CN1090275A - 咪唑羧酸类作血管紧张肽ii受体拮抗剂的前药 - Google Patents

咪唑羧酸类作血管紧张肽ii受体拮抗剂的前药 Download PDF

Info

Publication number
CN1090275A
CN1090275A CN93117634A CN93117634A CN1090275A CN 1090275 A CN1090275 A CN 1090275A CN 93117634 A CN93117634 A CN 93117634A CN 93117634 A CN93117634 A CN 93117634A CN 1090275 A CN1090275 A CN 1090275A
Authority
CN
China
Prior art keywords
alkyl
methyl
alkoxyl group
group
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN93117634A
Other languages
English (en)
Chinese (zh)
Inventor
R·J·阿德基
J·R·普卢伊特
C·L·恩辛格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of CN1090275A publication Critical patent/CN1090275A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN93117634A 1992-08-06 1993-08-06 咪唑羧酸类作血管紧张肽ii受体拮抗剂的前药 Pending CN1090275A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US926,795 1992-08-06
US07/926,795 US5310929A (en) 1992-08-06 1992-08-06 Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists

Publications (1)

Publication Number Publication Date
CN1090275A true CN1090275A (zh) 1994-08-03

Family

ID=25453732

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93117634A Pending CN1090275A (zh) 1992-08-06 1993-08-06 咪唑羧酸类作血管紧张肽ii受体拮抗剂的前药

Country Status (18)

Country Link
US (1) US5310929A (2)
EP (1) EP0654027A1 (2)
JP (1) JP2892838B2 (2)
CN (1) CN1090275A (2)
AU (1) AU688735B2 (2)
BR (1) BR9306911A (2)
CA (1) CA2141692C (2)
FI (1) FI950485A0 (2)
HU (1) HU9500349D0 (2)
IL (1) IL106553A0 (2)
MX (1) MX9304787A (2)
NO (1) NO950404D0 (2)
PL (1) PL307309A1 (2)
SG (1) SG47108A1 (2)
SK (1) SK13195A3 (2)
TW (1) TW239131B (2)
WO (1) WO1994003435A1 (2)
ZA (1) ZA935693B (2)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
JP3501484B2 (ja) * 1992-12-17 2004-03-02 三共株式会社 ビフェニル誘導体
WO1995024902A1 (en) * 1994-03-16 1995-09-21 Sankyo Company, Limited Ocular tension depressant
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
US5510495A (en) * 1994-09-19 1996-04-23 The Du Pont Merck Pharmaceutical Company Process for the isolation and purification of ester functionalized imidazole intermediates by selective hydrolysis
EP0782996B1 (en) * 1994-09-20 1999-02-17 Wakunaga Seiyaku Kabushiki Kaisha Process for producing n-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same
IT1292437B1 (it) 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
IT1295405B1 (it) 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
DE19820064A1 (de) * 1998-05-06 1999-11-11 Hoechst Marion Roussel De Gmbh Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19832429A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832428A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ES2154191B1 (es) * 1998-11-24 2001-10-16 Ferrer Int Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos.
GR20000100281A (el) * 2000-08-17 2002-05-24 Ιωαννης Ματσουκας Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων
DE60222409T2 (de) 2001-05-31 2008-09-25 Vicore Pharma Ab Trizyklische verbindungen, nützlich als angiotensin ii agonisten
WO2004065383A2 (en) * 2003-01-16 2004-08-05 Teva Pharmaceutical Industries Ltd. Novel synthesis of irbesartan
ES2390967T3 (es) 2004-01-20 2012-11-20 Aichi Prefecture Epítopo/péptido reconocido por LTC específico para Ep-CAM con restricción por ALH-A2402 y su utilización
US7157584B2 (en) * 2004-02-25 2007-01-02 Takeda Pharmaceutical Company Limited Benzimidazole derivative and use thereof
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
WO2006029057A1 (en) * 2004-09-02 2006-03-16 Teva Pharmaceutical Industries, Ltd. Purification of olmesartan medoxomil
AU2006240247A1 (en) * 2005-04-20 2006-11-02 Merck Sharp & Dohme Corp. Angiotensin II receptor antagonists
ES2302671T1 (es) * 2006-08-29 2008-08-01 Teva Pharmaceutical Industries Ltd. Procedimientos para la sintesis de 5-fenil-1-tritil-1h-tetrazol.
JP5269798B2 (ja) * 2006-10-09 2013-08-21 シプラ・リミテッド トリチルオルメサルタンメドキソミルおよびオルメサルタンメドキソミルの製造方法
AU2006351517B8 (en) * 2006-12-06 2012-01-19 Shenzhen Salubris Pharmaceuticals Co., Ltd. The salts of imidazol-5-carboxylic acid derivatives, preparation methods and use thereof
ES2768295T3 (es) * 2010-01-07 2020-06-22 Alkermes Pharma Ireland Ltd Profármacos de compuestos heteroaromáticos
EP2455388A1 (en) 2010-11-23 2012-05-23 LanthioPep B.V. Novel angiotensin type 2 (AT2) receptor agonists and uses thereof.
CN111018841B (zh) * 2013-11-01 2023-04-07 深圳信立泰药业股份有限公司 阿利沙坦酯无定形及其制备方法及含所述无定形的药物组合物
WO2021023698A1 (en) 2019-08-02 2021-02-11 Lanthiopep B.V Angiotensin type 2 (at2) receptor agonists for use in the treatment of cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
HU217958B (hu) * 1989-06-30 2000-05-28 E. I. Du Pont De Nemours And Co. Helyettesített imidazolszármazékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
EP0479892A1 (en) * 1989-06-30 1992-04-15 E.I. Du Pont De Nemours And Company Fused-ring aryl substituted imidazoles
GB8927277D0 (en) * 1989-12-01 1990-01-31 Glaxo Group Ltd Chemical compounds
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5137902A (en) * 1990-07-13 1992-08-11 E. I. Du Pont De Nemours And Company 4-alkylimidazole derivatives and anti-hypertensive use thereof
EP0573218B1 (en) * 1992-06-02 2001-03-07 Sankyo Company Limited 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use

Also Published As

Publication number Publication date
JPH08500103A (ja) 1996-01-09
WO1994003435A1 (en) 1994-02-17
ZA935693B (en) 1995-02-06
AU4790393A (en) 1994-03-03
JP2892838B2 (ja) 1999-05-17
MX9304787A (es) 1995-01-31
SK13195A3 (en) 1995-07-11
PL307309A1 (en) 1995-05-15
NO950404D0 (no) 1995-02-03
FI950485L (fi) 1995-02-03
TW239131B (2) 1995-01-21
IL106553A0 (en) 1993-12-08
HU9500349D0 (en) 1995-03-28
EP0654027A1 (en) 1995-05-24
FI950485A7 (fi) 1995-02-03
US5310929A (en) 1994-05-10
AU688735B2 (en) 1998-03-19
FI950485A0 (fi) 1995-02-03
SG47108A1 (en) 1998-03-20
CA2141692C (en) 2006-05-30
CA2141692A1 (en) 1994-02-17
BR9306911A (pt) 1998-12-08

Similar Documents

Publication Publication Date Title
CN1151155C (zh) 1,5-二氢-吡唑并[3,4-d]-嘧啶酮衍生物
CN1036263C (zh) 取代的唑类化合物的制备方法
CN1031057C (zh) 制备三唑[4，3-a][1，4]苯并二氮杂䓬和噻吩并[3，2-f][1，2，4]三唑并[43-9][1，4]二氮杂䓬的方法
CN1031570C (zh) 吡唑并吡啶化合物的制备方法
CN1183134C (zh) 三环后叶加压素激动剂
CN1037440C (zh) 血管紧张素ⅱ受体阻断剂2,3,6取代的喹唑啉酮的制造方法
CN1097753A (zh) 五员杂环、制备方法以及含有这些化合物的药物组合物
CN1073174A (zh) 杂环衍生物
CN86108308A (zh) 杂环氧代-2，3-二氮杂萘基乙酸
CN1890218A (zh) 微管蛋白抑制剂
CN1079468A (zh) 磺酰胺内皮素拮抗剂
CN1147515A (zh) 制备2-乙氧基-1-[[2'-(1h-四唑-5-基)联苯-4-基]甲基]苯并咪唑-7-羧酸1-(环己基氧基羰基氧基)乙酯的晶体的方法
CN1079649A (zh) 制备含咪唑基链烯酸的药物组合物的方法
CN1248251A (zh) 二取代双环杂环,其制备法及作为药物的用途
CN1099755A (zh) 环状衍生物、含该衍生物的药物组合物及制备方法
CN1040755C (zh) 杂环化合物的制备方法
CN1656086A (zh) 苯并呋喃衍生物
CN1155599C (zh) 三环三唑并苯并氮杂�衍生物、用于制备该衍生物的方法和抗变态反应剂
CN1875015A (zh) 苯并[b][1,4]二氧杂环庚三烯衍生物
CN1471521A (zh) 氨基烷基苯甲酰基-苯并呋喃或苯并噻吩类,它们的制备方法与含有它们的组合物
CN1061410A (zh) 取代吡咯，其制备方法，包含取代吡咯的制剂及其应用
CN1413205A (zh) 具有抗肿瘤活性的2－(1h－吲哚－3－基)－2－氧代－乙酰胺
CN1054066A (zh) 对及有关白三烯拮抗剂的改进
CN1064044C (zh) 杂环化合物，其制备及应用
HK1041264B (zh) 咪唑化合物及其作为腺苷脱氨酶抑制剂的用途

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication