ATE365741T1 - Synthetische metall-substituierte bacteriochloropyllderivate und ihre verwendung - Google Patents

Synthetische metall-substituierte bacteriochloropyllderivate und ihre verwendung

Info

Publication number
ATE365741T1
ATE365741T1 AT96938445T AT96938445T ATE365741T1 AT E365741 T1 ATE365741 T1 AT E365741T1 AT 96938445 T AT96938445 T AT 96938445T AT 96938445 T AT96938445 T AT 96938445T AT E365741 T1 ATE365741 T1 AT E365741T1
Authority
AT
Austria
Prior art keywords
bchl
bacterio
synthetic
metallated
metal
Prior art date
Application number
AT96938445T
Other languages
German (de)
English (en)
Inventor
Avigdor Scherz
Yoram Salomon
Hugo Scheer
Gerhard Hartwich
Alexander Brandis
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of ATE365741T1 publication Critical patent/ATE365741T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT96938445T 1995-11-24 1996-11-24 Synthetische metall-substituierte bacteriochloropyllderivate und ihre verwendung ATE365741T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11612695A IL116126A0 (en) 1995-11-24 1995-11-24 Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them

Publications (1)

Publication Number Publication Date
ATE365741T1 true ATE365741T1 (de) 2007-07-15

Family

ID=11068225

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96938445T ATE365741T1 (de) 1995-11-24 1996-11-24 Synthetische metall-substituierte bacteriochloropyllderivate und ihre verwendung

Country Status (18)

Country Link
US (1) US6333319B1 (2)
EP (1) EP0863903B1 (2)
JP (1) JP2000500763A (2)
CN (1) CN1085211C (2)
AT (1) ATE365741T1 (2)
AU (1) AU718961B2 (2)
BR (1) BR9611452A (2)
DE (1) DE69637149T2 (2)
DK (1) DK0863903T3 (2)
ES (1) ES2288757T3 (2)
HU (1) HU223379B1 (2)
IL (1) IL116126A0 (2)
MX (1) MX9804143A (2)
NO (1) NO323478B1 (2)
PL (1) PL188811B1 (2)
PT (1) PT863903E (2)
RU (1) RU2193038C2 (2)
WO (1) WO1997019081A1 (2)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413436B1 (en) * 1999-01-27 2002-07-02 Semitool, Inc. Selective treatment of the surface of a microelectronic workpiece
ATE347554T1 (de) * 1998-12-09 2006-12-15 Yeda Res & Dev Palladiumsubstituierte bakteriochlorophyllderivate und deren verwendung
US7045117B2 (en) * 1999-12-01 2006-05-16 Yeda Research And Development Co. Ltd. Method for tumor diagnosis comprising administering of palladium-substituted bacteriochlorophyll derivatives
IL133253A0 (en) * 1999-12-01 2001-04-30 Yeda Res & Dev Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them
WO2002013820A1 (en) * 2000-08-11 2002-02-21 Ceramoptec Industries, Inc. Photosensitizing ointment
RU2183956C1 (ru) * 2001-03-30 2002-06-27 Общество с ограниченной ответственностью "РАДА-ФАРМА" Фотосенсибилизатор и способ его получения
EP1277470A1 (fr) * 2001-07-17 2003-01-22 Steba Biotech N.V. Formulation galénique injectable pour utilisation dans un diagnostic ou une thérapie photodynamique et son procédé de préparation
IL148921A0 (en) * 2002-03-26 2002-09-12 Peptor Ltd Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy
RU2343829C2 (ru) * 2002-05-08 2009-01-20 Йеда Рисерч Энд Дивелопмент Ко. Лтд Сенсибилизированный оперативный bold-mri способ получения изображения
CN2595398Y (zh) 2002-09-25 2003-12-31 王健 动态加静态磁脉冲理疗仪
IL152900A0 (en) * 2002-11-17 2003-06-24 Yeda Res & Dev Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses
CA2437638A1 (en) 2003-08-20 2005-02-20 John Robert North Photodynamic therapy
CA2457214A1 (en) 2004-02-06 2005-08-06 Qlt Inc. Photodynamic therapy for the treatment of acne
WO2005120572A1 (en) 2004-06-09 2005-12-22 Qlt Inc. Photodynamic therapy for the treatment of hyperactive sebaceous gland disorders using topically applied hydrophobic green porphyrins
ZA200700169B (en) * 2004-06-07 2008-05-28 Yeda Res & Dev Cationic bacteriochlorophyll derivatives and uses thereof
AU2007282846A1 (en) * 2006-08-07 2008-02-14 Kodesh S.A Tetraarylporphine derivatives and uses thereof
PT2061512T (pt) * 2006-08-23 2020-01-14 Yeda Res & Dev Conjugados de péptidos com rgd e fotossensibilizantes de (bacterio)clorofila e as suas utilizações
KR20090113908A (ko) * 2007-02-23 2009-11-02 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 금속단백질 활성 억제용 항체 및 이를 함유하는 약학적 조성물
US20090036952A1 (en) 2007-07-30 2009-02-05 National Yang-Ming University Induction driven light module and use thereof
EP2244787A1 (en) * 2008-01-28 2010-11-03 Yeda Research And Development Company Ltd. Endoscopic imaging photodynamic therapy system and methods of use
AU2009219682B2 (en) 2008-02-27 2015-06-18 Yeda Research & Development Co. Ltd RGD-(bacterio)chlorophyll conjugates for photodynamic therapy and imaging of necrotic tumors
RU2415868C1 (ru) * 2009-09-10 2011-04-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Производные гемина, обладающие антимикробной активностью, или их фармацевтически приемлемые соли, способ получения, фармкомпозиция и применение
CN102584837A (zh) * 2012-01-18 2012-07-18 河北联合大学 天然叶绿素铁铬盐及制备方法
CN103405769A (zh) * 2013-03-07 2013-11-27 北京亿仁赛博医疗科技研发中心有限公司 光敏剂在制备治疗疾病的病毒灭活药物中的应用
ES2849427T3 (es) 2013-03-11 2021-08-18 Tookad Ip Sarl Método de producción de bacterioclorofila A
CN109679110B (zh) * 2018-12-25 2020-10-09 北京科技大学 一种基于菌绿素的纳米金属-有机框架光敏剂及制备方法
CN114005684B (zh) * 2021-11-05 2023-05-05 吉林大学 不饱和叶绿素的电化学聚合薄膜及其在超级电容器上的应用
WO2025191568A1 (en) * 2024-03-13 2025-09-18 Impact Biotech Ltd Process for preparing bacteriopheophorbide a

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171741A (en) * 1989-04-21 1992-12-15 Health Research, Inc. Bacteriochlorophyll-a derivatives useful in photodynamic therapy
DE4121876A1 (de) 1991-07-02 1993-01-14 Scheer Hugo Modifizierte bakteriochlorophylle, verfahren zu ihrer herstellung und ihre verwendung
IL102645A (en) 1992-07-26 1998-02-22 Yeda Res & Dev Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
US5591847A (en) * 1994-05-23 1997-01-07 Health Research, Inc. Long wavelength absorbing photosensitizers related to purpurin-18, bacteriopurpurin-18 and related compounds with imide linkages

Also Published As

Publication number Publication date
US6333319B1 (en) 2001-12-25
HUP9903582A3 (en) 2002-02-28
NO323478B1 (no) 2007-05-21
MX9804143A (es) 1998-09-30
PT863903E (pt) 2007-09-07
DE69637149D1 (de) 2007-08-09
PL188811B1 (pl) 2005-04-29
ES2288757T3 (es) 2008-01-16
IL116126A0 (en) 1996-01-31
WO1997019081A1 (en) 1997-05-29
BR9611452A (pt) 1999-02-17
HU223379B1 (hu) 2004-06-28
PL326745A1 (en) 1998-10-26
NO982348L (no) 1998-07-23
CN1085211C (zh) 2002-05-22
EP0863903B1 (en) 2007-06-27
AU718961B2 (en) 2000-05-04
NO982348D0 (no) 1998-05-22
DK0863903T3 (da) 2007-09-24
AU7585796A (en) 1997-06-11
EP0863903A1 (en) 1998-09-16
CN1207741A (zh) 1999-02-10
RU2193038C2 (ru) 2002-11-20
JP2000500763A (ja) 2000-01-25
DE69637149T2 (de) 2008-02-28
HUP9903582A2 (hu) 2000-02-28

Similar Documents

Publication Publication Date Title
ATE365741T1 (de) Synthetische metall-substituierte bacteriochloropyllderivate und ihre verwendung
US4830716B1 (en) Preparation of pharmaceutical grade amino acid chelates
Kizilcikli et al. Antimicrobial activity of a series of thiosemicarbazones and their ZnII and PdII complexes
DE3687399D1 (de) Porphyrinderivate, ihre herstellung und verwendung.
CA2045843A1 (en) Process for the preparation of dialkyl carbonates
EP0266182A3 (en) Gamma-lactonecarboxylic acid derivatives and their production
RU95117718A (ru) Катализатор и способ получения азота из аммиаксодержащего отходящего газа
GR3022020T3 (en) Acid rain abatement
YU44579B (en) Process for amicazine synthesis
IL78341A (en) Method of preparing 2,3,6-trichloropyridine and 2,3,5,6-tetrachloropyridine in the gas phase
RU96121458A (ru) Способ каталитического связывания двуокиси углерода
EP0787732A3 (en) Phthalocyanines
CA2046313A1 (en) Platinum (ii) complex and agent for treating malignant tumor
Yusuff et al. Synthesis of new mixed ligand complexes of copper (II) dithiocarbamates
Rakha et al. Ligational, thermal, corrosion inhibition and antimicrobial properties of salicylidinebenzenesulphonylhydrazone
Loeb Luschow et al. A VIOLET MIXED-VALENCE COPPER MERCAPTOETHYLAMINE COMPLEX GENERATED ELECTROCHEMICALLY OR BY REVERSIBLE INTERACTION WITH OXYGEN
PL234152A1 (2)
SU1664794A1 (ru) Способ получени 2,2 @ ,4-триметил-1,3-дитиолана
Sagiyama et al. Fe--Zn Alloying Behavior and the Coating Microstructure of Galvannealed Steel Sheets
Gaete et al. Complexes of N-methyl-4-mercaptopiperidine with some metal ions
Adeyemo et al. A cobalt (II) complex of vitamin B1
UA43783A (uk) Глутамілтриптофан металокомплекси, що проявляють імуностимулюючі властивості та спосіб їх одержання
CA2237056A1 (en) Synthetic metal-substituted bacteriochlorophyll derivatives and use thereof
Hasegawa et al. Reduction of ferri-protoporphyrin IX dimethyl ester by the 1, 2-dihydropyridine type redox resin
Rinaldi et al. Synthesis and chromatographic properties of Se-carboxymethyl-selenocysteamine (carboxymethyl, 2-aminoethyl selenide)

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0863903

Country of ref document: EP

REN Ceased due to non-payment of the annual fee