CN1085211C - 合成金属取代的细菌叶绿素衍生物及其应用 - Google Patents

合成金属取代的细菌叶绿素衍生物及其应用 Download PDF

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Publication number
CN1085211C
CN1085211C CN96199752A CN96199752A CN1085211C CN 1085211 C CN1085211 C CN 1085211C CN 96199752 A CN96199752 A CN 96199752A CN 96199752 A CN96199752 A CN 96199752A CN 1085211 C CN1085211 C CN 1085211C
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CN
China
Prior art keywords
bchl
general formula
bacteriochlorophyll
derivative
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN96199752A
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English (en)
Chinese (zh)
Other versions
CN1207741A (zh
Inventor
A·谢尔兹
Y·萨罗蒙
H·谢尔
G·哈特维赫
A·布兰迪斯
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Yeda Research and Development Co Ltd
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Yeda Research and Development Co Ltd
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Publication of CN1207741A publication Critical patent/CN1207741A/zh
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Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN96199752A 1995-11-24 1996-11-24 合成金属取代的细菌叶绿素衍生物及其应用 Expired - Fee Related CN1085211C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL11612695A IL116126A0 (en) 1995-11-24 1995-11-24 Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them
IL116126 1995-11-24

Publications (2)

Publication Number Publication Date
CN1207741A CN1207741A (zh) 1999-02-10
CN1085211C true CN1085211C (zh) 2002-05-22

Family

ID=11068225

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96199752A Expired - Fee Related CN1085211C (zh) 1995-11-24 1996-11-24 合成金属取代的细菌叶绿素衍生物及其应用

Country Status (18)

Country Link
US (1) US6333319B1 (2)
EP (1) EP0863903B1 (2)
JP (1) JP2000500763A (2)
CN (1) CN1085211C (2)
AT (1) ATE365741T1 (2)
AU (1) AU718961B2 (2)
BR (1) BR9611452A (2)
DE (1) DE69637149T2 (2)
DK (1) DK0863903T3 (2)
ES (1) ES2288757T3 (2)
HU (1) HU223379B1 (2)
IL (1) IL116126A0 (2)
MX (1) MX9804143A (2)
NO (1) NO323478B1 (2)
PL (1) PL188811B1 (2)
PT (1) PT863903E (2)
RU (1) RU2193038C2 (2)
WO (1) WO1997019081A1 (2)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413436B1 (en) * 1999-01-27 2002-07-02 Semitool, Inc. Selective treatment of the surface of a microelectronic workpiece
ATE347554T1 (de) * 1998-12-09 2006-12-15 Yeda Res & Dev Palladiumsubstituierte bakteriochlorophyllderivate und deren verwendung
US7045117B2 (en) * 1999-12-01 2006-05-16 Yeda Research And Development Co. Ltd. Method for tumor diagnosis comprising administering of palladium-substituted bacteriochlorophyll derivatives
IL133253A0 (en) * 1999-12-01 2001-04-30 Yeda Res & Dev Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them
WO2002013820A1 (en) * 2000-08-11 2002-02-21 Ceramoptec Industries, Inc. Photosensitizing ointment
RU2183956C1 (ru) * 2001-03-30 2002-06-27 Общество с ограниченной ответственностью "РАДА-ФАРМА" Фотосенсибилизатор и способ его получения
EP1277470A1 (fr) * 2001-07-17 2003-01-22 Steba Biotech N.V. Formulation galénique injectable pour utilisation dans un diagnostic ou une thérapie photodynamique et son procédé de préparation
IL148921A0 (en) * 2002-03-26 2002-09-12 Peptor Ltd Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy
RU2343829C2 (ru) * 2002-05-08 2009-01-20 Йеда Рисерч Энд Дивелопмент Ко. Лтд Сенсибилизированный оперативный bold-mri способ получения изображения
CN2595398Y (zh) 2002-09-25 2003-12-31 王健 动态加静态磁脉冲理疗仪
IL152900A0 (en) * 2002-11-17 2003-06-24 Yeda Res & Dev Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses
CA2437638A1 (en) 2003-08-20 2005-02-20 John Robert North Photodynamic therapy
CA2457214A1 (en) 2004-02-06 2005-08-06 Qlt Inc. Photodynamic therapy for the treatment of acne
WO2005120572A1 (en) 2004-06-09 2005-12-22 Qlt Inc. Photodynamic therapy for the treatment of hyperactive sebaceous gland disorders using topically applied hydrophobic green porphyrins
ZA200700169B (en) * 2004-06-07 2008-05-28 Yeda Res & Dev Cationic bacteriochlorophyll derivatives and uses thereof
AU2007282846A1 (en) * 2006-08-07 2008-02-14 Kodesh S.A Tetraarylporphine derivatives and uses thereof
PT2061512T (pt) * 2006-08-23 2020-01-14 Yeda Res & Dev Conjugados de péptidos com rgd e fotossensibilizantes de (bacterio)clorofila e as suas utilizações
KR20090113908A (ko) * 2007-02-23 2009-11-02 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 금속단백질 활성 억제용 항체 및 이를 함유하는 약학적 조성물
US20090036952A1 (en) 2007-07-30 2009-02-05 National Yang-Ming University Induction driven light module and use thereof
EP2244787A1 (en) * 2008-01-28 2010-11-03 Yeda Research And Development Company Ltd. Endoscopic imaging photodynamic therapy system and methods of use
AU2009219682B2 (en) 2008-02-27 2015-06-18 Yeda Research & Development Co. Ltd RGD-(bacterio)chlorophyll conjugates for photodynamic therapy and imaging of necrotic tumors
RU2415868C1 (ru) * 2009-09-10 2011-04-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Производные гемина, обладающие антимикробной активностью, или их фармацевтически приемлемые соли, способ получения, фармкомпозиция и применение
CN102584837A (zh) * 2012-01-18 2012-07-18 河北联合大学 天然叶绿素铁铬盐及制备方法
CN103405769A (zh) * 2013-03-07 2013-11-27 北京亿仁赛博医疗科技研发中心有限公司 光敏剂在制备治疗疾病的病毒灭活药物中的应用
ES2849427T3 (es) 2013-03-11 2021-08-18 Tookad Ip Sarl Método de producción de bacterioclorofila A
CN109679110B (zh) * 2018-12-25 2020-10-09 北京科技大学 一种基于菌绿素的纳米金属-有机框架光敏剂及制备方法
CN114005684B (zh) * 2021-11-05 2023-05-05 吉林大学 不饱和叶绿素的电化学聚合薄膜及其在超级电容器上的应用
WO2025191568A1 (en) * 2024-03-13 2025-09-18 Impact Biotech Ltd Process for preparing bacteriopheophorbide a

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171741A (en) * 1989-04-21 1992-12-15 Health Research, Inc. Bacteriochlorophyll-a derivatives useful in photodynamic therapy
DE4121876A1 (de) 1991-07-02 1993-01-14 Scheer Hugo Modifizierte bakteriochlorophylle, verfahren zu ihrer herstellung und ihre verwendung
IL102645A (en) 1992-07-26 1998-02-22 Yeda Res & Dev Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
US5591847A (en) * 1994-05-23 1997-01-07 Health Research, Inc. Long wavelength absorbing photosensitizers related to purpurin-18, bacteriopurpurin-18 and related compounds with imide linkages

Also Published As

Publication number Publication date
US6333319B1 (en) 2001-12-25
HUP9903582A3 (en) 2002-02-28
NO323478B1 (no) 2007-05-21
MX9804143A (es) 1998-09-30
PT863903E (pt) 2007-09-07
DE69637149D1 (de) 2007-08-09
PL188811B1 (pl) 2005-04-29
ES2288757T3 (es) 2008-01-16
IL116126A0 (en) 1996-01-31
WO1997019081A1 (en) 1997-05-29
BR9611452A (pt) 1999-02-17
HU223379B1 (hu) 2004-06-28
PL326745A1 (en) 1998-10-26
NO982348L (no) 1998-07-23
EP0863903B1 (en) 2007-06-27
AU718961B2 (en) 2000-05-04
NO982348D0 (no) 1998-05-22
DK0863903T3 (da) 2007-09-24
AU7585796A (en) 1997-06-11
EP0863903A1 (en) 1998-09-16
CN1207741A (zh) 1999-02-10
RU2193038C2 (ru) 2002-11-20
JP2000500763A (ja) 2000-01-25
DE69637149T2 (de) 2008-02-28
ATE365741T1 (de) 2007-07-15
HUP9903582A2 (hu) 2000-02-28

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