ATE347554T1 - Palladiumsubstituierte bakteriochlorophyllderivate und deren verwendung - Google Patents

Palladiumsubstituierte bakteriochlorophyllderivate und deren verwendung

Info

Publication number
ATE347554T1
ATE347554T1 AT99958470T AT99958470T ATE347554T1 AT E347554 T1 ATE347554 T1 AT E347554T1 AT 99958470 T AT99958470 T AT 99958470T AT 99958470 T AT99958470 T AT 99958470T AT E347554 T1 ATE347554 T1 AT E347554T1
Authority
AT
Austria
Prior art keywords
palladium
substituted
derivatives
bacteriochlorophyl
ch2oh
Prior art date
Application number
AT99958470T
Other languages
English (en)
Inventor
Avigdor Scherz
Yoram Salomon
Alexander Brandis
Hugo Scheer
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of ATE347554T1 publication Critical patent/ATE347554T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT99958470T 1998-12-09 1999-12-09 Palladiumsubstituierte bakteriochlorophyllderivate und deren verwendung ATE347554T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98403110 1998-12-09

Publications (1)

Publication Number Publication Date
ATE347554T1 true ATE347554T1 (de) 2006-12-15

Family

ID=8235584

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99958470T ATE347554T1 (de) 1998-12-09 1999-12-09 Palladiumsubstituierte bakteriochlorophyllderivate und deren verwendung

Country Status (22)

Country Link
US (1) US6569846B1 (de)
EP (1) EP1137411B1 (de)
JP (1) JP4796227B2 (de)
CN (1) CN1160069C (de)
AT (1) ATE347554T1 (de)
AU (1) AU771292B2 (de)
BR (1) BRPI9916096B8 (de)
CA (1) CA2353554C (de)
CY (1) CY1106450T1 (de)
DE (1) DE69934328T2 (de)
DK (1) DK1137411T3 (de)
ES (1) ES2277454T3 (de)
HK (1) HK1040638B (de)
HU (1) HU228208B1 (de)
IL (1) IL143591A0 (de)
NO (1) NO331426B1 (de)
NZ (1) NZ512093A (de)
PL (1) PL201172B1 (de)
PT (1) PT1137411E (de)
RU (1) RU2234508C2 (de)
SI (1) SI1137411T1 (de)
WO (1) WO2000033833A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7897140B2 (en) * 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
EP1318807A4 (de) * 2000-08-11 2008-02-20 Ceramoptec Gmbh Lichtsensibilisierende salbe
EP1277470A1 (de) * 2001-07-17 2003-01-22 Steba Biotech N.V. Injizierbare galenische Zubereitung zur Anwendung in einer photodynamischen Therapie oder Diagnose und Verfahren zu ihrer Herstellung
US7715901B2 (en) * 2002-05-08 2010-05-11 Yeda Research And Development Co. Ltd. Sensitized online BOLD-MRI imaging method
JP4529344B2 (ja) * 2002-06-03 2010-08-25 ニプロ株式会社 腫瘍組織の酸素濃度を上昇させるためのポルフィリン酸素輸液製剤
DE60328496D1 (en) 2002-06-27 2009-09-03 Health Research Inc Fluorinierte chlorin und bacteriochlorin photosensitizer für fotodynamische therapie
EP2036908A3 (de) * 2002-07-02 2009-05-13 Health Research, INC. Effiziente Synthese von Pyropheophorbid-A-Derivaten
IL152900A0 (en) * 2002-11-17 2003-06-24 Yeda Res & Dev Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses
RU2257898C1 (ru) * 2004-03-22 2005-08-10 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Фотосенсибилизатор, липосомальная форма фотосенсибилизатора и способ проведения фотодинамической терапии
AU2005251556B2 (en) * 2004-06-07 2011-04-14 Yeda Research And Development Co. Ltd. Cationic bacteriochlorophyll derivatives and uses thereof
GB2415372A (en) * 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
US20060222592A1 (en) * 2005-04-05 2006-10-05 Clemens Burda Nanoparticles and methods of manufacturing nanoparticles for electronic and non-electronic applications
EP2244787A1 (de) * 2008-01-28 2010-11-03 Yeda Research And Development Company Ltd. Fotodynamisches therapiesystem mit endoskopabbildung und einsatzverfahren
US8815213B2 (en) 2008-02-27 2014-08-26 Yeda Research And Development Co. Ltd. RGD-(bacterio)chlorophyll conjugates for photodynamic therapy and Imaging of Necrotic tumors
US20110070154A1 (en) * 2008-08-13 2011-03-24 Hyde Roderick A Artificial cells
GB0819594D0 (en) 2008-10-24 2008-12-03 Univ Coimbrra Process
EP2425873A1 (de) 2010-09-07 2012-03-07 Steba Maor SA Modellierung der Wirkung einer Glasfaser in einer Behandlung durch photodynamische Therapie, und Unterstützung der Planung einer solchen Behandlung
CN103405769A (zh) * 2013-03-07 2013-11-27 北京亿仁赛博医疗科技研发中心有限公司 光敏剂在制备治疗疾病的病毒灭活药物中的应用
WO2014140786A1 (en) 2013-03-11 2014-09-18 Steba Biotech S.A. Method for producing bacteriochlorophyll a
CN105377862B (zh) 2013-03-15 2019-09-13 希瑞·安·麦克法兰 用作光动力化合物的金属基配合物及其用途
SG11201808849TA (en) 2016-04-10 2018-11-29 Yeda Res & Dev Combinational therapies for treatment of cancer comprising a bacteriochlorophyll derivative
US10933134B2 (en) 2017-03-16 2021-03-02 Memorial Sloan Kettering Cancer Center Combination therapies for treatment of cancer
IL311461B1 (en) * 2024-03-13 2026-01-01 Impact Biotech Ltd Process for preparing palladium-bacteriophophorbide derivatives and their alkali metal salts

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002962A (en) * 1988-07-20 1991-03-26 Health Research, Inc. Photosensitizing agents
US5171741A (en) * 1989-04-21 1992-12-15 Health Research, Inc. Bacteriochlorophyll-a derivatives useful in photodynamic therapy
IL102645A (en) * 1992-07-26 1998-02-22 Yeda Res & Dev Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
RU2063971C1 (ru) * 1993-11-05 1996-07-20 Московская государственная академия тонкой химической технологии им.М.В.Ломоносова Способ получения производного гематопорфирина
IL115744A (en) * 1994-10-27 2000-07-16 Akzo Nobel Nv Peptides comprising a subsequence of human cartilage glycoprotein - 39
IL116126A0 (en) * 1995-11-24 1996-01-31 Yeda Res & Dev Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
NO331426B1 (no) 2011-12-27
HUP0105411A2 (hu) 2002-04-29
BR9916096A (pt) 2001-11-13
JP2002531497A (ja) 2002-09-24
BR9916096B1 (pt) 2013-11-19
RU2234508C2 (ru) 2004-08-20
PL348201A1 (en) 2002-05-06
ES2277454T3 (es) 2007-07-01
DE69934328D1 (de) 2007-01-18
HK1040638A1 (en) 2002-06-21
AU1583400A (en) 2000-06-26
CA2353554A1 (en) 2000-06-15
DK1137411T3 (da) 2007-03-26
HU228208B1 (en) 2013-01-28
IL143591A0 (en) 2002-04-21
CN1160069C (zh) 2004-08-04
HUP0105411A3 (en) 2003-12-29
DE69934328T2 (de) 2007-07-19
NO20012807D0 (no) 2001-06-07
PL201172B1 (pl) 2009-03-31
BRPI9916096B8 (pt) 2021-05-25
SI1137411T1 (sl) 2007-10-31
HK1040638B (en) 2007-06-15
CA2353554C (en) 2011-04-26
PT1137411E (pt) 2007-02-28
EP1137411A1 (de) 2001-10-04
EP1137411A4 (de) 2003-04-23
CY1106450T1 (el) 2011-10-12
NZ512093A (en) 2003-04-29
WO2000033833A1 (en) 2000-06-15
JP4796227B2 (ja) 2011-10-19
NO20012807L (no) 2001-08-08
EP1137411B1 (de) 2006-12-06
CN1334728A (zh) 2002-02-06
US6569846B1 (en) 2003-05-27
AU771292B2 (en) 2004-03-18

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