CN1023483C - 制备(±)-2，6-二甲基-4(m-硝基苯基)-1，4二氢吡咯啶-3，5-二羧酸-3-(1-苄吡咯烷-3-基)-5甲基酯非对映体a的右旋旋光异构体的一种新工艺 - Google Patents

制备(±)-2，6-二甲基-4(m-硝基苯基)-1，4二氢吡咯啶-3，5-二羧酸-3-(1-苄吡咯烷-3-基)-5甲基酯非对映体a的右旋旋光异构体的一种新工艺 Download PDF

Info

Publication number
CN1023483C
CN1023483C CN85107590A CN85107590A CN1023483C CN 1023483 C CN1023483 C CN 1023483C CN 85107590 A CN85107590 A CN 85107590A CN 85107590 A CN85107590 A CN 85107590A CN 1023483 C CN1023483 C CN 1023483C
Authority
CN
China
Prior art keywords
diastereomer
isomer
optical isomer
milliliters
optically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN85107590A
Other languages
English (en)
Chinese (zh)
Other versions
CN85107590A (zh
Inventor
玉泽一治
有马英纪
冈田实
礒村康男
克拉恩格·思开米各尔
亚麦斯赫·韦凯尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Airiri And Gombali
Astellas Pharma Inc
Original Assignee
Airiri And Gombali
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Airiri And Gombali, Yamanouchi Pharmaceutical Co Ltd filed Critical Airiri And Gombali
Publication of CN85107590A publication Critical patent/CN85107590A/zh
Application granted granted Critical
Publication of CN1023483C publication Critical patent/CN1023483C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN85107590A 1985-01-24 1985-10-11 制备(±)-2，6-二甲基-4(m-硝基苯基)-1，4二氢吡咯啶-3，5-二羧酸-3-(1-苄吡咯烷-3-基)-5甲基酯非对映体a的右旋旋光异构体的一种新工艺 Expired - Lifetime CN1023483C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP12051/85 1985-01-24
JP12051/1985 1985-01-24
JP1205185 1985-01-24

Publications (2)

Publication Number Publication Date
CN85107590A CN85107590A (zh) 1986-07-23
CN1023483C true CN1023483C (zh) 1994-01-12

Family

ID=11794796

Family Applications (1)

Application Number Title Priority Date Filing Date
CN85107590A Expired - Lifetime CN1023483C (zh) 1985-01-24 1985-10-11 制备(±)-2，6-二甲基-4(m-硝基苯基)-1，4二氢吡咯啶-3，5-二羧酸-3-(1-苄吡咯烷-3-基)-5甲基酯非对映体a的右旋旋光异构体的一种新工艺

Country Status (12)

Country Link
JP (1) JPS61267577A (th)
KR (1) KR900002342B1 (th)
CN (1) CN1023483C (th)
AT (1) AT390613B (th)
CA (1) CA1273931A (th)
DK (1) DK468385A (th)
ES (1) ES8607284A1 (th)
FI (1) FI83517C (th)
GR (1) GR852497B (th)
IT (1) IT1221762B (th)
MX (1) MX260A (th)
NO (1) NO166643C (th)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001278683A1 (en) * 2000-08-01 2002-02-13 Kaneka Corporation Novel carbonyl reductase, gene thereof and method of using the same
KR100939347B1 (ko) 2005-07-20 2010-01-29 (주)카이로드 광학적으로 순수한 (ｓ)-3-히드록시 피롤리딘의 제조방법
CN101643469B (zh) * 2008-12-27 2012-11-21 武汉百科药物开发有限公司 一种盐酸巴尼地平的合成工艺
EP4382529A1 (en) 2022-12-07 2024-06-12 Bayer Consumer Care AG A process for preparing pure (3s)-pyrrolidin-3-ol and pure (3s)-pyrrolidin-3-ol hydrochloride

Also Published As

Publication number Publication date
ES547696A0 (es) 1986-05-16
NO854062L (no) 1986-07-25
NO166643B (no) 1991-05-13
FI853697L (fi) 1986-07-25
KR860005637A (ko) 1986-08-11
IT8522489A0 (it) 1985-10-15
AT390613B (de) 1990-06-11
DK468385D0 (da) 1985-10-14
FI83517C (fi) 1991-07-25
CA1273931A (en) 1990-09-11
KR900002342B1 (ko) 1990-04-12
JPS61267577A (ja) 1986-11-27
MX260A (es) 1995-01-31
ES8607284A1 (es) 1986-05-16
FI853697A0 (fi) 1985-09-26
IT1221762B (it) 1990-07-12
GR852497B (th) 1986-02-18
DK468385A (da) 1986-07-25
NO166643C (no) 1991-08-21
ATA297085A (de) 1989-11-15
CN85107590A (zh) 1986-07-23
FI83517B (fi) 1991-04-15

Similar Documents

Publication Publication Date Title
US5994548A (en) Crystallisation of levibupivacaine and analogues thereof
NO964282D0 (no) Fremgangsmåte for fremstilling av enantiomerisk rene imidazolylforbindelser
JP4015696B2 (ja) レボブピバカインと同類のピペリジンカルボキサニリド麻酔剤の製造に用いるラセミ化法
CN85107590A (zh) Ym-09730非对映体a的右旋旋光异构体生产的一种新工艺
CN1015710B (zh) 黄皮酰胺的制备方法
US4219560A (en) Piperidine and pyrrolidine alcohols
KR930004358B1 (ko) α-시아노-3-펜옥시-4-플루오로벤질 퍼메트레이트의 특정 에난티오머쌍의 제조방법
US6156900A (en) Racemization of precursors to levobupivacaine and analogues thereof
JPH0635438B2 (ja) 光学的に活性な１，４‐ジヒドロピリジン類の製造方法
CZ20023694A3 (cs) Tosylátové soli 4-(p-fluorfenyl)-piperidin-3-methanolů
CN1094486C (zh) 亚苄基化合物及其制备方法
US4584313A (en) (Substituted-phenyl)-5-oxo-2-pyrrolidinepropanoic acids and esters thereof, and use for reversing electroconvulsive shock-induced amnesia
FR2523128A1 (fr) Nouveaux derives de la 1,4-dihydropyridine, leur preparation et medicaments contenant ces derives
SU1750424A3 (ru) Способ получени диэтилового эфира (Е)-4-[2-/3-(1,1-диметилэтокси)-3-оксо-1-пропенил/фенил]-1,4-дигидро-2,6-диметил-3,5-пиридиндикарбоновой кислоты
JP2004300070A (ja) ムスコンのアセタール付加体、その調製方法、並びに（±）−ムスコンの光学分割方法
CN1030570C (zh) 1，5-苯并硫氮杂环庚烷衍生物类的制备方法
CA2201780C (en) Racemisation of precursors to levobupivacaine and analogues thereof
JPS6363639A (ja) シクロプロパンカルボン酸エステルのジアステレオマ−の分離方法
JPH0517906B2 (th)
JPH0687828A (ja) 環化反応を用いるジフルオロメチル化合物の合成
JPH0320271A (ja) 光学活性な１，４―ジヒドロピリジン誘導体
JPH06503824A (ja) ジヒドロピリジンカルボン酸の製法
GB1590169A (en) 1,3-benzodioxine derivatives processes for preparing them and pharmaceutical compositions containing them
JPH0374665B2 (th)

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CX01 Expiry of patent term