 Astrazeneca Ab Eine sulfonimid-gruppe enthaltende oxazolidinone als antibiotika
JP2004534097A (ja) 2001-07-09 2004-11-11 フアルマシア・イタリア・エツセ・ピー・アー ＴＣＦ−４とβ−カテニンの相互作用阻害剤
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
JP2005529924A (ja) 2002-05-15 2005-10-06 ランバクシー ラボラトリーズ リミテッド フェニルオキサゾリジノン誘導体
WO2003097640A1 (en) 2002-05-22 2003-11-27 Orchid Chemicals & Pharmaceuticals Ltd. Oxazolidinone derivatives as antibacterial agents
WO2004009587A1 (en) 2002-07-22 2004-01-29 Orchid Chemicals & Pharmaceuticals Ltd Oxazolidinone derivatives as antibacterial agents
BR0215921A (pt) 2002-07-29 2005-09-13 Ranbaxy Lab Ltd Derivados de oxazolidinona utilizáveis como antimicrobianos e processo de sua preparação
US7217726B2 (en) * 2002-08-22 2007-05-15 Orchid Chemicals & Pharmaceuticals Limited Antibacterial agents
US6875784B2 (en) 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
ATE344036T1 (de) * 2002-11-21 2006-11-15 Pharmacia & Upjohn Co Llc N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinon-5- carbonsäureamid-derivate und verwandte verbindungen als antibakterielle mittel
GB0229526D0 (en) 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229518D0 (en) 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
CN1237056C (zh) 2002-12-25 2006-01-18 中国科学院上海药物研究所 噁唑烷酮类化合物、其制备方法和用途
AU2003215861A1 (en) * 2003-04-07 2004-11-01 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
JP2006522791A (ja) 2003-04-09 2006-10-05 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗微生物性［３．１．０］ビシクロヘキシルフェニルオキサゾリジノン誘導体および類似体
WO2004113329A1 (en) 2003-06-20 2004-12-29 Orchid Chemicals And Pharmaceuticals Ltd. Oxazole derivatives as antibacterial agents
WO2005003087A2 (en) 2003-07-01 2005-01-13 Orchid Chemicals And Pharmaceuticals Ltd. Oxazole derivatives as antibacterial agents
CA2529292A1 (en) 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
AU2004256086B2 (en) 2003-07-02 2007-12-06 Kyorin Pharmaceutical Co., Ltd. Oxazolidinone antibiotics and derivatives thereof
WO2005036169A2 (en) * 2003-10-03 2005-04-21 Cumbre Inc. Fluorescent probes for ribosomes and method of use
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
WO2005082897A1 (en) 2004-01-28 2005-09-09 Pharmacia & Upjohn Company Llc Oxazolidinone antibacterial agents
WO2005082900A2 (en) 2004-01-28 2005-09-09 Pharmacia & Upjohn Company Llc Oxazolidinone amidoximes as antibacterial agents
WO2005116024A1 (en) 2004-05-25 2005-12-08 Astrazeneca Ab 3- (4- (2-dihydroisoxazol-3-ylpyridin-5-yl) phenyl) -5-triazol-1-ylmethyloxazolidin-2-one derivaives as mao inhibitors for the treatment of bacterial infections
US20080064689A1 (en) 2004-05-25 2008-03-13 Astrazeneca Ab 3-[4-(6-Pyridin-3-Yl)-3-Phenyl] -5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents
WO2006035283A1 (en) 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
WO2006043121A1 (en) 2004-10-20 2006-04-27 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
WO2006109056A1 (en) 2005-04-12 2006-10-19 Vicore Pharma Ab New tricyclic angiotensin ii agonists
EP1745784A1 (en) 2005-06-27 2007-01-24 Ferrer Internacional, S.A. Oxazolidinone derivatives and use thereof as antibiotics
EP1902048A1 (en) 2005-07-06 2008-03-26 Pharmacia & Upjohn Company LLC Oxazolidinone carboxamides containing azetidine and cyclobutane as antibacterial agents
KR20070038236A (ko) 2005-10-05 2007-04-10 일동제약주식회사 신규 옥사졸리디논 포름 아미드 유도체 및 그 제조방법
CA2637052A1 (en) 2006-01-19 2007-07-26 Laboratorios Salvat, S.A. Dicarbonylic compounds with antibacterial activity
WO2007093904A1 (en) 2006-02-14 2007-08-23 Pfizer Products Inc. Benzoxazinone and benzoxazepinone oxazolidinones as antibacterial agents
CN100406455C (zh) 2006-02-20 2008-07-30 中国科学院上海药物研究所 含三氮唑基的噁唑烷酮类化合物及其制备方法和用途
KR20080110877A (ko) 2006-03-31 2008-12-19 재단법인 이쯔우 연구소 헤테로환을 갖는 신규 화합물
EP2170874A4 (en) 2007-06-22 2011-08-31 Orchid Res Lab Ltd NEW COMPOUNDS AND THEIR USE
CN101434584A (zh) 2007-11-15 2009-05-20 中山大学 具有抗菌活性的手性噁唑烷酮类化合物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103450173A (zh) * 2013-09-07 2013-12-18 吉首大学 吡咯酮-苯基-噁唑烷酮型化合物及其制法和用途
CN103450173B (zh) * 2013-09-07 2015-06-03 吉首大学 吡咯酮-苯基-噁唑烷酮型化合物及其制法和用途

Also Published As

Publication number Publication date
EP2367820A2 (en) 2011-09-28
RU2522582C2 (ru) 2014-07-20
US20110245258A1 (en) 2011-10-06
WO2010058423A2 (en) 2010-05-27
JP5662940B2 (ja) 2015-02-04
US8841306B2 (en) 2014-09-23
ZA201103978B (en) 2012-09-26
WO2010058423A9 (en) 2011-04-28
AU2009318783A1 (en) 2011-06-23
KR20110092309A (ko) 2011-08-17
JP2012509313A (ja) 2012-04-19
CA2743971A1 (en) 2010-05-27
MX2011005365A (es) 2011-06-24
EP2367820A4 (en) 2012-06-20
WO2010058423A3 (en) 2010-12-09
EP2367820B1 (en) 2016-09-21
AR074387A1 (es) 2011-01-12
RU2011124795A (ru) 2012-12-27

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Application publication date: 20111019