CN107001381A - 制备阿片类化合物的方法 - Google Patents

制备阿片类化合物的方法 Download PDF

Info

Publication number
CN107001381A
CN107001381A CN201580035299.7A CN201580035299A CN107001381A CN 107001381 A CN107001381 A CN 107001381A CN 201580035299 A CN201580035299 A CN 201580035299A CN 107001381 A CN107001381 A CN 107001381A
Authority
CN
China
Prior art keywords
compound
formula
amount
molar equivalents
inorganic base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580035299.7A
Other languages
English (en)
Chinese (zh)
Inventor
M.孔扎
V.莱勒克
H.金泽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noramco LLC
Original Assignee
Noramco LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noramco LLC filed Critical Noramco LLC
Publication of CN107001381A publication Critical patent/CN107001381A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN201580035299.7A 2014-05-05 2015-04-28 制备阿片类化合物的方法 Pending CN107001381A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461988523P 2014-05-05 2014-05-05
US61/988523 2014-05-05
US14/689712 2015-04-17
US14/689,712 US9701688B2 (en) 2014-05-05 2015-04-17 Process for the preparation of opioid compounds
PCT/US2015/027912 WO2015171354A2 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Publications (1)

Publication Number Publication Date
CN107001381A true CN107001381A (zh) 2017-08-01

Family

ID=54354748

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580035299.7A Pending CN107001381A (zh) 2014-05-05 2015-04-28 制备阿片类化合物的方法

Country Status (9)

Country Link
US (1) US9701688B2 (2)
EP (1) EP3140308B8 (2)
JP (2) JP6792745B2 (2)
CN (1) CN107001381A (2)
AU (3) AU2015256416B2 (2)
CA (2) CA3208298A1 (2)
DK (1) DK3140308T3 (2)
ES (1) ES2946177T3 (2)
WO (1) WO2015171354A2 (2)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201716830D0 (en) * 2017-10-13 2017-11-29 Cambrex Charles City Inc New Process
WO2023102489A1 (en) * 2021-12-03 2023-06-08 Board Of Regents Of The University Of Nebraska Compounds, nanoparticles, and pharmaceutical compositions for the treatment of drug addiction

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
EP2101774A2 (en) 2006-11-22 2009-09-23 Progenics Pharmaceuticals, Inc. 7,8-saturated-4,5-epoxy-morphinanium analogs
ES2407033T3 (es) 2007-05-04 2013-06-11 Mallinckrodt Llc Procedimientos mejorados para la preparación de opiáceos 6-alfa-hidroxi-n-alquilados
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
CN101861315B (zh) 2007-11-20 2013-01-16 日产化学工业株式会社 2-氮杂金刚烷类的制造方法
KR20110014974A (ko) * 2008-03-31 2011-02-14 썬 파마슈티컬 인더스트리스 리미티드 모르피난 유사체의 개선된 제조 방법
WO2010017573A1 (en) 2008-08-11 2010-02-18 Tasmanian Alkaloids Pty Limited PROCESS FOR MAKING MORPHINAN-6α-OLS
CA2738089C (en) 2008-09-30 2017-07-18 Mallinckrodt Inc. Processes for the hydrogenation of opiate alkaloid derivatives
CA2738246C (en) 2008-09-30 2017-09-05 Mallinckrodt Inc. Processes for the alkylation of secondary amine groups of morphinan derivatives
PL2342207T3 (pl) 2008-09-30 2016-05-31 SpecGx LLC Sposoby alkilowania norbuprenorfiny ze zmniejszonym powstawaniem zanieczyszczeń
EP2342208B1 (en) 2008-09-30 2014-06-04 Mallinckrodt LLC Recycling process for increasing the yield of a grignard reaction in the preparation of opiate alkaloid derivatives
ES2560537T5 (es) 2008-09-30 2022-01-21 SpecGx LLC Procesos para aumentar el rendimiento de la hidrólisis del grupo 3-O-metilo y 17-N-nitrilo en la preparación de derivados alcaloides opiáceos
CA2752744A1 (en) 2009-02-17 2010-08-26 Mallinckrodt Inc. Process for the reductive alkylation of normorphinans
WO2010121369A1 (en) 2009-04-24 2010-10-28 Brock University Processes for the preparation of morphinane and morphinone compounds
US20110269964A1 (en) * 2010-04-29 2011-11-03 Mallinckrodt Inc. N-Alkylation of Opiates
CA2802294C (en) * 2010-06-11 2016-05-10 Rhodes Technologies Process for n-dealkylation of tertiary amines
SMT201700177T1 (it) * 2010-11-05 2017-05-08 H Lundbeck As Procedimento per la fabbricazione di naltrexone
WO2012149633A1 (en) * 2011-05-02 2012-11-08 Brock University Processes and intermediates in the preparation of morphine analogs via n-demethylation of n-oxides using cyclodehydration reagents
ES2692885T3 (es) 2011-10-03 2018-12-05 Johnson Matthey Plc Proceso para preparar buprenorfina
CA2863242A1 (en) 2012-02-03 2013-08-08 Tomas Hudlicky Process for the preparation of morphine analogs via the reaction of organometallic reagents with an oxazolidine derived from morphinans
AR090916A1 (es) * 2012-05-03 2014-12-17 Lundbeck & Co As H Metodo para la fabricacion de naltrexona

Also Published As

Publication number Publication date
DK3140308T3 (da) 2023-06-19
JP2017514846A (ja) 2017-06-08
CA2947012C (en) 2023-09-26
CA2947012A1 (en) 2015-11-12
WO2015171354A2 (en) 2015-11-12
AU2018203948A1 (en) 2018-06-21
AU2015256416B2 (en) 2018-03-08
AU2015256416A1 (en) 2016-11-24
EP3140308A2 (en) 2017-03-15
US20150315205A1 (en) 2015-11-05
WO2015171354A3 (en) 2016-03-17
JP6792745B2 (ja) 2020-12-02
US9701688B2 (en) 2017-07-11
EP3140308B1 (en) 2023-05-24
JP2020073598A (ja) 2020-05-14
CA3208298A1 (en) 2015-11-12
EP3140308B8 (en) 2023-06-28
ES2946177T3 (es) 2023-07-13
AU2018203948B2 (en) 2019-12-19
AU2020201990A1 (en) 2020-04-09

Similar Documents

Publication Publication Date Title
EP2300479B1 (en) Nalmefene hydrochloride dihydrate
JP6215399B2 (ja) ナルトレキソンの製造方法
JP2020073598A (ja) オピオイド化合物を調製するプロセス
CN107074869A (zh) 制备阿片类化合物的方法
CN1939920B (zh) 东罂粟碱类化合物及其医药用途
EP2970320B1 (en) Morphine sulfate methanolic solvate, processes for making same and related compositions and methods for treating pain
TWI516491B (zh) 製造拿淬松的方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20170801