CN106103717A - 用于调节共济失调蛋白2表达的组合物 - Google Patents

用于调节共济失调蛋白2表达的组合物 Download PDF

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Publication number
CN106103717A
CN106103717A CN201580012549.5A CN201580012549A CN106103717A CN 106103717 A CN106103717 A CN 106103717A CN 201580012549 A CN201580012549 A CN 201580012549A CN 106103717 A CN106103717 A CN 106103717A
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ataxin
certain embodiments
modified
compound
nucleic acid
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Chinese (zh)
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S·M·弗赖尔
G·洪
C·F·贝内特
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Priority to CN202310849672.9A priority Critical patent/CN116970607A/zh
Publication of CN106103717A publication Critical patent/CN106103717A/zh
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CN201580012549.5A 2014-03-19 2015-03-19 用于调节共济失调蛋白2表达的组合物 Pending CN106103717A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310849672.9A CN116970607A (zh) 2014-03-19 2015-03-19 用于调节共济失调蛋白2表达的组合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461955705P 2014-03-19 2014-03-19
US61/955,705 2014-03-19
US201461982131P 2014-04-21 2014-04-21
US61/982,131 2014-04-21
PCT/US2015/021608 WO2015143246A1 (en) 2014-03-19 2015-03-19 Compositions for modulating ataxin 2 expression

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CN106103717A true CN106103717A (zh) 2016-11-09

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CN202310849672.9A Pending CN116970607A (zh) 2014-03-19 2015-03-19 用于调节共济失调蛋白2表达的组合物

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US (4) US10308934B2 (2)
EP (2) EP3119888B1 (2)
JP (3) JP6902869B2 (2)
KR (1) KR102352589B1 (2)
CN (2) CN106103717A (2)
AU (2) AU2015231130C1 (2)
BR (1) BR112016020472B1 (2)
CA (1) CA2942340A1 (2)
CL (1) CL2016002346A1 (2)
CY (1) CY1124526T1 (2)
DK (1) DK3119888T3 (2)
ES (1) ES2890677T3 (2)
HR (1) HRP20211397T1 (2)
HU (1) HUE055877T2 (2)
IL (1) IL247600B (2)
LT (1) LT3119888T (2)
MX (1) MX389437B (2)
PL (1) PL3119888T3 (2)
PT (1) PT3119888T (2)
RS (1) RS62526B1 (2)
RU (2) RU2702838C2 (2)
SG (2) SG10201808063PA (2)
SI (1) SI3119888T1 (2)
SM (1) SMT202100562T1 (2)
WO (1) WO2015143246A1 (2)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109529018A (zh) * 2019-01-10 2019-03-29 南方医科大学南方医院 Atxn2l用于制备逆转胃癌奥沙利铂耐药的药物的用途
CN112423767A (zh) * 2018-07-25 2021-02-26 Ionis制药公司 用于减少atxn2表达的化合物和方法
CN113005123A (zh) * 2017-10-23 2021-06-22 普利维尔治疗公司 用于神经变性疾病的基因疗法
CN113330116A (zh) * 2018-12-14 2021-08-31 比奥根Ma公司 用于治疗和预防肌肉萎缩性脊髓侧索硬化症的组合物和方法
WO2025067482A1 (zh) * 2023-09-28 2025-04-03 大睿生物 调控atxn2表达的dsrna分子

Families Citing this family (16)

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EP3119888B1 (en) 2014-03-19 2021-07-28 Ionis Pharmaceuticals, Inc. Compositions for modulating ataxin 2 expression
US10006027B2 (en) 2014-03-19 2018-06-26 Ionis Pharmaceuticals, Inc. Methods for modulating Ataxin 2 expression
EP4285912A3 (en) 2015-09-25 2024-07-10 Ionis Pharmaceuticals, Inc. Compositions and methods for modulating ataxin 3 expression
WO2017087282A1 (en) 2015-11-18 2017-05-26 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (lrrk2) for the treatment of parkinsons disease
US10370667B2 (en) 2015-11-18 2019-08-06 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of parkinsons disease
AU2016381174A1 (en) 2015-12-31 2018-05-31 Ionis Pharmaceuticals, Inc. Methods for reducing Ataxin-2 expression
JOP20190104A1 (ar) 2016-11-10 2019-05-07 Ionis Pharmaceuticals Inc مركبات وطرق لتقليل التعبير عن atxn3
EP4663758A3 (en) 2018-05-09 2026-04-29 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing atxn3 expression
IL278785B2 (en) 2018-05-22 2025-03-01 Ionis Pharmaceuticals Inc Modulators of apol1 expression
JP7379387B2 (ja) * 2018-06-05 2023-11-14 エフ． ホフマン－ラ ロシュ アーゲー Ａｔｘｎ２発現を制御するためのオリゴヌクレオチド
US12429487B2 (en) 2018-12-06 2025-09-30 Biogen Ma Inc. Neurofilament protein for guiding therapeutic intervention in amyotrophic lateral sclerosis
US11286485B2 (en) 2019-04-04 2022-03-29 Hoffmann-La Roche Inc. Oligonucleotides for modulating ATXN2 expression
EP3947677A1 (en) * 2019-04-04 2022-02-09 F. Hoffmann-La Roche AG Oligonucleotides for modulating atxn2 expression
WO2022026531A1 (en) * 2020-07-29 2022-02-03 Alnylam Pharmaceuticals, Inc. Atxn2 irna compositions and methods of use thereof for treating or preventing atxn2-associated neurodegenerative diseases
KR20250028434A (ko) * 2022-06-24 2025-02-28 일라이 릴리 앤드 캄파니 Atxn2 rna 간섭 작용제
KR20250178496A (ko) 2024-06-19 2025-12-29 이양원 Pcr 장치

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US20070224624A1 (en) * 1996-05-08 2007-09-27 Pulst Stefan M Nucleic acid encoding spinocerebellar ataxia-2 and products related thereto
CN101052717A (zh) * 2004-05-11 2007-10-10 α基因株式会社 诱发rna干扰的多核苷酸以及使用该多核苷酸的基因表达抑制方法
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