PL2342207T3 - Sposoby alkilowania norbuprenorfiny ze zmniejszonym powstawaniem zanieczyszczeń - Google Patents
Sposoby alkilowania norbuprenorfiny ze zmniejszonym powstawaniem zanieczyszczeńInfo
- Publication number
- PL2342207T3 PL2342207T3 PL09789380T PL09789380T PL2342207T3 PL 2342207 T3 PL2342207 T3 PL 2342207T3 PL 09789380 T PL09789380 T PL 09789380T PL 09789380 T PL09789380 T PL 09789380T PL 2342207 T3 PL2342207 T3 PL 2342207T3
- Authority
- PL
- Poland
- Prior art keywords
- norbuprenorphine
- alkylation
- processes
- reduced impurity
- impurity formation
- Prior art date
Links
- YOYLLRBMGQRFTN-IOMBULRVSA-N Norbuprenorphine Chemical compound C([C@@H](NCC1)[C@]23CC[C@]4([C@H](C3)[C@](C)(O)C(C)(C)C)OC)C3=CC=C(O)C5=C3[C@@]21[C@H]4O5 YOYLLRBMGQRFTN-IOMBULRVSA-N 0.000 title 1
- 230000029936 alkylation Effects 0.000 title 1
- 238000005804 alkylation reaction Methods 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000012535 impurity Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19478408P | 2008-09-30 | 2008-09-30 | |
| EP09789380.4A EP2342207B1 (en) | 2008-09-30 | 2009-09-29 | Processes for the alkylation of norbuprenorphine with reduced impurity formation |
| PCT/US2009/005371 WO2010039216A1 (en) | 2008-09-30 | 2009-09-29 | Processes for the alkylation of norbuprenorphine with reduced impurity formation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2342207T3 true PL2342207T3 (pl) | 2016-05-31 |
Family
ID=41349350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09789380T PL2342207T3 (pl) | 2008-09-30 | 2009-09-29 | Sposoby alkilowania norbuprenorfiny ze zmniejszonym powstawaniem zanieczyszczeń |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8293906B2 (pl) |
| EP (1) | EP2342207B1 (pl) |
| AU (1) | AU2009300386B2 (pl) |
| CA (1) | CA2738758C (pl) |
| ES (1) | ES2560877T3 (pl) |
| PL (1) | PL2342207T3 (pl) |
| WO (1) | WO2010039216A1 (pl) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2674915C (en) | 2006-10-17 | 2015-06-30 | Penick Corporation | Process for preparing oxymorphone |
| EP2073636B1 (en) * | 2006-10-17 | 2012-09-05 | Penick Corporation | Process for preparing oxymorphone |
| US20080125592A1 (en) * | 2006-10-17 | 2008-05-29 | Penick Corporation | Process for preparing oxymorphone, naltrexone, and buprenorphine |
| WO2010039216A1 (en) | 2008-09-30 | 2010-04-08 | Mallinckrodt Inc. | Processes for the alkylation of norbuprenorphine with reduced impurity formation |
| US20110269964A1 (en) * | 2010-04-29 | 2011-11-03 | Mallinckrodt Inc. | N-Alkylation of Opiates |
| US9315514B2 (en) | 2012-08-27 | 2016-04-19 | Rhodes Technologies | 1,3-dioxanomorphides and 1,3-dioxanocodides |
| US9701687B2 (en) | 2014-05-05 | 2017-07-11 | Noramco, Inc. | Process for the preparation of opioid compounds |
| US9701688B2 (en) | 2014-05-05 | 2017-07-11 | Noramco, Inc. | Process for the preparation of opioid compounds |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1136214A (en) * | 1965-06-15 | 1968-12-11 | Reckitt & Sons Ltd | Thebaine and oripavine derivatives |
| GB1593191A (en) | 1977-03-23 | 1981-07-15 | Reckitt & Colmann Prod Ltd | Derivatives of morphine |
| EP0040074B1 (en) | 1980-05-08 | 1985-07-31 | Northeastern University | N-substituted aporphines, a method of inducing emesis and a method of controlling psychosis utilising the same |
| DE19606761A1 (de) | 1996-02-23 | 1997-08-28 | Bayer Ag | Verbessertes Verfahren zur Herstellung von Halogenmethylcyclopropanen und besonders reine Halogenmethylcyclopropane |
| CN1233645C (zh) | 2001-09-14 | 2005-12-28 | 中国人民解放军军事医学科学院毒物药物研究所 | 新的东罂粟碱衍生物及其医药用途 |
| US7119100B2 (en) * | 2001-09-14 | 2006-10-10 | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences, P.L.A. China | Oripavine derivatives and their uses as pharmaceuticals |
| JP2009522357A (ja) | 2006-01-05 | 2009-06-11 | マリンクロッド・インコーポレイテッド | ブプレノルフィンのための出発物質としてのオリパビンの使用 |
| CA2674915C (en) | 2006-10-17 | 2015-06-30 | Penick Corporation | Process for preparing oxymorphone |
| AU2009300390B2 (en) | 2008-09-30 | 2015-05-14 | SpecGx LLC | Processes for the production of buprenorphine with reduced impurity formation |
| WO2010039216A1 (en) | 2008-09-30 | 2010-04-08 | Mallinckrodt Inc. | Processes for the alkylation of norbuprenorphine with reduced impurity formation |
-
2009
- 2009-09-29 WO PCT/US2009/005371 patent/WO2010039216A1/en not_active Ceased
- 2009-09-29 PL PL09789380T patent/PL2342207T3/pl unknown
- 2009-09-29 EP EP09789380.4A patent/EP2342207B1/en not_active Revoked
- 2009-09-29 AU AU2009300386A patent/AU2009300386B2/en active Active
- 2009-09-29 US US12/586,854 patent/US8293906B2/en active Active
- 2009-09-29 CA CA2738758A patent/CA2738758C/en active Active
- 2009-09-29 ES ES09789380.4T patent/ES2560877T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009300386B2 (en) | 2015-07-02 |
| US8293906B2 (en) | 2012-10-23 |
| EP2342207A1 (en) | 2011-07-13 |
| AU2009300386A1 (en) | 2010-04-08 |
| CA2738758C (en) | 2016-11-29 |
| CA2738758A1 (en) | 2010-04-08 |
| US20100081820A1 (en) | 2010-04-01 |
| EP2342207B1 (en) | 2015-11-11 |
| ES2560877T3 (es) | 2016-02-23 |
| WO2010039216A1 (en) | 2010-04-08 |
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